BRAIN METASTASES

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 104 participants will receive the combination treatment. The goal is to see if the drugs…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study tests whether two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 adults with this condition will receive the combination and be monitored for side effects and tumor response. The goal is to find a better treat…

This study is for people with brain metastases (cancer that spread to the brain from elsewhere) that are low-risk. It tests whether adding precise radiation (stereotactic radiosurgery) after initial drug therapy can better control the brain tumors. About 316 adults will be random…

This study tests whether adding the targeted drug abemaciclib to standard radiation therapy can better control breast cancer that has spread to the brain. About 31 adults with hormone receptor-positive, HER2-negative breast cancer will receive both treatments. The goal is to see …

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. About 46 adults with cancer that has spread to the brain will receive the combination. The goal is to improve tumor response and de…

This early-stage trial tests whether customizing radiotherapy based on how a person's tumor responds can improve safety and effectiveness. It involves 45 adults with certain lung cancers, brain metastases, or solid tumors. The goal is to see if adapting radiation doses can better…

This study tests two ways to treat lung cancer that has spread to the brain. One group gets focused radiation plus a drug called bevacizumab; the other gets whole-brain radiation that tries to protect the memory center. The goal is to see which approach better controls the brain …

This study is for people whose brain tumors (from cancers elsewhere in the body) have grown back after radiation. It tests whether a laser treatment called LITT, with or without repeat radiation, can control the tumor better than standard care. About 261 participants will be foll…

This study looks at two ways of giving focused radiation (radiosurgery) to people with brain metastases that are 4 cm or smaller. One method uses a 0mm margin around the tumor, the other uses a 2mm margin. The goal is to find out which approach better controls the tumor while cau…

This study is for people with breast cancer that has spread to the brain (at least two tumors). Participants receive an immunotherapy drug called pembrolizumab every three weeks, plus a precise, one-time radiation treatment to just one of the brain tumors. The goal is to see if t…

This study tests whether a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) can stop or slow the growth of kidney cancer that has spread to the brain. About 20 adults with untreated brain metastases will receive the drugs. The goal is to see if this approach i…

This study tests a drug called repotrectinib in 20 people with a specific type of lung cancer (ROS1-positive) that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. Participants take the drug by mouth, and doctors monitor safety and how w…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. It aims to see if these combinations can shrink brain tumors and how safe they are. About 33 adults whose melanoma has grown aft…

This study compares two standard radiation techniques for people with large brain metastases (tumors that spread from other cancers). About 54 adults will be randomly assigned to receive either staged stereotactic radiosurgery or fractionated stereotactic radiotherapy. The goal i…

This study looks at whether people with lung cancer that has spread to the brain can safely delay radiation therapy if they take the targeted drug alectinib. It involves 56 adults with specific genetic changes. The goal is to see if alectinib alone controls brain tumors as well a…

This early-phase study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, and others). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 554 …

This study tests a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. It aims to improve tumor control and reduce side effects for people with cancers of the pancreas, lung, kidney, prostate, liver, and others. About 400 particip…

This study tests whether adding a nitroglycerin patch (a heart medication) to standard radiation therapy can better shrink brain tumors in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the brain. About 74 adults will receiv…

This study tests whether two drugs, niraparib and dostarlimab, can control advanced cancers that have spread to the brain. About 120 adults with certain cancer types (like BRCA-mutated cancers, lung cancer, or triple-negative breast cancer) and growing brain tumors will receive t…

This study tests whether a combination of three immunotherapy drugs (relatlimab, nivolumab, and ipilimumab) can shrink or stabilize melanoma tumors that have spread to the brain. About 60 adults with melanoma brain metastases will receive the drugs intravenously. The main goal is…

This study tests a combination of three drugs (datopotamab deruxtecan, carboplatin, and pembrolizumab) in people with non-small cell lung cancer that has spread to the brain and has not been treated yet. The goal is to see if the treatment shrinks brain tumors. About 46 adults wi…

This study looks at 90 people with cancer that has spread to the brain to find the best time to give radiation after surgery. Doctors will compare giving radiation before, during, or after the operation to see which approach best prevents the tumor from coming back. The goal is t…

This study is testing whether adding focused radiation after surgery or laser heat therapy helps control recurrent brain metastases better than surgery/laser therapy alone. Researchers will compare two approaches: one group gets additional radiation after their procedure, while t…

This study compares a powerful 7T MRI to standard 1.5T/3T scans to see if it can detect very small brain metastases earlier in people with small-cell lung cancer who choose not to have preventive brain radiation. About 20 adults will get both types of scans over time. The goal is…

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. Th…

This early-phase study is testing a new radioactive tracer called [18F]-αvβ6-BP for PET/CT scans in people with non-small cell lung cancer that has spread to the brain. The goal is to see if this scan can find tumors more accurately than current methods. About 20 adults with this…

