Massachusetts General Hospital

This study looks at two ways to help people who have had a stroke lower their blood pressure: checking blood pressure at home, and attending group medical visits to learn about blood pressure management. The researchers want to see if combining both methods works better than home…

This study looks at whether adding nutrition counseling and stress management to standard medication can help people with Crohn's disease or ulcerative colitis achieve remission. About 160 adults with active IBD will be randomly assigned to different combinations of dietitian and…

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination helps keep the cancer from growing for at least 6 …

This early-stage trial tests a drug called ASTX727 in people with a specific type of brain tumor (IDH mutant glioma) that has come back or is growing. The main goal is to find the safest dose. About 18 adults will take part, and researchers will also track how long the tumor stay…

This study looks at whether a medication called SGLT2 inhibitor, already used for diabetes and kidney disease, can improve blood flow to the heart in women with HIV who also have diabetes or kidney problems. About 80 women will be randomly assigned to health education alone or he…

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 mutation. The goal is to see if the drug can stop or slow cancer growth. About 30 participants will take the pill and be monitored for tumor response and side effects.

This study tests if the drug eplerenone improves heart blood flow better than a standard blood pressure pill (chlorthalidone) in women who had preeclampsia during pregnancy and now have chronic high blood pressure. About 90 women will take one of the two medications daily for 48 …

This study tests a drug called sacituzumab govitecan, given before surgery, in people with localized triple-negative breast cancer. The goal is to see if it can eliminate all cancer in the breast and lymph nodes. Some participants may also receive pembrolizumab. The study involve…

This study tests a drug called NPC-1 (made of parthenolide and ipriflavone) in 40 adults aged 55+ with Alzheimer's disease, mild cognitive impairment, or subjective cognitive decline. The goal is to see if it safely changes blood markers linked to Alzheimer's brain changes. Parti…

This study tests whether a high-intensity statin, a low-dose anti-inflammatory drug (colchicine), or both can slow the buildup of artery plaque in people with a high genetic risk for heart disease. About 200 adults aged 40–75 with early, non-blocking plaque will take the medicati…

This study tests whether the drug abatacept can reduce serious heart problems in cancer patients who develop heart inflammation (myocarditis) from immune checkpoint inhibitor therapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo, an…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) can help people with obesity lose mostly fat while keeping muscle and bone. About 63 adults will receive one of three treatments for 52 weeks, plus lifestyle advice. The goa…

This study tests a new therapy called InTEGRA that combines 12-step support with motivational counseling to help teens aged 14-21 reduce alcohol and drug use. About 294 teens with substance use disorder will be randomly assigned to InTEGRA or standard therapy. The goal is to see …

This study tests a combination of four drugs (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) in 50 adults whose multiple myeloma has returned or stopped responding to treatment. The main goal is to see how many patients respond to this drug cocktail. This is n…

This study tests whether drinking 6 grams of instant coffee daily for a period can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. The study involves 80 participants and uses advanced scans and blood tests to measur…

This study tests a program called CHAMPION that helps children with both asthma and overweight. It compares doing the program in-person versus online to see which works better. About 500 children aged 4-17 with asthma and a high BMI will take part. The goal is to improve their we…

This study tests whether meal replacements can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and improve blood sugar control. About 20 participants will follow an intensive nutrition program for several weeks. The goal is to see if this approach…

This study looks at whether giving a specific inhaler (Airsupra) to adults with asthma right in the emergency department can reduce the chance of another asthma attack needing urgent care within 3 months. About 1,860 people aged 18 to 55 who are being sent home from the ER with s…

This study tests a combination of three drugs (zanubrutinib, bendamustine, and rituximab) in people with Waldenström macroglobulinemia who have not yet received treatment. The goal is to see how well the combination shrinks the cancer and to check for side effects. About 55 adult…

This study tests whether giving G-CSF (a drug that boosts white blood cells) alongside standard chemoradiation can help preserve brain structure and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be rand…

This early-phase study tests the safety of combining two drugs (atezolizumab and bevacizumab) with targeted radiation (SBRT) in people with liver cancer that cannot be surgically removed. About 20 participants will receive the combination to see if it is tolerable and how well it…

This study tests whether giving a sleep-promoting drug called dexmedetomidine at night can lower the risk of delirium (sudden confusion) in older adults after heart surgery. About 1,800 patients aged 60 and older will receive either the drug or a placebo through an IV or under th…

This study tests whether giving a higher dose of radiation to the most risky parts of a retroperitoneal sarcoma (a rare tumor deep in the abdomen) before surgery is safe and effective. About 80 adults with this cancer will receive either proton or photon radiation, followed by tu…

This study looks at whether adding a special care program (GRACE) to yearly wellness visits can help older adults with multiple health issues avoid hospital stays and feel better. About 6,000 people aged 65 and older with complex needs will take part. The goal is to see if this a…

This study tests whether the drug canakinumab can reduce inflammation in the arteries of people who have had a heart attack or stent procedure. About 120 adults, some with a specific genetic change called TET2 CHIP, will receive either the drug or a placebo. The goal is to see if…

This study tests whether the drug ivosidenib can prevent acute myeloid leukemia (AML) from returning in patients who have a specific IDH1 gene mutation and have already received a stem cell transplant. About 75 adults aged 18 to 75 will be randomly assigned to take either ivoside…

This study tests a program called ADELANTE, designed to help Latinos with HIV who are not virally suppressed. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the program le…

