Could lung fluid proteins reveal a new way to track severe lung injury?

NCT ID NCT01270295

Completed Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and track them over several days. The goal is to understand if these proteins could serve as markers of lung cell damage and help guide future care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If certain RAGE-related proteins are found at higher levels in patients with lung injury, they could become biomarkers to help diagnose or monitor the condition.
What could go wrong: This is an observational study, so it cannot prove cause and effect. The findings may not lead to any new tests or treatments, and the small size may limit how broadly they apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LUNG INJURY ACUTE RESPIRATORY DISTRESS SYNDROME MECHANICAL VENTILATION

Contacts and locations

Locations

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

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