Memorial Sloan Kettering Cancer Center

This study tests whether giving an extra-high radiation dose directly to the main prostate tumor, plus standard radiation to the rest of the prostate, can cure intermediate-risk prostate cancer or keep it from coming back longer. About 91 men with intermediate-risk prostate cance…

This study tests whether adding the drug nivolumab to standard chemotherapy (ABVD) can improve the chance of cure for people with high-risk Hodgkin lymphoma. It involves 82 participants with untreated stage III or IV disease. The goal is to see if the combination is safe and help…

This study tests whether adding an experimental drug (BMS-986205) to the immunotherapy nivolumab can shrink tumors or stop them from growing in people with endometrial cancer that has come back or not gone away. About 24 adults with certain types of endometrial cancer will receiv…

This study is testing whether combining two immunotherapy drugs, pembrolizumab and BCG, can keep high-risk bladder cancer from coming back. About 45 people with early-stage but aggressive bladder cancer will receive this combination as their first treatment. The goal is to see if…

This early-phase study is testing whether combining two drugs (cabozantinib and nivolumab) with radiation therapy is safe for people whose kidney cancer has spread to the brain. Only 2 participants are enrolled, and the main goal is to see if they can tolerate the treatment witho…

This study tests whether adding daratumumab to three standard drugs (carfilzomib, lenalidomide, dexamethasone) is safe and effective for people newly diagnosed with multiple myeloma. The main goal is to see how many patients achieve minimal residual disease (MRD) negativity, mean…

This study tests the drug pembrolizumab in people with early-stage NK/T-cell lymphoma who have not yet had chemotherapy. The goal is to see if the drug can shrink the cancer. Nineteen participants are enrolled at Memorial Sloan Kettering Cancer Center.

This early-stage study tests whether adding N-acetylcysteine (N-AC), a common supplement, to standard CAR T-cell therapy (Yescarta) is safe for people with lymphoma. The goal is to find the best dose of N-AC that causes few or mild side effects. Nine participants are enrolled in …

This study tests whether adding a drug called Voraxaze (glucarpidase) to the standard treatment of methotrexate and rituximab can safely lower methotrexate levels in the blood of people with central nervous system lymphoma. About 58 participants will receive the combination, and …

This early-phase study tests whether HB-200 can help people with HPV16-positive head and neck cancer who have completed standard treatment but still have signs of HPV DNA in their blood. The blood test (NavDx) suggests microscopic cancer may be present, even though scans and exam…

This study tests whether two drugs, palifermin and leuprolide acetate, can speed up immune system recovery after a stem cell transplant for blood cancers like leukemia and lymphoma. About 82 participants will receive these drugs alongside their transplant. The goal is to see if t…

This early-stage study tests a new treatment for B-cell acute lymphoblastic leukemia (B-ALL) using a patient's own immune cells, called T cells. The T cells are collected from the blood, genetically modified in a lab to recognize and attack leukemia cells, and then infused back i…

This study looks at whether giving precise radiation (SBRT) to tumors that have just started to grow can help people with metastatic triple-negative breast cancer or non-small cell lung cancer live longer without their disease getting worse. About 107 adults took part. The goal i…

This study tests a different, experimental dosing schedule of the chemotherapy drug capecitabine combined with the investigational drug neratinib in people with advanced HER2-positive breast cancer. The goal is to find the safest dose that still works. About 34 adults with stage …

This study tests an experimental drug called ensartinib in people with advanced melanoma that has a specific genetic abnormality (ALK alteration). The goal is to see if the drug can shrink tumors or keep them stable for at least 24 weeks. Participants must have already tried othe…

This study tests whether adding the drug blinatumomab to standard oral targeted therapy (TKI) can better treat adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). About 17 participants will receive the combination after initial treatment. The goal…

This study looks at two ways to help cancer patients quit smoking before surgery and stay smoke-free afterward. One method involves gradually cutting down on cigarettes before quitting, then using a nicotine patch. The other method uses counseling and a nicotine patch alone. The …

This study tests whether combining a cancer-killing virus (T-VEC) with an immunotherapy drug (pembrolizumab) can shrink or control advanced sarcoma tumors. About 41 adults with metastatic or locally advanced sarcoma that cannot be surgically removed are participating. The main go…

This early-phase study tests if giving the drug Lutathera directly into the liver's main artery is safe and practical for people with neuroendocrine tumors that have spread mostly to the liver. Ten adults with this type of cancer will receive two injections into the liver artery,…

