Memorial Sloan Kettering Cancer Center

This study tests a three-drug combination (ivosidenib, azacitidine, and venetoclax) followed by maintenance therapy with ivosidenib alone in people aged 60 and older with newly diagnosed acute myeloid leukemia that has an IDH1 mutation. The goal is to see if this approach helps k…

This study tests a two-part vaccine (bivalent vaccine with OPT-821 adjuvant) plus an oral immune booster (β-glucan) in 94 people with high-risk neuroblastoma that is in complete remission. The goal is to see which schedule of β-glucan helps the vaccine produce stronger antibodies…

This study tests whether the drug ulixertinib is safe and works for people with histiocytic neoplasms, a rare group of blood disorders. About 38 adults will take the drug and be monitored for tumor shrinkage and side effects. The goal is to see if the drug can control the disease…

This early-phase trial tests a new treatment for people with a type of stomach cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to target cancer cells and then given directly into the abdomen. The ma…

This study tests whether a drug called BV, combined with standard chemotherapy (AVD), works better than standard treatment alone for people with newly diagnosed, early stage, bulky Hodgkin lymphoma. BV targets and kills cancer cells with a specific marker (CD30), while AVD stops …

This study tests a chemotherapy plan called N10 for children with high-risk neuroblastoma, a serious nerve cell cancer. The goal is to see if it works well and is safe enough to use as a first treatment. About 45 children under 19 with newly diagnosed high-risk neuroblastoma will…

This study tests the safety and effectiveness of combining two drugs, lorlatinib and ramucirumab, for people with advanced ALK-rearranged non-small cell lung cancer. About 56 participants will receive different doses to find the best one with the fewest side effects. The goal is …

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, can clear remaining cancer DNA in people with colorectal cancer who still have signs of disease after surgery and chemotherapy. About 284 adults with microsatellite stable colorectal cancer or liver m…

This study tests whether a daily pill called isoquercetin (a natural compound found in fruits) can reduce blood markers linked to dangerous clots in people with ovarian cancer. About 90 participants receiving first-line chemotherapy will take either isoquercetin or a placebo for …

This early-phase study tests the safety of a new drug, BMS-986504, when given with standard cancer treatments. It is for people with advanced mesothelioma, stomach/esophageal cancer, or bladder cancer that has a specific genetic change (MTAP deletion). The goal is to find the bes…

This study tests a drug called mirdametinib in people with certain brain or spinal cord tumors (gliomas). The goal is to see if it is safe and can shrink or control the tumors. About 26 adults will take part, and the drug works by blocking a specific pathway that helps tumors gro…

This early-phase study is testing whether adding two immunotherapy drugs (cemiplimab and cetuximab) to standard chemotherapy before surgery is safe and effective for people with advanced head and neck cancer. The goal is to see if this approach might allow patients to skip radiat…

This study tests whether giving lower doses of radiation over a shorter time, along with standard chemotherapy, can effectively treat HPV-positive throat cancer. About 74 participants will receive this experimental treatment to see if it controls the cancer as well as the usual h…

This study compares the usual treatment (osimertinib) with osimertinib plus chemotherapy in people with advanced EGFR-mutant lung cancer. Researchers want to see if the combination can better stop the cancer from growing or spreading. About 571 adults with detectable cancer DNA i…

This study tests whether enzalutamide, alone or with mifepristone, can control advanced breast cancer that is androgen receptor-positive and triple-negative or low in estrogen receptors. About 201 adults with this aggressive cancer will be randomly assigned to one of these drug c…

This study tests whether the drug talquetamab can improve outcomes for people with multiple myeloma who have already received a type of CAR T-cell therapy called ide-cel. About 17 participants will receive talquetamab as a follow-up treatment. The goal is to see if this approach …

This study tests two new drug combinations (ivonescimab with Dato-DXd or osimertinib) in people with advanced EGFR-mutant non-small cell lung cancer that has stopped responding to standard treatments. The goal is to find the safest dose and see if the combinations can shrink tumo…

This study tests whether two drugs, azacitidine and venetoclax, can eliminate or reduce tiny amounts of leukemia that remain after standard chemotherapy in adults with acute myeloid leukemia (AML). Participants will receive the drug combination before undergoing a donor stem cell…

This early-phase study tests whether adding abemaciclib to the standard drug ruxolitinib is safe and effective for people with myelofibrosis, a type of bone marrow cancer. About 18 adults who have been on ruxolitinib for at least 12 weeks will take both drugs. The main goal is to…