This study tests whether a higher dose of the drug omalizumab can help people with food allergies tolerate larger amounts of allergenic foods like peanut, cashew, walnut, egg, or milk. About 30 adults with confirmed allergies will receive the drug and then take a food challenge t…

This study is for people with stage III colon cancer who have finished standard chemotherapy. It uses a blood test to look for tiny bits of cancer DNA that might remain after surgery. If the test finds cancer, participants are offered extra treatment (like FOLFIRI or other drugs)…

This study tests whether the drug elranatamab can lower the chance of multiple myeloma worsening after treatment with idecabtagene vicleucel (a CAR T-cell therapy). About 32 adults whose cancer did not respond or came back after prior treatments will receive elranatamab as a cons…

This study tests if freezing part of a growing tumor (cryoablation) combined with two immunotherapy drugs (ipilimumab and nivolumab) can help control advanced melanoma that stopped responding to prior treatment. About 37 adults with unresectable melanoma will receive the combinat…

This early-stage study tests two drugs, mezigdomide and talquetamab, together in people whose multiple myeloma has come back or stopped responding to other treatments. The main goal is to find the safest dose and schedule. About 25 adults will take part, and researchers will watc…

This early-stage study tests the safety of a drug called momelotinib given during and after a stem cell transplant for people with myelofibrosis, a rare bone marrow cancer. The goal is to find the highest safe dose and see how well patients tolerate it. About 28 adults with inter…

This study tests whether giving repeated BCG vaccines (traditionally used for tuberculosis) can improve blood sugar control in children aged 8 to 18 with type 1 diabetes. Researchers will measure changes in HbA1c, blood sugar swings, and insulin needs over time. The goal is to se…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to find which approach is safer and works better. About 50 hospitali…

This study compares a new combination of two drugs (venetoclax and azacitidine) to standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML). The goal is to see if the new combo works as well or better at controlling the disease. About 172 participants wi…

This study compares two FDA-approved medication combinations to treat postmenopausal osteoporosis in women aged 45 and older who have a high risk of fractures. The goal is to see which regimen better improves bone density in the lower spine over 12 months. Participants must not h…

This study tests whether giving multiple doses of the BCG vaccine (traditionally used for tuberculosis) can improve blood sugar control and reduce insulin needs in children aged 8 to 18 who were recently diagnosed with type 1 diabetes. The trial involves 100 participants and meas…

This study looks at whether switching to a once-daily anti-rejection drug (Envarsus XR) can improve memory and thinking in older kidney transplant patients compared to staying on a twice-daily drug (Prograf). About 92 people who have had a kidney transplant for at least a year wi…

This study tests proton beam radiation for children with neuroblastoma, a nerve cell cancer. Unlike standard radiation, protons target the tumor more precisely, sparing healthy tissues. Researchers want to see if this reduces long-term side effects like heart, lung, or growth pro…

This study tests a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal is to see how many participants achieve undetectable measurable re…

This study tests a new combination of two drugs (elranatamab and isatuximab) given as shots under the skin for people with multiple myeloma that has come back or stopped responding to at least two prior treatments. The goal is to see if the combo can shrink tumors in more patient…

This study tests whether time-restricted intermittent fasting can reduce liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). Researchers will enroll 25 participants to follow a fasting schedule and measure changes in liver fat using MRI. The …

This study tests a 12-week phone coaching program for 280 adults with heart failure. The program uses positive psychology and motivational interviewing to help patients better follow their diet, exercise, and medication plans. Participants also receive supportive text messages fo…

This early-phase study tests an experimental drug called ziftomenib in 22 adults with acute myeloid leukemia (AML) who have already had a stem cell transplant. The goal is to see if taking ziftomenib after transplant is safe and can help prevent the cancer from coming back. Parti…

This study tests if adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to stress, intense exercise, or eating disorders. Participants receive either romosozumab or placebo for 6 months, plus estrog…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people on popular weight-loss drugs (like Wegovy or Mounjaro) keep their muscle and strength. About 100 adults who recently started or plan to start thes…

This study tests a drug called epcoritamab in 30 people with large B-cell lymphoma that has come back or not responded to treatment. Participants cannot have a stem cell transplant. The goal is to see if the drug can control the cancer for at least 12 months. Epcoritamab is given…

This study tests a small cap placed on cut nerve endings after a finger amputation to prevent painful nerve growths called neuromas. About 20 adults who recently had a traumatic finger amputation will receive the Tulavi Allay™ Nerve Cap during surgery. Researchers will track pain…

This study tests whether a special machine can revive fatty donor livers so they can be safely transplanted. About 200 adults waiting for a liver transplant will receive a liver treated with this machine. If successful, it could increase the number of available donor livers and r…

This study tests whether combining two drugs, afatinib and pemigatinib, is safe and can shrink tumors in people with advanced solid cancers that have certain genetic changes (FGFR alterations). About 70 adults whose standard treatments have stopped working will take part. The mai…

This study tests whether taking spironolactone for three months after giving birth can help lower blood pressure and improve heart health in women who had preeclampsia or high blood pressure during pregnancy. The trial includes 204 women who were overweight before pregnancy and n…

This study tests two drugs—palbociclib alone or combined with pembrolizumab—in people whose cancer has spread to the brain and is growing despite prior treatment. The goal is to see if these drugs can shrink or stabilize brain tumors. About 45 adults with solid tumors (Cohort 1) …

This study tests proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and affects quality of life and side effects. Participants receive targeted proton beams to shrink or stabilize their tumors whil…

