Massachusetts General Hospital

This study tests whether oxytocin nasal spray can help teenagers with obesity manage their weight. Over 12 weeks, participants aged 10-18 will take the spray or a placebo four times daily. Researchers will measure changes in body mass index, body fat, and appetite to see if oxyto…

This study tests whether canakinumab, an anti-inflammatory drug, can reduce blood vessel inflammation in people with coronary artery disease. Some participants have a genetic change called TET2 clonal hematopoiesis, which may increase inflammation. 120 adults will receive either …

This phase 2 study tests whether the drug ivosidenib can help prevent acute myeloid leukemia (AML) from coming back after a stem cell transplant. About 75 adults with a specific IDH1 gene mutation will receive either ivosidenib or a placebo daily. The main goal is to see if the d…

This phase 2 trial is testing a combination of three drugs—zanubrutinib, bendamustine, and rituximab—in people with previously untreated Waldenström macroglobulinemia, a rare type of blood cancer. The study will enroll 56 participants to see how well the treatment shrinks or cont…

This study tests a drug called NPC-1 (made of two natural compounds) in 40 adults aged 55+ with early Alzheimer's, mild cognitive impairment, or subjective memory concerns. The goal is to see if it safely changes blood markers linked to Alzheimer's brain changes. Participants tak…

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can lower uric acid levels and reduce inflammation in people with gout. Sixty adults with gout and high uric acid will take either the drug or a placebo daily for 12 weeks. Researchers will measure chan…

This phase 2 study is testing a drug called sacituzumab govitecan, alone or with pembrolizumab, given before surgery to people with localized triple-negative breast cancer. The goal is to see if these drugs can eliminate all cancer cells in the breast and lymph nodes before surge…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

This study compares two anti-rejection drugs in older kidney transplant recipients: a once-daily extended-release version (Envarsus XR) versus the standard twice-daily immediate-release version (Prograf). Researchers will measure changes in thinking, memory, and other cognitive s…

This early-stage trial tests whether high doses of inhaled nitric oxide gas are safe and potentially helpful for critically ill pneumonia patients on breathing machines. About 34 adults will receive either the gas or a sham treatment for 5 days. Researchers will monitor blood oxy…

This study tests a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if the treatment can make the cancer undetectable in the bloo…

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection dai…

This study tests a tool called Savvy, which includes phone exercises, a weekly pill organizer, and text reminders, to help stroke survivors take their blood pressure medication as prescribed. Researchers will compare medication adherence and blood pressure control between those u…

This study tests whether freezing part of a growing tumor (cryoablation) can help two immunotherapy drugs, ipilimumab and nivolumab, work better in people with advanced melanoma that has stopped responding to initial treatment. About 37 adults whose melanoma is growing despite pr…

This early-phase trial is testing whether combining two targeted drugs, pemigatinib and afatinib, is safe and can shrink tumors in people with advanced solid cancers that have specific FGTR gene changes. The study includes up to 70 participants whose cancers have spread or cannot…

This pilot study is testing whether combining two immunotherapy drugs (botensilimab and balstilimab) with precise, high-dose radiation (SBRT) can safely treat colorectal cancer that has spread to the liver and is not responding to standard chemotherapy. The study will enroll 15 a…

This study tests a device called RELiZORB that adds digestive enzymes directly to liquid food given through a feeding tube. It is for people who have trouble digesting food after pancreatitis. The goal is to see if it improves symptoms and quality of life. About 60 adults will ta…

This study tests whether eating a very low-calorie diet for three days before surgery can reduce wound complications in people with soft tissue sarcoma of the leg. Participants will drink special nutritional supplements instead of regular food. The goal is to see if this short-te…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This phase 4 trial tests whether giving the NSAID ketorolac (Toradol) for the first five days after orthopedic trauma surgery can reduce the chance of patients still needing opioids six months later. About 458 adults aged 18–70 with acute musculoskeletal injuries requiring surger…

This study tests if the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. Researche…

This study is testing a type of radiation called proton beam therapy for children with neuroblastoma, a nerve cell cancer. Unlike standard radiation, proton therapy targets the tumor more precisely, which may spare nearby healthy organs and reduce side effects. The study will enr…

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will par…

This phase 2 trial is testing the drug talazoparib (Talzenna) in 30 people with metastatic breast cancer that has spread beyond the breast. The cancer must have a specific BRCA gene mutation found only in the tumor (not inherited). Talazoparib works by blocking proteins that help…

This phase 2 pilot study tests whether granulocyte colony stimulating factor (G-CSF), a drug that boosts white blood cells, can help preserve brain structure and thinking skills in people with a specific type of glioblastoma (MGMT-methylated) undergoing standard chemoradiation. A…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left after surgery and chemotherapy for stage III colon cancer. If the test is positive, patients may get extra treatment with chemotherapy or immunotherapy to try to wipe out any remaining cancer ce…

This study tests whether adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to intense exercise, stress, or an eating disorder. Participants receive either romosozumab or a placebo for 6 months, pl…

This study tests a small absorbable cap placed over cut nerve endings during finger amputation surgery. The goal is to prevent painful neuromas (nerve balling) that often cause chronic pain. Twenty adults who have had a traumatic finger amputation will be followed for up to a yea…

This study tests whether giving adults with acute asthma a specific rescue inhaler (Airsupra) right in the emergency department can reduce the chance of another asthma attack within 3 months. About 1,860 participants will either receive Airsupra or continue usual care. The goal i…

This study aims to see how well two different FDA-approved medication regimens improve bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will receive one of the two treatments for 12 months. The main goal is…

This early-stage trial is testing a drug called ASTX727 in adults with a type of brain tumor (glioma) that has an IDH mutation and has come back or is growing. The drug combines two substances to try to stop cancer cells from growing. The main goal is to find the highest safe dos…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This early-stage study tests two drugs—mezigdomide (a pill) and talquetamab (an injection)—in people with multiple myeloma that has come back or stopped responding to prior treatments. The main goal is to find a safe dose and schedule. About 25 participants will receive the drugs…

