Medical College Of Wisconsin

This study aims to see if a common type of diabetes drug (GLP-1 RA) can improve the buildup of harmful fats in the liver of people who have fatty liver disease, diabetes, and obesity. Researchers will compare liver and blood samples from 30 people who have been on the drug for a …

This study is testing an oral drug called pacritinib for men with advanced prostate cancer that has spread and is no longer responding to standard hormone-blocking treatments. About 32 participants will take the drug twice daily to see if it can slow the cancer's growth. The main…

This is an early-stage study testing the safety of a new type of treatment called FT836 CAR T-cell therapy, given alongside an existing drug called daratumumab. It is for adults with advanced multiple myeloma that has come back or stopped responding to at least three prior treatm…

This study is preparing for a larger trial to see if regular singing can improve blood vessel health and lower future heart disease risk in older adults who already have coronary artery disease. Researchers will test whether group singing (in-person or virtual) or solo singing is…

This study is testing whether a nutritional supplement called MitoQ can help women with preeclampsia, a serious pregnancy complication. Researchers will enroll 80 pregnant patients to see if MitoQ improves blood vessel function in the mother and placenta, which could help prolong…

This study is testing whether a dietary supplement called propionic acid can improve blood vessel function in people with coronary artery disease. Researchers want to see if this gut-derived acid reduces inflammation and helps blood vessels work better. The study will enroll 20 p…

This is a first-in-human study to test the safety of a new type of CAR-T cell therapy for adults with B-cell cancers like lymphoma that have come back or stopped responding to other treatments. The therapy uses a patient's own modified immune cells designed to attack cancer by ta…

This early study is testing a new two-step approach for adults with certain brain tumors that are hard to remove completely because they sit in critical brain areas. First, doctors implant a small device to gently stimulate the brain area tied to the tumor, causing a temporary we…

This study is testing whether adding two newer drugs, mosunetuzumab and polatuzumab vedotin, to a modified chemotherapy regimen can better treat aggressive lymphoma in older adults. The goal is to see if this combination improves the chance of a complete response and allows some …

This early-stage study is testing whether a new vaccine, combined with an existing immunotherapy drug, is safe and practical for patients whose cancer has spread to the brain or spinal fluid. It will involve about 20 patients whose cancer has worsened despite standard treatments.…

This study is testing if a virtual lifestyle program tailored for Puerto Rican men can help them lose weight. Researchers will compare a program focused on healthy eating and physical activity to one giving only general health information. The goal is to see if the culturally rel…

This study is testing an experimental drug called linvoseltamab for people with multiple myeloma whose cancer has returned after receiving a specific type of CAR-T cell therapy. The trial aims to see if this new treatment can help control the disease and is safe for these patient…

This study is testing whether quercetin, a natural supplement, can help protect and improve the function of tiny blood vessels in people with obesity. Researchers will enroll 40 obese adults aged 18-40 and measure their blood vessel responses before and after taking the supplemen…

This study is testing if fosamprenavir, a drug approved for HIV, can help people with laryngopharyngeal reflux (LPR), a common throat condition causing cough and hoarseness. Current acid-reducing medicines often don't work for LPR. Researchers believe this HIV drug might block a …

This study is testing a new computer-based decision tool designed to help doctors better protect cancer survivors from heart problems. The tool will be tested with 60 cancer survivors who are at risk for heart disease. Researchers want to see if the tool is easy for doctors and p…

This study is testing whether adding warm, sterile fluid into the womb during labor can help protect newborns from serious breathing problems. It will enroll 320 pregnant people who have thick meconium (baby's first stool) in their amniotic fluid, which can cause breathing issues…

This is a first-in-human study to test the safety and early effectiveness of a new personalized immunotherapy. It is for adults with certain advanced blood cancers (like Hodgkin lymphoma and others) that have a marker called CD30 and have come back or not responded to at least tw…

This study aims to see if providing healthy lifestyle education about diet, exercise, and nutrition to women before they get pregnant or in early pregnancy can improve their heart health and lower the risk of pregnancy complications like gestational diabetes and preeclampsia. Res…

This early-stage study is testing if adding a bile acid pill called Ursodeoxycholic Acid (UDCA) to standard antibiotic treatment can prevent C. difficile (C. diff) infection from returning. It will enroll 30 high-risk adults who have just been treated for C. diff. The goal is to …

This study is testing whether mindfulness training, with or without wearable sensors, can help prevent preeclampsia—a serious high blood pressure disorder during pregnancy. Researchers will enroll 90 pregnant women at risk for this condition and randomly assign them to receive mi…

This pilot study aims to prevent serious health problems from postpartum preeclampsia, a dangerous high blood pressure condition that can start after childbirth. Researchers will test a blood marker to identify 60 at-risk pregnant women in Nepal. Women flagged as high-risk may re…

This study is testing whether a non-invasive electrical stimulation treatment, applied to the spine through the skin, can help improve balance in people who have had surgery for a degenerative neck spinal cord condition. Participants will be randomly assigned to receive either re…

This study is testing whether a 16-week lifestyle program focused on diet and exercise can help improve physical function and quality of life for people living with multiple myeloma. Researchers will enroll 184 adults who have been diagnosed for at least one year and are medicall…

This study is testing whether a gentle light therapy can prevent and treat painful mouth sores in children receiving cancer treatment. Researchers will work with 50 children to see if the light therapy is practical to use and if it helps reduce the sores, pain, and need for stron…

This study is testing if a new oral drug called FOS-SA can reduce heartburn and regurgitation in people whose acid reflux symptoms continue despite taking standard medications. About 60 adults will take either the study drug or a placebo pill twice daily for 8 weeks while trackin…

This study is testing whether a 3-week outpatient rehabilitation program can reduce long-lasting symptoms from traumatic brain injuries and related conditions in veterans and first responders. Researchers will compare participants who receive the program to those who don't, measu…

This study aims to understand why some people regain weight after stopping popular injectable weight loss drugs. Researchers will measure a brain protein and other body metrics in 52 adults before and after they stop their medication due to insurance changes. The goal is to ident…

This study aims to understand why people with type 2 diabetes often experience dangerous blood pressure spikes during exercise, which increases their risk of heart attack and stroke. Researchers will measure blood pressure, heart rate, and blood vessel function in 40 participants…

This study aims to create a large collection of blood samples and health information from patients receiving stem cell transplants or gene therapy for serious non-cancer blood diseases like aplastic anemia and sickle cell disease. Researchers will collect samples before and after…

This study aims to see if adding a genetic risk score to standard heart disease check-ups helps patients and doctors in everyday clinics make better decisions about starting preventive medication. Researchers will enroll 200 adults without heart disease from one rural and one urb…

This study aims to understand if consuming sugar-free sweeteners (like those in diet sodas) affects heart and blood vessel health in young adults with type 1 diabetes. Researchers will measure sweetener levels in the blood and check blood vessel function in 20 participants after …