Memorial Sloan Kettering Cancer Center

This study looked at whether switching from durvalumab to sotorasib can better control locally advanced non-small cell lung cancer in people with a KRAS G12C mutation who still have signs of cancer after chemoradiation. Ten participants were randomly assigned to either switch to …

This study tested two ways to use the drug pomalidomide in people with multiple myeloma that had come back or stopped responding to treatment. All 23 participants first received a combination of clarithromycin, pomalidomide, and dexamethasone (ClaPD). Then, half got a stem cell t…

This study tested two common antibiotics, cefoxitin and piperacillin-tazobactam, to see which one better prevents surgical site infections after a complex pancreatic surgery called pancreatoduodenectomy. About 967 adults having this surgery took part. The goal was to find the mos…

This study tested whether combining two drugs, fulvestrant and abemaciclib, can shrink or control a specific type of uterine cancer (hormone-receptor-positive endometrial cancer). 28 adults with this cancer received the drug combination. The main goal was to see how many patients…

This small pilot study tested a drug called BGJ398 in 4 people with a type of bladder cancer that had returned after standard therapy. The drug targets a specific genetic change in the tumor. The main goal was to see if the tumors would disappear completely after 7 weeks of treat…

This study tested whether giving anti-testosterone medications before, during, and after high-dose, targeted radiation can prevent prostate cancer from returning in men with very high-risk disease. Sixty-four participants received the combination treatment. The main goal was to s…

This study tested the drug ibrutinib, alone or with chemotherapy, in 93 adults with a rare type of brain lymphoma (PCNSL or SCNSL). The goal was to find the safest dose and see if it improves how well the cancer responds to treatment. The trial combined ibrutinib with standard ch…

This study tested whether adding a radioactive drug called radium-223 to standard targeted radiation (SBRT) helps men with prostate cancer that has returned in a few spots but is still hormone-sensitive. Twelve men participated, receiving either SBRT alone or SBRT plus radium-223…

This early study tested a drug called enasidenib in 4 adults with clonal cytopenia of undetermined significance (CCUS) who have a specific IDH2 gene mutation. The goal was to see if the drug could safely improve low blood cell counts. Researchers believe enasidenib may block the …

This study tested whether the drug nivolumab can safely prevent primary central nervous system lymphoma (PCNSL) from returning in patients who still had signs of tumor DNA in their spinal fluid after finishing initial chemotherapy. Fourteen adults with PCNSL received nivolumab as…

This study tested a new type of PET scan (89Zr-DFO-huJ591) to see if it can find prostate cancer that has spread to other parts of the body, especially bones. 77 men with metastatic prostate cancer received both a standard PET scan and the experimental scan. Researchers compared …

This study tested whether a device called Nevisense, which measures electrical signals in the skin, can provide useful information about atypical moles during routine skin cancer screening. Forty adults with many moles (100 or more) and at least three large moles took part. The g…

This study looked at whether family grief therapy helps cancer patients and their families communicate and support each other during palliative care and after the patient's death. 700 families participated, with some receiving standard care and others attending 6 or 10 therapy se…

This early-phase study tested the safety of adding the drug rucaparib to standard radiation therapy for women with triple negative breast cancer who still had cancer after chemotherapy. 31 women participated. The main goal was to find safe dose levels and watch for side effects. …

This study tested whether a 30-week walking program is safe and tolerable for cancer patients who were hospitalized for COVID-19. Only 3 people took part, and the main goal was to see if the exercise caused few or mild side effects. The walking plan was adjusted to each person's …

This study tested whether colesevelam, a medicine used for high cholesterol, could safely reduce diarrhea in people with multiple myeloma who take lenalidomide. 25 participants took colesevelam for 4 weeks. The goal was to see if their diarrhea improved to a mild level or better.

This study tested a special therapy called Managing Anxiety from Cancer (MAC) to see if it helps reduce anxiety in people aged 65 and older who have cancer, and also in their caregivers. The therapy was compared to usual care. The study included 26 participants and focused on imp…

This study tested whether a Community Health Worker program could help at-risk Chinese community members in New York City get lung cancer screening. About 99 people participated, including Chinese immigrants who were current or past smokers. The program was compared to simply giv…

This study looked at anxiety in 126 men who use penile injection therapy after major pelvic surgery. Participants filled out questionnaires before and during training, and at a 4-month follow-up. The goal was to better understand and measure injection-related anxiety.

This study looked at whether a low-dose vaginal estrogen tablet (Vagifem) is safe for women who have had breast cancer and are taking hormone-blocking drugs called aromatase inhibitors. 31 postmenopausal women with a history of breast cancer used the tablet for vaginal dryness, a…

This study tested whether a hyperspectral camera system can measure blood flow and oxygen levels in the skin of healthy volunteers. Eight people aged 18 to 45 took part. The goal was to see if the camera could detect changes when blood vessels tighten or relax. This is early rese…