New hope for severe aplastic anemia: bone marrow transplant from partial matches shows promise

NCT ID NCT06517641

Recruiting now Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a bone marrow transplant from a partially matched donor (like a parent or sibling) for people newly diagnosed with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. Participants receive chemotherapy and immune-suppressing drugs before and after the transplant to help the new marrow take hold. The goal is to see if this approach improves survival and reduces complications like graft-versus-host disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bone marrow transplant with chemotherapy drugs (ATG, fludarabine, cyclophosphamide) and immune-suppressing drugs (tacrolimus, mycophenolate mofetil)
What this could lead to: If successful, this could offer a new, effective treatment option for severe aplastic anemia patients who lack a fully matched donor, potentially improving survival and reducing complications.
What could go wrong: This is a phase II trial with only 60 participants, so results are preliminary. The transplant carries risks like graft-versus-host disease, graft failure, and infection, and patients may need long-term immune-suppressing drugs.

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Conditions

The condition(s) this trial relates to.

acquired aplastic anemia aplastic anemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE APLASTIC ANEMIA

Contacts and locations

Locations

Blood and Marrow Transplant Center at Northside Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Health System
RECRUITING

Durham, North Carolina, 27705, United States
Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21218, United States
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Stanford University
RECRUITING

Stanford, California, 94305, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
UNC Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Kansas Medical Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73117, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37235, United States
Washington University School of Medicine, Barnes-Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States

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