This study tests whether adding a new drug (liposomal irinotecan) to standard chemotherapy before chemoradiation can completely eliminate cancer in people with advanced gastroesophageal junction or esophagogastric cancer. About 40 adults with stage T3/4 or node-positive disease w…

This study tests whether low-intensity focused ultrasound can help people with severe brain injury who have not fully regained consciousness. Researchers will measure changes in behavior and brain activity after the ultrasound sessions, and also interview family members about the…

This study tests a combination of three drugs (venetoclax, obinutuzumab, and possibly acalabrutinib) in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded to prior treatment. The goal is to eliminate remaining ca…

This study tests a tool called Savvy that combines phone exercises, a weekly pill organizer, and text reminders to help stroke survivors take their medication as prescribed. The goal is to see if it improves medication adherence and blood pressure control. The study involves 150 …

This study is testing whether adding a patient's own platelet-rich plasma (PRP) to standard hip labral repair surgery leads to better outcomes. About 400 adults with hip labral tears will be randomly assigned to receive surgery with or without PRP. The goal is to see if PRP impro…

This study aims to find the best way to help people in Uganda and South Africa whose HIV medications are no longer fully suppressing the virus. Researchers will compare three different approaches: following current guidelines, using personalized testing to choose new drugs, or im…

This is a small, early-stage study to see if giving high doses of inhaled nitric oxide (a gas) is safe and might help adults with severe pneumonia who are on a breathing machine. Researchers will compare the gas treatment to a placebo (sham treatment) in 34 patients. The main goa…

This study aims to find the best way to manage gout by comparing two common treatment strategies. It will enroll 650 adults with gout from primary care clinics. Researchers will see if it's better to treat based on a specific blood urate level target or to treat mainly to prevent…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see tumor edges more clearly during bone or soft tissue mass removal. About 100 adults with benign or malignant masses will receive the dye before surgery, and a special camera will captur…

This study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a PET-MR scan. Researchers want to see if it can safely and accurately find clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 healthy volunteers …

This study looks at whether a special PET scan (flotufolastat F 18) can find prostate cancer that has come back in men with very low PSA levels (0.20 ng/mL or less) after prostate removal surgery. About 50 men will get the scan to see how often it detects cancer. The goal is to i…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The tool alerts their doctor to discuss lung cancer screening CT. The goal is to see if this alert increases the number of high-risk patients who get sc…

This study tests whether injecting a near-infrared dye near a lung tumor can help surgeons see the tumor and the first lymph node it drains to during surgery. About 100 adults having lung surgery will receive the dye, and doctors will check if it safely improves detection of canc…

This study involves 25 adults with Crohn's disease who are scheduled for possible surgery. Researchers will use a PET/MR scan with a special tracer that binds to collagen to see if it can accurately tell the difference between scar tissue (fibrosis) and active inflammation in nar…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation to measure collagen buildup, which ma…

This study is testing a new imaging technique called Brillouin microscopy to see if it can help diagnose corneal conditions like keratoconus and ectasia. Researchers will scan the corneas of healthy volunteers and patients with these conditions to compare their biomechanical prop…

This study is testing a new type of PET/MRI scan to see if it can give doctors a clearer picture of liver cirrhosis, liver cancer, and related high blood pressure. About 45 adults with cirrhosis will get this scan. The goal is to improve how doctors detect and monitor these serio…

This study is testing better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will enroll 300 adults who have had a possible allergic reaction to these drugs. Participants will receive skin tests and car…

This early-phase study is testing a special imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with idiopathic pulmonary fibrosis. The go…

This study tests a special PET scan that looks for collagen buildup in the lungs, an early sign of scarring in interstitial lung disease. Researchers will compare scans from 30 people: 8 healthy relatives of patients with lung scarring and 22 people with early lung abnormalities …

This study looks at whether molecules in saliva and blood can help doctors quickly identify when heart failure is getting worse. Researchers will compare levels of these molecules in people with stable chronic heart failure, those with sudden worsening symptoms, and healthy contr…

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without needing sedation. About 30 healthy adults and people with Lynch syndrome or inflammatory bowel disease will try it. The goal is to see if the device can get clear images and be…

This study is testing a new way to find ovarian cancer earlier by looking at DNA from a uterine wash and proteins in the blood. Researchers will collect samples from 250 women before surgery for a suspected ovarian mass. The goal is to see if these tests can tell the difference b…

This study is testing whether a simple, at-home smell test can help detect early signs of Alzheimer's and other brain disorders. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute smell test using scratch-an…

This study tests a new, compact imaging capsule that people swallow to take pictures of the esophagus. The goal is to see if it is safe and easy to use for detecting Barrett's esophagus, a condition that can lead to cancer. About 120 healthy volunteers and people with Barrett's e…

This study tests a preventive program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can stop these symptoms from turning into a serious mental illness. Researchers wil…

This study tests a brain health program for adults aged 50 and older who have mild memory problems but not dementia. The program is offered at senior centers and focuses on healthy lifestyle changes like exercise, diet, and social activity. Researchers want to see if the program …

This study tests whether a simple writing exercise can prevent post-traumatic stress disorder (PTSD) in women who had a stressful childbirth. In the days after giving birth, participants will write about their birth experience for 15 minutes on three consecutive days. Researchers…

This study is developing a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program adapts a proven problem-solving approach to address barriers like depression and anxiety. Researchers will test if the program is practi…

This study tests a program called PrEP My Way, designed to help young women aged 16-24 in Kisumu, Kenya, keep using HIV prevention medicine (PrEP). Participants can choose between a daily pill, a long-acting shot, or a vaginal ring, plus get support from peers. The goal is to see…

