MECHANICAL VENTILATION

This study compared two ways of using a breathing machine during emergency abdominal surgery to see which one leads to fewer lung problems and deaths. Over 700 adults took part. One method used higher air pressure and extra breaths to open the lungs, while the other used lower pr…

This study tested if using mild electrical pulses on the diaphragm and abdominal muscles helps patients who have been on a breathing machine (ventilator) for a long time to breathe on their own again. 300 adults who had been on a ventilator for at least 21 days took part. The goa…

This study tested whether giving a combination of two sedative drugs (dexmedetomidine and esketamine) at night can improve sleep quality for adults in the intensive care unit who need a breathing machine or high-flow oxygen. Researchers measured sleep stages using brain monitorin…

This study tested whether adding a painkiller called nefopam to standard care could lower the amount of strong opioids needed by ICU patients on breathing machines. 60 adults were randomly assigned to receive either nefopam or a placebo alongside usual sedation. The goal was to s…

This study looked at how changing a ventilator setting called 'pressure rise time' affects breathing in 17 newborns on breathing machines. The goal was to see if different settings change how well the babies breathe and how the ventilator works with them. The results could help d…

This study looked at 77 adults in the intensive care unit who needed a tracheostomy (a breathing tube through the neck) while on a ventilator. Doctors used either a camera (bronchoscopy) or ultrasound to guide the procedure. The goal was to see how each method affected breathing …

This study tested whether giving sedation through inhalation (breathing it in) instead of standard IV drugs could reduce the energy delivered to the lungs by the ventilator (mechanical power) in 40 ICU patients. Lower mechanical power may mean less lung injury and better outcomes…

This study tested a new way to use a breathing machine (ventilator) to better protect the lungs of patients with breathing failure. 18 adults who needed a ventilator for more than 24 hours took part. The new method, called VentCoach, was compared to standard care to see if it cou…

This study looked at 64 adults on breathing machines to see if changes in a chest muscle (parasternal intercostal) could help doctors know the right time to remove the tube. Researchers measured muscle thickening during a breathing test. The goal was to find a simple, non-invasiv…

This study looked at 78 adults who had heart surgery and needed a breathing machine afterward. Researchers compared using a manual bag versus a mechanical ventilator while moving patients from the operating room to the ICU. The main goal was to see how each method affected blood …

This study tested a personalized online tool called TRACH-Support that helps families and medical teams decide whether to use a tracheostomy (a tube in the throat) for patients who need long-term breathing help. 105 family members and healthcare providers used the tool and gave f…

This study looked at 40 ICU patients to see if eye pressure changes when they stop using a breathing machine and start breathing on their own. Researchers measured eye pressure before and after the switch using a simple, non-invasive device. The goal was to learn more about eye h…

This study observed 66 ICU patients on mechanical ventilators to see if ultrasound measurements of the diaphragm differ between two breathing modes. Researchers measured diaphragm thickness during controlled and spontaneous breaths, and also during a sedation pause. The goal was …

This study looked at 60 adults with severe lung injury (ARDS) on breathing machines. It compared two ventilation methods—APRV and low tidal volume—to see which one better protects the right side of the heart from strain. The goal was to find out if one method reduces heart compli…

This study examined 236 adults in the surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was related to how long they needed the breathing machine. The goal w…

This study tested whether an automatic device (IntelliCuff) is better than manual checks for keeping the cuff pressure of breathing tubes in the right range for children in intensive care. 32 children on ventilators were monitored for 24 hours with each method. The goal was to se…

This study tested whether a personalized strategy for removing breathing tubes (weaning) from intensive care unit patients works better than usual care. The approach used daily checks and chose the best method based on each patient's risk factors, like obesity or heart disease. T…

This study observed over 2,200 brain-injured patients in intensive care units worldwide to see how doctors use breathing machines. The goal was to describe different ventilation strategies and explore how they relate to patient recovery. No treatments were tested, and there was n…

This study observed 91 ICU patients on breathing machines who needed a tracheostomy (a tube in the windpipe). Researchers compared those who kept getting tube feeding until the procedure to those who fasted for 6-8 hours. The goal was to see if feeding increased the risk of aspir…

This study looked at how changing the ventilator's air volume and pressure during surgery affects pressure inside the lungs and chest. Researchers used a small balloon placed in the esophagus to measure these pressures in 150 adults having elective surgery. The goal was to better…

This study tested two methods of removing a breathing tube after digestive surgery to see which one helps patients breathe better. 208 adults having surgery lasting over an hour took part. One group had the tube removed the usual way, and the other had it removed while still conn…

This study looked at whether a simple test using positive end-expiratory pressure (PEEP) can predict if a patient on a breathing machine needs more fluids. The test was done on 66 adults in the ICU who were already on ventilators. The goal was to see if this test could replace mo…

This study tested whether using physical restraints (like wrist straps) less often in ICU patients on breathing machines could reduce the time they spend in delirium (confusion). 423 adults were randomly assigned to either routine restraint use or restraint only for severe agitat…

This study looked at 110 adults on breathing machines to see if a special deep breath (a sigh) can help doctors measure lung stiffness and find out if the lungs can be opened up more. The goal was to see if using sigh information to adjust machine settings improves breathing comp…

This study tested a new way of helping patients breathe after a lung injury. It compared different levels of a special ventilator mode called NAVA to see how it affected breathing and comfort. Fifteen adults in intensive care took part. The goal was to learn how the body responds…

This study looked at whether giving extra oxygen during heart surgery with a heart-lung machine affects kidney function afterward. 104 adults having planned heart surgery took part. The goal was to gather information to help design larger studies, not to prove a treatment works.

This study looked at how different levels of positive pressure from a breathing machine affect oxygen levels and lung strain during laparoscopic (keyhole) surgery. 101 adults without lung disease took part. Researchers measured mechanical power (a measure of lung stress) and oxyg…

This study looked at 28 ICU patients on breathing machines to see if a diaphragm ultrasound could detect a specific breathing problem called double triggering. Researchers compared ultrasound results to standard ventilator readings. The goal is to find better ways to monitor and …

This small study tested whether electrically stimulating the diaphragm (the main breathing muscle) could improve lung function in brain dead organ donors whose lungs were initially not good enough for transplant. Three donors received a temporary pacing device. The goal was to se…

This study looked back at the medical records of 50 children (ages 1 month to 18 years) who were on breathing machines for more than 72 hours. The goal was to see if adding inhaled gases (halogenated agents) could reduce the amount of standard sedatives and painkillers needed. Th…

This study looked at 80 obese adults having spine surgery to see if customizing the breathing machine's pressure settings improves oxygen levels and reduces lung problems after surgery. One group received standard settings, while the other had settings tailored to their lung flex…

This study followed 156 adults who were being weaned from a breathing machine using a tracheostomy (a tube in the throat). The goal was to measure how long weaning takes, how often patients feel short of breath or uncomfortable, and how this affects their quality of life and ment…

This study looked at 30 patients on breathing machines to see if the pressure in the tube's cuff (the balloon that holds the tube in place) can show how hard they are working to breathe. Normally, doctors use a thin tube down the esophagus to measure this, which is uncomfortable.…