New drug zorifertinib aims to fight lung cancer in the brain
NCT ID NCT07143045
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a drug called zorifertinib as the first treatment for people with advanced non-small cell lung cancer that has a specific gene mutation (EGFR) and has spread to the brain or spinal cord. The trial will enroll 800 participants and compare zorifertinib to other similar drugs. The main goal is to see if zorifertinib helps people live longer and controls the cancer better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- zorifertinib
- What this could lead to
- If successful, zorifertinib could become a new first-line option for people with this type of lung cancer that has spread to the brain, potentially improving survival and controlling the disease longer.
- What could go wrong
- This is an observational study, not a randomized controlled trial, so results may be less definitive. Side effects are possible, and the drug may not prove better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Cancer Hospital of Guangxi Medical University
NOT_YET_RECRUITINGNanning, Guangxi, 530000, China
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Beijing Tumor Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100000, China
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Capital Medical University Affiliated Beijing Chest Hospital
RECRUITINGBeijing, Beijing Municipality, 100000, China
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Chengdu Third People's Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, 610000, China
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Chongqing University Affiliated Cancer Hospital
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, 404100, China
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Dalian University of Technology Affiliated Central Hospital (Dalian Central Hospital)
NOT_YET_RECRUITINGDalian, Shandong, 116000, China
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First Hospital of Jilin University
NOT_YET_RECRUITINGChangchun, Jilin, 130000, China
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Foshan First People's Hospital
RECRUITINGFoshan, Guangdong, 510000, China
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Fujian Cancer Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, 350000, China
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Guangdong Provincial People's Hospital
RECRUITINGGuangzhou, Guangdong, 510000, China
-
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITINGHarbin, Heilongjiang, 150000, China
-
Henan Cancer Hospital
NOT_YET_RECRUITINGZhenzhou, Henan, 450000, China
-
Heyou Hospital, Shunde District, Foshan City
NOT_YET_RECRUITINGFoshan, Guangdong, 528000, China
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Hunan Cancer Hospital
NOT_YET_RECRUITINGChangsha, Hunan, 410000, China
-
Jiangsu Provincial People's Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, 210000, China
-
Meizhou People's Hospital
RECRUITINGMeizhou, Guangdong, 510000, China
-
Nanjing Chest Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, 210000, China
-
Northern Jiangsu People's Hospital
NOT_YET_RECRUITINGYangzhou, Jiangsu, 225000, China
-
People's Liberation Army Army Specialized Medical Center
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, 404100, China
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Qingdao University Affiliated Hospital
NOT_YET_RECRUITINGQingdao, Shandong, 266000, China
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Shanxi Bethune Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, 030000, China
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Shenzhen Hospital, Cancer Hospital, Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGShenzhen, Shenzhen, 518000, China
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Shenzhen Third People's Hospital
NOT_YET_RECRUITINGShenzhen, Shenzhen, 518000, China
-
Sichuan Cancer Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, 610000, China
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The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITINGHefei, Anhui, 230000, China
-
The First Affiliated Hospital of Guangxi Medical University
NOT_YET_RECRUITINGNanning, Guangxi, 530000, China
-
The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITINGNanchang, Jiangxi, 330000, China
-
The First Affiliated Hospital of Xiamen University
NOT_YET_RECRUITINGXiamen, Fujian, 350000, China
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The First Hospital of China Medical University
NOT_YET_RECRUITINGShenyang, Liaoning, 110000, China
-
Tianjin Cancer Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 30000, China
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITINGWuhan, Hubei, 430000, China
-
Xiangya Hospital, Central South University
NOT_YET_RECRUITINGChangsha, Hunan, 41000, China
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Yunnan Cancer Hospital
NOT_YET_RECRUITINGKunming, Yunnan, 650000, China
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Yunnan Provincial First People's Hospital
NOT_YET_RECRUITINGKunming, Yunnan, 650000, China
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