This phase 2 trial tests a combination of three drugs (venetoclax, obinutuzumab, and acalabrutinib) in 40 people with relapsed or refractory CLL or SLL. The treatment is adjusted based on how well the cancer responds (measured by minimal residual disease). The main goal is to see…

This study looks at whether a 12-week home resistance exercise program can help transgender women and gender-diverse individuals starting estrogen-based hormone therapy maintain muscle mass and strength. Hormone therapy can increase the risk of muscle loss (sarcopenia), which may…

This study tests whether spironolactone, a blood pressure pill, can help women who had high blood pressure during pregnancy avoid long-term heart issues. About 200 women with overweight and recent hypertensive pregnancy will take the drug or a placebo daily for 12 weeks after del…

This early-stage trial tests the safety and best dose of the drug momelotinib when given before, during, and after a stem cell transplant for people with myelofibrosis, a serious bone marrow disorder. About 28 participants will receive momelotinib pills daily for up to 13 cycles.…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) helps people with obesity lose mostly fat while keeping muscle and bone. 63 adults will receive either the combo, tirzepatide alone, or bimagrumab alone for 52 weeks. The go…

This early-phase study tests an investigational drug called ziftomenib in adults with acute myeloid leukemia (AML) who have had a stem cell transplant. The goal is to find a safe dose and see if the drug can help prevent the cancer from coming back. About 22 participants will tak…

This study tests different approaches to help people with HIV whose current medication (tenofovir, lamivudine, and dolutegravir, or TLD) is no longer working. It involves 648 adults and teens in Uganda and South Africa. The goal is to find the best strategy to get the virus under…

This study tests two types of radiation therapy—proton beam or advanced photon (IMRT)—given before surgery for retroperitoneal sarcoma, a rare tumor deep in the abdomen. The goal is to find the highest safe dose that can be delivered to high-risk areas of the tumor while protecti…

This study tests a physical activity program called ActiveGirls in 40 girls ages 8-12 who are at higher risk for PCOS and insulin resistance. Some girls get health coaching plus text messages, while others get only texts. Researchers will see if the program is acceptable and if i…

This study tests two treatments for people whose cancer has spread to the brain and is growing despite prior therapy. One group receives palbociclib alone; the other gets palbociclib plus pembrolizumab. The goal is to see if these drugs can shrink or stabilize brain tumors. About…

This phase 2 study tests whether the drug elranatamab can lower the chance of multiple myeloma worsening after treatment with idecabtagene vicleucel (a CAR-T cell therapy). The study will enroll 32 adults with relapsed or refractory multiple myeloma. Participants will receive elr…

This study tests a volume assessment guidance algorithm (VAGA) to help doctors decide how much and what type of IV fluid to give cirrhosis patients with acute kidney injury. Fifty hospitalized adults with cirrhosis and kidney injury will be randomly assigned to receive either VAG…

This study tests two drugs, elranatamab and isatuximab, given as shots under the skin for people with multiple myeloma that has returned or not responded to at least two prior treatments. The goal is to see if the combination can shrink tumors and control the disease. About 30 pa…

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can keep the cancer from growing for at least 6 mo…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This phase 2 study tests the drug epcoritamab in 30 people with relapsed or refractory large B-cell lymphoma who are not eligible for a stem cell transplant. Epcoritamab is a bispecific antibody that helps the immune system target and kill cancer cells. The main goal is to see ho…

This study tests the safety of combining two drugs (atezolizumab and bevacizumab) with targeted radiation (SBRT) in 20 adults with liver cancer that cannot be surgically removed. The goal is to see if this triple therapy is tolerable and can help control the disease. Participants…

This study tests if higher doses of omalizumab (Xolair) can help people with food allergies tolerate more of their trigger foods. Thirty participants with allergies to peanut, cashew, walnut, egg, or milk will receive either 5 mg/kg or 15 mg/kg of omalizumab for 16 weeks. The goa…

This study tests a combination of four drugs (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) in 50 adults whose multiple myeloma has returned or not responded to prior treatments. The main goal is to see how many patients respond to the therapy. This is not a …

This study tests a program called ADELANTE for Latinos with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the health worker progra…

This study tests whether a drug called dexmedetomidine, which promotes sleep, can prevent delirium (sudden confusion) in patients aged 60 and older after heart surgery. Delirium is common in the ICU and can lead to longer hospital stays and worse recovery. The trial will compare …

This study tests whether meal replacement products can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower blood sugar. Twenty participants will use meal replacements and be monitored for weight loss and blood sugar changes. The goal is to s…

This pilot study tests whether time-restricted intermittent fasting can lower liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). Researchers will measure liver fat changes using advanced imaging and track quality of life. The goal is to find…

This study tests whether long-term use of ketamine (given by IV) followed by esketamine (a nasal spray) can reduce suicide risk in people with major depression who are at high risk. One hundred adults hospitalized for depression will receive up to 8 ketamine infusions, then 13 we…

This study tests a program called CHAMPION that helps children with overweight or obesity and asthma live healthier lives. The program includes doctor visits, diet advice, and health coaching. Researchers want to see if doing the program entirely online works as well as meeting i…

This study tests whether adding a new drug (liposomal irinotecan) to standard chemotherapy before chemoradiation can completely eliminate cancer in people with advanced gastroesophageal cancer. About 40 adults with stage T3/4 or node-positive disease will receive the combination,…

This study tests whether adding diet advice and stress management sessions to standard advanced therapy helps people with Crohn's disease or ulcerative colitis reach remission. About 160 adults with active IBD will be split into four groups, each receiving different combinations …

This trial tests whether a machine called Normothermic Machine Perfusion (NMP) can revive moderately fatty donor livers so they can be safely transplanted. Researchers will place livers with 30-60% fat on the machine, check their quality, and transplant those that meet safety cri…

This study is testing whether adding platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMAC) to standard hip labral repair surgery helps people recover better. About 400 adults with hip labral tears will be randomly assigned to get surgery alone or surgery plus one …

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study is testing two common ways to manage gout: one that aims to lower uric acid levels to a specific target, and another that treats flare symptoms as they happen. Researchers will track 650 adults with gout over two years to see which approach leads to fewer gout attacks …

This study compares two ways to help stroke survivors control their blood pressure: home monitoring alone versus home monitoring plus group medical visits. High blood pressure is the leading cause of a second stroke, so the goal is to find a better method to keep blood pressure i…

This phase 3 trial tests whether abatacept (Orencia) can reduce major heart complications in cancer patients who develop myocarditis (heart inflammation) from immune checkpoint inhibitors. About 390 hospitalized adults will receive either abatacept or placebo plus standard care. …

This study looks for better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will test 300 adults with a history of possible allergic reactions using skin tests and controlled drug challenges. The goal i…

This early-phase trial is testing whether a single dose of a hormone pill can help diagnose oxytocin deficiency in young people with hypopituitarism. Researchers will give the pill to 20 participants and measure oxytocin-related substances in blood and saliva. The goal is to deve…

This study is testing whether a special PET scan using flotufolastat F 18 can detect prostate cancer that has come back after surgery, even when PSA levels are very low (0.20 ng/mL or less). Researchers will scan 50 men with a history of prostate cancer and a rising PSA after pro…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss lung cancer screening. The goal is to see if this alert helps more high-risk people get a lung cancer screening CT…

This study tests if a special dye called indocyanine green (ICG) can help surgeons see the edges of bone or soft tissue tumors during surgery. About 100 adults with benign or malignant masses will receive the dye before their tumor is removed. The goal is to see if using the dye …

This study tests a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, a sign of early scarring. Researchers will scan 30 people, including relatives of patients with pulmonary fibrosis and those with early lung abnormalities. The goal is to see…

This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the bowel of people with Crohn's disease. The goal is to see if the scan can tell the difference between scarred (fibrotic) strictures and inflamed ones, which would help doctors d…

This study explores whether a simple, at-home smell test can help detect early signs of Alzheimer's and other memory disorders. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute scratch-and-sniff test using…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This pilot study tests a new device called the Retro-TCE capsule, which is a small camera attached to a string that is inserted into the lower gut to take pictures without needing sedation. The study will enroll 30 people, including healthy volunteers and those with Lynch syndrom…

This study looks at whether molecules in saliva can help doctors quickly tell if heart failure is getting worse. Researchers will collect saliva and blood samples from 90 adults with stable or worsening heart failure. The goal is to develop a simple, non-invasive test that could …

This study tests whether injecting a near-infrared dye called indocyanine green (ICG) around a lung tumor can help surgeons see the tumor and the first lymph node it drains to during surgery. About 100 adults having lung surgery will receive the dye, and a special camera will det…

This study is testing a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of 168 volunteers, including healthy people and those with keratoconus or post-LASIK ectasia, t…

This study tests whether a special PET scan can measure a protein called fibrin in the brains of people with Alzheimer's disease. Researchers will scan 30 volunteers, including healthy older adults and those with Alzheimer's, to see if fibrin levels differ. The goal is to improve…

This study tests a new, compact imaging system that uses a tethered capsule to take detailed pictures of the esophagus. Researchers want to see if it is safe, easy to use, and produces good images in healthy people and those with Barrett's esophagus. The goal is to prepare for a …

This study aims to improve how doctors see liver damage (cirrhosis), liver cancer, and high blood pressure in the liver using a special PET/MRI scan. About 45 adults with cirrhosis will get this scan to see if it gives clearer pictures than current methods. The goal is to make di…

This study is testing a new way to detect ovarian cancer early. Researchers will take a sample of fluid from the womb (uterine lavage) and a blood sample from 250 women before they have surgery for a suspected ovarian growth. After surgery, they will check whether the woman had c…

This study tests whether eating more plants and fewer animal foods can lower colorectal cancer risk. Researchers will measure changes in bile acids, gut bacteria, and other markers in 40 adults who have had colon polyps removed. Participants follow a self-guided diet for several …

This study tests whether a device that flashes light and plays sound at 40Hz can prevent Alzheimer's disease in people at risk. 200 adults aged 55-90 with a family history of Alzheimer's will use the device at home for 60 minutes daily over 12 months. Researchers will measure cha…

This study is testing a short, 6-session group program called Resilience Training for Teens. The goal is to see if it can help high school students who have mild symptoms of depression, anxiety, or unusual feelings avoid developing more serious mental illnesses. The study will in…

This study tests a simple writing exercise for new mothers who had a stressful childbirth. In the days after giving birth, participants write about their experience for 15 minutes a day for three days. The goal is to see if this can prevent post-traumatic stress disorder (PTSD) a…

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The …

This study tests a program called PrEP My Way that helps young women aged 16-24 in Kisumu, Kenya stay on HIV prevention medication. Participants can choose between a daily pill, a long-acting shot, or a vaginal ring, plus get support from peers. The goal is to see if offering cho…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study tests whether giving HIV self-testing kits and counseling to postpartum women in South Africa helps them and their male partners start PrEP (HIV prevention) or HIV treatment. About 120 women and their partners will take part. The goal is to see if this approach is feas…

This study is testing whether a long-acting injectable HIV prevention drug, called cabotegravir, can work for people who inject drugs. The trial will enroll 100 adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sexual contact. Pa…

This early-phase study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower biological markers linked to colorectal cancer risk. Researchers will enroll 20 adults aged 18-50 with a BMI between 27 and 40 who have had a recent colonoscopy. The goal is to s…

