Can a single antibody turn down the immune storm in ARDS?
NCT ID NCT06513949
First seen Jul 28, 2026 · Last updated Jul 30, 2026 · Updated 2 times
Summary
This trial tests whether an antibody called IC14 can reduce dangerous lung inflammation in people with acute respiratory distress syndrome (ARDS), a severe condition where the lungs fill with fluid. Hospitalized patients on a ventilator receive either IC14 or a placebo, and researchers measure oxygen levels and markers of inflammation over 28 days. The goal is to see if blocking a protein called CD14 can calm the immune system and improve breathing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a monoclonal antibody called atibuclimab (IC14) that blocks CD14 to reduce inflammation
- What this could lead to
- If effective, IC14 could offer a new way to treat acute respiratory distress syndrome by calming the immune system's overreaction in the lungs.
- What could go wrong
- This is an early Phase 2 trial with only 56 participants, so results may not apply broadly. Blocking CD14 could also impair the body's ability to fight infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Harborview Medical Center
RECRUITINGSeattle, Washington, 98104, United States
-
University of Washington
RECRUITINGSeattle, Washington, 98195, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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