MECHANICAL VENTILATION

This study tests whether using lung ultrasound to personalize ventilator settings can reduce deaths in people with acute respiratory distress syndrome (ARDS). About 538 adults on breathing machines will be assigned to either standard care or a personalized plan based on their lun…

Thick meconium in the amniotic fluid affects about 1 in 7 pregnancies and can cause breathing problems in newborns. The PEARL trial tests whether infusing warm sterile fluid into the uterus during labor reduces these risks. The study will enroll 320 pregnant people at 36 weeks or…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard physical therapy helps ICU patients on breathing machines recover muscle strength. About 150 adults will be randomly assigned to get either physical therapy alone or physical therapy plus NMES…

This study tests whether a personalized program of nutrition and physical activity, started early in the ICU and continued at home, helps people recover better after being on a breathing machine and heart-support drugs. 830 adults will be randomly assigned to either this program …

This study tests whether levosimendan, a drug that strengthens heart and breathing muscles, can help critically ill patients get off a ventilator faster. About 250 adults who have been on a breathing machine for over 48 hours and failed a breathing test will receive either the dr…

This study tests whether using lung ultrasound to guide removal of extra fluid helps patients on breathing machines in the ICU breathe on their own sooner. About 1,000 adults who need a ventilator for at least another day will be randomly assigned to have fluid removal guided by …

This study tests whether giving acetaminophen (Tylenol) and ketorolac (Toradol) to children on ventilators can better control pain and reduce the need for strong opioids. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly assigned to rece…

This study compares two methods of breathing trials for overweight and obese ICU patients before removing their breathing tube. One hundred adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned to either pressure support venti…

This pilot study tests whether using a lower breathing rate on ventilators is safe and practical for critically ill patients. About 56 adults on breathing machines will be randomly assigned to either the new lower-rate approach or standard care. The goal is to see if the new meth…

This study looks at whether a brief increase in airway pressure (called a recruitment maneuver) after suctioning helps restore lung volume in ICU patients on ventilators. About 32 adults will be enrolled, and each will act as their own control, receiving both the maneuver and no …

This study compares two ways of using a breathing machine during weight-loss surgery in 34 obese patients. One method controls the flow of air, the other controls the volume. Researchers want to see which method keeps the lungs and heart more stable during surgery. Participants w…

This study looks at how the pressure settings on a breathing machine during robot-assisted prostate surgery affect the lungs afterward. Researchers will use lung ultrasound to check for changes in lung health. The goal is to find better ways to set the breathing machine to protec…

This study compares two ways of using a breathing machine during surgery for a slipped disk in the lower back. One method controls the flow of air, the other controls the volume. Researchers want to see which keeps oxygen levels higher after patients are turned onto their stomach…

This study tests a new, less invasive way to check diaphragm function in patients on breathing machines. Researchers will use ultrasound to measure diaphragm movement during a spontaneous breathing trial. The goal is to see if this method can help doctors decide when patients are…

This study looks at 50 newborn infants who need a breathing machine (mechanical ventilation). Researchers want to see if measuring tiny changes in skin moisture (skin conductance) can help tell how much pain or stress the baby feels. They will also test if holding the baby skin-t…

This study watches how different ICUs around the world help patients on breathing machines get better. It will look at what kinds of exercises and therapies are used, and how they affect recovery and quality of life. The goal is to find the best ways to help these patients recove…

This study looks at how the AbClo device, a non-invasive abdominal binder used to keep the abdomen closed after surgery, affects lung function in 18 intensive care patients on ventilators. Researchers will measure lung pressure and volume before and after adjusting the device to …

This study aims to create a prediction tool that helps doctors decide which ICU patients who have been on a breathing machine will benefit most from early rehabilitation. Researchers will collect data from 250 patients and use machine learning to build an algorithm. The goal is t…

This study tests a new AI system called IntelliLung that suggests ventilator settings for ICU patients on breathing machines. Researchers will compare how often doctors' settings match the AI's recommendations. About 530 adults on ventilators will take part across multiple hospit…

This study looks at whether doing periodic lung recruitment maneuvers (a technique to reopen collapsed lung areas) during spine surgery helps reduce lung collapse compared to the standard single-time approach. Sixty adults having elective spine surgery while lying face-down will …

This study tests whether a personalized lung volume optimization maneuver can improve heart and lung function in children on ventilators. It includes two groups: children recovering from heart surgery and those with severe respiratory failure. Researchers will adjust ventilator p…

This study is testing whether a special physiotherapy assessment, called the EPIC Assessment, can predict which patients in the intensive care unit will have trouble after their breathing tube is removed. About 330 adults on ventilators for more than 48 hours will be evaluated. T…

This study is collecting information from over 2,600 adults on breathing machines to find simple ways to predict if removing the breathing tube might fail. The goal is to create an easy-to-use tool for doctors at the bedside. This research does not test a new treatment but aims t…

This study aims to translate a pain scale called ESCID into Turkish and check if it works for ICU patients on breathing machines who cannot talk. Pain is common in these patients but often missed. The researchers will test the scale on 50 adults to see if it reliably measures pai…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departments will …

This study observes how doctors decide when to remove breathing tubes (extubation) in extremely preterm infants born before 28 weeks. Researchers will track 100 babies in the NICU, asking doctors daily why they choose to extubate or not. The goal is to understand current practice…

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels…

This study tests two ways of using a breathing machine during weight-loss surgery in people with obesity. One method controls the flow of air, the other controls the volume. Researchers will measure oxygen levels and airway pressures to see which approach keeps lungs working bett…

This study looks at how to adjust breathing machine settings for people with moderate-to-severe ARDS, a serious lung condition. Researchers will use a special imaging technique to see how air and blood flow match up in the lungs. The goal is to find the best settings for each pat…

This study looks at how short periods of high oxygen affect blood flow in the brains of ICU patients on breathing machines. Researchers will briefly increase the oxygen given through the ventilator and use ultrasound to monitor brain artery blood flow. The goal is to understand t…

This study follows 150 adult patients on ventilators in the ICU to see how often they develop joint contractures (stiff joints). Researchers measure joint movement regularly and track factors like sedation and immobility. The goal is to find what causes these contractures and hel…

This study looks at whether using extra monitoring devices during major abdominal surgery can help high-risk patients (aged 50 and older) spend less time on a breathing machine afterward. One group will receive standard care, while the other will have additional sensors and a spe…

This study is testing a new method for giving muscle relaxants to patients with severe breathing problems who are on a breathing machine. The goal is to see if this approach is safe and possible, and if it helps patients breathe on their own more easily. About 23 adults in the ho…

This study watches 60 ICU patients on breathing machines to see if a new device (SERA) can measure breathing effort and oxygen use. The goal is to find better ways to predict who can safely breathe without the machine. Participants are already getting a standard breathing test, a…

This study looks at how changing the way a ventilator lets patients breathe out (called RCexp) affects air and blood flow in the lungs of people with ARDS. Researchers will use a special imaging technique (EIT) to measure these changes in 60 adults on ventilators. The goal is to …

This study looks at how the breathing drive and effort of patients in the ICU change when the ventilator pressure support is adjusted. Forty adults who had major abdominal surgery and are on a breathing machine will have their ventilator settings changed in small steps. Researche…

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. …

This study looks at whether giving ICU doctors a special score (ProVent-14) helps them better predict if a patient on a breathing machine for two weeks will survive for a year. About 238 doctors and nurses will participate, each caring for a patient on a ventilator. The goal is t…