This study is testing a web-based tool that estimates a person's risk of developing Crohn's disease based on their lifestyle and family history. Researchers will enroll 80 healthy people who have a parent or sibling with inflammatory bowel disease. Participants will receive perso…

This study tests whether wearing a smartwatch that tracks activity and body composition, along with exercise reminders, can help people on GLP-1 drugs (like Ozempic or Wegovy) maintain muscle and strength. About 100 adults who recently started or plan to start these medications w…

This study tests whether portable HEPA air cleaners placed in elementary school classrooms can lower the amount of viruses in the air and reduce infections among students, teachers, and their families. About 200 participants from grades K-5 will be randomly assigned to classrooms…

This study tests a behavioral program called QuitVaping, which combines counseling sessions with text message support, to help teenagers aged 14-18 quit vaping. About 400 participants who vape nicotine at least weekly will be randomly assigned to either the QuitVaping program or …

This pilot study compares two discharge pain plans for adults after major orthopedic surgery: one with opioids and one without. Researchers want to see if it's possible to run a larger trial that could reduce opioid use. About 100 patients will be randomly assigned to either plan…

This study tests whether a mild electrical pulse to the ear (taVNS) can change how the brain and stomach interact in people with chronic indigestion or gastroparesis. Researchers will use brain scans and stomach electrical readings to see if the stimulation helps. The goal is to …

This study tests a 9-week phone-based program called WISH that teaches positive psychology exercises to people with irritable bowel syndrome (IBS). The goal is to see if the program is practical and helpful for improving symptoms. Researchers will compare it to an educational con…

This study tests whether having patients with advanced chronic kidney disease (stages 4 and 5) report their symptoms monthly through an electronic questionnaire, with results shared with their kidney doctors, can improve symptom management and quality of life. The trial will enro…

This study tests a behavioral program called InSTILL for nursing home residents who feel stressed or depressed. Twenty participants will attend six sessions to learn life management and emotion regulation skills. The main goal is to see if the program is practical and well-liked,…

This study tests whether eating only during an 8-hour window each day (time-restricted eating) can help people with bipolar disorder who are overweight and depressed lose weight and improve their mood. Forty adults will be randomly assigned to either follow this eating pattern fo…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests a mobile app that delivers an 8-week cognitive-behavioral therapy program for adults with Avoidant/Restrictive Food Intake Disorder (ARFID). ARFID is a serious eating disorder that makes it hard to eat enough or try new foods, and many people cannot access treatm…

This pilot study tests whether a nurse-led, group-based virtual coping program called RESTORE is feasible and acceptable for people who have finished treatment for triple-negative breast cancer. The program teaches skills like problem-solving, relaxation, and mindfulness to help …

This pilot study is testing a web-based tool called GA-STOMA designed to help older adults (65+) recover and adapt after fecal ostomy surgery. The tool provides a survey and personalized tips to support recovery. The study will check if the tool is easy to use and acceptable to p…

This pilot study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special PET scans to measure changes in artery inflammation before and after the program. The goal is to see i…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests whether a nasal spray containing oxytocin (a natural hormone) can help adults with binge-eating disorder eat less often in binges. About 60 adults will receive either the oxytocin spray or a placebo for 8 weeks. Researchers will track changes in binge frequency a…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study tests a care transition program called OSCAR-S for adults aged 65 and older who are having planned colorectal surgery. The program provides extra support from a nurse coach to help patients and families manage recovery at home after leaving the hospital. The goal is to…

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in older adults (65+) after hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surge…

This study tests whether a video and a trained navigator can help parents of children with cancer better communicate their goals and values to the medical team. About 567 parents will either get the video tool or usual care. The goal is to see if this leads to more discussions ab…

This study at Massachusetts General Hospital tests whether adding coaching sessions to standard ketamine or esketamine treatment can help people with treatment-resistant depression. About 20 adults already on maintenance ketamine will receive 12 coaching sessions over 3 months. T…

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study tests whether adding an unexpected element (like singing) during memory reactivation, combined with the drug propranolol, can reduce physical stress responses to traumatic memories in people with PTSD. Eighty adults with trauma history will be randomly assigned to stan…

This study tests if a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both lasers on small skin areas and report their pain levels. Researchers will also take photos and use imaging to tra…

This study tests a program called Sentinel that trains stem cell transplant doctors to provide palliative care—like managing symptoms and coping strategies—as part of routine care. The goal is to see if it's feasible and acceptable for patients. Forty adults undergoing stem cell …

This study tests two experimental drugs, siltuximab and erenumab, to see if they can safely reduce chronic pain in people with schwannomatosis, a condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either a drug or a placebo. The …

This study tests a new, self-directed writing program for people with long-term muscle or bone pain who also struggle with negative thoughts about their pain (called pain catastrophizing). The program involves 8 writing sessions done at home. The goal is to see if people find it …

This study tests whether a special palliative care program (called PEACE) can improve quality of life for people with blood cancers like lymphoma, leukemia, or multiple myeloma who are receiving adoptive cellular therapy (ACT). About 90 participants will be randomly assigned to e…

This study is testing a smartphone app called PDAC-PATHWAYS designed to provide information and support to people with pancreatic cancer who are about to start neoadjuvant therapy (treatment before surgery). The app includes educational modules and tools to help patients cope. Re…

This study tests a 12-week program that combines positive psychology and motivational interviewing to help people who have had a heart attack become more physically active. The program is delivered remotely via phone and text messages. Researchers will compare activity levels and…

This study tests a 12-week phone program that uses positive psychology and motivational interviewing to help 280 heart failure patients stick to their diet, exercise, and medications. Participants get weekly phone sessions and text messages. The goal is to see if this approach im…

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. Resear…

This study tests a 6-session virtual program called Resilient Together-YOD for people recently diagnosed with young onset dementia (before age 65) and their care-partners. The program teaches coping and communication skills to prevent chronic emotional distress. Researchers will …