This early-phase study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower the risk of early-onset colorectal cancer. Researchers will measure changes in cancer-related markers in blood, urine, and tissue from 20 adults aged 18-50 with a BMI between 27 …

This study is testing a new group therapy called Resilience Training for Teens. It is for high school students ages 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. The goal is to see if this therapy can help prevent them from developing more serious ment…

This study tests a program that gives HIV self-test kits and counseling to postpartum women in South Africa who don't have HIV but have a partner with unknown status. The goal is to see if this helps women start PrEP (HIV prevention medicine) and helps partners who test positive …

This study is testing whether a long-acting injectable HIV prevention medication, called cabotegravir, works well for adults who inject drugs. One hundred participants will receive the shot along with support services. The goal is to see how many people stick with the treatment a…

This study tests whether putting special air filters (HEPA cleaners) in elementary school classrooms can lower the amount of viruses in the air and reduce how often students, teachers, and their families get sick. About 200 children and adults from inner-city schools will take pa…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if learning their personal risk motivates them to make healthy lifestyle and diet changes that might p…

This study looks at whether a 12-week home resistance exercise program can prevent muscle loss in transgender women and gender-diverse individuals starting estrogen-based hormone therapy. About 60 participants will be randomly assigned to either the exercise program or standard n…

This study tests whether combining virtual reality (VR) with pleasant scents can lower pain and anxiety in 80 adults undergoing heart or lung surgery. Participants will either receive the VR and scented necklace sessions before and after surgery or continue with standard care. Th…

This study compares a 10-week program called GetActive+ (which combines mind-body techniques with walking) to usual care for 200 older adults aged 55+ who have had musculoskeletal pain for at least 3 months. The goal is to see if the program improves physical function, such as wa…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will measure pain levels and brain activity in 80 adults aged 18-60 who have had back pain for over 6 months. The goal is to see if tACS can chang…

This study tests whether a special exercise program, guided by a physical therapist, can improve strength and walking ability in adults with myotonic dystrophy type 2 (DM2). About 24 participants will be split into groups that exercise with a therapist virtually or on their own. …

This study compares two medications used to sedate patients during endoscopy (a procedure to look inside the body). The goal is to see if a newer drug called remimazolam works as well as or better than the standard drug propofol. About 100 adults having planned endoscopy will tak…

This study tests a program designed to help improve thinking and memory in refugees and asylum seekers who have had a traumatic brain injury (TBI). Researchers want to see if the program is practical and well-liked. About 50 people will be split into two groups: one starts the pr…

This study tests whether a single dose of intravenous iron (ferric derisomaltose) can improve exercise capacity in people with heart failure with preserved ejection fraction who also have iron deficiency. About 66 adults will receive either the iron infusion or a placebo, and the…

This study tests tenapanor, a drug already approved for irritable bowel syndrome, to see if it can help with constipation in people with cystic fibrosis. About 25 adults will take one tablet twice daily for 4 weeks. Researchers will track bowel movements and use questionnaires to…

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Researchers will give turmeric to 60 adults aged 40 and older and track changes in their symptoms and daily function. The goal is to see if this natural option offers …

This study tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm repair. Ten adults having elective surgery will try the program to see if it is feasible and helpful. The goal is to improve readiness and recovery, not to cure the aneurysm.

This study tests a self-guided digital app called DREAMLAND to see if it can improve quality of life and emotional health for adults with acute myeloid leukemia (AML) who are receiving intensive chemotherapy. About 200 participants will use either DREAMLAND or a standard wellness…

This study tests a specially adapted mindfulness program for older Black adults (age 50+) who have both chronic pain and mild to moderate depression. The goal is to see if this program can improve quality of life and reduce how much pain interferes with daily activities, compared…

This study tests a new program to help older adults (65+) recover after ostomy surgery. The program gives personalized advice and tracks progress to improve quality of life. Researchers want to see if it is easy to use and helpful for patients and their doctors.

This study tests a non-invasive technique called auricular transcutaneous vagal nerve stimulation (taVNS), which uses a small device to stimulate a nerve in the ear. The goal is to see if it can improve stomach sensitivity and digestion in people with functional dyspepsia or gast…

This study tests a support program for people recently diagnosed with a malignant brain tumor. The program includes a guide and one-on-one coaching sessions to help patients cope. Researchers want to see if the program is practical and helpful. About 50 adults from Massachusetts …

This study looks at whether limiting calories before surgery can reduce wound healing problems in people with soft tissue sarcoma of the leg. About 32 adults who need radiation and then surgery will either follow a calorie-restricted diet or eat normally. The goal is to see if th…

This study tests whether heated yoga, sauna sessions, or a mindfulness app can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will be assigned to one of the three approaches and monitored for changes in…

This study tests a program called WISH, which uses positive psychology exercises (like gratitude and optimism) to help people with irritable bowel syndrome (IBS). Researchers want to see if it's practical and can improve gut-brain communication. About 50 adults with IBS will eith…

This study tests whether a type of talk therapy (Cognitive Processing Therapy) for PTSD can also reduce heart disease risk. Thirty adults with PTSD and signs of heart risk will receive either therapy or be placed on a waitlist. Researchers will measure changes in brain activity, …

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients during stem cell transplants. The goal is to see if this program is practical and helpful for patients. About 40 adults receiving a stem cell transplant at Massachusett…

