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Can a Radiation-Free scan reveal how ARDS treatments reshape lung blood flow?

NCT ID NCT05801224

Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This study investigates whether a bedside, radiation-free imaging technique called electrical impedance tomography (EIT) can detect changes in lung blood flow in patients with acute respiratory distress syndrome (ARDS). Researchers will give patients inhaled nitric oxide, a gas that widens lung blood vessels, and also use prone positioning, to see if EIT can track how these treatments affect regional perfusion. The goal is to see if EIT could serve as a practical tool to guide ARDS care, potentially replacing more complex imaging methods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inhaled nitric oxide gas
What this could lead to
If successful, this could lead to a bedside, radiation-free way to guide treatments for ARDS, potentially improving oxygen levels and outcomes.
What could go wrong
This is an early, exploratory study with a small number of participants. The imaging technique may not prove reliable enough to replace standard methods, and results may not apply to all ARDS patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult intubated and mechanically ventilated patients (≥ 18 years old) admitted to the intensive care unit (ICU) * ARDS diagnosis with mild to moderate severity by Berlin criteria1 (100 mmHg \< PaO2/FiO2 \<= 300 mmHg) * Presence of an arterial line for blood gas measurement and blood pressure monitoring and of a central line for hypertonic saline injection Exclusion Criteria: * Suspected pregnancy, pregnancy or less than six weeks postpartum * Younger than 18 years or older than 80 years * Baseline methemoglobin ≥ 5% * Subjects enrolled in another interventional research study * Presence of pneumothorax * Usage of any devices with electric current generation, such as a pacemaker or internal cardiac defibrillator * Preexisting chronic lung disease or pulmonary hypertension * Past medical history of lung malignancy or pneumonectomy, or lung transplant * Left ventricle ejection fraction \<20% * Hemodynamic instability is defined as: * Persistent systolic blood pressure \<90 mmHg and/or \>180 mmHg despite the use of vasopressor or vasodilators, or * Requiring an increment in inotropic vasopressors over the past two hours just before enrollment: more than 15 mcg/min for norepinephrine and dopamine, more than 10 mcg/min in epinephrine, and more than 50 mcg/ min for phenylephrine. * Hypernatremia (serum sodium \> 150 mEq/L) * Patients cannot be enrolled for DECT if they have: * History of allergic reaction to intravenous contrast * Renal dysfunction on the day of the study (serum creatinine \> 1.5 mg/dL)

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome Ventilation perfusion mismatch

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

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