This study tests whether a special PET scan called Axumin can help doctors tell the difference between actual tumor growth and a temporary reaction to immunotherapy in people with brain metastases. About 20 adults on immunotherapy will receive the scan. The goal is to improve tre…

This study tests whether a special PET scan (FES PET/CT) can improve detection and treatment planning for brain metastases in people with estrogen-receptor positive breast cancer. About 20 participants will receive the scan before standard radiation therapy and be followed for 12…

This study tests a special PET scan (18F-Fluciclovine) to see if it can better detect brain metastases and tell them apart from changes caused by earlier treatments. About 20 adults with known or suspected brain metastases will get the scan before and after treatment. The goal is…

This study tests a new program designed to help adults with brain metastases manage common thinking and memory problems. The program offers different levels of support based on each person's needs, from educational materials to one-on-one coaching. Researchers want to see if the …

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. The ma…

This study tests a special way of giving whole-brain radiation (called pulsed reduced dose-rate) to people with brain metastases. The goal is to see if this method can protect memory and thinking while still treating the tumors. About 53 adults with solid tumors that spread to th…

This study looks at two radiation treatments for people with 4 to 15 brain tumors that have spread from other cancers. One treatment is CyberKnife radiosurgery, which delivers high-dose radiation in 1 or 2 sessions. The other is whole-brain radiotherapy, which requires 10 session…

This study looks at whether people with brain metastases can safely avoid taking dexamethasone (a steroid) before and after surgery. Researchers want to see if skipping the drug reduces the need for it later and helps the immune system. The trial involves 35 adults with new brain…

This study compares two radiation approaches for people with 5 to 15 brain metastases from cancers that are not blood cancers. One group gets focused radiation only to the tumors (SRS), while the other gets whole-brain radiation that avoids the memory center plus a drug to protec…

This study looks at inflammation in brain tumors using a special PET scan called [C-11]-CS1P1. About 104 adults with brain cancer or tumors that spread to the brain will get two scans over two years. The goal is to see how inflammation patterns relate to MRI results, treatments, …

This study compares two radiation techniques for people with 1 to 5 brain tumors that have spread from other cancers. Half the participants will receive standard radiation with a 2 mm safety margin, while the other half will get radiation with no extra margin. The goal is to see …

This study compares a new MRI technique called CEST to the standard method for diagnosing radiation damage (radionecrosis) in brain metastases from lung cancer. About 60 adults who have had radiation therapy for brain metastases will receive both scans. The goal is to see if CEST…

This study looks at whether using an MRI scanner during surgery for brain metastases helps surgeons remove tumors more completely. About 154 adults will be randomly assigned to have surgery with or without this special imaging. The goal is to see if the MRI guidance leads to bett…

This study uses special MRI scans to see how radiation treatment for brain tumors affects thinking and memory. Researchers will follow 15 people with newly diagnosed brain metastases who are getting stereotactic radiosurgery. The goal is to better understand the brain changes tha…

This study aims to develop a new MRI technique to help doctors tell the difference between tumor growth caused by cancer and growth caused by radiation treatment in people with brain metastases. Researchers will test this imaging method on 119 healthy volunteers and patients who …

This study looks at genetic differences between the original stomach or esophageal cancer and any brain tumors that spread from it. Researchers will analyze stored tissue samples from 30 patients to see if key markers like HER2, MSI, PD-L1, and CLDN18.2 change. The goal is to und…

This study is testing a new type of MRI scan that can show how brain tumors use energy. The goal is to see if this scan can tell which brain metastases are more aggressive or resistant to radiation therapy. About 276 adults with brain metastases will get this special scan before …

This study looks at whether a special PET scan using 18F-Fluciclovine can find leftover brain tumor that standard MRI might miss after surgery. About 20 adults who had brain metastasis removed and are scheduled for radiation will get an optional PET scan before radiation. The goa…

This study looks at whether regular MRI brain scans after radiation therapy can find cancer that has spread to the brain before it causes symptoms. About 60 adults with stage III non-squamous lung cancer will get MRI scans at set times. The goal is to see if this monitoring reduc…

This study tests a new approach called pharmacoscopy, which quickly analyzes a patient's own brain tumor cells in the lab to see which drugs kill the cancer while sparing healthy cells. The goal is to see if this personalized method helps patients with brain metastases who have r…

This study looks at whether a special imaging agent called 18F-fluciclovine can help doctors see if radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT sca…

This study is testing a new MRI technique called CEST that can measure the acidity (pH) inside brain tumors like gliomas and metastases. Researchers will scan 800 patients to see if pH levels can help predict where tumors might come back and how long patients survive. The goal is…

This study tests a faster, more detailed MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can tell the difference between a brain tumor coming back and radiation-induced brain damage. About 60 adults who have had brain radiation, have new or untreated bra…