BRAIN METASTASES

This early-stage study is testing the safety of combining a targeted cancer drug (Trastuzumab Deruxtecan) with precise radiation therapy for people with HER2-positive breast cancer that has spread to the brain. The goal is to see if this combination can better control the cancer …

This study is testing if a shorter, more condensed schedule of targeted brain radiation works better than a longer one for controlling tumors that have spread to the brain from cancers like melanoma or kidney cancer. It will involve 264 adults with 1 to 5 brain tumors that are co…

This study compares two different radiation treatments for adults with lung cancer that has spread to many areas of the brain. One treatment combines a targeted radiation with a drug (bevacizumab) to shrink tumors. The other uses a special whole-brain radiation that tries to spar…

This early-stage study is testing whether a new vaccine, combined with an existing immunotherapy drug, is safe and practical for patients whose cancer has spread to the brain or spinal fluid. It will involve about 20 patients whose cancer has worsened despite standard treatments.…

This study aims to find the better first treatment for people with a specific type of lung cancer (EGFR-mutated NSCLC) that has spread to the brain. It will compare a higher dose of the targeted drug furmonertinib taken alone against a lower dose of the same drug combined with tw…

This study is testing an investigational drug called SHR-A1811 for women with advanced HER2-positive breast cancer that has spread to the brain. It aims to see if the drug is safe and effective at controlling the cancer in the brain and spinal fluid. The trial will include two gr…

This study is testing if a type of CT scan called Dual-Energy CT (DECT) can work as well as MRI scans for planning radiation therapy. Doctors need very clear pictures to map out tumors and avoid damaging healthy organs during radiation. The study will enroll 80 patients with canc…

This study is for people whose cancer has spread to the brain. It compares two ways of delivering whole brain radiation therapy, both designed to protect thinking and memory. One method avoids the hippocampus, a key memory area. The other avoids the hippocampus plus several other…

This study is testing a new type of PET scan to see if it can provide a clearer picture of inflammation inside brain tumors. Adults with a primary brain tumor or cancer that has spread to the brain will get one or two of these special scans. The goal is to learn if this scan can …