BRAIN METASTASES

This study is testing whether a combination of two drugs, tucatinib and T-DM1, can help control solid tumors that have spread to the brain. It is for up to 30 adults with HER2-positive metastatic cancer who have brain metastases that do not require immediate surgery or radiation.…

This study is comparing two different radiation treatments for patients with 4-15 brain metastases (cancer that has spread to the brain). It aims to see if a more targeted, shorter treatment (CyberKnife radiosurgery) is as effective as the standard whole-brain radiation, while po…

This study is testing a combination of three immunotherapy drugs (relatlimab, nivolumab, and ipilimumab) in people whose melanoma skin cancer has spread to their brain. The main goal is to see if this treatment can shrink or control the brain tumors for at least six months. It wi…

This study is testing a drug called repotrectinib for people with a specific type of lung cancer (ROS1-positive NSCLC) that has spread to the brain. The main goal is to see if the drug is safe and can shrink or control the brain tumors. It will enroll about 20 participants who wi…

This study is testing a personalized approach to find better drug treatments for cancer that has spread to the brain (brain metastases). Researchers will take a small sample of a patient's tumor during surgery and quickly test many different drugs on it in the lab to see which on…

This study is testing a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—to see if they can safely slow or stop the growth of kidney cancer that has spread to the brain. It is for adults with this specific type of cancer who have not yet received treatment for t…

This study compares two radiation treatments for patients whose cancer has spread to the brain (5-15 tumors). One treatment uses highly focused radiation on just the tumors (SRS), while the other treats the whole brain but tries to spare the memory center, combined with a drug (m…

This study is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. It will measure how many participants are still alive 6 months after receiving the treatment. Th…

This early-stage trial is testing new combinations of targeted drugs for people with melanoma skin cancer that has spread to the brain. It aims to see if these drugs can shrink brain tumors in patients whose cancer has continued to grow despite prior immunotherapy. The study will…

This study is testing a new oral drug, S241656, alone and in combination with other cancer therapies. It aims to find a safe and effective dose for adults with advanced cancers, including lung, pancreatic, and colorectal cancers, that have specific genetic mutations like KRAS or …

This study is testing two different treatment approaches for brain tumors that have returned or worsened after initial radiation therapy. It compares a minimally invasive laser surgery (LITT) with or without repeat radiation to standard medical management. The goal is to see whic…

This study is testing a combination of three drugs for people with non-small cell lung cancer that has spread to the brain and who have not yet received treatment for their advanced cancer. The goal is to see how well this three-drug combo can shrink the tumors in the brain. The …

This study is for people with a specific type of advanced lung cancer (ALK-positive NSCLC) that has spread to the brain but isn't causing major symptoms. It's comparing two treatment strategies: taking the targeted drug alectinib alone versus taking alectinib plus a precise form …

This study is testing a new radiation therapy approach that uses MRI scans during treatment to adjust radiation beams in real time. Researchers want to see if this method can better target tumors while sparing healthy tissue in patients with various cancers including pancreatic, …

This study is testing whether patients with brain tumors that have spread from other cancers can safely have surgery without receiving the steroid medication dexamethasone. Researchers want to see if avoiding steroids helps preserve the immune system's ability to fight cancer. Th…

This study is testing whether adding a drug called abemaciclib to precise radiation therapy can better control breast cancer that has spread to the brain. It will involve about 31 patients whose breast cancer is hormone-sensitive and has formed a limited number of brain tumors. T…

This study is testing whether a combination of two existing cancer drugs can help control tumors that have spread to the brain. It is enrolling about 104 adults with specific cancers, including triple-negative breast cancer and non-small cell lung cancer, that have spread to the …

This study is testing whether adding targeted radiation to drug therapy helps control cancer that has spread to the brain. Researchers want to see if giving radiation right after drug therapy works better than waiting until tumors start growing again. The trial includes 316 adult…

This study compares two standard radiation techniques for treating large brain tumors that have spread from other cancers. It aims to see which method—delivering radiation in two sessions spaced weeks apart versus delivering it in three to five daily sessions—is better at control…

This study tests whether using a smaller radiation margin (0mm) works as well as the standard larger margin (2mm) for treating brain tumors that have spread from other cancers. Researchers want to see if the smaller margin can control the tumors just as effectively while causing …

This study is for adults whose brain cancer has returned after previous radiation treatment. It compares two approaches: receiving a second, precise radiation treatment after either surgery or laser therapy, versus just having close monitoring after those procedures. The main goa…

This study is testing whether regular MRI brain scans after radiation treatment can detect cancer that has spread to the brain before it causes symptoms. It involves 60 adults with stage III non-squamous lung cancer who have finished radiation. Researchers will compare how often …