This study tests the safety of combining the drug RP-3500 with palliative radiation therapy in people whose metastatic solid tumors have a specific change in the ATM gene. About 49 adults with advanced cancer will receive the combination to find the highest dose with few side eff…

This study tests whether a chemotherapy plan used for children with acute lymphoblastic leukemia (ALL) can work safely and effectively in adults aged 18 to 60 with a specific type of ALL (Philadelphia chromosome-negative). The goal is to see if this approach can wipe out the leuk…

This early-phase trial tests whether a personalized cell therapy called lifileucel (LN-144) can be safely given to people with melanoma that has spread to the brain. Participants must have tumors that can be surgically removed to harvest immune cells, which are then multiplied in…

This study tests a combination of four drugs (carfilzomib, lenalidomide, dexamethasone, and daratumumab) given before and after a stem cell transplant for people with multiple myeloma that has come back after previous treatments. The goal is to see if this intensive approach can …

This study tests two drugs, vemurafenib (a pill) and obinutuzumab (an infusion), in 30 people with untreated hairy cell leukemia. The goal is to see if the combination can achieve a complete response, meaning no signs of cancer after treatment. Participants take vemurafenib for 4…

This study looks at whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have very low levels of cancer cells (called MRD-negative) after taking venetoclax can stop the drug and stay healthy for at least a year. About 81 adults who are al…

This early-phase study looks at whether giving the immunotherapy drug nivolumab together with standard chemotherapy before surgery is safe and practical for people with a type of lung cancer called malignant pleural mesothelioma. About 22 participants will receive the combination…

This study tested a combination of two chemotherapy drugs, irinotecan and carboplatin, as the first treatment for people newly diagnosed with intermediate- or high-risk rhabdomyosarcoma, a type of muscle cancer. The goal was to see if this drug pair could shrink tumors and be saf…

This study tests a combination of two drugs, venetoclax and obinutuzumab, in 100 people with chronic lymphocytic leukemia (CLL) who have not had treatment before. The goal is to see how well the combo controls the cancer and improves survival. Participants must be fit and meet sp…

This study tests a drug called niraparib in people with advanced soft tissue sarcoma that has certain DNA repair mutations. The goal is to see if the drug can shrink tumors or slow their growth. About 8 adults with inoperable or metastatic sarcoma will receive niraparib and be mo…

This study tests whether the chemotherapy drug ixazomib can help control AL amyloidosis after initial treatment. Seventeen adults with this rare disease receive ixazomib to prevent or delay relapse. The goal is to improve event-free survival by stopping organ damage and the need …

This study tests if a shorter course of hormone therapy (ADT) combined with standard radiation and brachytherapy is safe and effective for men with high-risk prostate cancer. The goal is to prevent the cancer from coming back or spreading. About 50 men are taking part.

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or slow the growth of advanced adenoid cystic carcinoma and other salivary gland cancers that have returned or spread. About 64 participants will receive the combination to see how well it works and how …

This study tests whether the drug pembrolizumab can shrink or stop the growth of a returning brain cancer called malignant glioma in people whose tumors have many genetic mutations. The drug works by activating the immune system to attack cancer cells. The study enrolled 27 adult…

This early-phase trial tests a new treatment for multiple myeloma, a type of blood cancer. Doctors take a patient's own immune cells, modify them in the lab to recognize and attack cancer cells (BCMA-targeted CAR T cells), and give them back. The study also looks at combining the…

This early-phase study is testing whether a combination of three drugs—belantamab mafodotin, nirogacestat, and pomalidomide—is safe for people with multiple myeloma that has returned or stopped responding to prior treatments. The main goal is to find the safest dose of belantamab…

This study tests whether a precise, high-dose radiation treatment (SBRT) can restore the effectiveness of immunotherapy drugs called checkpoint inhibitors in people with metastatic cancer. About 69 adults with melanoma, lung, bladder, kidney, or head/neck cancers whose tumors hav…

This study tests whether adding the immunotherapy drug atezolizumab and targeted radiation (SBRT) to standard hormone therapy can better control metastatic prostate cancer that hasn't been treated yet. About 28 men will receive the combination and be followed for 2 years to see i…

This study tests whether a drug called PDR001, combined with either trametinib or dabrafenib, is safe and effective for people with thyroid cancer that no longer responds to standard radioactive iodine treatment. The trial enrolled 19 adults whose cancer had worsened. The main go…

