Medical College Of Wisconsin

This study tests whether a combination of an over-the-counter supplement (MitoQ) and a brief arm-cuff inflation (ischemic conditioning) can improve blood vessel function in 30 stroke survivors. Poor vascular health after a stroke raises the risk of another stroke and heart proble…

This early-phase study tests whether MRI-guided radiation therapy can safely treat rectal cancer while allowing patients to keep their rectum. About 22 adults with stage I to III rectal cancer will receive tailored radiation and chemotherapy. The main goal is to check for serious…

This study compares a 5-day course of antibiotics to the usual 7-14 day course for children aged 3 months to 18 years hospitalized with uncomplicated pneumonia. The goal is to see if the shorter treatment is just as effective and causes fewer side effects. About 236 children will…

This study tests a two-step treatment for people with multiple myeloma that has come back or stopped responding to other therapies. First, patients receive a drug called talquetamab to help control the cancer, followed by a one-time infusion of their own modified immune cells (ci…

This study tests two remote programs—peer support groups and strengths-based case management—to help rural adults aged 50+ with HIV stick to their medications and improve quality of life. Researchers will enroll 352 participants across 17 Southern U.S. states. The goal is to see …

This early-stage study tests whether adding the drug venetoclax to two other medications (5-azacitidine and vorinostat) followed by standard chemotherapy can improve treatment response in children and young adults with acute myeloid leukemia that has come back or not responded to…

This study tests whether giving radiation to the main lung tumor before starting targeted therapy (a pill called a TKI) can delay cancer growth in people with advanced non-small cell lung cancer that has a specific gene mutation. About 34 adults who have not yet been treated will…

This study tests a new type of CAR-T cell therapy that targets two proteins (CD19 and CD20) on cancer cells. It is for adults with certain B cell blood cancers (like lymphoma or leukemia) that have not responded to other treatments. The goal is to see if these specially engineere…

This study tests whether a specially trained nurse case manager can help formerly incarcerated Black men with poorly controlled type 2 diabetes improve their blood sugar levels, blood pressure, and quality of life. One hundred participants will be randomly assigned to receive eit…

This early-phase study tests a new treatment for adults with B-cell lymphomas (like non-Hodgkin lymphoma) that have come back or not responded to prior therapies. It combines a targeted oral drug (pirtobrutinib) with specially engineered immune cells (LV20.19 CAR T-cells). The go…

This study tests whether adjusting cancer treatment based on how the tumor responds can help more people with localized pancreatic cancer complete their full treatment plan and have surgery. About 125 adults with resectable or borderline resectable pancreatic cancer will receive …

This study compares two radiation approaches given before surgery for pancreatic cancer that can be removed or is locally advanced. About 102 participants will receive either stereotactic body radiation therapy (SBRT) or standard radiation with chemotherapy. The main goal is to s…

This study tests whether using a tumor's RNA profile (PurIST test) to choose chemotherapy before surgery improves outcomes for people with pancreatic cancer that can be removed. About 84 adults with resectable or borderline resectable disease will receive 12 weeks of personalized…

This early-stage trial tests a new treatment for people with certain blood cancers (like Hodgkin lymphoma) that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in the lab to better attack cancer cells. The m…

This study tests a bone marrow transplant for people newly diagnosed with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The transplant uses marrow from a partially matched family member or unrelated donor. The goal is to improve surviv…

This study tests a combination of four drugs (bortezomib, isatuximab, cyclophosphamide, and dexamethasone) as an initial treatment for people with multiple myeloma who also have kidney problems and are eligible for a stem cell transplant. The goal is to see how well this treatmen…

This early-stage study aims to find a safe and effective dose of a new oral drug, iadademstat, when given alongside a standard chemotherapy drug, azacitidine. It is for adults with higher-risk forms of myelodysplastic syndrome (MDS), a type of bone marrow cancer. The main goal is…

This study is testing whether a new technology called optical coherence tomography (OCT) can help doctors more accurately diagnose ear infections in children. About 235 children with ear complaints will get a standard exam plus an OCT scan. Researchers will compare how often anti…

This study looks at whether a bedside ultrasound done during a regular clinic visit can accurately diagnose fatty liver disease. Researchers will compare the results from the portable ultrasound with standard radiology imaging. The goal is to make diagnosis faster and more conven…

