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Brain waves reveal hidden effects of breathing machines on injured brains

NCT ID NCT07716787

Knowledge-focused Sponsor: Shengli Oilfield Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study monitors brain electrical activity and blood flow in critically ill patients with acute brain injury who are on a breathing machine. Researchers adjust the machine's pressure settings and perform lung reopening maneuvers, then use EEG and ultrasound to see how the brain responds. The goal is to better understand how breathing support affects brain function, which could lead to safer ventilation strategies in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors tailor breathing machine settings to protect brain function in critically ill patients.
What could go wrong
This is a small observational study, not a treatment trial. It may not lead to clear clinical guidelines, and individual responses may vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Admission to the neurocritical care unit with acute brain injury requiring intensive care management. * Receiving invasive mechanical ventilation. * Undergoing clinically indicated recruitment maneuvers and positive end-expiratory pressure (PEEP) adjustments. * Availability of an adequate temporal acoustic window for transcranial Doppler monitoring. * Written informed consent obtained from the participant or a legally authorized representative. Exclusion Criteria: * Pregnancy. * Hemodynamic instability precluding recruitment maneuvers or PEEP adjustments. * Severe cardiac dysfunction judged by the treating physician to contraindicate study procedures. * Inability to obtain adequate transcranial Doppler signals. * Conditions preventing EEG monitoring, including extensive scalp injury or dressings that preclude electrode placement. * Withdrawal of informed consent.

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Conditions

The condition(s) this trial relates to.

brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute brain injury Mechanical ventilation Neurocritical care

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shengli Oilfield Central Hospital

    RECRUITING

    Dongying, Shandong, 257034, China

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