Adult acute respiratory distress syndrome

This study tests whether a personalized breathing machine strategy can improve survival in people with acute respiratory distress syndrome (ARDS), a severe lung condition. About 1,100 adults on ventilators will be randomly assigned to either standard care or a precision approach …

This study tests a new drug called GEn-1124 in 52 adults with acute respiratory distress syndrome (ARDS), a severe lung condition. The drug is given as an IV infusion twice daily for 5 days, starting as soon as possible after diagnosis. The main goal is to check if the drug is sa…

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This early-stage trial tests a new drug called PRS CK STORM, made from a mix of immune and fat cells, to see if it can safely calm the 'cytokine storm'—a dangerous overreaction of the immune system—in people with severe lung infections from COVID-19, flu, or RSV. The study will e…

This study tests whether the steroid methylprednisolone can help critically ill patients with severe inflammation from sepsis or acute respiratory distress syndrome (ARDS). About 150 adults will receive a high dose, low dose, or placebo for up to 7 days. Researchers will measure …

This study tests whether using lung ultrasound to personalize ventilator settings can reduce deaths in people with acute respiratory distress syndrome (ARDS). About 538 adults on breathing machines will be assigned to either standard care or a personalized plan based on their lun…

This early-stage trial tests a new antibody called HT31-1 in 24 healthy volunteers to see if it is safe and how the body processes it. The antibody targets a protein linked to inflammation in acute respiratory distress syndrome (ARDS), a severe lung condition often caused by infe…

This study compares two ways of positioning patients with severe lung failure (ARDS) who are on a breathing machine: lying on the stomach for more than 48 hours straight versus 16 to 24 hours each day. The goal is to see which approach helps more people survive. About 780 adults …

This study tests whether pirfenidone, a drug already used for a different lung disease, can prevent scarring in patients with severe acute respiratory distress syndrome (ARDS). About 130 people on ventilators will receive either pirfenidone or a placebo through a feeding tube. Th…

This study tests a drug called bevacizumab in hospitalized adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and oxygen levels. The goal is to find a saf…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or an active drug to see if the treatments improve survival and are safe. The go…

This Phase 2 trial tests a drug called paridiprubart in hospitalized adults with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo as a single IV dose. The main goal is to see …

This study tests a medicine called vilobelimab in adults hospitalized with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and is safe…

This study tests whether using a real-time lung imaging tool (EIT) to guide breathing therapy helps people who have been on a breathing machine for a long time. The goal is to see if this personalized approach helps them breathe on their own sooner compared to standard therapy. T…

This study compares two medications (calfactant and poractant alfa) given through a thin tube to help premature babies breathe. The babies are born before 30 weeks and have respiratory distress syndrome. The goal is to see which drug works better at reducing the need for a breath…

This Phase 3 trial tests a new inhaled medication called APC-0101 in 520 premature babies born between 26 and 33 weeks who have respiratory distress syndrome. The drug is a surfactant that helps keep tiny air sacs in the lungs open. Some babies receive the active drug through a s…

This Phase 3 trial tests whether giving the lungs a near-complete rest (apneic ventilation) early after starting ECMO helps people with the most severe form of acute respiratory distress syndrome (ARDS). About 280 participants will be randomly assigned to either near-apneic venti…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This study looks at two different ways to use ventilators for children with acute respiratory distress syndrome (ARDS), a serious lung condition. The goal is to see which method helps children recover faster and breathe better. About 160 children will take part, and the results w…

This study tests whether giving L-carnitine, a natural substance, to premature babies with respiratory distress syndrome (RDS) can help them survive and gain weight better. Researchers will compare babies who get L-carnitine plus standard care to those who get standard care alone…

This study tests a new drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily for up to 28 days alongside standard care. The goal is to see if it is safe and helps patients recover faster from pneumonia caused by COVID-19 or ot…

This study is testing whether adding umbilical cord stem cells or their secretions to standard care can help people with severe lung injury (ARDS) caused by pneumonia-related sepsis. The goal is to see if these treatments can shorten hospital stays and lower the risk of death. Th…

This phase 3 trial tests whether a single intravenous dose of ExoFlo, made from bone marrow stem cell vesicles, can lower the death rate in hospitalized adults with moderate-to-severe ARDS. About 970 participants will receive either ExoFlo or a placebo. The main goal is to see if…

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This early-phase trial tests whether stem cells from umbilical cords are safe for people with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 36 adults will receive an injection of these cells to find the safest dose and check for si…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The trial will include 99 adults with acute respiratory distress syndrome or kidney injury. Half will receive standard care plus the d…

This study tests an experimental drug called YD0743 in adults with sepsis who develop severe lung failure (ARDS) and need a breathing machine. The main goal is to see if the drug helps patients spend fewer days on the ventilator compared to a placebo. About 309 ICU patients will …

This study tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with acute lung injury caused by sepsis. Sepsis triggers severe inflammation that often damages the lungs, and current treatments are limited. The trial will compare standard care plus …