This study tests whether N-acetylcysteine, a drug already used for liver protection and lung mucus thinning, can help people with severe COVID-19. The idea is that it may boost the immune system to fight the virus better. About 48 very ill adults in the hospital or on a ventilato…

This study tests a newer imaging method using a green dye (ICG) and near-infrared light to find sentinel lymph nodes in people with early-stage vulvar cancer. It compares this method to the current standard imaging. About 22 participants will receive both types of imaging during …

This early-phase study tests the safety of a new imaging drug called PARPi-FL in 12 people with head and neck cancer. The drug is designed to help take detailed pictures of tumors using a PET scan. The goal is to see if this method is safe and can improve how doctors see the canc…

This early-phase study tests a new imaging drug called F-Glutamine, which is used with PET scanners to see if it can find tumors in people with solid cancers or lymphoma. Researchers want to learn how the drug moves through the body and how long it stays in the blood. If successf…

This study tests a new breath test (electronic nose) to see if it can detect early-stage lung cancer. Researchers will compare the breath test results with standard biopsy results in 119 adults with suspicious lung nodules. The goal is to find a non-invasive way to diagnose lung …

This study tests if benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. About 51 adults with solid tumors or blood cancers who have moderate to severe skin side effects will receive the drug. The goal is to lower blood eosinophil lev…

This study looks at whether giving men a deeper level of muscle relaxation during robotic prostate surgery can lower the pressure in the belly during the operation and reduce pain afterward. About 139 men having robotic prostatectomy will be randomly assigned to either deep or mo…

This study tests a new type of therapy called poetic dignity therapy for LGBTQ+ cancer patients. The therapy helps patients share their life story through a poem that can be given to loved ones. The goal is to see if this approach is practical and helps patients feel a greater se…

This study looks at whether acupuncture or massage works better for long-term pain relief in people with advanced cancer. About 300 adults with certain advanced cancers will receive one of the two treatments. The goal is to see which approach improves pain, related symptoms, and …

This study compares two acupuncture techniques (electro-acupuncture and auricular-acupuncture) with standard care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are randomly assigned to one of three groups: two receive acupuncture for …

This study tests whether a game-based exercise plan can help childhood cancer survivors (ages 10-16) become more physically active. The plan involves both the child and a parent or caregiver. Researchers will also see if it improves the child's quality of life. About 48 survivors…

This study looks at whether flibanserin, a drug for low sexual desire, can be safely taken by breast cancer survivors who are on hormone therapies like tamoxifen. About 43 women with a history of breast cancer and no current disease will take flibanserin for 24 weeks. The main go…

This study tests whether acupuncture can reduce frequent nighttime urination (nocturia) in prostate cancer survivors. About 60 survivors will receive 10 acupuncture sessions over several weeks. Researchers will check if acupuncture is practical and helpful for improving sleep, mo…

This study is developing and testing a mobile app to help people who have survived breast cancer or rare cancers cope with their fear of the cancer returning. About 252 survivors will try different versions of the app to see which is most helpful and easy to use. The goal is to c…

This study tests two ways of giving high-dose radiation to people with cancer that has spread to bones, spine, soft tissue, or lymph nodes. One group gets the radiation in one day, the other over three days. The goal is to see which schedule better controls tumors and has fewer s…

This study looks at whether adding personalized supportive care (like help with symptoms and emotional support) to standard cancer treatment helps patients feel more comfortable discussing their health and future. About 83 adults with advanced solid tumors who are starting a phas…

This study tests whether a mindfulness program called MORE can help people with chronic cancer pain feel better. Researchers are enrolling 76 adults who have had cancer and still have pain for at least 3 months. Participants will learn mindfulness techniques to focus on the prese…

This study examines what normal breast tissue looks like on MRI and mammogram to see if it affects a woman's risk of developing breast cancer. Researchers are comparing images and health information from over 2,100 women, including those with and without breast cancer. The goal i…

This study aims to create a test that predicts how well different chemotherapy drugs will work for people with advanced pancreatic cancer. Researchers will analyze tumor cells from blood and tissue samples from 74 participants. The goal is to help doctors choose the most effectiv…

This study collects information from men with low-risk prostate cancer and their partners or close allies to understand how they make treatment decisions. Researchers use questionnaires to measure anxiety, uncertainty, and treatment preferences. The goal is to learn what influenc…

This study looks at 230 adults with cancer that has spread to their bones who need surgery. The goal is to improve how doctors estimate survival by combining the patient's own health assessment with the doctor's evaluation. This could help guide treatment decisions and set realis…