This study tests whether a physical therapist-guided exercise program can improve strength and walking ability in adults with myotonic dystrophy type 2 (DM2). Twenty-four participants will be split into three groups, each doing the same exercises but with different levels of ther…

This study tests a smartphone app called TEC-S designed to help adults who have frequent suicidal thoughts. Twenty participants will use the app for one week to see if it is safe and acceptable, and whether it reduces their desire to die by suicide. The goal is to gather early da…

This study tests an 8-week program that combines positive psychology and motivational interviewing to help people with type 2 diabetes increase their physical activity. The program is delivered remotely via phone and text messages. Researchers will measure changes in activity lev…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

This study tests a mobile app called PROMOTE designed to help lung cancer survivors improve their physical function, manage shortness of breath and sleep problems, and adopt healthier habits. About 250 adults with early-stage lung cancer will either use the app for 12 weeks or re…

This study is testing a new digital application called SHIFT to see if it can improve sexual health, quality of life, and reduce distress in people who have had a stem cell or bone marrow transplant. The trial will enroll 300 adult survivors who are at least three months post-tra…

This study tests whether tenapanor, a drug already approved for irritable bowel syndrome with constipation, can help people with cystic fibrosis who have constipation. Twenty-five adults will take a 50 mg tablet twice daily for 4 weeks and track their bowel movements and symptoms…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will enroll 80 adults aged 18-60 who have had low back pain for at least 6 months. Participants will receive either real tACS or a sham (fake) sti…

This study tests a virtual, 4-session sleep program based on cognitive behavioral therapy for insomnia (CBT-I) in 198 cancer survivors. Participants are randomly assigned to the program or usual care. The goal is to see if the program reduces insomnia severity, improves sleep qua…

This study tests a virtual cognitive rehabilitation program designed for refugees and asylum seekers who have had a traumatic brain injury (TBI) and struggle with thinking and memory. The program includes 8 virtual sessions led by trained bilingual staff, covering brain injury ed…

This study tests whether a virtual cognitive behavioral therapy program can help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home. The goal is to see if the program is easy to use and helpful for improving…

This study tests a group-based telehealth program called HORIZONS for adults living with chronic graft-versus-host disease (cGVHD) after a stem cell transplant. The program includes 8 sessions led by a therapist to help with self-management and quality of life. Researchers will c…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether a single dose of intravenous iron (ferric derisomaltose) can improve exercise capacity in people with heart failure with preserved ejection fraction who also have iron deficiency. About 66 adults will receive either the iron infusion or a placebo, and the…

This study tests a 4-month coaching program for pregnant or recently postpartum doctors-in-training. Half the participants get one-on-one and group coaching sessions; the other half do not. Researchers will measure burnout, well-being, and confidence through surveys at the start,…

This study tests a new approach for chemotherapy-induced peripheral neuropathy (CIPN) — nerve pain, numbness, or tingling after cancer treatment. Instead of real needles, participants watch a video of acupuncture being applied and imagine it is happening to them. The trial will e…

This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to m…

This study tests whether a single injection of Purified Cortrophin Gel can safely reduce pain from an acute gout flare. About 150 adults with gout will receive either a 40-unit or 80-unit dose and report their pain levels over the next week. The goal is to find the best dose for …

This study looks at how well a special implant (IlluminOss) works for people with pelvic fractures from cancer that has spread or from aging. The goal is to see if it reduces pain and helps patients move better. About 100 adults will be followed for up to 2 years after surgery, r…

This study tests whether tranexamic acid (TXA), a drug that reduces bleeding, can decrease fluid drainage after breast reduction surgery. 160 adults having bilateral breast reduction will be randomly assigned to receive IV TXA or not, and each breast will get either TXA or saline…

This pilot study tests a brief psychotherapy program for young adults (ages 25-39) with cancer and their caregiving partners. The therapy uses cognitive-behavioral and couples therapy techniques to improve coping and maintain the relationship. The study will enroll 20 couples to …

This phase 2 trial is testing whether the drug ruxolitinib (Jakafi) can reduce symptoms like fatigue and itching in people with low-risk essential thrombocythemia (ET) or polycythemia vera (PV). About 60 participants will take the pill daily, and researchers will measure symptom …

This study tests a support program called NeuroPathways for people recently diagnosed with a malignant brain tumor. The program includes an information guide and four one-on-one coaching sessions to help patients cope. Researchers want to see if the program is practical and helpf…

This study tests whether using a mild electrical brain stimulation device at home for four weeks can help adults with ADHD. Researchers will compare two different stimulation strengths to see if symptoms and thinking skills improve. The trial involves 60 adults aged 18 to 65 with…

This study looks at how well people tolerate laser treatment for port wine birthmarks using an FDA-approved 532 nm laser. Fifteen adults with non-facial birthmarks will receive three monthly treatments, comparing the standard single high-energy pulse to multiple low-energy pulses…

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Sixty adults will take either turmeric or a placebo three times a day for six weeks. Researchers will measure changes in pain and hand function to see if turmeric offe…

This study is testing a new program called POISE for people with stage IV non-small cell lung cancer who are on targeted therapy. The program includes four visits with a specially trained palliative care clinician to help patients cope with uncertainty and manage their cancer. Re…

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Researchers want to see if it improves physical function, mood, and daily activity compared to usual care. T…

This study tests a five-session palliative care program called TARGET-PC for people with metastatic breast cancer and their caregivers. The goal is to help patients talk with their doctors about their goals and values for care, and to have those preferences documented. The study …

This pilot study from Massachusetts General Hospital is testing whether whole body hyperthermia (like a sauna) can reduce Long COVID symptoms, especially fatigue. Researchers will enroll 21 adults aged 18-65 who have had COVID-19 at least 12 weeks prior. Participants will lie in …

This study compares heated yoga, sauna sessions, and a mindfulness app to see which best reduces symptoms of depression. Researchers at Massachusetts General Hospital are recruiting 120 adults aged 18-65 with moderate to severe depression. Participants will attend twice-weekly se…

This study looks at whether doing heated or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression. Participants will practice yoga and report their mood changes over time.

