Medical College Of Wisconsin

This study is testing whether a special nurse support program helps formerly incarcerated Black men manage their type 2 diabetes. One hundred men will be randomly assigned to receive either standard diabetes information or the new program, which includes phone-based coaching on d…

This early-phase trial is testing a combination treatment for adults with B-cell lymphomas that have come back or stopped responding to standard therapies. The approach involves giving patients a daily oral drug (pirtobrutinib) before and after an infusion of their own geneticall…

This study is testing whether a simple, at-home arm cuff exercise can protect the tiny blood vessels of frail older adults from damage caused by physical stress. Researchers want to see if repeatedly inflating a blood pressure cuff on the arm for two weeks makes these vessels mor…

This early study is testing whether metformin, a medication commonly used for diabetes, is safe and well-tolerated in premature infants who have or are at high risk for a serious lung condition called bronchopulmonary dysplasia (BPD). Researchers will give different doses of the …

This study is testing whether giving radiation to the main lung tumor before starting targeted drug therapy can help delay cancer progression in patients with advanced lung cancer that has specific genetic changes. The trial will enroll 34 patients who haven't had previous treatm…

This study aims to understand how well a drug called blinatumomab works for adults with B-cell acute lymphoblastic leukemia (B-ALL) when used in real-world hospital settings, not just in controlled clinical trials. Researchers will collect data from 200 patients across multiple c…

This study is testing which of two radiation therapy methods works better to shrink pancreatic tumors before surgery. About 102 patients with pancreatic cancer that might be removable by surgery will be randomly assigned to receive either a newer, shorter radiation treatment or a…

This study is testing a personalized approach to treat pancreatic cancer before surgery. Doctors will analyze a small tumor sample to determine its genetic subtype. Based on this result, patients will receive one of two standard chemotherapy regimens that is predicted to work bes…

This study is testing two remote support programs to help older adults with HIV who live in rural Southern US communities. Researchers want to see if online peer support groups and personalized case management can help people stick to their medication, keep their virus under cont…

This study is testing a new type of personalized cell therapy for adults whose B-cell blood cancers have come back or not responded to standard treatments. The therapy, called CAR-T, is engineered to attack cancer cells using two targets (CD19 and CD20) instead of one, which may …

This early-stage study is testing whether higher doses of radiation, precisely targeted using real-time MRI guidance, can effectively treat rectal cancer while allowing patients to keep their rectum. The main goal is to find the highest dose that is safe and doesn't cause severe …

This study is testing whether a shorter, 5-day course of antibiotics works as well as the standard longer course (usually 7-14 days) for children hospitalized with uncomplicated pneumonia. Researchers will enroll 236 children aged 3 months to 18 years and randomly assign them to …

This study is testing whether adding a new drug called isatuximab to a standard three-drug combination is safe and more effective for people newly diagnosed with multiple myeloma who also have kidney problems. The goal is to see if this four-drug treatment helps more patients ach…

This study is testing whether a gentle, non-drug electrical stimulation device worn on the ear can help children with cyclic vomiting syndrome (CVS). CVS causes severe, repeated episodes of vomiting and pain that often lead to emergency room visits. Researchers will compare the r…

This trial is testing a bone marrow transplant as the first treatment for people newly diagnosed with severe aplastic anemia, a rare disease where the body stops making enough blood cells. It aims to see if transplants using half-matched family members or unrelated donors can be …

This study compares two common treatment schedules for a persistent, non-cancerous narrowing of the food pipe (esophagus) that makes swallowing difficult. Researchers want to know if placing a temporary, tube-like stent early in treatment works better and is safer than trying mul…

This study is testing whether adding a drug called venetoclax to two other medications (5-azacitidine and vorinostat) followed by standard chemotherapy can better control a severe blood cancer called acute myeloid leukemia (AML) in children and young adults. It is for patients wh…

This study aims to find the safest time to deliver babies diagnosed with gastroschisis, a condition where the intestines develop outside the body. Researchers are comparing two approaches: planned delivery at 35 weeks of pregnancy versus waiting until 38 weeks. The goal is to see…

This study is testing a personalized treatment approach for pancreatic cancer that can be surgically removed. Doctors will adjust a patient's chemotherapy based on how well the initial treatment is working, as measured by scans and blood tests. The goal is to see if this adaptive…

This study is testing whether using a drug called talquetamab before a personalized cell therapy (cilta-cel) is safe and feasible for people with multiple myeloma that has returned or stopped responding to treatment. The research will enroll 31 adults who have already tried at le…

This study is testing if an over-the-counter antioxidant supplement called MitoQ, or a technique that briefly restricts arm blood flow, can improve blood vessel health in people who have had a stroke. The goal is to see if these methods can help reduce the risk of a second stroke…

This study is testing a personalized approach to help children with chronic nausea, vomiting, and related symptoms like dizziness and fatigue. Researchers will use a special software to measure the body's nervous system and then apply gentle ear nerve stimulation, sometimes combi…

This study is testing if a small, wearable glucose sensor can be used instead of the standard, lengthy annual test to screen for diabetes in adults with cystic fibrosis. About 30 participants will wear the sensor for 10 days and compare its results to the current standard test. T…

This study is testing whether a simple ultrasound performed right in the doctor's office can effectively diagnose fatty liver disease. It will compare results from this quick bedside scan to the standard, more involved imaging tests currently used. The goal is to see if this fast…

This study is testing whether offering at-home self-sampling kits makes people more likely to complete their recommended anal cancer screening appointments. It involves about 570 adults at increased risk for anal cancer in three U.S. cities. Researchers want to see if letting peo…