This early-stage trial is testing personalized radiation therapy approaches for small cell lung cancer and brain tumors. The study aims to make radiation treatment safer and more effective by adjusting it based on how each patient's tumors respond during therapy. Researchers will…

This study is testing whether combining two drugs, niraparib and dostarlimab, can help control advanced cancer that has spread to the brain. It will enroll 120 adults with specific types of cancer, including lung and breast cancer, who have active brain tumors that are growing. T…

This study is testing whether using an MRI machine during surgery helps doctors remove brain tumors more completely. Researchers want to see if this advanced imaging helps surgeons see the tumor better in real-time, which could lead to better outcomes and fewer follow-up surgerie…

This study compares two approaches to radiation treatment for brain tumors that have spread from other cancers. Researchers want to see if using no extra margin around the tumor (0 mm) works as well as the standard 2 mm margin at keeping tumors from growing back. The goal is to c…

This study is testing whether adding a new drug called azeliragon to a precise form of radiation therapy is safe and more effective at controlling brain tumors that have spread from other cancers. It will involve about 46 adult patients with small brain tumors. The main goal is t…

This study is testing if a specialized type of PET scan, called an FES PET/CT, can help doctors better see and plan radiation treatment for breast cancer that has spread to the brain. The scan will be given to 20 patients before their standard radiation treatment. Researchers wil…

This study is testing whether a special type of PET/CT scan using a tracer called 18F-fluciclovine can better identify and monitor brain metastases (cancer that has spread to the brain). Researchers want to see if this scan can more clearly show active cancer versus treatment sid…

This study is testing a new type of MRI scan, called CEST, to see if it can create better maps of brain tumors. It will be added to standard PET/MRI exams for 800 patients with glioma or brain metastases. The goal is to see if measuring the acidity (pH) inside tumor tissue can he…

This study is testing a special microscope called the CONVIVO system. It is used during brain tumor surgery to help surgeons see the difference between healthy brain tissue and tumor tissue in real time. The images from the device are compared to standard lab tests from small tis…

This study is developing a new type of MRI scan to help doctors tell the difference between brain tumors that are growing because cancer is getting worse and tumors that appear larger due to swelling from radiation treatment. The research involves healthy volunteers and patients …

This study is testing a new type of PET scan to see if it can better detect and track the spread of non-small cell lung cancer, especially when it has reached the brain. Researchers will compare this new scan to standard imaging methods in about 20 patients. The goal is to see if…

This study is testing if a very powerful 7T MRI scanner can detect tiny brain tumors earlier than standard MRI scanners in people with small-cell lung cancer. It involves 20 patients who have chosen not to receive preventive brain radiation. Researchers will compare the 7T scan r…

This study is testing whether a new type of PET scan, using a tracer called 18F-Fluciclovine, can help doctors see leftover or returning brain cancer cells more clearly after surgery. It aims to improve how doctors plan follow-up radiation treatment by finding tumor areas that a …

This study is testing if a special type of PET-CT scan using a tracer called Axumin can help doctors better understand brain metastases in patients on immunotherapy. It aims to tell the difference between real cancer growth and harmless swelling that looks like growth on standard…

This study is testing a new, faster type of MRI scan to help doctors tell the difference between a brain tumor that has come back and damage caused by previous radiation treatment. Currently, this often requires risky brain surgery to confirm. The research involves 60 people, inc…

This study is testing a more precise form of whole brain radiation therapy designed to protect healthy brain tissue while treating cancer that has spread to the brain. Researchers want to see if this approach improves patients' quality of life and reduces symptoms like memory pro…

This study is testing a new support program designed to help adults with brain metastases manage the thinking and memory problems that often come with their condition. The program screens patients for these issues and offers different levels of support, from educational materials…

This study aims to understand why some patients experience memory and thinking problems after receiving targeted radiation for brain tumors. Researchers will use special MRI scans on 15 patients over one year to see if changes in the brain's wiring are linked to these cognitive d…

This study is testing whether a new type of imaging scan, called an 18F-fluciclovine PET/CT, can better show if radiation treatment is working for large brain tumors that have spread from cancer elsewhere in the body. Researchers will enroll 20 adults with these large brain metas…

This study aims to understand if the molecular markers used to guide treatment in stomach and esophageal cancers change when the cancer spreads to the brain. Researchers will analyze stored tissue samples from 30 patients to compare the original tumor with its brain metastasis. T…

This study is testing a new type of MRI scan to see if it can help doctors better understand brain tumors that have spread from other cancers. Researchers want to see if this scan, which looks at tumor metabolism, can predict how well a tumor will respond to targeted radiation tr…