This study tests a behavioral health program called InSTILL for nursing home residents who feel depressed and their main support person (like a family member or friend). The program aims to help them cope with stress and transitions. About 100 pairs (resident and caregiver) will …

This study tests a digital app called DREAMLAND designed to improve quality of life and emotional well-being for adults with acute myeloid leukemia (AML) undergoing intensive chemotherapy. About 200 hospitalized patients will either use DREAMLAND or a standard wellness app. Resea…

This study tests whether a single intravenous dose of allopregnanolone, compared to a placebo, can help people with PTSD better process and reduce the power of traumatic memories. The trial involves 96 adults with chronic PTSD and uses skin conductance and startle responses to me…

This study looks at whether adding physical therapy to steroid injections helps people with frozen shoulder more than steroid injections alone. About 260 adults with frozen shoulder will be split into two groups: one gets physical therapy plus steroid shots, the other gets steroi…

This study tests two mind-body programs designed to reduce anxiety, depression, and emotional distress in cardiac arrest survivors and their caregivers. About 84 pairs (survivor and a family member or friend who helps them) will participate. The goal is to see if the programs are…

This study tests a 6-session counseling program called BMT-CARE for caregivers of people receiving a bone marrow transplant. The goal is to see if it improves the caregiver's quality of life compared to standard support. The study will enroll 800 caregivers and also look at what …

This study tests whether bezafibrate, a drug currently used for high cholesterol, can safely improve depression in people with bipolar disorder. Thirty adults with bipolar I or II who are already on a mood-stabilizing medication will take bezafibrate for 8 weeks. Researchers will…

This pilot study tests a mindfulness-based program called Quiet Focus, adapted for older Black adults (age 50+) who have both chronic pain and mild depression. Researchers want to see if it's feasible and acceptable, and whether it can improve quality of life and reduce pain inte…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This pilot study tests whether cognitive behavioral therapy (a type of talk therapy) for PTSD can also reduce the risk of heart disease. Researchers will measure inflammation, heart rate variability, and brain activity in 30 adults with PTSD and heart risk factors. Half will rece…

This study tests a type of talking therapy called exposure-based cognitive behavioral therapy (CBT) for adults who have both functional dyspepsia (a stomach condition causing pain and fullness) and avoidant/restrictive food intake disorder (ARFID), leading to weight loss. Fifty p…

This pilot study tests whether a 12-week nutrition and exercise program is feasible for patients with myeloproliferative neoplasms (MPNs), a group of blood cancers. Thirty participants will take virtual and in-person classes to learn healthier eating and physical activity habits.…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a pill called pregnenolone can help reduce depression in people with HIV. Participants take either the study drug or a placebo for 8 weeks while staying on their current antidepressants. Researchers will use brain scans and mood questionnaires to see if t…

This study tests whether giving emergency room doctors a computer-generated risk score for suicide can help prevent suicide attempts. About 4,000 adults coming to the ER for psychiatric issues will be randomly assigned so that their doctor either sees or does not see their risk s…

This study tests whether taking high doses of nicotinamide riboside (a form of vitamin B3) for two weeks can improve brain energy metabolism in 50 healthy adults. Researchers will use special MRI scans and blood tests to measure changes in key brain chemicals. There is no direct …

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study is testing whether low-intensity focused ultrasound can help people with severe brain injuries who have not fully recovered consciousness. Researchers will measure changes in behavior and brain activity after ultrasound sessions. The study involves 36 participants and …

This study looks at whether stopping tube feeding for at least 8 hours before a procedure helps or harms recovery in critically ill patients on breathing machines. About 1,072 adults in the ICU will be randomly assigned to either fast or continue feeding until right before their …

This study looks at whether levels of nitric oxide in spinal fluid can predict dangerous blood vessel spasms after a type of brain bleed called subarachnoid hemorrhage. Researchers will compare nitric oxide levels in 40 patients with and without this condition. The goal is to fin…

This study aims to see if wearable devices like Fitbit or Apple Watch can help predict complications and recovery in patients undergoing surgery or treatment for chronic diseases or cancer. Researchers will use machine learning to analyze data from 2,400 adults. The goal is to ca…

This study follows 27 pregnant women living at high altitude in Bolivia and compares them to women at sea level. Researchers will use heart ultrasounds and blood tests to see how the body adapts to low oxygen levels during pregnancy. The goal is to better understand why some wome…

This study tests whether using a new classification system (RTSS-Voice) to document voice therapy sessions helps people with muscle tension dysphonia, a condition causing hoarseness and vocal strain. Researchers will compare outcomes from clinicians' first year using the system t…

This study looks at whether a single session of mindfulness-based neurofeedback can change brain patterns linked to repetitive negative thinking in adolescents. Researchers will compare 50 teens with high repetitive negative thinking to 50 healthy teens, using real or fake neurof…

This study looks at whether giving tube feedings during the day instead of at night can improve sleep and body rhythms in patients recovering from heart surgery in the ICU. Researchers will monitor sleep patterns and body temperature in 30 adults. The goal is to learn if simple c…

This study is building a large database of health information from 5,000 people with ALS and other motor neuron diseases. Participants share details like symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then shared with resea…

This study looks at whether a medication called elinzanetant, which is used for hot flashes, can also improve blood vessel health in women aged 40-65. Participants must have moderate to severe hot flashes and at least two heart risk factors like obesity or high blood pressure. Th…

This study follows 40 people with Angelman syndrome over one year to see how their communication, motor skills, and behaviors change. Participants visit the study site five times for tests, brain activity monitoring (EEG), and sleep tracking. The goal is to better understand the …

This study is creating a large database of up to 5,000 children who received radiation therapy for cancer. Researchers want to see if proton beam therapy causes fewer long-term side effects than standard photon radiation. By collecting routine medical information, the registry wi…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study records brain activity from epilepsy patients who already have electrodes implanted for medical reasons. While listening to sentences and stories, their neural signals are analyzed to map how the brain processes language. The goal is to understand the brain's language …

This study tests whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Over 30 participants will receive both real and sham (placebo) s…

This study is testing a simple, non-invasive device that uses motion sensors on the chest and belly to measure breathing effort in children. The goal is to see if it can detect breathing problems early and help doctors decide when to start, increase, or stop breathing support. Th…

This study uses three brain imaging methods—PET, MRI, and EEG—to see how epilepsy alters brain metabolism and electrical activity. Researchers will compare scans from 30 adults with and without epilepsy. No treatment is given; the goal is to better understand the condition.

