Laser zaps recurrent brain tumors: new trial tests minimally invasive option

NCT ID NCT05124912

Recruiting now Disease control Sponsor: Monteris Medical Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people whose brain metastases have come back or caused radiation damage after initial treatment. It compares a laser-based procedure (LITT) plus standard care against standard care alone (steroids or repeat radiation). The goal is to see if LITT can better control tumor growth and help patients stop using steroids sooner. About 261 participants will be enrolled across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Laser Interstitial Thermal Therapy (LITT) using the NeuroBlate System
What this could lead to: If successful, this could offer a more effective, less invasive option to control recurrent brain tumors or radiation damage after initial treatment.
What could go wrong: This is a mid-stage trial with 261 participants, so results are not yet proven. Risks include surgical complications from LITT and the possibility that the treatment may not improve survival or reduce steroid use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain Neoplasm Metastasis Recurrence secondary neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES RADIATION NECROSIS RECURRENT METASTASES RECURRENT TUMOR

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Duke University Hospital
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Kettering Health
RECRUITING

Kettering, Ohio, 45429, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
UCLA
RECRUITING

Los Angeles, California, 90095, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
WashU
RECRUITING

St Louis, Missouri, 63130, United States

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