ACUTE RESPIRATORY DISTRESS SYNDROME

This study tests whether a drug called bevacizumab can help people hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 adults will receive either the drug or a placebo, and researchers will check survival rates at 28, 60, and 90 days. …

This study is testing whether stem cells from umbilical cords can help people with severe lung injury caused by pneumonia-related sepsis. The trial will compare standard care against adding stem cells or a stem cell byproduct (secretome) to see if they reduce hospital stay and de…

This study tests an experimental drug called paridiprubart in adults hospitalized with moderate-to-severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and is s…

This study tests an experimental drug called vilobelimab in hospitalized adults with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival a…

This study tests whether keeping patients with severe lung failure (ARDS) on their stomachs for more than 48 hours straight helps them survive better than the usual 16-24 hour daily sessions. About 780 adults on breathing machines will be randomly assigned to one of the two appro…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or one of the active drugs to see if they improve survival and recovery. The goa…

This study looks at whether keeping patients with severe lung failure (ARDS) on their stomach for 40 hours at a time, instead of the usual 16 hours, can lower the chance of death. About 800 adults on breathing machines will be randomly assigned to one of the two positions. The go…

This study tests whether giving the lungs a complete rest (near apneic ventilation) right after starting ECMO helps people with the most severe form of acute respiratory distress syndrome (ARDS). About 280 adults on ECMO will be randomly assigned to either near-apneic ventilation…

This study tests an experimental drug called rhu-pGSN added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. ARDS is a life-threatening lung condition where fluid builds up in the air sacs, mak…

This study compares two types of breathing machines (high-frequency oscillation and conventional ventilation) in very premature babies born between 24 and 31 weeks who have lung injury. The goal is to see which method reduces the risk of chronic lung disease (bronchopulmonary dys…

This study tests a treatment called ExoFlo, made from stem cell particles, for people hospitalized with moderate-to-severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 970 adults aged 18-75 will receive either ExoFlo or a placebo through an IV. The …

This study is testing a new treatment for people with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. The treatment uses stem cells from donated umbilical cords, given as an injection. The main goal is to see if it is safe and to find the …

This study tests a device called PrismaLung+ that removes extra carbon dioxide from the blood of critically ill patients who are on breathing machines. The goal is to see if using this device along with the breathing machine helps patients more than the breathing machine alone. A…

This study tests an experimental drug called AV-001 in people hospitalized with pneumonia caused by COVID-19 or other respiratory infections. The drug is given daily through an IV alongside standard care. The goal is to see if it is safe and helps patients recover more quickly. A…

This study looks at whether safely sitting up patients with severe lung injury (ARDS) is possible and helpful. Researchers will compare sitting upright to the usual face-down position in 32 adults. The goal is to see if upright positioning is safe and can improve oxygen levels.

This study looks at whether placing adults with Acute Respiratory Distress Syndrome (ARDS) in an upright position in bed can improve their breathing while on a ventilator. About 40 participants will be randomly assigned to either upright positioning or standard care with the head…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study involves 20 adults with severe lung injury (ARDS) who are on a breathing machine. Researchers will use a non-invasive imaging method called electrical impedance tomography (EIT) to measure how much the lungs are being overstretched or collapsed when the patient is lyin…

This study follows 100 adults who needed ECMO (a machine that helps the heart and lungs) after severe heart or lung failure. Researchers will track muscle loss, strength, and quality of life over time to understand what helps or hinders recovery. The goal is to find ways to impro…

This study looks at 170 adults in intensive care with Acute Respiratory Distress Syndrome (ARDS), a severe lung condition. Researchers want to see if a blood test measuring a clotting factor (EV-TF) can predict which patients will develop a pulmonary embolism (a dangerous blood c…

This study looks at patients recovering from Acute Respiratory Distress Syndrome (ARDS) who are on a breathing machine. Doctors want to see if increasing the pressure in the ventilator can reduce the effort patients need to breathe on their own, which may prevent further lung dam…

This study looks at 500 adults with a severe lung condition called ARDS. Researchers want to see if grouping patients by their inflammation levels can help doctors choose the best treatments, like fluids, breathing support, or steroids. The goal is to improve survival and reduce …

This study follows 550 children who needed ECMO (a machine that does the work of the lungs) after severe breathing failure. Researchers will track their abilities and quality of life for one year after leaving the ICU. They will also compare two ways of starting ECMO to see which…

This study looks at how the heart and lungs affect each other in adults with acute respiratory distress syndrome (ARDS), a severe lung injury often caused by infections. Researchers will track 500 intensive care patients on ventilators using heart ultrasounds and medication recor…

This study looks at a phenomenon called 'avalanche' in the lungs of people with acute respiratory distress syndrome (ARDS), a severe lung condition. Researchers want to see if small airways pop open unevenly during breathing support from a ventilator. The goal is to better unders…

This study observes 1,000 adults in intensive care with moderate-to-severe acute respiratory distress syndrome (ARDS) to learn how prone positioning (lying face down) affects survival and recovery. Researchers will explore whether lung shape on CT scans can guide treatment, and w…

This study looks at how certain white blood cells (macrophages) in the lungs react to inflammation in people with Acute Respiratory Distress Syndrome (ARDS) who are on a breathing machine. Researchers will collect lung fluid, blood, and nose samples from 56 ICU patients to compar…

This study looks at how the time it takes for a patient to exhale affects lung function in adults with acute respiratory distress syndrome (ARDS) who are on a ventilator. Researchers will use a special imaging technique called EIT to measure how air and blood flow are distributed…