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Lying on stomach longer may save more lives in severe lung failure

NCT ID NCT06854627

Disease control Sponsor: Pontificia Universidad Catolica de Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways of positioning patients with severe lung failure (ARDS) who are on a breathing machine: lying on the stomach for more than 48 hours straight versus 16 to 24 hours each day. The goal is to see which approach helps more people survive. About 780 adults will take part, and researchers will track their health for up to 90 days.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 780 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Endotracheal intubation and mechanical ventilation for less than 72 hours * Moderate-severe ARDS defined as: 1. Within 1 week of a known clinical insult or new or worsening respiratory symptoms 2. Bilateral infiltrates not fully explained by effusions, lobar/lung collapse, or nodules 3. Respiratory failure not fully explained by cardiac failure or fluid overload 4. PaO2/FiO2 \< 150 mmHg in supine position * Prone positioning has been indicated by the attending physician, OR has already been initiated within the last 16 hours Exclusion Criteria: * Contraindications for prone positioning such as intracranial pressure \> 20 mmHg, massive hemoptysis, recent tracheal surgery or sternotomy or abdominal surgery with an open wound, recent facial trauma or facial surgery, unstable spine, femur, or pelvic fractures, or a single anterior chest tube with air leaks * Patient on extracorporeal membrane oxygenation (ECMO) before randomization * Chronic respiratory failure requiring oxygen therapy or non-invasive ventilation (NIV) * Known pregnancy * Anticipating withdrawal of life support or shift to palliative care

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    38 sites in 6 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clínica Las Condes

    RECRUITING

    Santiago, Chile

  • Clínica San Carlos de Apoquindo

    RECRUITING

    Santiago, Chile

  • Clínica Santa Maria

    RECRUITING

    Santiago, Chile

  • Clínica Universidad de La Sabana y Unisabana Center for Translational Science (UCTS) de la Universidad de La Sabana

    RECRUITING

    Cundinamarca, Colombia

  • Clínica Universidad de los Andes

    RECRUITING

    Santiago, Chile

  • Complejo Asistencial Dr. Sótero del Rio

    RECRUITING

    Santiago, Chile

  • Complejo Asistencial Dr. Victor Ríos Ruiz

    RECRUITING

    Los Ángeles, Chile

  • Hospital Barros Luco

    RECRUITING

    Santiago, Chile

  • Hospital Base San Jose de Osorno

    RECRUITING

    Osorno, Chile

  • Hospital Britanico

    RECRUITING

    Buenos Aires, Argentina

  • Hospital Carlos Van Buren

    RECRUITING

    Valparaíso, Chile

  • Hospital Civil Fray Antonio Alcalde

    RECRUITING

    Guadalajara, Mexico

  • Hospital Clínico Herminda Martín

    RECRUITING

    Chillan, Chile

  • Hospital Clínico UC Christus

    RECRUITING

    Santiago, Chile

  • Hospital Clínico Universidad de Chile

    RECRUITING

    Santiago, Chile

  • Hospital Del Salvador Providencia

    RECRUITING

    Santiago, Chile

  • Hospital Dr. Hernán Henríquez Aravena

    RECRUITING

    Temuco, Chile

  • Hospital Dra. Eloisa Diaz

    RECRUITING

    Santiago, Chile

  • Hospital Español

    RECRUITING

    Montevideo, Uruguay

  • Hospital Eugenio Espejo

    RECRUITING

    Quito, Ecuador

  • Hospital Franco Ravera Zunino

    RECRUITING

    Rancagua, Chile

  • Hospital General San Juan del Río

    RECRUITING

    Querétaro, Mexico

  • Hospital Guillermo Grant Benavente

    RECRUITING

    Concepción, Chile

  • Hospital Juárez de México

    RECRUITING

    Mexico City, Mexico

  • Hospital Leonardo Guzmán

    RECRUITING

    Antofagasta, Chile

  • Hospital Padre Hurtado

    RECRUITING

    Santiago, Chile

  • Hospital Pasteur

    RECRUITING

    Montevideo, Uruguay

  • Hospital Privado de comunidad

    RECRUITING

    Mar del Plata, Argentina

  • Hospital Regional Dr. Ernesto Torres Galdames

    RECRUITING

    Iquique, Chile

  • Hospital San Juan de Dios de Curicó

    RECRUITING

    Curicó, Chile

  • Hospital San Martin de la Plata, Argentina

    RECRUITING

    La Plata, Argentina

  • Hospital Santiago Oriente Dr. Luis Tizné Brousse

    RECRUITING

    Santiago, Chile

  • Hospital Vera Barros

    RECRUITING

    La Rioja, Argentina

  • Hospital de Quilpué

    RECRUITING

    Quilpué, Chile

  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

    RECRUITING

    Mexico City, Mexico

  • Instituto Nacional de Enfermedades Respiratorias

    RECRUITING

    Mexico City, Mexico

  • Sanatorio Güemes

    RECRUITING

    Buenos Aires, Argentina

  • Sanatorio Mitre

    RECRUITING

    Buenos Aires, Argentina

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