This study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…

This study follows 500 infants who have a close family member with celiac disease. Researchers track their genes, diet, gut bacteria, and other factors from birth to see what leads to the disease. The goal is to find ways to predict or prevent celiac disease in children who are a…

This study collects genetic data from 1,200 people with T-cell or NK-cell lymphoma to see if machine learning can predict who will respond to treatment. Researchers hope to find patterns that explain why some patients relapse or become resistant to therapy. The goal is to pave th…

This study tests whether giving emergency department patients information about local dental and social resources—plus phone navigation help—can increase the number of people who actually go to a dentist. About 2,927 adults with unmet dental needs will be split into three groups:…

This study looks for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 people will receive either a cholera vaccine or a typhoid vaccine (as a comparison) and give blood samples over two years. The goal is to f…

This study will look at up to 1.2 million patients to see how long they fast before surgery and whether longer fasting leads to problems like nausea, low blood pressure, or kidney injury. Researchers want to find out if current fasting guidelines are too strict and might actually…

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes a 14-day course of the drug and measure blood sugar, insulin, and other factors after a s…

This study aims to learn more about how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity during speech tasks while participants undergo deep brain stimulation (DBS) surgery. The study does not test…

This study looks at whether telling people their genetic risk for coronary artery disease helps them lower cholesterol and improve heart health over one year. Researchers will enroll 500 adults aged 30-75 who are not on cholesterol medication. Half will get their genetic risk sco…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will take part. Researchers will use special PET/MRI scans to measure changes in artery and brain activity …

This study looks at how chemotherapy affects thinking and the brain in older adults (age 60+) with breast cancer. Researchers will track changes in memory and thinking skills, and use brain scans to see if certain proteins are linked to these changes. The goal is to better unders…

This study looks at how the brain recovers arm movement after a stroke. Researchers will study 50 people who had a stroke 3 to 6 months ago and have trouble moving their arm. Some will get 30 hours of special arm therapy over 6 weeks, while others get usual care. The goal is to l…

This study looks at how the liver's immune system reacts to a chemotherapy drug called melphalan, given directly to the liver through a special procedure. It involves 10 adults with uveal melanoma that has spread to the liver. The goal is to understand immune changes, not to test…

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have some depression symptoms. Using smartphone surveys several times a day, researchers track cannabis use, mood, and suicidal thoughts to see how they change over time. The goal is to learn when an…

This study looks at whether online videos or a call with a peer navigator can help adults with neurofibromatosis 1 (NF1) who have low health literacy better understand their condition and care recommendations. Fifty participants across the U.S. will receive personalized care lett…

This study aims to see if low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers will enroll 900 participants to check how many people join the study and how well the scans find cancer. The goal is to improve early …

This study looks at whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain connections in healthy older adults and people with very early Alzheimer's disease. About 80 participants aged 40-99 will receive daily stimulation…

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will ask 150 older adults (70+) to wear a watch that tracks sleep and to give blood samples. The goal is to fi…

This study tests whether a noninvasive technique called transcranial alternating current stimulation (tACS) can change brain rhythms linked to working memory. Thirty-two healthy adults will receive either active or placebo tACS while performing memory tasks. Researchers will use …

This study tests whether showing a video about advance care planning and hospice to patients with life-limiting illnesses can increase their use of hospice services and help document their care wishes. Researchers will enroll 500 adults with a one-year prognosis or less who recei…

This study looks at whether adding a special care program (GRACE) to regular annual check-ups can help older adults with multiple health issues avoid hospital stays and feel better. About 6,000 people aged 65 and older who speak English or Spanish will take part. The goal is to s…

This small study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a brain measurement technique (TMS-EEG) can safely track brain activity during sedation without…

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants …

This early-phase study tests a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. Researchers will scan 40 volunteers, including healthy people and those with Parkinson's disease, multiple system atrophy…

This study uses a special type of MRI called diffusion tensor imaging to look at the structure of heart muscle in people with heart failure, recent heart attacks, or thickened heart walls. Researchers want to see how the heart's muscle fibers change over time, which may help expl…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling that can occur after treatment—as early as possible. Researchers use arm measurements and patient surveys to track changes in symptoms, function, and quality of life. The goal is to improve outcome…

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if…

This study looks at how the drug romosozumab affects bone-making cells in postmenopausal women with osteoporosis. Researchers will take small bone samples to count these cells early and late in treatment. The goal is to understand why the drug works, not to test a new treatment. …

This study is observing 3000 adults with various types of heart failure to learn how the disease develops and progresses. Researchers will collect medical records, blood samples, and imaging data to identify distinct patient groups. The goal is to match the right treatments to th…

This study will use advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in 10 people with PTSD who also have heart disease or risk factors. Participants will follow a gradually increasing exercise program. The goal is to understand whet…

This study aims to find less invasive ways to measure Duchenne muscular dystrophy activity. Researchers will collect urine and blood samples from 100 participants, including boys with Duchenne or Becker muscular dystrophy and healthy adults. They will look for RNA biomarkers that…