This study will test a new FDA-approved device that measures electrical resistance in the esophagus to diagnose GERD and eosinophilic esophagitis. Researchers want to see if it can replace multiple tests, saving time and money. About 50 adults with chronic reflux or swallowing pr…

This study looks at whether using a sit-stand desk at work can help prevent type 2 diabetes in people who are overweight and sit most of the day. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours daily at their desk, or to a c…

This study tests whether giving theophylline, a drug used for asthma, can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. About 30 infants will receive the drug soon after birth. The goal is to see if this app…

This study tests whether providing healthy meals, nutrition support, and health coaching to high-risk pregnant women can lower their chances of developing gestational diabetes, high blood pressure, or preeclampsia. About 100 women in early pregnancy will be randomly assigned to e…

This study looks at three different ways to manage pain after childbirth in mothers who are being treated for opioid use disorder. The goal is to find which method works best for pain relief and may also help reduce anxiety, depression, and improve overall well-being. About 20 wo…

This study tests a special way of giving whole-brain radiation (called pulsed reduced dose-rate) to people with brain metastases. The goal is to see if this method can protect memory and thinking while still treating the tumors. About 53 adults with solid tumors that spread to th…

This study is testing whether metformin, a medicine used for diabetes, is safe and tolerable for premature infants who have or are at risk for bronchopulmonary dysplasia (BPD), a chronic lung condition. The trial has two phases: one for older premature infants already diagnosed w…

This study looks at whether doing vestibular physical therapy before surgery or radiosurgery can improve balance in people with vestibular schwannoma (a non-cancerous brain tumor). About 36 adults with small tumors will either get pre-treatment rehab or not, and their balance wil…

This study tests if wearing a special band around the outside of the throat can reduce nighttime symptoms of acid reflux, like coughing, choking, or a lump in the throat. Researchers will enroll 350 adults with GERD and track how their symptoms change. The goal is to find a simpl…

This study compares two standard treatments for benign esophageal strictures that don't respond to usual care. One approach starts with frequent dilations and only uses a temporary stent if dilations fail; the other places a stent early on. Researchers will track how quickly the …

This study tests a special exercise method called low load blood flow restriction training for people with disabilities who struggle with standard workouts. The approach uses a cuff on the arm to lightly restrict blood flow during easy exercises, aiming to build muscle strength a…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce stomach and bowel symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related autonomic nervous system problems. Researchers will measure changes in digestive …

This study is for children aged 11-18 with conditions like cyclic vomiting or functional dyspepsia, where the gut and brain don't communicate properly. Researchers will use a special tracking software to measure nerve activity and then give a personalized, non-invasive ear stimul…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm and skin, and examine placental vessels after delivery. The goal is to s…

This study tests a non-invasive device that stimulates the vagus nerve through the ear to reduce vomiting episodes in children with Cyclic Vomiting Syndrome. About 120 children will be randomly assigned to receive either the active device or a sham (inactive) device. The goal is …

This study tests whether a gentle brain stimulation technique called TMS, combined with word-finding therapy, can improve speaking ability in people who have trouble finding words after a stroke. About 50 adults who had a left-hemisphere stroke at least one month ago will receive…

This study tests whether a special brace called SPIO Core-Max helps infants aged 6 to 18 months with cerebral palsy improve their head, trunk, and arm control. Researchers will measure changes in posture and quality of life over 6 months. The goal is to see if this simple support…

This study tests a special device that people with swallowing problems (dysphagia) use to exercise their throat muscles. Over six weeks, participants do three daily sessions with the device and have X-ray swallowing tests before and after. The goal is to see if the device improve…

This study looks at how a special throat exerciser affects swallowing in healthy young and older adults. Researchers want to see if the device makes the muscles used for swallowing work harder. The goal is to gather basic information, not to treat any condition. About 60 healthy …

This study gathers information from 200 adults with B-cell acute lymphoblastic leukemia who received blinatumomab as part of their regular care, not in a clinical trial. Researchers will look at how many patients achieve complete remission and how long they survive. The goal is t…

This study aims to learn more about how the upper part of the esophagus (striated esophagus) works during swallowing. Researchers will measure muscle pressures and movements in healthy adults and people with swallowing problems. No treatment or medication is given—only observatio…

This study looks at whether delivering babies with gastroschisis at 35 weeks is better than waiting until 38 weeks. Gastroschisis is a birth defect where the baby's intestines stick out through a hole in the belly wall. The study will track 300 pregnant women and their babies to …

This study looks at whether group or solo singing is a practical activity for older adults with coronary artery disease. Researchers want to see if people will stick with it and if it could lower heart disease risk. The study involves 32 participants and focuses on attendance and…

This study aims to find hidden heart problems in fetuses that might lead to stillbirth. Researchers will use a special, non-invasive monitor called fetal magnetocardiography (fMCG) to check the heart's electrical activity in 30 pregnant women with high-risk conditions. The goal i…

This study looks at how tumors and nearby healthy organs change in size and shape during and after radiation therapy. By analyzing scans from 500 people who have already completed radiation, researchers hope to learn more about these changes. The goal is to use this information t…

This study looks at breast cancer risk and screening in people taking hormone therapy. Researchers will collect breast imaging data and talk to participants about their experiences and barriers to screening. The goal is to better understand how to support this group. About 130 ad…

This study looks at why stroke survivors' leg muscles get tired faster than normal. Researchers will measure blood flow to the leg during exercise and test a safe, non-invasive technique called ischemic conditioning to see if it can improve blood flow and reduce muscle fatigue. T…

This study looks at why some hormone receptor-positive breast cancers become resistant to standard hormone-blocking therapy. About 100 women with early-stage breast cancer will receive anti-estrogen treatment for 4-12 weeks before surgery. Researchers will analyze tumor samples t…

This study follows up to 500 people who received CAR-T cell therapy for blood cancers like leukemia, lymphoma, or multiple myeloma. Researchers will track participants for up to 15 years to see if any new cancers develop. The goal is to understand the long-term safety of this tre…

This study aims to learn the step-by-step process that causes type 1 diabetes. Researchers believe a person's immune system, guided by genes and environment, plays a key role. Participants include families with a history of type 1 diabetes and healthy controls. They provide a blo…

This study compares a continuous glucose monitor (CGM) worn on the skin for 10 days to the standard 2-hour oral glucose test for detecting diabetes in people with cystic fibrosis. Researchers want to see if the CGM is easier and just as accurate for screening. The study involves …

This study aims to see if a blood test can detect tumor DNA (ctDNA) in people with soft tissue sarcoma. Currently, doctors need to take a piece of the tumor (biopsy) to diagnose and monitor the disease, which can be risky and difficult. Researchers will collect blood samples from…

This study aims to better understand how electrical stimulation of the brain during awake surgery affects hand strength and movement. Researchers will test different stimulation settings in 20 adults with brain tumors to find which ones help or hinder hand function. The goal is t…

This study looks at whether a natural process called autophagy (cell cleanup) is reduced in people with type 2 diabetes and if that harms small blood vessels. About 60 adults (some with diabetes, some healthy) will take either trehalose (a sugar that may activate autophagy) or a …

This study looks at how social needs—like food, housing, or safety—affect the health and self-care of African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand what helps or hinders their care, then design a program tailored t…

This study looks at how the muscles that help control bowel movements get tired and how they can be strengthened. Researchers will test if doing resisted exercises can make these muscles stronger and improve symptoms of fecal incontinence. The study includes both healthy voluntee…

This study looks at whether a simple technique called ischemic conditioning can protect small blood vessels in frail older adults during intense exercise. Sixty people aged 65 to 85 will use a blood pressure cuff at home for two weeks. Researchers will measure blood vessel functi…

This study aims to understand how the upper throat and esophagus work together to prevent stomach contents from flowing back into the throat in people with GERD. Researchers will measure pressure and use video to detect when acid reaches the throat. The study involves 300 adults …

This study looks at whether analyzing the genetic makeup of a person's pancreatic tumor can help doctors pick more effective treatments. Researchers will review medical records from 1000 adult patients to see how often personalized therapy is used and how well it works. The goal …

This study looks at whether letting people collect their own anal samples at home can increase the number of high-risk individuals who follow through with clinic appointments for anal cancer screening. About 572 participants from Chicago, Houston, and Milwaukee will be involved. …

This study looks at whether small, natural differences in a gene called PTGS-1 make some babies more likely to develop a serious lung condition (PPHN) if their mothers took over-the-counter pain medicines like ibuprofen during pregnancy. Researchers will compare 200 newborns—some…

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study looks at whether small differences in certain genes make very low birth-weight babies (under 1500 grams) more likely to develop chronic lung disease and other serious problems of prematurity. Researchers will also check blood markers to help predict these complications…