MECHANICAL VENTILATION

This study looks at whether esketamine, a drug related to ketamine, can safely sedate and prevent confusion (delirium) in 80 adults with sepsis who need a breathing machine. The goal is to see if it reduces time on the ventilator and improves survival. Current sedatives can cause…

This study follows 312 older adults who were in the ICU for critical illness to see how their physical activity during the hospital stay relates to their recovery. Researchers measure disability, physical function, and cognitive function at 3 and 12 months after leaving the ICU. …

This study looks at how much energy critically ill patients on breathing machines use during routine bed exercises. By measuring oxygen consumption with a special device in the ventilator, researchers hope to understand the physical demands of these exercises. The goal is to make…

This study looks at a care approach called a time-limited trial (TLT) for patients in the ICU who need a breathing machine. Doctors, patients, and families agree to try treatments for a set time, then check if the patient is recovering. The goal is to find the best way to use TLT…

This study looks at whether repeated measurements of certain biomarkers in the blood can help predict if a patient in the ICU will need to be put back on a breathing tube after it is removed. The study involves 266 adults who have been on a ventilator for more than 48 hours and a…

This study looks at whether the type of breathing machine setting used in the ICU affects how well patients recover. Over 4,700 critically ill adults on ventilators will take part across multiple hospitals. Researchers will switch the entire ICU's ventilator mode every two months…

This quality improvement study tests a digital tool (Respiratory Knowledge Portal) that gives ICU teams real-time feedback on ventilator settings and patient data. The goal is to help staff follow best practices, reduce ventilator-associated events, and improve outcomes for the 8…

This study looks at how the amount of air left in the lungs after breathing out affects diaphragm strength in people on ventilators. Researchers will first test healthy volunteers to understand the relationship, then check if the same holds true for ICU patients. The goal is to c…