This study tests a radioactive drug called I-MIBG in people with neuroblastoma or related tumors that have not responded to standard treatments. The drug targets cancer cells and delivers radiation directly to them. Researchers want to see if it can shrink tumors and how safe it …

This study is for people with breast or lung cancer that has spread to 1 to 5 spots in the body. It tests whether giving a special, high-dose radiation treatment (SBRT) to all those spots, along with standard care, can keep the cancer from getting worse longer than standard care …

This early-phase study tests whether combining valemetostat with atezolizumab is safe for people with extensive-stage small cell lung cancer. Researchers will find the best dose of valemetostat and check for side effects. The goal is to control the cancer after initial treatment,…

This study tests whether Ivonescimab can shrink or control advanced leiomyosarcoma that cannot be removed by surgery. About 20 adults who have already tried 1 to 3 other treatments will receive the drug. The goal is to see if it is safe and effective with fewer side effects.

This study tests whether giving a personalized dose of the chemotherapy drug fludarabine before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (B-ALL). About 130 participants will be randoml…

This study compares standard chemotherapy (gemcitabine and oxaliplatin) alone versus adding a liver-directed treatment (HAI FUDR/dexamethasone) for people with bile duct cancer that has spread only to the liver and can't be surgically removed. The goal is to see if the combinatio…

This study tests whether adding a new drug called tinengotinib to standard hormone therapy (abiraterone or enzalutamide) is safe and effective for men with metastatic castration-resistant prostate cancer (mCRPC). About 50 participants will receive the combination to find the best…

This study tests whether a drug called TSR-042, followed by standard chemotherapy and radiation, can shrink or eliminate advanced solid tumors that have a specific genetic flaw (mismatch repair deficiency). About 200 adults with locally advanced tumors that haven't spread will re…

This study is testing whether a special PET scan called 68Ga PSMA-PET/CT can find cancer spots in people with advanced bladder cancer or melanoma that has spread. About 20 participants will get both the new scan and the standard scan to compare. The goal is to see if the new scan…

This study is testing a new PET scan that uses a special form of iodine (iodine-124) to see how much radioactive iodine thyroid cancer tumors absorb. The goal is to help doctors decide if standard radioiodine treatment will work or if another therapy would be better. About 60 adu…

This study tests whether watching an educational video can encourage women to choose a preventive surgery called opportunistic salpingectomy (removal of fallopian tubes) to lower their risk of ovarian cancer. About 266 women aged 45 and older who are already scheduled for non-gyn…

This study tests if placing an antibiotic called Stimulan Rapid Cure directly into the surgical site can lower the chance of infection in women receiving tissue expanders during mastectomy. About 392 women will take part. The goal is to see if this approach reduces infections and…

This study tests whether a comprehensive prevention program can reduce the risk of lymphedema (arm swelling) in women with breast cancer who have lymph nodes removed. About 285 participants will be followed for at least a year. The program focuses on helping lymph fluid drain pro…

This study looks at whether a plant-based diet, omega-3 and curcumin supplements, or a placebo can change gut bacteria in people with MGUS or smoldering multiple myeloma—early conditions that can lead to multiple myeloma. Researchers will measure butyrate levels in stool to see i…

This study is testing a mobile app called TEAMWork that gives breast cancer patients advice on talking to their employers and doctors about work. The goal is to help patients keep their jobs during and after treatment. Researchers are asking about 546 patients to try the app and …

This study tests whether Revaree Plus, a vaginal moisturizer, can help relieve vaginal dryness in women being treated for hormone-receptor-positive breast cancer. About 60 participants will use the product for 8 weeks. Researchers will measure changes in vaginal health using a st…

This study looks at whether different amounts of aerobic exercise can help people with gastrointestinal cancer tolerate chemotherapy better. Researchers want to find a safe and practical exercise level that reduces side effects and helps patients complete their full treatment pla…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. Twenty participants will try the session and report how helpful it was. The goal is to see if this quick support can imp…

This study looks at whether acupuncture is a practical treatment for joint pain in cancer survivors. It will include 60 English- or Spanish-speaking adults from diverse backgrounds who have had cancer and ongoing pain. The main goal is to see if offering acupuncture in community …

This study looks at how different amounts of aerobic exercise (like walking or biking) affect heart and lung fitness in women who have finished treatment for early-stage breast cancer. About 152 post-menopausal women will take part. The goal is to find the best exercise program t…

This study compares two different approaches to help men regain erectile function after prostate cancer surgery. About 224 men who had surgery within the past 9 months will participate. The goal is to see which method leads to better sexual rehabilitation outcomes.