This study looks for new gene changes that may increase cancer risk. Researchers compare the genes of cancer patients with those of their healthy parents and family members. The goal is to find gene changes that appear only in the patient and not in the rest of the family. This c…

This study gathers information from cancer patients and their household members to better understand COVID-19 infections. Participants fill out online surveys about their health and lifestyle. The goal is to create a registry to track how COVID-19 affects cancer treatment and out…

This study looks at whether a special computer program can analyze ultrasound images to measure liver tumors in people with pancreatic or gastrointestinal cancer that has spread to the liver. About 19 participants will get both a standard contrast CT and two research ultrasounds.…

This study tests whether a special PET scan tracer called 18F-FAC can show how much of a standard chemotherapy drug gets into pancreatic tumors. About 30 adults with pancreatic cancer will get a PET scan before starting treatment. The goal is to learn more about drug uptake, not …

This study looks at how small changes in CT scan settings affect the way we measure tumors in the abdomen. Researchers will take extra CT scans of 169 people with colorectal cancer that has spread to the liver. The goal is to find out which tumor measurements stay reliable even w…

This study looks at how the drug tucatinib enters and works in brain tumors from HER2+ cancers (like breast, lung, or stomach cancer). Nine people will take tucatinib before brain surgery, and researchers will test the removed tumor tissue to find genetic clues about why some can…

This study looks at how proton beam radiation affects brain networks and thinking skills in children and young adults (ages 6-25) treated for brain tumors. Researchers will use special MRI scans taken at rest and compare them with cognitive tests and quality-of-life surveys. Both…

This study is creating large registries for non-communicable diseases (like cancer and diabetes) in sub-Saharan Africa. It will collect health data from nearly 7,000 adults, including healthy volunteers, to better understand these diseases. Researchers will also study gut bacteri…

This study aims to improve how MRI scans work by testing new software and hardware in healthy adults aged 18 and older. Researchers will compare standard images with new ones to see if the new methods provide clearer pictures. About 667 participants will undergo MRI scans, and th…

This study looks at whether a biopsy taken before treatment can help predict how well patients with metastatic or recurrent triple negative breast cancer will respond to a combination of cisplatin (chemotherapy) and radiation. About 49 adults with this type of breast cancer will …

This study looks at whether a home-based treadmill walking program can change certain markers of prostate cancer progression in men with low-risk disease who are not receiving active treatment. About 36 men on active surveillance will either follow a prescribed exercise plan or c…

This study looks at whether it is practical to use a tool called BREAST-Q REACT for women recovering from breast-conserving surgery or mastectomy with reconstruction. The tool shows scores from surveys about physical well-being, arm symptoms, and daily activities, and gives tips …

This study collects blood and tissue samples from 7,000 people with and without breast cancer. Researchers will use these samples to study what causes breast cancer and find better ways to prevent, diagnose, and treat it. No direct treatment is given — this is a tissue bank for f…

This study looks at how diet, lifestyle, and genetics influence the risk of endometrial cancer. Researchers will compare women who have or had the cancer with those who do not. The goal is to identify factors that may lead to the disease. About 1,315 women from New Jersey are tak…

This early-phase study uses a tiny amount of a radioactive drug called 124I-PUH71 to see where it goes in the body and how long it stays in the blood. Researchers want to learn how it collects in tumors in people with lymphoma, myeloma, or other solid cancers. The results will he…

This study looks at how bacteria living in the gut and diet may increase colon cancer risk in people with Lynch syndrome or other inherited colon polyp conditions. Researchers collect stool, colon tissue samples, and diet/lifestyle questionnaires from 77 participants during routi…

This study looks at tissue from liver tumors that were destroyed by heat or cold (ablation). The goal is to see if a lab test can tell whether the treatment completely killed the cancer cells, which CT scans cannot always do. About 150 people with liver cancer that spread from an…

This study collects DNA samples and medical information from people who have certain gene changes that may be linked to cancer. Researchers want to learn more about how these less-studied gene mutations affect cancer risk. The goal is to help doctors give better advice to familie…

This study looks at tumor samples from people with bone cancer to understand why some tumors don't respond to chemotherapy. Researchers will also study why high pressure builds up inside tumors and how that affects drug effectiveness. Blood samples will help identify factors that…

This study follows 600 people with early-stage bladder cancer to see how lifestyle choices like smoking and body weight affect the chance of the cancer coming back. Researchers will track who has a recurrence and compare it to their habits. The goal is to understand what factors …