This study aims to find less invasive ways to measure muscle disease activity in people with muscular dystrophies. Instead of painful muscle biopsies, researchers will use blood and urine samples along with painless ultrasound and electrical tests on the arms and legs. The goal i…

This study looks at the spinal fluid and brain activity of people with myotonic dystrophy type 1, a condition that affects muscles and thinking. Researchers want to find early signs of disease in the fluid that surrounds the brain. About 88 adults will take part, including some w…

This study is testing a blood test that looks for tiny pieces of prostate cancer cells floating in the bloodstream. The goal is to see if the number of these cells can tell doctors how advanced the cancer is and if it comes back after surgery. About 200 men with early-stage prost…

This study aims to find less invasive ways to measure disease activity in myotonic dystrophy by looking for RNA markers in blood and urine instead of taking muscle biopsies. Researchers will compare samples from 215 people with and without the condition to see if these markers ca…

This study looks at people who have back pain after a previous spinal fusion surgery. It compares two surgical options: a simpler surgery to relieve pressure on nerves, or a more complex surgery that also extends the fusion. The goal is to see which approach leads to better recov…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. It includes 3,600 adults who speak English or Spanish and have obesity, are due for colorectal or cervical cancer screening, o…

This pilot study works with staff at community health centers to find and fix barriers to colorectal cancer screening. Researchers will hold focus groups and test strategies using rapid-cycle methods. Only 2 participants are enrolled, and the study measures how acceptable, feasib…

This study looks at how prolonged exposure therapy helps people with PTSD. Researchers will track 50 adults over 17 weeks, using brain scans, heart rate, and questionnaires before, during, and after treatment. The goal is to understand the mechanisms behind the therapy, not to te…

This study talks to patients aged 45-54 and health center staff to find out what makes it hard to get colorectal cancer screening. Researchers will interview participants and survey staff to learn about barriers and what might help. The goal is to improve screening rates in this …

This study looks at why some people don't get a follow-up colonoscopy after a positive FIT stool test and tests simple strategies to help them complete it. Researchers will work with 45 patients from Codman Square Health Center to find out what works best. The goal is to make sur…

This study looks at how different areas of the brain communicate in healthy adults. Researchers use a safe, non-invasive technique called transcranial magnetic stimulation (TMS) along with EEG and MRI to measure brain activity. The goal is to better understand brain connectivity,…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

This study tests whether wearing noise-canceling earplugs can lower stress and reduce heart disease risk in people annoyed by traffic noise. Researchers will use brain and blood vessel scans to measure changes over 6 months in 26 adults with heart risk factors. The goal is to see…

This study is investigating why some people continue to have pain long after surgery. Researchers will use brain scans and questionnaires to understand the mechanisms behind chronic post-surgical pain in 110 adolescents and adults. The goal is to improve how doctors choose treatm…

This study aims to create a 'viability index' to predict whether a donated liver will work well after transplant. Researchers will collect small tissue samples from livers before and after transplant in 60 adults with liver cirrhosis. By measuring certain markers, they hope to de…

This study tests a 4-session drug education program called iDECIDE for middle and high school students who recently violated their school's substance use policy. About 300 students will be randomly assigned to either take the program right away or wait. Researchers will measure c…

This study will follow 100 active-duty Navy SEALs over 4 years to see if repeated exposure to blasts affects their brain health. Researchers will use brain scans and blood tests to look for early signs of injury. The goal is to develop a way to detect blast-related brain damage b…

This study uses MRI scans to measure bone marrow fat and bone density in adolescents with cystic fibrosis compared to healthy teens. Researchers want to understand why bone problems occur in cystic fibrosis. The study involves 36 participants aged 13-20 and does not test any drug…

This study uses MRI scans to look at bone marrow fat in teenagers newly diagnosed with Crohn's disease, comparing them to healthy teens. The goal is to understand if Crohn's affects bone health early on. Researchers will also measure bone density using other imaging methods. The …

This study uses a noninvasive device to stimulate a nerve in the ear and see how it changes brain and stomach activity. Researchers will use MRI scans to measure these effects in healthy adults and people with stomach discomfort. The goal is to better understand how the brain and…

This registry enrolls 5,000 pregnant women aged 18-45 who take psychiatric medications like antidepressants or ADHD drugs. Researchers track infant health for one year after birth to see if these medications increase the risk of major birth defects. The goal is to provide better …

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This pilot study tests a new swallowable capsule that uses optical coherence tomography (OCT) to take detailed images of the esophagus and collect targeted tissue samples from areas of concern in people with Barrett's esophagus. The goal is to see if this less invasive method can…

This study is testing a new device called a wireless thermal capsule, which is swallowed and measures temperature as it travels through the digestive tract. The goal is to see if it can reliably detect small temperature changes that might indicate inflammation from diseases like …

This study tests whether brief phone calls or text messages from a trained clinician can help people hospitalized for suicidal thoughts use their safety plan. Participants answer questions on their smartphone up to 4 times a day and may receive a just-in-time intervention based o…

This study tests whether a short educational video can encourage Hispanic current and former smokers to get screened for lung cancer. Researchers will enroll 2,000 people aged 50-80 who smoke or quit recently. Participants watch the video and answer surveys to identify barriers a…

This study aims to find out which of two educational programs better helps adults with Neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their regular checkups. Participants live across the U.S. and do not currently visit a sp…

This study uses a non-invasive brain stimulation technique called iTBS to explore how stimulating specific brain networks changes mood, thinking, and brain activity in people with major depression and healthy volunteers. Researchers aim to understand the brain mechanisms behind t…

This pilot study tests whether linking people who take medication for opioid use disorder to recovery community centers (RCCs) leads to better recovery outcomes. Researchers will compare two groups: one that visits an RCC and one that chooses other recovery activities. The goal i…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…

This study aims to create an ethical framework for using advanced brain technologies like MRI and EEG to detect consciousness in patients with disorders of consciousness. Researchers will survey and interview patients, family members, and clinicians to understand their views on s…