This study is testing a new scanning device called OCT, which works like an ultrasound for the ear, to see if it helps doctors more accurately diagnose ear infections in children. Researchers will compare diagnoses made with the usual ear exam tool to those made with the new scan…

This study is testing a new, FDA-approved device called Mivu that measures the lining of the food pipe (esophagus) during a routine endoscopy. The goal is to see if this quick, one-step test can accurately diagnose conditions like GERD (chronic acid reflux) and eosinophilic esoph…

This study is testing if a drug called theophylline can prevent kidney injury in newborns who experience a lack of oxygen to the brain at birth. It will enroll 30 infants who are already receiving standard cooling therapy. The main goal is to see if it's feasible to run a larger …

This study is testing whether providing free healthy meals and weekly health coaching to pregnant women can prevent serious complications like gestational diabetes and preeclampsia. Researchers will compare 100 at-risk pregnant women who receive the meal program and coaching to t…

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study is testing if two gentle, non-invasive methods of stimulating a key nerve (through the ear or with sound) can reduce severe stomach and digestive symptoms in teenagers with hypermobile Ehlers-Danlos syndrome (hEDS). Researchers will enroll 90 teens with hEDS and relate…

This study is testing whether a soft band worn around the neck can help reduce nighttime acid reflux symptoms. Researchers want to see if gentle external pressure can prevent stomach acid from rising into the throat during sleep. The study will involve 350 adults who continue to …

This study is testing three different methods to control pain after birth for people who are taking medications for opioid use disorder. It aims to find which approach works best for pain relief and if it also helps reduce feelings of anxiety and depression. The study will involv…

This study is observing if a special compression garment, called the SPIO Core-Max Expedition, helps improve movement and quality of life for infants with cerebral palsy. It will compare infants receiving standard therapy alone to those using the garment along with therapy over s…

This small, early-stage study is testing if a very low dose of the medication naltrexone can help reduce chronic nerve pain caused by a spinal cord injury. Ten adults with this type of pain will take a daily pill for 12 weeks to see if their pain levels go down and their quality …

This study is testing whether a combination of magnetic brain stimulation and speech therapy can help stroke survivors who have trouble finding words. Researchers will use brain scans to target the stimulation precisely, comparing it to a less-targeted approach. The goal is to se…

This study is testing whether a daily exercise routine using a special balloon device can strengthen the muscles that control bowel movements. Researchers want to see if making these muscles work against resistance until they tire (fatigue) will make them stronger over six weeks.…

This study is testing a simple neck-worn device designed to strengthen throat muscles and improve swallowing in people with dysphagia (swallowing difficulty). Over 160 adults will use the device at home for six weeks while researchers track their progress with swallowing tests. T…

This study aims to understand breast cancer screening experiences for people taking hormone therapy. Researchers will collect breast imaging data and interview participants about their screening experiences, feelings, and any barriers they face. The goal is to identify ways to im…

This study aims to learn why some early-stage, hormone-sensitive breast cancers stop responding to standard hormone-blocking drugs. Researchers will give 100 patients hormone therapy for 4-12 weeks before their scheduled surgery and then analyze the removed tumor tissue. By compa…

This study aims to understand hidden heart rhythm problems in fetuses that may lead to stillbirth. Researchers will use a safe, non-invasive magnetic heart monitor on 200 pregnant people with high-risk conditions like prior stillbirth or major fetal heart defects. The goal is to …

This study aims to understand if a device worn around the neck can increase the workload of muscles used for swallowing. Researchers will measure pressure changes in the throat of 60 healthy adults while they swallow different substances. The goal is to gather basic knowledge tha…

This study aims to understand the step-by-step process that leads to type 1 diabetes. Researchers will follow 4,000 participants, including families affected by the disease and healthy volunteers, for up to 10 years. They will collect blood samples and health information to learn…

This study is testing whether a simple blood test can detect sarcoma DNA, which could help doctors diagnose and monitor the disease without needing repeated tumor biopsies. Researchers will collect blood samples from 50 sarcoma patients at different stages of treatment to look fo…

This study aims to understand why muscles tire more quickly in people who have had a stroke, focusing on how blood flow is regulated during exercise. Researchers will test a simple, non-invasive technique called ischemic conditioning—using a blood pressure cuff on the thigh—to se…

This study aims to understand how the body normally prevents stomach contents from flowing back up into the throat, a problem for people with GERD. Researchers will compare muscle pressure responses in the throats and food pipes of 300 people, including healthy volunteers and tho…

This study aims to monitor the long-term health of 500 patients who have already received CAR-T cell therapy for various blood cancers in earlier trials. Researchers will follow these patients for up to 15 years to check for any late-developing side effects, such as new cancers o…

This study aims to understand how a natural cellular cleanup process, called autophagy, affects the function of tiny blood vessels in people with Type 2 Diabetes. Researchers will compare 60 adults, some with diabetes and some healthy, by testing their blood vessel function befor…

This study aims to understand why some very small, premature babies develop serious health problems like chronic lung disease, while others do not. Researchers will collect small blood samples from 1,100 infants weighing less than 3.3 pounds to look for differences in their genes…

This study aims to understand if a specific gene (PTGS1) makes some babies more susceptible to developing a serious lung condition called PPHN when their mothers take common over-the-counter pain medicines (NSAIDs) during pregnancy. Researchers will compare the genes of 200 babie…

This study aims to understand how challenges like unstable housing, food insecurity, and financial strain affect the health of African American adults living with both chronic kidney disease and type 2 diabetes. Researchers will interview participants and collect health data to i…