Half-Matched stem cell transplant offers hope for children with blood disorders
NCT ID NCT04356469
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests a new type of stem cell transplant for children with severe blood disorders like sickle cell disease or aplastic anemia. The transplant uses stem cells from a parent or other half-matched family donor, which are specially processed to remove certain immune cells. The goal is to see if this approach is safe and helps the child's body accept the donor cells without serious complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TCR alpha beta T-cell and CD19 B-cell depleted stem cell graft
- What this could lead to
- If successful, this approach could offer a safer transplant option for children with severe blood disorders who lack a fully matched donor.
- What could go wrong
- This is a small Phase 2 study, so results may not apply broadly. Risks include graft failure, infection, or graft-versus-host disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BONE MARROW FAILURE SYNDROME are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Johns Hopkins All Children's Hospital
RECRUITINGSt. Petersburg, Florida, 33701, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a gentler chemo-radiation combo make stem cell transplants safer for blood cancers?
- New stem cell processing method offers hope for patients without a perfect donor match
- New transplant approach aims to tame bone marrow failure
- New trial aims to slash deadly bloodstream infections from hospital tubes
- New hope for older adults with rare blood disorder: safer transplant regimen under study
- Stem cell harvest trial aims to unlock gene therapy for rare blood disorders