This study tests if giving the drug methylprednisolone before major liver surgery can lower the chance of problems like infections and shorten hospital stays. About 750 adults having planned major liver removal will be randomly assigned to receive either the drug or standard care…

This early study tests a live bacterial treatment called SER-155 for people who have diarrhea and colon inflammation from cancer immunotherapy. The goal is to see if it is safe and can reduce symptoms without needing strong immune-suppressing drugs. About 15 adults will take SER-…

This study compares three types of remote medical interpreting (simultaneous, consecutive, and video) to see which one leads to fewer errors when Spanish- or Mandarin-speaking breast cancer patients talk with their English-speaking doctors. About 700 patients with stage II or III…

This study looks at whether a new type of MRI scan, which uses a special imaging agent called hyperpolarized pyruvate, gives the same results each time it's used in the same person. About 109 people with solid tumors will get two of these scans to check for consistency. The goal …

This study looks at whether a new telehealth option can safely reduce the number of in-person doctor visits for people with breast or prostate cancer. About 1,750 participants from Memorial Sloan Kettering will be split into groups to compare standard care versus enhanced telehea…

This study looks at whether people with unexplained weight loss who are at high risk for lung cancer are more likely to have or develop the disease. Researchers will use low-dose CT scans and blood tests to find lung cancer earlier. The goal is to improve survival by catching can…

This study is testing a questionnaire called PRO-AYA, designed to measure the well-being and quality of life of adolescents and young adults (ages 15-39) with cancer. Researchers want to see if the survey is reliable and works well in both English and Spanish. The goal is to impr…

This study reviews the medical records of about 4000 people who had surgery for esophageal cancer. The goal is to see how the edge of the removed tissue (called the margin) relates to how long patients live and whether the cancer comes back. No new treatments or procedures are gi…

This study tests whether special PET scans can better find where prostate cancer has spread in the body. About 300 men with progressive prostate cancer will get two types of PET scans to see if the new method is more accurate than standard scans. The goal is to improve how doctor…

This study looks at how a protein called Ki67 changes in breast cancer cells after 2 weeks of hormone therapy. Researchers want to see if women with a BRCA2 gene mutation have a different response compared to those without the mutation. About 42 postmenopausal women with ER+/HER2…

This study looks at how lymphedema patients' quality of life changes over time, comparing those who choose surgery (a lymph node transfer) with those who choose non-surgical care. Researchers will follow 600 adults aged 18 to 80 with arm or leg swelling. The goal is to understand…

This study aims to learn more about colorectal cancer in people under 50. Researchers will collect blood, tissue, and stool samples from both patients and healthy volunteers to build a database. The goal is to find clues about what causes this cancer in younger adults. No new tre…

This study creates a database of health information from 500 adults with bone metastases that cause symptoms. Researchers will track how long participants live and collect details about their treatments. The goal is to learn more about the condition to help improve care for futur…

This study aims to safely collect health information from wearable devices and smartphones of up to 3,644 people with solid tumors. Researchers want to see if this data can help understand how cancer affects the body and how patients respond to treatment. The goal is to build a l…

This study tests two noninvasive eye scanners to see which gives clearer images of eye tumors. About 60 adults with an eye tumor will have both scans. The goal is to improve how doctors detect and track these tumors without surgery.

This study tests whether teaching oncology care providers empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. Over 1,200 doctors, nurse practitioners, and physician assistants across the U.S. will be trained and evaluated usi…

This study is adapting a program called CONVO for Spanish-speaking Latinx adults with solid tumors. In the program, nurses have a conversation with each patient about their personal health-related values as part of routine cancer care. The goal is to make sure the program works w…

This study aims to create a simple, less invasive test to find pancreatic cancer at an early stage and monitor how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers in…

This study looks at whether a new test that checks spinal fluid for tumor DNA can find signs of brain relapse in people with aggressive B-cell lymphoma who are at high risk. About 50 participants will provide spinal fluid samples during their first treatment. The goal is to see h…

This study creates a registry of DNA and health information from 750 people with kidney cancer, their family members, and healthy volunteers. The goal is to learn more about how to prevent, find, and treat kidney cancer. Participants provide a blood or saliva sample and answer he…

This study tests a new 3D technology that combines standard medical scans (like CT or MRI) with a 3D image of the patient's head and neck to help surgeons during surgery. About 27 adults scheduled for head and neck surgery at Memorial Sloan Kettering will participate. Researchers…

This study aims to understand why different people have different risks and outcomes for breast cancer. Researchers will collect blood, tissue samples, and survey data from 800 adults in South Florida. The goal is to find genetic and non-genetic factors that may explain these dif…