Medical College Of Wisconsin

This study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers. About 450 adults with myeloid cancers who have signs of disease before transplant will be assigned to treatment …

This early-phase study tests a new type of immune cell therapy (CAR T cells) that targets two proteins on cancer cells at once. It is for adults with B-cell non-Hodgkin lymphoma whose cancer has not responded to or has returned after other treatments. The main goal is to find a s…

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This early-phase study tests a new kind of CAR T-cell therapy for people with multiple myeloma that has come back or not responded to at least three prior treatments. The cells are 'armored' to resist a protein (TGF-beta) that normally blocks their attack. Up to 30 adults will re…

This phase 2 trial tests an oral drug called pacritinib in 32 men with metastatic castrate-resistant prostate cancer that has worsened after standard treatments. The drug is taken twice daily, and the main goal is to see if it can delay cancer growth for at least six months. Part…

This study tests whether high-protein drinks during labor can keep blood sugar in a healthier range for pregnant women with insulin-treated diabetes. Sixty women will be randomly assigned to drink either a high-protein beverage or standard clear liquids every four hours during la…

This phase 2 trial tests a drug called linvoseltamab in 34 people with multiple myeloma whose cancer returned after BCMA CAR T-cell therapy. Linvoseltamab is a bispecific antibody that helps the immune system attack myeloma cells. The main goal is to see how many patients respond…

This study tests whether fosamprenavir, an FDA-approved HIV medication, can help people with laryngopharyngeal reflux (LPR) who haven't gotten better with standard acid reducers. LPR causes chronic cough, hoarseness, and throat clearing, and current treatments often fall short. R…

This study tests a new combination of drugs (mosunetuzumab and polatuzumab vedotin) plus chemotherapy for elderly patients (70 and older) with a newly diagnosed type of lymphoma called diffuse large B-cell lymphoma. The goal is to see if this approach helps more patients achieve …

This study tests whether virtual classes about healthy eating and exercise can help Puerto Rican men lose weight. About 48 men will take part in online sessions for 4 months, with follow-up meetings. The goal is to see if the program is practical and leads to meaningful weight lo…

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses and blood pressure in 180 participants. The goa…

This phase 2 trial tests whether quercetin, a dietary supplement found in many fruits and vegetables, can improve the function of tiny blood vessels in young adults with obesity. Forty participants will take either quercetin or a placebo daily for 30 days. Researchers will measur…

This early-phase trial tests a new type of CAR T-cell therapy called FT836, given together with the drug daratumumab, in 12 adults with multiple myeloma that has come back or stopped responding to at least three prior treatments. The main goal is to see if the combination is safe…

This study in Nepal tests whether a blood test before delivery can predict which women will develop dangerous high blood pressure after giving birth. Women at high risk will receive a care bundle including remote blood pressure monitoring, education, and medication to manage thei…

This study looks at whether a GLP-1 receptor agonist, a drug already used for diabetes and obesity, can improve fat buildup in the liver and blood in people with MASLD. Researchers will measure changes in fats, proteins, and genes in 30 participants who already take the drug. The…

This early study tests a new approach for people with slow-growing brain tumors located in areas that control movement. A small device placed on the skull delivers mild electrical stimulation while patients do physical therapy, aiming to retrain the brain so that critical functio…

This study looks at whether taking propionic acid (a natural substance made by gut bacteria) can improve blood vessel function and reduce inflammation in 20 adults with coronary artery disease. Participants will take the supplement for 4 weeks, and researchers will measure change…

This study tests whether light therapy (photobiomodulation) can prevent mouth sores in children receiving chemotherapy. Fifty children aged 0-30 will receive daily light treatments during hospital stays and at home. Researchers will check if the therapy is easy to use and accepta…

This study looks at whether giving patients and their doctors a polygenic risk score — a genetic test that estimates future risk of coronary heart disease — helps more people start taking statins to prevent heart problems. Researchers will enroll 200 adults aged 40-69 without pri…

This early-phase trial tests whether adding Ursodeoxycholic Acid (UDCA) to standard antibiotics can prevent Clostridioides difficile (C. diff) infection from returning. About 30 adults with C. diff and risk factors for recurrence will take UDCA three times daily for up to eight w…

This study will test whether giving women healthy lifestyle education before they get pregnant or in early pregnancy can improve their heart health and lower the chance of problems like gestational diabetes and preeclampsia. Two hundred women at risk for preeclampsia will be rand…

This study will test if mindfulness training, with or without a wearable biosensor watch, can help prevent preeclampsia in pregnant women at moderate to high risk. 90 women will be split into three groups: mindfulness plus the watch, mindfulness alone, or standard prenatal care. …

This study tests whether a 16-week lifestyle program focused on nutrition and physical activity can improve physical function, quality of life, and biological aging markers in people with multiple myeloma. About 184 participants will be randomly assigned to either start the progr…

This study tests whether a noninvasive device that sends mild electrical pulses to the spinal cord, combined with balance training, can improve balance in adults who still have trouble walking after surgery for degenerative cervical myelopathy. 45 participants will be randomly as…

This phase 2 trial tests whether a combination of fosamprenavir (an HIV medication) and sodium alginate (a seaweed-based thickener) can ease heartburn and regurgitation in people whose reflux doesn't improve with standard acid-blocking pills. Sixty adults aged 18 to 65 will take …

This study tests whether taking omega-3 supplements before surgery can change the types of fats found in breast tumors. About 35 adults with early-stage breast cancer will take the supplement for 4 to 28 weeks while also receiving standard cancer treatments. The goal is to see if…

This early-stage trial will test whether an oral drug called gallium maltolate can reach brain tumors in people with recurrent glioblastoma. Eight participants will take the drug for about two weeks before surgery, and researchers will measure gallium levels in the removed tumor …

This study will test a new, non-invasive forehead thermometer (Temple Touch Pro) in 20 children in the pediatric intensive care unit who need their body temperature carefully controlled. The goal is to see if this simple sticker-like device gives the same accurate readings as sta…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young people aged 15-24 with type 1 diabetes. Researchers will measure blood vessel function before and after drinking a sweetened sports drink. The goal is to under…

This study follows 52 adults who are about to stop taking injectable weight loss drugs due to insurance changes. Researchers will measure a brain protein called Agouti-related peptide (AgRP) and track weight changes over 3 months. The goal is to see if this protein can predict wh…

This study looks at why people with type 2 diabetes have dangerously high blood pressure during exercise, raising their risk of heart attack and stroke. Researchers will test if damaged blood vessels and cell stress are to blame. The study involves 40 adults with and without diab…

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…