New trial aims to improve radiation for large brain tumors
NCT ID NCT07227610
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial compares two standard radiation approaches for people with large brain metastases (tumors that spread from other cancers). One method gives two radiation doses a month apart; the other gives three daily doses. The study will track tumor control, side effects, and quality of life in 54 participants to see which approach works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (staged stereotactic radiosurgery or fractionated stereotactic radiotherapy)
- What this could lead to
- If successful, this trial could identify which radiation schedule better controls large brain tumors while reducing the need for steroids or additional procedures.
- What could go wrong
- This is a small, early-phase study (54 participants) comparing two existing treatments, so it may not show a clear winner. Risks include radiation necrosis and tumor progression.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Medical University of South Carolina Hollings Cancer Center
RECRUITINGCharleston, South Carolina, 29425, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Pinpoint radiation may spare the brain in lung cancer that spreads
- Spinal fluid DNA test could personalize brain cancer therapy
- Focused radiation doses put to the test for large brain tumors
- Brain scan breakthrough: amino acid PET may solve a tricky diagnosis dilemma
- Spared brain region may shield memory during whole brain radiation