MECHANICAL VENTILATION

This study tests whether a simple clinical score can help doctors decide the right time to remove breathing tubes in brain-injured patients. About 660 adults with acute brain injury who need a ventilator will take part. The goal is to reduce the number of patients who need to be …

This study tests whether using lung ultrasound to personalize breathing machine settings can reduce deaths in patients with acute respiratory distress syndrome (ARDS), a severe lung condition with a 30% death rate. About 538 adults on ventilators will be assigned to either standa…

This study tests whether using lung ultrasound to guide removal of extra fluid can help ICU patients on breathing machines get off the ventilator sooner. About 1,000 adults who need a ventilator for at least another day will be randomly assigned to either ultrasound-guided fluid …

This study tests if levosimendan, a drug that strengthens heart and breathing muscles, can help critically ill patients get off a breathing machine faster. About 250 adults who have struggled to wean from ventilation will receive either the drug or a placebo. The goal is to see i…

This study is testing a new method to help patients with severe lung failure who are on breathing machines. Researchers want to see if carefully adjusting a muscle-relaxing medication can help these patients breathe more safely on their own. The trial will check if this approach …

This study compares two methods (pressure support ventilation and T-piece) used to test if overweight ICU patients are ready to have their breathing tube removed. About 100 adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned…

This study tests whether a newer sedative called ciprofol works as well as the standard drug propofol for keeping ICU patients calm while on a breathing machine, but with fewer side effects like dangerously low blood pressure. About 366 adults who need sedation for 6-24 hours wil…

This study tests whether adding gentle electrical stimulation to the legs, alongside standard physical therapy, helps critically ill patients on breathing machines maintain or regain muscle strength. About 150 adults in the ICU will be randomly assigned to receive either physical…

This study compares two standard pain medicines, fentanyl and hydromorphone, in 300 ICU patients who need a breathing machine. The goal is to see if one leads to better outcomes, such as using less opioid medicine overall and improving recovery. Participants will receive one of t…

This study tests whether adding non-opioid pain medicines (acetaminophen/Tylenol and ketorolac/Toradol) can improve pain control and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years with acute respiratory failure w…

This study is testing if using advanced monitoring equipment during surgery can help high-risk patients breathe on their own sooner after major abdominal surgery. It will involve 100 patients aged 50 and older. The goal is to see if this detailed monitoring leads to less time on …

This study tests a new AI tool called IntelliLung that gives recommendations on how to set a ventilator for patients who need help breathing. Researchers want to see how often doctors' settings match the AI's suggestions. The study includes 530 adults in the ICU who are on a brea…

This study looks at whether ICU doctors, nurses, and other clinicians make better predictions about a patient's chance of surviving one year when they are given a special risk score called ProVent-14. The score uses simple medical information measured on day 14 of being on a brea…

This study observes rehabilitation practices in intensive care units (ICUs) around the world for patients who need a breathing machine (mechanical ventilation) for at least 48 hours. Researchers want to understand what types of rehab are used, how often, and how they affect patie…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort patients need to breathe on their own. It will include 12 adults in the ICU who are already using a ventilator to help them breathe. Researchers will test four different pressure …

This study observes 1,500 adults with acute brain injury who need a breathing machine (ventilator) for at least 24 hours. Researchers want to understand how and when patients are safely taken off the ventilator, and what affects their recovery. The goal is to find better ways to …

This study compares two ways of using a breathing machine during weight-loss surgery in 40 adults with obesity. The goal is to see which method keeps oxygen levels higher and puts less pressure on the lungs. Results may help doctors choose safer ventilation for future surgeries.

This study aims to translate and test a pain scale called ESCID for Turkish-speaking ICU patients who are on breathing machines and cannot talk. Pain is common in these patients but often missed, leading to worse outcomes. Researchers will check if the Turkish version is reliable…

This study is creating a tool to predict which ICU patients who needed a breathing tube will benefit most from early physical therapy. Researchers will collect data from 250 adults to build an algorithm that helps doctors decide who should get rehab. The goal is to improve recove…

This study looks at how short bursts of high oxygen affect blood flow in the brains of ICU patients on breathing machines. Researchers will temporarily increase oxygen levels and use a non-invasive ultrasound to monitor brain artery blood flow. The goal is to learn more, not to p…

This study watches how patients' breathing changes when the ventilator support level is adjusted after major abdominal surgery. About 40 adults in the surgical ICU will take part. The goal is to find the best ventilator settings to avoid complications and help recovery.

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed on a breathing machine in the emergency room. About 3,090 adults on ventilators will take …

This study looks at how doctors decide when to take extremely preterm babies (born before 28 weeks) off a breathing machine in their first two weeks of life. Researchers will ask doctors daily why they choose to remove the tube or keep it in, and then check if those decisions lea…

This study looks at whether a brief increase in airway pressure after suctioning can reopen collapsed lung areas and improve lung volume in ICU patients on ventilators. About 32 adults will be randomly assigned to receive either suctioning alone or suctioning followed by a recrui…

This study is collecting information from over 2,600 adults who are ready to have their breathing tube removed after passing a breathing test. The goal is to find simple signs that can predict if the tube will need to be put back in. Researchers hope to create a simple bedside to…

This study watches 150 adult ICU patients on breathing machines to see how often they develop joint stiffness (contractures). Researchers measure joint movement and track factors like sedation and immobility. The goal is to find ways to prevent these problems and improve recovery…

This study looks at whether a special physiotherapy assessment, called the EPIC Assessment, can predict if a patient in the intensive care unit will have trouble after their breathing tube is removed. About 330 adults who have been on a ventilator for more than 48 hours will be e…

This study looks at how adjusting breathing machine settings and body position can improve lung function in people with moderate-to-severe acute respiratory distress syndrome (ARDS). Researchers will use a special imaging technique to see which parts of the lung are getting air a…

This study looks at how a device called AbClo, which gently holds the belly together after surgery, affects breathing in patients whose abdomen is left open. Researchers will measure lung pressure and volume before and after adjusting the device, and again after the abdomen is cl…

This study tests whether a personalized program of nutrition and physical therapy, started early in the ICU and continued at home, helps people recover better after being on a breathing machine and heart-support medications. About 830 adults will be randomly assigned to either th…

This study tests a personalized breathing maneuver in children on ventilators—either after heart surgery or with severe lung failure. The goal is to see if adjusting the breathing machine settings can improve heart and lung function, reduce time on the ventilator, and lower the n…

This study tests whether using a slower breathing rate on ventilators is safe and practical for critically ill patients. About 84 adults in the ICU who need a breathing tube will be randomly assigned to either a standard or a slower, gentler ventilation method. The goal is to see…

This study observes 60 ICU patients on breathing machines to see if a special device can measure breathing effort and predict who will successfully breathe on their own. Participants will have their breathing muscles and oxygen use monitored during a standard breathing test. The …

This study looks at whether doing lung-opening maneuvers several times during spine surgery (instead of just once) can reduce partial lung collapse. About 60 adults having elective spine surgery while lying face-down will take part. Doctors will use lung ultrasound to check how w…

This study looks at how the time it takes for a patient to exhale affects lung function in adults with acute respiratory distress syndrome (ARDS) who are on a ventilator. Researchers will use a special imaging technique called EIT to measure how air and blood flow are distributed…