This study looks at how well the IlluminOss pelvic implant works for people with pelvic fractures caused by cancer that has spread to the bone or by age-related bone weakness. About 100 participants will receive the implant as part of their normal care, and researchers will track…

This study tests a short counseling program for young adults (ages 25-39) with cancer and their caregiving partners. The goal is to help them cope with stress and keep their relationship strong. About 20 couples will take part in 8 therapy sessions to see if the program is practi…

This study tests a program called QuitVaping, which combines counseling and text messages to help teenagers stop vaping nicotine. About 400 teens aged 14-18 who vape at least weekly will be randomly assigned to either the QuitVaping program or standard advice and resources. The g…

This study trains psychotherapists to provide personalized talk therapies to cancer patients and their caregivers who are feeling high levels of distress, anxiety, depression, pain, or insomnia. Therapists will choose from proven treatments like cognitive behavioral therapy or mi…

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app improves mood, reduces cannabis use, and is easy to use.

This study tests whether whole body hyperthermia, a sauna-like procedure, can reduce Long COVID symptoms, especially fatigue. Researchers at Massachusetts General Hospital will enroll 21 adults aged 18-65 who have had COVID-19 and now suffer from ongoing symptoms. Participants wi…

This study tests whether cannabidiol (CBD), a non-intoxicating cannabis compound, can reduce brain inflammation in 80 adults with chronic low back pain and mild-to-moderate depression. Participants will receive either CBD or a placebo, and researchers will measure changes in brai…

This study tests a virtual, therapist-led sleep program (cognitive behavioral therapy for insomnia) in 198 cancer survivors who have chronic insomnia. Participants are in different phases of cancer survivorship, including those still on treatment or with metastatic cancer. The go…

This study tests a new supportive care program called POISE for people with advanced non-small cell lung cancer who are on targeted therapy. The program includes four visits with a palliative care clinician to help patients cope with uncertainty and manage their cancer. Researche…

This study tests a digital app called SHIFT designed to help stem cell transplant survivors improve their sexual health, quality of life, and reduce distress. About 300 adults who had a transplant more than three months ago and have sexual concerns will use the app or receive sta…

This study tests a 12-week remote program that combines positive psychology and motivational interviewing, plus text messages, to help 280 people who have had a heart attack become more physically active. Participants wear an activity tracker to measure changes in moderate-to-vig…

This study looks at whether doing heated or non-heated yoga can improve symptoms of depression. Researchers will enroll 120 adults aged 18 to 65 who have moderate depression. Participants will be assigned to either heated or non-heated yoga classes, and their mood and well-being …

This study tests an 8-week remote program that combines positive psychology and motivational interviewing to help 280 adults with type 2 diabetes increase their physical activity. Participants receive coaching and text messages over 16 weeks. The goal is to see if this approach b…

This study is testing a new program called QUIT-AD to help people living with HIV or TB in Cape Town, South Africa, quit smoking. The program combines existing methods to support smoking cessation and improve HIV/TB treatment outcomes. Researchers will enroll 86 daily smokers to …

This study tests whether a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both lasers on small skin areas and report their pain levels. Researchers will also track healing time and blood …

This study looks at whether adding physical therapy to steroid injections helps people with frozen shoulder more than steroid injections alone. About 260 adults with frozen shoulder will be split into two groups: one gets physical therapy plus steroid shots, the other gets steroi…

This study tests a mobile app called PROMOTE designed to help lung cancer survivors improve their physical function, manage shortness of breath and sleep problems, and eat healthier. About 250 people with early-stage lung cancer will either use the app for 12 weeks or receive sta…

This study tests a new type of whole brain radiation that spares normal tissue, aiming to reduce side effects and improve quality of life for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. Res…

This study tests whether a medicine called bezafibrate, usually used for cholesterol, can safely help with depression in people with bipolar disorder. Thirty adults with bipolar depression will take bezafibrate along with their usual mood-stabilizing medication for 8 weeks. Resea…

This study tests a new approach to help breast cancer survivors with nerve pain caused by chemotherapy. Instead of real needles, participants watch guided acupuncture videos at home. The study is small (20 people) and focuses on whether this method is practical and satisfying, no…

This study tests a group-based telehealth program called HORIZONS for adults who have chronic graft-versus-host disease after a stem cell transplant. The program is designed to help patients better manage their condition and improve their quality of life. About 350 participants w…

This study tests a type of talking therapy (exposure-based CBT) for adults who have both functional dyspepsia (stomach pain or fullness after eating) and avoidant/restrictive food intake disorder (ARFID) with weight loss. The goal is to see if the therapy helps people eat more co…

This study tests a program called InSTILL for nursing home residents who feel down and their main support person. The program teaches ways to handle stress and build resilience. Researchers want to see if it's practical and helpful compared to usual care. About 100 pairs of resid…

This study tests a brief, 6-session virtual program for people recently diagnosed with young onset dementia (before age 65) and their care-partners. The goal is to prevent long-term emotional distress and improve well-being for both. About 388 pairs will participate, and the prog…

This study tests whether a simple, self-directed writing program can help people with chronic muscle or joint pain who tend to catastrophize (expect the worst). Ten adults with chronic pain will try the 8-session writing intervention at home. Researchers will check if people find…

This study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special PET scans to measure changes in artery inflammation. The goal is to see if managing stress can help improve …

This study tests a program called BMT-CARE designed to support caregivers of patients receiving a bone marrow transplant. The goal is to see if the program improves the caregiver's quality of life and reduces their stress. The study will involve 800 caregivers and compare those w…

