Can a warm fluid wash away newborn breathing risks? PEARL trial aims to find out

NCT ID NCT07274527

Recruiting now Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Thick meconium in the amniotic fluid affects about 1 in 7 pregnancies and can cause breathing problems in newborns. The PEARL trial tests whether infusing warm sterile fluid into the uterus during labor reduces these risks. The study will enroll 320 pregnant people at 36 weeks or later, randomly assigning them to receive the infusion or standard care. Researchers will also check cord blood for inflammation and follow up at 12 months to see if children develop normally.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: warm lactated ringer's solution infused into the uterus
What this could lead to: If it works, this could provide a simple, standardized way to reduce breathing problems in newborns exposed to thick meconium during labor.
What could go wrong: This is a single trial with 320 participants, and earlier studies on amnioinfusion had mixed results. The benefits may be small or not apply to all hospitals.

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Conditions

The condition(s) this trial relates to.

acidosis disorder perinatal asphyxia Perinatal Death perinatal disease pregnancy disorder with abortive outcome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMNIOINFUSION CORD BLOOD CPAP MATERNAL MORBIDITY MECHANICAL VENTILATION MECONIUM NEONATAL ACIDOSIS NEONATAL BRAIN INJURY NEONATAL RESPIRATORY DISTRESS RELATED CONDITIONS NICU ADMISSION PERINATAL DEATH PERINATAL MORBIDITY SURFACTANT

Contacts and locations

Locations

Froedtert Hospital and Medical College of Wisconsin Birth Center
RECRUITING

Milwaukee, Wisconsin, 53045, United States

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