This study tests whether a real-time lung imaging tool called electrical impedance tomography (EIT) can help doctors choose the best ventilator pressure for patients with lung injury after severe trauma or major surgery. The trial will compare EIT-guided pressure settings to the …

This Phase 3 trial tests an experimental drug called STSA-1002 in 406 adults with acute respiratory distress syndrome (ARDS) caused by a viral infection. Participants receive either the drug or a placebo added to standard care. The main goal is to see if the drug lowers the chanc…

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study looks at whether keeping patients with severe lung failure (ARDS) on their stomachs for 40 hours at a time, instead of the usual 16 hours, can lower the chance of death. About 800 adults on breathing machines will be randomly assigned to one of the two positions. The g…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This study tests whether gently cooling the body (to 34-35°C) combined with muscle-paralyzing drugs can help people with severe lung injury (ARDS) recover. About 340 adults on ventilators will be randomly assigned to cooling plus paralytics or usual care. The main goal is to see …

This study tests whether a special breathing machine called high-frequency oscillation ventilation (HFOV) works better than standard mechanical ventilation for very premature babies (born at 24 to 31 weeks) who have acute respiratory distress syndrome (ARDS). The goal is to see i…

This pilot study tests whether placing ARDS patients in an upright position in bed can improve their breathing while on a ventilator. Forty adults with ARDS will be randomly assigned to either upright positioning or standard head-of-bed elevation. The main goal is to see if uprig…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study looks at whether two simple blood test results—the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio—can help predict which children with severe burns will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will foll…

This study looks at whether using lung and heart ultrasound can help emergency doctors give the right treatment faster to older adults (over 65) who come to the ER with sudden breathing trouble. About 504 participants will be enrolled. The goal is to see if ultrasound reduces the…

This study looks at two substances in the blood—endocan and copeptin—in 40 premature babies born between 28 and 36 weeks who have breathing trouble (respiratory distress syndrome). Researchers will measure these markers on the first day of life to see if they can predict how seve…

This study tests whether a computer alert can help doctors remember to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. Blood clots are a serious risk for some hospitalized patients, even after discharge. The trial will include 400 adults ag…

This study compares two ways of giving a lung-opening medicine (surfactant) to premature babies with breathing problems. The newer method uses a soft mask placed in the throat instead of a breathing tube down the windpipe. Researchers want to see if the gentler method works just …

This study looks at whether adding a gentle chest-squeezing technique to standard postural drainage can immediately improve oxygen levels and reduce breathing difficulty in preterm infants with respiratory distress syndrome. Fourteen babies born by C-section will be randomly assi…

This study tests whether safely raising patients with acute respiratory distress syndrome (ARDS) to an upright position (verticalization) is feasible and safe. Researchers will compare upright positioning with standard prone positioning in 32 adults. The goal is to see if upright…

This study looks at 50 children (over 1 year old) in intensive care who are on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers want to see if two methods can reliably measure airway opening pressure, which could help doctors personalize ventilati…

This study looks at preterm infants who need breathing support from a machine called nasal CPAP. Researchers want to find out how much oxygen actually reaches the baby's lungs by placing a small tube in the back of the mouth and using soft bands around the chest to measure lung e…

This study looks at how a pregnant woman's body handles caffeine and how much of it reaches her unborn baby. Researchers will give a small dose of caffeine to 30 women at risk of preterm delivery before a planned C-section. Blood samples from the mother, placenta, and newborn wil…

This study looks at how different sedatives affect the breathing of patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. Twenty adults in the ICU will receive both standard intravenous propofol and inhaled isoflurane (a gas used in anesthesia) for sho…

This study looks at whether being treated at a high-altitude hospital affects survival for children with acute respiratory distress syndrome (severe lung failure). Researchers will collect data from 1,600 children in intensive care units around the world. The goal is to understan…

This study uses electrical impedance tomography (EIT), a non-invasive imaging method, to measure how air moves between the lungs in patients with acute respiratory distress syndrome (ARDS) who are on ventilators. Researchers aim to detect delays in lung inflation that could help …

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study is testing whether two non-invasive tools—ultrasound and electrical impedance tomography (EIT)—can help doctors monitor breathing muscles in patients with acute respiratory failure who are using non-invasive breathing support. Up to 100 adults will be enrolled, with me…

This observational study looks at 30 adults with acute respiratory failure on mechanical ventilation. Researchers want to see if a bedside device called electrical impedance tomography (EIT) can reliably guide ventilator pressure settings, compared to the current gold standard (C…

This study aims to better understand why some patients with ARDS (a severe lung condition) get very sick while others recover. Researchers will collect blood and lung fluid from 50 ICU patients to study their immune cells and inflammation patterns. The goal is to identify differe…

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This pilot study tests whether sodium bicarbonate (baking soda) can be used safely as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on breathing machines. Researchers will compare it to standard hypertonic saline in 41 ICU patients.…

