Immunotherapy shows promise against aggressive brain tumors

NCT ID NCT02658279

First seen Mar 07, 2026 · Last updated May 07, 2026 · Updated 14 times

Summary

This study tests whether the drug pembrolizumab can shrink or stop the growth of a returning brain cancer called malignant glioma in people whose tumors have many genetic mutations. The drug works by activating the immune system to attack cancer cells. The study enrolled 27 adults whose cancer came back after standard treatments like radiation and chemotherapy.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Md Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    Basking Ridge, New Jersey, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of California, Los Angeles

    Los Angeles, California, 90095, United States

  • University of Miami

    Miami, Florida, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

Conditions

Explore the condition pages connected to this study.