New radiation method aims to shield brain function during cancer treatment

NCT ID NCT05045950

Recruiting now Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This phase II trial tests a special way of delivering whole-brain radiation called pulsed reduced dose-rate (PRDR) along with the drug memantine to help protect memory and thinking in people with brain metastases. About 53 adults with solid tumors that have spread to the brain will receive 30 Gy of radiation in 10 sessions using the PRDR technique. The main goal is to see if patients can complete the treatment as planned, with a focus on preserving neurocognitive function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pulsed reduced dose-rate whole-brain radiation therapy and memantine (Namenda)
What this could lead to: If successful, this approach could help preserve memory and thinking skills in patients needing whole-brain radiation for brain metastases.
What could go wrong: This is a small, early-phase trial with only 53 participants, so results may not apply broadly. The treatment may still cause cognitive decline or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

Clement J. Zablocki Veterans Affairs Medical Center
RECRUITING

Milwaukee, Wisconsin, 53295, United States
Froedtert Hospital & the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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