MECHANICAL VENTILATION

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving …

This study tested two different ways of using a breathing machine during emergency abdominal surgery. One method used higher air pressure to keep the lungs open, while the other used lower pressure to avoid overstretching the lungs. The goal was to see which approach led to fewer…

This study tested a new way of using mechanical ventilators, called VentCoach, to better protect the lungs of ICU patients with breathing failure. 18 adults on ventilators were randomly assigned to either the VentCoach protocol or standard care. The main goal was to see if doctor…

This study compares a new sedative called ciprofol to the standard drug propofol in 366 ICU patients who need a breathing tube. The goal is to see if ciprofol can sedate patients just as well but with fewer episodes of dangerously low blood pressure. Participants will be randomly…

This study tests whether repeated acupressure can help reduce agitation, pain, and sleep disturbances in intensive care unit (ICU) patients who are on mechanical ventilators. Participants receive either real acupressure or a light touch (sham) twice daily for four days. Researche…

This completed trial tested whether electrical stimulation of the diaphragm and abdominal muscles helps patients who have been on a breathing machine for a long time to breathe on their own sooner. 300 adults who had been on a ventilator for at least 21 days received either real …

This study tested whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for fentanyl (a strong opioid) in critically ill patients on mechanical ventilators. Sixty adults were randomly assigned to receive either nefopam plus standard care or standa…

This study tested whether giving a combination of two sedative drugs (dexmedetomidine and esketamine) at night can improve sleep quality for ICU patients who need a breathing tube or high-flow oxygen mask. The trial involved 174 adults aged 50 and older after surgery. Researchers…

This study looks at whether repeated measurements of certain biomarkers during a spontaneous breathing trial can help predict which ICU patients will need to be re-intubated within 7 days. Researchers will follow 266 adults who have been on a ventilator for more than 48 hours and…

This study tests an artificial intelligence program designed to predict the best time to remove a breathing tube (extubation) from patients in intensive care. Researchers will use data from 1500 adults who were on a ventilator for at least 72 hours across four hospitals. The AI a…

This study tested two simple, drug-free interventions for premature babies on breathing machines: feeding them breast milk at times that match the mother's body clock, and exposing them to the mother's scent while giving the mother the baby's scent. Researchers tracked how quickl…

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 …

This study looked at how a low dose of ketamine, a medicine often used for anesthesia, affects breathing and brain activity in 15 critically ill patients who were on breathing machines (ventilators) in the ICU. The goal was to see if ketamine could help stimulate breathing and im…

This study looked at 120 critically ill patients on breathing machines to see if a quick, non-invasive test called P0.1 could predict whether they would need the tube reinserted after removal. The test measures the effort to breathe in the first split second of inhalation. Resear…

This study tested whether a personalized approach to removing breathing tubes in the ICU works better than standard care. About 691 adults on ventilators for over 24 hours were included. Doctors used daily checks and chose the best method (T-piece or pressure support) based on ea…

This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and …

This study examined 236 adults in a surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was linked to how long they stayed on the ventilator. The goal was to b…

This study looked at 28 ICU patients on breathing machines to see if a diaphragm ultrasound could catch a specific breathing problem called double triggering. Researchers compared the ultrasound results to standard ventilator readings. The goal is to find a better way to monitor …

This small study tested a device that paces the diaphragm in brain dead organ donors whose lungs were too damaged for transplant. The goal was to see if this approach could improve lung function enough to make the lungs usable. Only 3 people took part, so the results are very ear…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This study tested a new breathing machine mode called NAVA in 15 patients recovering from acute lung injury. The goal was to see how their bodies responded to different levels of support from the machine. The study did not aim to treat or cure the lung injury, but to gather infor…

This study observed 91 ICU patients on breathing machines who needed a tracheostomy (a tube in the windpipe). One group continued receiving liquid food through a feeding tube until just before the procedure, while the other group fasted for 6-8 hours as usual. Researchers tracked…

This study looked at 64 adults on breathing machines to see if changes in a chest muscle (parasternal intercostal) could predict when the breathing tube could be safely removed. Researchers measured muscle thickness during breathing trials. The goal was to find a simple, non-inva…

