New combo aims to make lymphoma therapy safer
NCT ID NCT03684980
First seen Mar 23, 2026 · Last updated Apr 28, 2026 · Updated 6 times
Summary
This study tests whether adding the drug Voraxaze (glucarpidase) to the standard treatment for central nervous system lymphoma can safely lower methotrexate levels in the blood. About 58 adults with B-cell lymphoma in the brain or spine are taking part. The goal is to reduce side effects while keeping the treatment effective.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cleveland Clinic (Data Collection and Specimen Collection)
Cleveland, Ohio, 44195, United States
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Dana Farber Cancer Institute (Data Collection and Specimen Analysis)
Boston, Massachusetts, 02115, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Conditions
Explore the condition pages connected to this study.