MECHANICAL VENTILATION

This study aims to find which of two short breathing tests better prepares overweight and obese ICU patients to have their breathing tubes safely removed. Researchers will randomly assign 100 eligible adults to try either a pressure support ventilation or a T-piece method for one…

This study is testing a simple 4-point clinical checklist to help doctors decide when it's safe to remove breathing tubes from brain-injured patients who are still unconscious. The goal is to reduce the risk of failed tube removal, which can lead to pneumonia and other complicati…

This study is testing if using advanced monitoring equipment during major abdominal surgery can help high-risk patients breathe on their own faster after the operation. It will involve 100 patients aged 50 and older who are having planned cancer-related abdominal surgery. The goa…

This study is testing a specific breathing technique, called a lung volume optimization maneuver, for children in two critical situations. For kids recovering from heart surgery, it aims to see if the technique improves heart function and lung mechanics, potentially shortening th…

This study aims to see if using a simple lung ultrasound scan to guide personalized ventilator settings can help more patients survive Acute Respiratory Distress Syndrome (ARDS), a severe lung condition. Researchers will compare this personalized approach to standard ventilator c…

This study is testing if a brief, controlled increase in breathing machine pressure right after clearing a patient's breathing tube helps keep their lungs properly inflated. Researchers will compare this technique to standard suctioning alone in 32 sedated ICU patients on ventila…

This study is testing a new way to use muscle-relaxing drugs for patients in the ICU with severe breathing failure who are on a ventilator. Instead of completely paralyzing the patient, doctors aim to use a lower dose to allow some safe, gentle breathing effort. The goal is to se…

This study is testing if using a simple, safe bedside lung ultrasound can help doctors better guide fluid removal in critically ill patients on ventilators. The goal is to see if this approach helps patients breathe on their own sooner, potentially reducing their time in the ICU.…

This study is testing if a personalized recovery program that starts early in the ICU and continues at home helps patients regain strength and mobility better than usual care. It will involve 830 adults who were on a ventilator and blood pressure medication in the ICU. The progra…

This study is testing a new checklist, called the EPIC Assessment, to help doctors decide when it's safe to take a patient off a ventilator (breathing machine). Specially trained physiotherapists will perform the assessment on 330 ICU patients who are ready to try breathing on th…

This study aims to prevent a terrifying experience called 'awareness with paralysis,' where emergency room patients on breathing machines are awake but can't move. It will test if making a shorter-acting paralytic drug the standard choice reduces this risk and lowers rates of PTS…

This study is testing whether a drug called levosimendan can help critically ill patients who are struggling to breathe on their own after being on a ventilator. The drug is designed to strengthen the diaphragm muscle to help with breathing. Researchers will compare the drug to a…

This study is testing if adding common non-opioid pain medications (like IV Tylenol and Toradol) can better control pain and reduce the need for strong opioid drugs in children who are critically ill and on a breathing machine. Researchers will enroll about 644 children aged 2 mo…

This study aims to find out if one of two commonly used pain and sedation medicines (fentanyl or hydromorphone) is better for adults in the ICU who need help breathing from a machine. Researchers will compare the drugs to see if one leads to patients needing less total medication…

This study is testing if adding electrical muscle stimulation to standard physical therapy helps patients in the intensive care unit (ICU) who are on breathing machines. 150 participants will be randomly assigned to receive either standard therapy alone or standard therapy plus g…

This study aims to understand how a specific setting on a breathing machine affects how air and blood flow are distributed in the lungs of patients with Acute Respiratory Distress Syndrome (ARDS). Researchers will enroll 60 adult patients who are on a ventilator for ARDS. They wi…

This study is a small, first-step trial to see if a specific, slower breathing machine setting is safe and practical to use in intensive care units (ICUs). It will involve 84 adult patients who are on a breathing machine for severe lung problems. The goal is to gather information…

This study aims to better understand how patients on breathing machines adjust to different levels of support after major abdominal surgery. Researchers will observe 40 stable adult patients in the surgical ICU, measuring their breathing effort as the machine's support is careful…

This study aims to better understand the process of taking patients with acute brain injuries off mechanical breathing machines (ventilators). Researchers will observe 1,500 adult patients to see how they fare during this 'weaning' process and what outcomes they have. The goal is…

This study is testing a new AI-based decision support system called IntelliLung. It aims to see how often doctors' ventilator settings match the recommendations made by the AI system. The study will observe over 500 adult patients in intensive care who are on breathing machines.

This study aims to find better ways to predict when a critically ill patient in the ICU is ready to breathe on their own after using a ventilator. Researchers will test a new, non-invasive sensor that measures muscle activity and oxygen use during a short breathing test. The goal…

This study aims to understand how doctors decide when to remove breathing tubes from extremely premature babies and why some babies need the tube put back in. Researchers will observe 100 babies born before 28 weeks and record doctors' daily decisions about breathing support duri…

This study aims to understand how brief increases in oxygen affect blood flow in the brains of critically ill patients on breathing machines. Researchers will temporarily adjust the oxygen levels for 80 ventilated ICU patients and use a non-invasive ultrasound to monitor brain ar…

This study aims to translate and test a Turkish version of a pain assessment scale for intensive care unit (ICU) patients who are on breathing machines and cannot communicate. The goal is to create a reliable tool that helps nurses and doctors better recognize pain in these vulne…

This study aims to understand how a medical device used to hold an open surgical wound together affects patients' breathing. Researchers will measure lung pressure, volume, and oxygen levels in 18 sedated ICU patients before and after adjusting the device. The goal is to see if c…

This study aims to understand how often and why joint stiffness (contractures) develops in sedated adult patients on breathing machines in the ICU. Researchers will observe 150 patients, measuring their joint movement regularly during their ICU stay, but will not change their sta…

This study aims to find out which of two common breathing machine settings works better for patients during weight loss surgery. Researchers will compare how well each method maintains oxygen levels and manages pressure in the lungs of 40 adult patients with obesity. The goal is …

This study aims to see if a simple ultrasound scan of chest muscles can help doctors predict the best time to take a patient off a breathing machine. It will observe 64 adults who have been on a ventilator for at least a day and are ready to try breathing on their own. The goal i…

This study aims to understand how adjusting a specific pressure setting on a breathing machine (ventilator) affects how hard a patient's own breathing muscles have to work. Researchers will test four different pressure levels in 12 adult patients who are stable but need ventilato…

This study aims to see if giving ICU doctors a specific score helps them make better predictions about whether a patient on a long-term breathing machine will survive one year. It involves over 200 ICU doctors and nurses who care for these patients. The goal is to improve how med…

This study aims to better understand how to personalize breathing machine settings for patients with severe lung failure (ARDS). Researchers will observe 40 sedated patients to see how different air pressures and body positions affect how well air and blood flow match in the lung…