This study looks at whether giving tranexamic acid (a drug that reduces bleeding) during breast reduction surgery can decrease fluid buildup and help surgical drains come out sooner. About 160 adults having elective breast reduction will be randomly assigned to receive the drug o…

This study tests whether people with myeloproliferative neoplasms (a type of blood disorder) can stick with a 12-week program focused on healthy eating and physical activity. Researchers want to see if at least 70% of the 30 participants complete 9 weeks of the program. The goal …

This study looks at how well people tolerate laser treatment for port wine birthmarks using an FDA-approved 532 nm laser. Researchers want to compare the standard single high-energy pulse with a new approach using multiple low-energy pulses. Fifteen adults with non-facial port wi…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. Parents are randomly assigned to one of three programs and tracked for 8 months. The goal is to see if these programs reduce how much parents acc…

This study is for adults with major depression who are at high risk for suicide. Participants will receive IV ketamine and nasal esketamine over 24 weeks to see if these treatments are safe, tolerable, and effective at reducing suicidal thoughts. The goal is to find better ways t…

This study tests whether a safe, non-invasive brain stimulation device used at home for four weeks can reduce ADHD symptoms and improve focus in adults. Sixty participants aged 18-65 with ADHD will use the device daily and complete questionnaires and computer tasks. The goal is t…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study is testing a smartphone app called TEC-S designed to help adults who have frequent suicidal thoughts. The app uses a technique called evaluative conditioning to change how people react to triggers. Researchers want to see if the app is safe, easy to use, and can reduce…

This study is testing a smartphone app called PDAC-PATHWAYS designed to provide information and support to people with pancreatic cancer who are about to start treatment. About 50 participants will use the app to see if it is helpful and easy to use. The goal is to improve the pa…

This study tests whether a single intravenous dose of allopregnanolone, a natural brain chemical, can help people with PTSD better process traumatic memories. About 96 adults with chronic PTSD will receive either the drug or a placebo and then undergo memory tests. The goal is to…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can improve quality of life for adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to either g…

This study tests two experimental drugs, siltuximab and erenumab-aooe, to see if they can safely reduce chronic pain in people with schwannomatosis, a condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will be randomly assigned to receive one…

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. The programs use mind-body techniques to reduce anxiety, depression, and emotional distress. About 84 pairs (survivor plus caregiver) will participate to see if the programs are f…

This study tests a digital sleep improvement program (a mobile app and a wrist tracker) in 50 older adults (65+) who are having hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surgery. Participants must have mild i…

This study tests whether an 8-week course of intranasal oxytocin (a hormone nasal spray) can reduce how often adults with binge-eating disorder binge eat. About 60 adults aged 18-70 will receive either oxytocin or a placebo. The goal is to see if the treatment is safe and effecti…

This study tests whether the drug ruxolitinib can reduce bothersome symptoms in people with low-risk essential thrombocythemia (ET) or polycythemia vera (PV). About 60 adults with significant symptom burden will take ruxolitinib and be monitored for improvement. The goal is sympt…

This study tests a five-session palliative care program for people with metastatic breast cancer and their caregivers. The goal is to help patients talk with their doctors about their goals and preferences for care. Researchers will see if the program leads to better documentatio…

This study tests whether giving a low-dose nonsteroidal anti-inflammatory drug (ketorolac) for the first five days after orthopedic trauma surgery can reduce the risk of chronic opioid use. About 458 adults with serious bone injuries will be randomly assigned to receive either st…

This small pilot study aims to see if a virtual cognitive behavioral therapy program for insomnia is practical and well-liked by people with cirrhosis. Ten adults with cirrhosis and sleep problems will try the program from home. The main goal is to measure how many people enroll …

This study tests whether a supplement called pregnenolone can improve depression in people with HIV. Researchers will give 120 participants either pregnenolone or a placebo pill, while allowing them to continue their current antidepressants. Brain scans and mood questionnaires wi…

This study is testing two different doses of an injectable medication called Cortrophin Gel to see which works better and is safer for quickly reducing the intense pain of a sudden gout attack. About 150 adults who are having a gout flare will receive a single injection and then …

This study is testing a new online program designed to help adults manage chronic facial pain. The program teaches relaxation and coping skills through five short video sessions. Researchers want to see if the program is easy to use and acceptable to participants before testing i…

This study will examine the medical records of up to 1.2 million people who had surgery or a procedure with anesthesia. Researchers want to see if the time spent fasting before surgery affects things like nausea, low blood pressure, or kidney problems. The goal is to learn if cur…

This study aims to find biological markers in people who are at risk for inherited prion diseases like Creutzfeldt-Jakob disease. Researchers will collect blood, spinal fluid, and cognitive test results from 150 participants to see if they can predict when symptoms might begin. T…

This study looks at bone health in teenagers with cystic fibrosis (CF) compared to healthy teens. Researchers will use MRI and other scans to measure bone marrow fat and bone density. The goal is to understand why teens with CF may have weaker bones and how factors like blood sug…

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have some depression symptoms. Researchers use smartphone surveys several times a day to track cannabis use, mood, and suicidal thoughts. The goal is to understand how cannabis use and withdrawal aff…

This study observes brain activity related to speech in 80 people with Parkinson's disease, essential tremor, or dystonia who are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record electrical signals from brain regions involved in speech while par…

This study is for women aged 60 and older with newly diagnosed breast cancer who are scheduled for chemotherapy. Researchers want to understand how chemotherapy affects thinking skills and the brain over time. Participants will complete thinking tests and some may have brain scan…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will track sleep with a watch and collect blood samples from 150 older adults. The goal is to find early warni…

