Focused radiation doses put to the test for large brain tumors
NCT ID NCT03726359
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This trial investigates the safest and most effective dose of fractionated stereotactic radiation therapy (FSRT) for people with large brain metastases (tumors that have spread from other cancers). Participants receive radiation in several small doses over 1.5 to 2 weeks. The study aims to find the maximum dose that can be given without causing severe side effects, and to measure how well the tumors respond. Results will help design future larger studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fractionated Stereotactic Radiation Therapy (FSRT)
- What this could lead to
- If successful, this could establish a standard dosing regimen for FSRT in large brain metastases, improving tumor control while limiting side effects.
- What could go wrong
- This is an early-phase dose-finding study with only 30 participants, so results may not apply broadly. There is a risk of radiation-related toxicities, including brain swelling or necrosis.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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