New combo therapy for brain metastases from kidney cancer passes early safety check

NCT ID NCT06132945

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 28 times

Summary

This early-phase study is testing whether combining two drugs (cabozantinib and nivolumab) with radiation therapy is safe for people whose kidney cancer has spread to the brain. Only 2 participants are enrolled, and the main goal is to see if they can tolerate the treatment without serious side effects. The study also tracks quality of life and how well the treatment shrinks tumors.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen (All Protocol Activities)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Cancer Suffolk - Commack (All Protocol Activities)

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth (All Protocol Activities)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (All Protocol Activities)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester (All Protocol Activities)

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.