Can a Lung-Opening maneuver change a key injury marker in ARDS?
NCT ID NCT01600651
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated ICU patients within 24 hours of ARDS onset. Each patient receives both a real and a sham maneuver in random order, and researchers compare sRAGE levels afterward. The goal is to understand how ventilatory interventions influence lung injury, which could inform better treatment approaches.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Recruitment maneuver (a brief lung-opening procedure during mechanical ventilation)
- What this could lead to
- If successful, this could clarify whether recruitment maneuvers influence lung injury markers, potentially guiding safer ventilation strategies for ARDS patients.
- What could go wrong
- This is a small, early-phase study (24 patients) focused on a biomarker, not clinical outcomes. Results may not generalize, and the maneuver carries risks like lung injury or bacterial spread.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE RESPIRATORY DISTRESS SYNDROME are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could simply sitting up ease breathing in severe lung failure?
- Could lung fluid proteins reveal a new way to track severe lung injury?
- Could a spirometer test guide breathing support in respiratory failure?
- Which ventilator setting saves more lungs? a Head-to-Head test
- Can a single antibody turn down the immune storm in ARDS?
- Can a standardized ECMO roadmap save more lives in ARDS?