MECHANICAL VENTILATION

This study compares fentanyl and hydromorphone (Dilaudid) for sedating patients on mechanical ventilators in the ICU. About 300 adults will be randomly assigned to one of the two drugs. The main goal is to see if one leads to lower total opioid use. The results could help guide s…

This study tests esketamine, a drug related to ketamine, for sedation and delirium prevention in 80 septic patients who need a breathing tube. The goal is to see if esketamine can reduce time on the ventilator and improve survival compared to standard sedatives. The trial is acti…

This study was designed to observe how patients with acute brain injury are taken off mechanical ventilation (breathing machines) in the ICU. It planned to include adults with brain injury who needed a ventilator for at least 24 hours, but the study was withdrawn before enrolling…

This study looks at whether the type of breathing machine setting used in the intensive care unit (ICU) affects how well patients recover. Researchers will switch the ventilator mode used across entire ICUs every two months and track outcomes like days alive without a breathing m…

This study tests whether a software tool called the Respiratory Knowledge Portal (RKP) can help ICU teams reduce complications in patients on breathing machines. Researchers will collect data from 875 patients to see if the tool improves how alarms are set, helps wean patients of…

This study looks at how much energy critically ill patients on ventilators use during routine passive physiotherapy. By measuring oxygen consumption with a special device in the breathing tube, researchers hope to understand the physical demands of these exercises. The goal is to…

This study looks at a care approach called a time-limited trial (TLT) for ICU patients who need a breathing machine. Doctors, patients, and families agree to try treatments for a set time, then check if the patient is recovering. The goal is to see if this approach can reduce ICU…

This study follows 312 older adults who survived a critical illness to see how much they moved during their ICU stay. Researchers want to learn if more activity leads to less disability, better mobility, and clearer thinking 3 to 12 months later. The goal is to find ways to impro…

This observational study looks at how the amount of air left in the lungs after breathing out affects measurements of diaphragm strength. Researchers will test 30 healthy volunteers and then compare results with ventilated ICU patients. The goal is to develop a way to correct dia…