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study looked at 423 adults on breathing machines in intensive care units (ICUs). Half were physically restrained only if severely agitated, while the other half were restrained routinely. Researchers measured how many days patients were free of delirium (confusion) over the …

This study looked at how changing the speed at which a ventilator reaches its target pressure affects breathing in 17 newborns on breathing support. The researchers tested different settings and measured changes in airway pressure and gas exchange. The goal was to find out if thi…

This study tested two methods of removing a breathing tube after digestive surgery to see which one helps patients breathe better. 208 adults having surgery lasting over an hour took part. One group had the tube removed the usual way, and the other had it removed while still conn…

This study tested a simple method to see if giving extra fluids would help patients on breathing machines who are in shock. Doctors used a short increase in breathing machine pressure (PEEP test) to predict fluid needs. The goal was to avoid unnecessary fluids. The study involved…

This study looked at 80 obese adults having spine surgery to see if adjusting the breathing machine based on lung stiffness works better than using a fixed setting. The goal was to improve oxygen levels during surgery and reduce lung complications afterward. Researchers measured …

This study looked at 78 adults who had heart surgery and needed a breathing tube while being moved to the intensive care unit. Researchers compared using a manual bag (AMBU bag) versus a mechanical ventilator (Hamilton C1) to see which method kept blood pressure and oxygen levels…

This study looked at 77 ICU patients on breathing machines who needed a tracheostomy. Doctors used either a camera (bronchoscopy) or ultrasound to guide the procedure. The goal was to see which method caused fewer changes in breathing and blood gas levels. The results could help …

This study looked at whether measuring the pressure in the cuff of a breathing tube can accurately assess how hard a patient is working to breathe while on a ventilator. Researchers compared this new method to the standard, more invasive technique that uses a sensor in the esopha…

This study looked at 66 ICU patients on breathing machines to see if ultrasound could measure diaphragm thickness differently depending on the machine's settings. Researchers compared two modes: one where the machine controls all breaths and one where the patient triggers some br…

This study followed 156 critically ill patients who had a tracheostomy to help them come off a breathing machine (ventilator). Researchers measured how long the weaning process took, how often patients felt short of breath or uncomfortable, and how this affected their quality of …

This study looked at 40 ICU patients on breathing machines to see how their eye pressure changed when they started breathing on their own. Researchers measured eye pressure non-invasively before and after the switch. The goal was to understand if the transition affects eye pressu…

This study tested whether an automatic device (IntelliCuff) or manual checks by nurses better maintain safe air pressure in breathing tubes for 32 children in intensive care. The goal was to see which method keeps pressure in the ideal range and reduces nurse workload. Results wi…

This study looked at 101 patients having laparoscopic (keyhole) abdominal surgery to compare two different levels of positive pressure used by the breathing machine. One group got a standard low pressure, the other got an 'optimum' pressure tailored to their lungs. The goal was t…

This study tested a personalized online decision-support tool called TRACH-Support. The tool is designed to help families and doctors make shared decisions about tracheostomy and prolonged mechanical ventilation. Researchers enrolled 105 participants, including family members of …

This study looked at 60 adults with acute respiratory distress syndrome (ARDS) on breathing machines. It compared two ventilation methods—airway pressure release ventilation (APRV) and low tidal volume (LTV) ventilation—to see which one better protects the right side of the heart…

This completed study observed 150 adults undergoing elective surgery with general anesthesia. Researchers used an esophageal balloon to measure how changes in ventilator settings (tidal volume and PEEP) affect pressure inside the lungs and chest. The goal was to better understand…

This study tested whether a ventilator-delivered sigh breath can help measure how much of the lung can be reopened (recruitability) in patients on breathing support. 110 adults on pressure support ventilation received two short test periods with different pressure settings. The g…

This study reviewed medical records of 50 children on breathing machines to see if inhaled sedatives (halogenated gases) could reduce the need for other sedative drugs. The goal was to see if these gases help lower doses of medications like midazolam and morphine. The study is co…