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study observes breathing patterns in 30 premature infants (born at 32 weeks or earlier) before and after removing their breathing tubes. Soft elastic bands placed on the chest and abdomen measure how well the chest and belly work together. The goal is to see if these measure…

This study looks at patients recovering from acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see if increasing the pressure in the ventilator (called PEEP) can reduce the effort patients need to breathe on their own, which may protec…

This study compares lung ultrasound to standard chest X-rays in very preterm infants (born before 32 weeks) who need breathing support. The goal is to see if ultrasound can safely reduce the number of X-rays, lowering radiation exposure. About 180 babies will be randomly assigned…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study tracks lung ultrasound images over time in preterm babies born before 32 weeks who need surfactant for breathing problems. Researchers want to see if the way surfactant is given changes how the lungs look on ultrasound. About 68 babies will take part to help doctors le…

This study looks at how tilting the body (trunk inclination) changes lung mechanics in 40 adults with moderate to severe ARDS who are on ventilators. Researchers will measure lung pressures and use electrical imaging to see how different positions and ventilator settings affect l…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study observes 500 adults in intensive care with acute respiratory distress syndrome (ARDS) who are on mechanical ventilation. Researchers will use heart ultrasounds and medication data to track how often right heart failure occurs and how it changes over time. The goal is t…

This study is enrolling 4,000 adults in intensive care with ARDS, sepsis, or pneumonia. Researchers will collect blood, urine, and swab samples, plus track recovery for up to a year. The goal is to identify different patient subtypes and find clues that could lead to better treat…

This study looks at how certain white blood cells (macrophages) in the lungs respond to inflammation in people with Acute Respiratory Distress Syndrome (ARDS) who are on breathing machines. Researchers will collect lung fluid samples and blood to compare immune responses from dif…

This study looks at 170 adults with severe breathing failure (ARDS) in the ICU. Researchers will take a blood sample to measure a clotting marker and then check if those who develop a pulmonary embolism (a blood clot in the lung) have higher levels. The goal is to see if this blo…

This study looks at how to adjust breathing machine settings for people with moderate-to-severe ARDS, a serious lung condition. Researchers will use a special imaging technique to see how air and blood flow match up in the lungs. The goal is to find the best settings for each pat…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study aims to measure lung function in premature infants with bronchopulmonary dysplasia (BPD) using a technique called forced oscillometry. Researchers will compare these measurements with those from healthy full-term infants. The goal is to better understand lung mechanics…

This study observes 325 adults with acute breathing failure who are using non-invasive breathing support like high-flow oxygen or a mask ventilator. Researchers want to find out which patients end up needing a breathing tube. The goal is to better predict and prevent treatment fa…

This study looks at 20 adults with severe acute respiratory distress syndrome (ARDS) who are on a ventilator and placed face-down (prone position). Researchers will use electrical impedance tomography (EIT), a non-invasive imaging tool, to measure lung overdistension and collapse…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study is observing how prone positioning (lying face down) affects patients with moderate-to-severe ARDS, a serious lung condition. Researchers will track 1000 adults in intensive care to see if factors like lung shape or brain injury influence outcomes. The goal is to learn…

This study looks at 500 adults with a severe lung condition called ARDS to see if they fall into two different inflammatory groups. By identifying these groups, doctors hope to choose the right treatments—like fluids, breathing support, or steroids—for each patient. The goal is t…

This study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …

This study explores whether using both lung and brain ultrasound can help doctors choose the best ventilator pressure for patients with acute respiratory distress syndrome (ARDS) and acute brain injury. About 30 critically ill adults on breathing machines will be enrolled. The go…

This study looks at how small airways open during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). Researchers want to see if an 'avalanche-like' pattern occurs, which could worsen lung injury. 50 adults with moderate-to-severe ARDS will be moni…

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study aims to observe how often and what types of aerosol medicines are given to ARDS patients on breathing machines. Researchers will collect data from multiple countries to understand current practices and identify gaps in knowledge. The study does not test a new treatment…

This study is for preterm infants who need breathing help. It tests whether a low or high air flow rate changes carbon dioxide levels in their blood. 45 babies will be monitored for three hours at each flow setting. The goal is to find the safest and most effective flow rate for …

This study looks at how changing the way a ventilator lets patients breathe out (called RCexp) affects air and blood flow in the lungs of people with ARDS. Researchers will use a special imaging technique (EIT) to measure these changes in 60 adults on ventilators. The goal is to …

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study tracks complications from a lung-opening procedure used in children under 14 with acute respiratory distress syndrome (ARDS) who are on a breathing machine. The procedure, called alveolar opening maneuver with PEEP titration, aims to improve oxygen levels but can cause…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study involves 60 critically ill patients in the ICU who are on breathing machines (ventilators). Researchers want to see if a new scoring system can automatically detect when a patient is struggling to breathe. The goal is to improve how doctors monitor and care for these p…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …