Medical College Of Wisconsin

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses in the skin and track blood pressure. The trial…

This study tests whether giving tailored maintenance therapy after a stem cell transplant can prevent relapse in people with myeloid cancers like leukemia or myelodysplastic syndrome. About 450 adults will be assigned to treatment based on whether tests detect leftover cancer cel…

This early-phase study tests a new treatment called FT836 CAR T-cell therapy combined with daratumumab in 12 adults with multiple myeloma that has returned or not responded to at least three prior treatments. The main goal is to check safety and find the right dose. Participants …

This study looks at whether a GLP-1 RA drug (used for diabetes and weight loss) can improve fat levels in the liver and blood of people with MASLD (fatty liver disease). About 30 adults with MASLD, diabetes, and obesity will take the drug and have liver biopsies and blood tests t…

This study tests whether a blood test before delivery can predict which mothers will develop dangerously high blood pressure after giving birth. About 60 women at risk will be monitored and given extra care if needed. The goal is to catch problems early and reduce emergency visit…

This early study tests whether a small device placed on the brain can, along with physical therapy, retrain healthy brain areas to take over functions threatened by a tumor. The goal is to allow surgeons to remove more of the tumor without causing permanent weakness or speech pro…

This study tests whether placing warm sterile fluid into the womb during labor can reduce breathing problems in newborns when the fluid around the baby is stained with thick meconium (the baby's first poop). About 320 pregnant women at 36 weeks or later will be randomly assigned …

This study tests a 4-month virtual program designed for Puerto Rican men over 35 who are overweight. Participants join online classes about healthy eating and physical activity, led by a community health promoter. The goal is to see if the program is practical and helps men lose …

This study tests whether drinking high-protein beverages during labor can help keep blood sugar levels stable in pregnant women with insulin-treated diabetes. About 60 women will be randomly assigned to drink either a clear protein drink or standard clear liquids (like juice or b…

This study looks at whether a supplement called propionic acid can improve blood vessel function in 20 people with coronary artery disease. Researchers will measure changes in artery health and inflammation over 4 weeks. The goal is to see if this gut-related compound can help ma…

This early-phase study tests whether a special vaccine (SV-BR-1-GM) combined with an immunotherapy drug (pembrolizumab) is safe and feasible for people with solid tumors that have spread to the brain or spinal cord. About 20 adults whose cancer has worsened despite standard treat…

This study tests a drug called pacritinib in 32 men with advanced prostate cancer that has spread and stopped responding to standard hormone therapies. The goal is to see if pacritinib can slow or stop cancer growth for at least six months. Participants must have a biopsy showing…

This study tests whether adding two targeted drugs (mosunetuzumab and polatuzumab vedotin) to a standard chemotherapy backbone can help older adults (70+) with a newly diagnosed, aggressive type of lymphoma called diffuse large B-cell lymphoma. About 31 participants will receive …

This early-phase study tests a new type of immunotherapy called CAR T cells that target two proteins (CD20 and CD19) on cancer cells. It is for adults with B-cell lymphoma that has returned or not responded to prior treatments. The main goal is to find the safest dose and monitor…

This study tests whether fosamprenavir, an FDA-approved HIV medication, can treat laryngopharyngeal reflux (LPR) — a condition causing chronic cough, hoarseness, and throat clearing. About 104 adults with LPR who did not improve with standard acid-reducing therapy will receive ei…

This study is testing an experimental drug called linvoseltamab for people with multiple myeloma whose cancer has returned after receiving a specific type of CAR-T cell therapy. The trial aims to see if this new treatment can help control the disease and is safe for these patient…

This study tests whether mindfulness training, with or without wearable biosensors, can help prevent preeclampsia in pregnant women at moderate to high risk. 90 women will be randomly assigned to one of three groups: mindfulness plus biosensors, mindfulness alone, or standard pre…

This study tests whether teaching women about healthy eating, activity, and other lifestyle habits before or during early pregnancy can improve their heart health and lower the risk of problems like gestational diabetes and preeclampsia. About 200 women at risk for these complica…

This study tests if light therapy can prevent and treat painful mouth sores in children with cancer. About 50 kids will receive light therapy every other day while in the hospital. Researchers will compare their results to past patients who did not get the therapy. The goal is to…

This early-phase trial tests whether adding ursodeoxycholic acid (UDCA) to standard antibiotics can prevent Clostridioides difficile (C. diff) infection from returning. About 30 adults with C. diff and risk factors for recurrence will take UDCA three times daily for up to 8 weeks…

This study tests whether a new drug called Fosamprenavir-Sodium Alginate can reduce heartburn and regurgitation in people whose acid reflux doesn't improve with standard proton pump inhibitors. About 60 adults aged 18-65 will take the drug or a placebo twice daily for 8 weeks and…

This study tests a 16-week lifestyle program that encourages healthier eating and exercise habits in people with multiple myeloma. Researchers want to see if these changes improve physical function, quality of life, and blood markers of aging. About 184 adults who have had myelom…

This study tests whether a gentle electrical stimulation applied to the skin over the spinal cord (tSCS) can boost balance in adults who still have trouble walking steadily after surgery for a neck condition called degenerative cervical myelopathy. Forty-five participants will be…

This study aims to find out if a protein from the brain, called AgRP, can predict who will regain weight after stopping injectable weight loss medications. Researchers will measure AgRP levels and weight changes in 52 adults over 3 months after they stop the drug. The goal is to …

This study will test a new, non-invasive forehead thermometer (Temple Touch Pro) in 20 children in the pediatric intensive care unit who need their body temperature carefully controlled. The goal is to see if this simple skin sensor can accurately replace the standard internal pr…

This study collects blood samples and health information from 375 people with non-cancerous blood diseases like aplastic anemia, sickle cell disease, and thalassemia who are getting a stem cell transplant or gene therapy. The goal is to create a biobank that helps researchers und…

This study looks at whether the supplement quercetin can help blood vessels work better in people with obesity. Researchers will measure how small blood vessels respond to certain substances. 40 participants aged 18-40 with a BMI over 30 will be involved. The goal is to understan…

This study looks at why people with type 2 diabetes have dangerously high blood pressure during exercise. Researchers will test if damaged blood vessels and cell stress cause this problem. The goal is to find new ways to make exercise safer and reduce heart attack and stroke risk…

This study looks at whether adding a person's genetic risk score to standard heart disease risk checks helps doctors and patients decide together on prevention steps, like taking statins. About 200 adults aged 40-69 with no prior heart disease or statin use will take part in rura…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young adults with type 1 diabetes. Twenty people aged 15-24 will drink a sports drink and have their blood vessel function measured. The goal is to understand if the…

This early-phase trial will test whether an oral drug called gallium maltolate can reach brain tumor tissue in 8 people with recurrent glioblastoma. Participants take the drug before surgery, and researchers compare gallium levels in their removed tumor tissue to samples from unt…

This study is testing a new computer-based decision aid designed to help cancer survivors and their heart doctors. The tool, accessed through electronic health records, aims to improve decisions about heart-protective medications and monitoring tests. Researchers want to see if b…