This study looks for simpler, less painful ways to track muscular dystrophy. Instead of taking a small piece of muscle (biopsy), researchers will check blood and urine samples and use painless ultrasound and electrical tests on arm and leg muscles. The goal is to find new markers…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will take part. Researchers will use special PET/MRI scans to measure changes in artery and brain activity …

This study looks at whether suvorexant, a drug approved for insomnia, can reduce brain activity linked to cannabis use. Twenty adults who use cannabis daily or near-daily will take the medication for 14 days and have two brain scans. The goal is to see if the drug lowers the brai…

This study tests a new swallowable capsule that takes detailed images of the esophagus and collects tiny tissue samples from suspicious areas. The goal is to see if this method can safely and effectively gather tissue for genetic analysis, potentially improving early detection of…

This registry enrolls pregnant women aged 18-45 who take psychiatric medications like antidepressants or ADHD drugs. Researchers will track the health of their babies for the first year of life to see if the medications cause birth defects. The goal is to fill gaps in current saf…

This study looks at whether telling people their genetic risk for heart disease (called a polygenic risk score) helps them lower their cholesterol and improve their heart health over one year. About 500 adults aged 30-75 who are not on cholesterol medication will be randomly assi…

This study follows 10,000 breast cancer patients to detect arm swelling (lymphedema) early after treatment. Researchers use arm measurements and patient surveys to understand how swelling affects daily life and quality of life. The goal is to improve screening and outcomes by cat…

This study follows 100 active-duty Navy SEALs over 4 years to see if repeated exposure to blasts affects their brain health. Researchers will use brain scans and blood tests to look for early signs of injury. The goal is to create a test that can detect blast-related brain damage…

This study works with clinics in Massachusetts to offer proven programs for weight management, cancer screening, and mental health to adults in underserved areas. Researchers will track changes in body mass index, cancer screening rates, and mental health scores. The goal is to r…

This study is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of a protein called alpha-synuclein in the brain using PET scans. Researchers will scan 40 people, including those with Parkinson's disease, multiple system atrophy, dementia with Lewy …

This study looks at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers will collect samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotio…

This study compares two pain management plans for patients leaving the hospital after major bone surgery: one that uses opioids and one that does not. The goal is to see if it is possible to run a larger trial on this topic. About 100 adults who had orthopedic surgery will take p…

This study looks at how a gentle, noninvasive nerve stimulation (applied to the ear) changes activity in the brain and stomach. Researchers will use MRI scans and heart/stomach monitors to measure these effects in healthy adults and people with functional dyspepsia. The goal is t…

This study collects blood samples from up to 1,000 adults with PSP, CBS, MSA, or related brain conditions, plus their family members. Researchers will analyze DNA to find genes linked to these diseases. The goal is to better understand what causes these disorders, not to test a t…

This study looks at how the drug romosozumab affects bone cells in postmenopausal women with osteoporosis. Researchers want to understand why the drug works better at certain times during treatment. About 16 women who are already prescribed romosozumab will join, and the team wil…

This study is building a large database of health information from up to 5,000 people with ALS and similar motor neuron diseases. Participants share details like their symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then sha…

This study tests whether showing a video about advance care planning to patients with life-limiting illnesses can increase their use of hospice services. About 500 adults expected to live one year or less will watch the video at home and then discuss their care wishes with their …

This study follows 8,000 adults who have had a stroke to understand why some develop memory and thinking problems afterward. Researchers will use brain scans, blood tests, and thinking assessments to find risk factors for dementia. The goal is to help doctors identify high-risk p…

This study looks at how gentle electrical stimulation on the scalp can change brain rhythms linked to working memory. Researchers will test 32 healthy adults using a noninvasive technique called tACS while measuring brain activity with EEG. The goal is to understand how brain wav…

This study uses a non-invasive brain stimulation technique called rTMS to see how stimulating different brain networks changes mood, thinking, and brain activity. Researchers will compare results from people with major depression and healthy volunteers to understand why rTMS work…

This study is testing whether wearable devices like Fitbits and Apple Watches can help predict and detect early complications after heart or lung surgery. Researchers will use machine learning to analyze data from 1,200 patients. The goal is to catch problems sooner and improve r…

This study uses three types of brain scans (PET, MRI, and EEG) to see how epilepsy affects brain activity and energy use. Researchers will compare people with epilepsy to healthy volunteers. The goal is to better understand the disease, not to test a treatment.

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve memory and brain function in older adults with mild memory problems or early Alzheimer's. About 30 participants will receive daily stimulation sessions over two weeks, with memory …

This study looks at how the brain and body respond during prolonged exposure therapy for PTSD. Researchers will track 50 adults before, during, and after 10 therapy sessions to find markers that predict who benefits most. The goal is to gather data that could lead to more effecti…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life for both. About 388 pairs will participate, and the program focuses on building coping skills …

This study looks at whether giving emergency room patients with dental problems extra help—like lists of nearby dentists and social services (for housing, food, etc.)—can get them to actually go to a dentist. About 2,900 adults will be split into three groups: one gets general in…

This study looks at tiny particles called extracellular vesicles that are released from fat tissue. Researchers want to understand how these particles carry signals that might affect the heart and liver, especially in people with obesity. About 100 adults having weight loss surge…

This study tests two different educational programs to see which one helps adults with Neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their annual checkups. The study is fully online and open to people across the U.S. who d…

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely and gives useful measurements. No treatment or …

This study tests if a non-invasive brain stimulation technique called tDCS can improve executive functions like memory, attention, and decision-making. Researchers will enroll 600 adults with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, …

This study looks at why some people don't get a follow-up colonoscopy after a positive FIT (stool) test for colorectal cancer. Researchers will test simple strategies to help more people complete the colonoscopy, especially in underserved communities. About 45 adults aged 45-75 f…

This study looks at why Hispanic current and former smokers may not get screened for lung cancer and tests whether an educational video can help. About 2,000 participants will watch the video and answer surveys. The goal is to find better ways to encourage screening in this commu…

This study tests a new wireless pill that measures temperature inside the gut. The goal is to see if it can help detect diseases like Crohn's disease. Ten healthy adults will swallow the capsule and researchers will check if it sends accurate temperature readings.

This study looks at the spinal fluid and brain activity of people with myotonic dystrophy type 1 to find early signs of the disease. Researchers will compare these markers between affected and healthy volunteers. No treatment is given; the goal is to better understand the conditi…

This study uses a special PET-MR scan to measure the activity of an enzyme called histone deacetylase in the heart. Researchers will compare levels in people with aortic stenosis or diabetes to healthy volunteers. The goal is to better understand how this enzyme relates to heart …

This study looks at whether stopping tube feeding for at least 8 hours before a procedure helps or harms recovery in critically ill patients on breathing machines. About 1,072 participants will be randomly assigned to either fast or not fast before their procedure. Researchers wi…

This study looks at whether a blood or urine sample can detect and measure the activity and severity of myotonic dystrophy, a type of muscular dystrophy. Currently, doctors often need to take a small piece of muscle (biopsy) to check how the disease is progressing. The goal is to…

This study looks at whether a physical activity program can help improve hormone health and reduce diabetes risk in girls ages 8 to 12 who may be at higher risk for PCOS. About 40 girls will either get a full program with coaching and messages or a lighter version with just messa…

This study aims to create a test that can tell doctors if a donated liver is healthy enough to transplant. Researchers will take small tissue samples from livers before and after transplant and look for markers that predict how well the liver will work. The goal is to safely use …

This study is testing a simple, non-invasive device that uses motion sensors on the chest and belly to measure breathing effort in children. The goal is to see if it can detect breathing problems early, even before they are obvious to doctors. About 20 children aged 28 days to 17…

This study looks at why some people have long-lasting pain after surgery. Researchers will use brain scans and questionnaires to understand the pain better. The goal is to find better ways to treat each person's pain in the future. About 110 teens and adults who have had pain for…

This study looks at 1,200 people with T-cell or NK-cell lymphoma to see how their genes affect treatment success. Researchers will use machine learning to find patterns that predict which treatments work best. The goal is to move toward personalized care for this rare cancer.

This study looks at whether telling people they have a high genetic risk for heart disease helps them improve their heart health over one year. Researchers will compare a group that learns their genetic risk to a group that gets standard care. The study involves 200 adults aged 4…

This study aims to find better ways to help people get screened for colorectal cancer at community health centers. Researchers will talk with staff and look at health records to see what works. The goal is to make screening easier and more common.

This study looks at whether a blood test can detect cancer cells shed by prostate tumors, potentially reducing the need for biopsies. Researchers will compare the number of these cells in the blood before and after prostate removal surgery in 200 men with early-stage prostate can…

This study looks at the best way to treat a spine condition called adjacent segment disease, which can happen after a previous back fusion surgery. Researchers are comparing two surgical options: a simpler surgery that just takes pressure off the nerves (decompression) versus a m…

This study is collecting health information from 3000 adults with different types of heart failure to learn how the disease develops and changes over time. Researchers will use blood tests, imaging, and medical records to find patterns that could help doctors choose the best trea…

This study tests a care transition program designed for older adults (65+) recovering from colorectal surgery. The goal is to see if the program helps reduce hospital readmissions and improves recovery after discharge. About 30 participants will be enrolled to check if the progra…

This pilot study is testing whether connecting people who take medication for opioid use disorder to recovery community centers (RCCs) leads to better recovery outcomes. Researchers will compare two groups: one that visits an RCC and one that chooses other recovery activities. Th…

This study looks at bone health in teenagers who were just diagnosed with Crohn's disease. Researchers will use MRI and other scans to measure bone marrow fat and bone density, comparing them to healthy teens. The goal is to understand how Crohn's affects bones early on. About 92…

This study looks at whether using a standard system to describe voice therapy sessions helps people with muscle tension dysphonia (a voice disorder). About 600 adults will take part across five voice clinics. Researchers will compare how well patients do in the first year their t…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes the drug for two weeks and measure blood sugar, insulin, and other factors after a test meal.…

This study looks at how to ethically use advanced brain tools like MRI and EEG to detect hidden consciousness in people with severe brain injuries. Researchers will interview patients, families, and caregivers to understand their views on using these technologies. The goal is to …

This study tests a program called iDECIDE for about 300 middle and high school students who recently broke their school's drug rules. Instead of punishment, the program teaches about drug effects and brain development. Researchers will check if students learn more, change their a…

This study tests a coaching program for pregnant doctors or those who recently gave birth. About 48 participants will be randomly assigned to receive coaching or not. The goal is to see if coaching reduces burnout and improves well-being. Researchers will use surveys and intervie…

This study looks at how different areas of the brain communicate in healthy adults. Researchers use safe, non-invasive methods like magnetic pulses and brain wave recordings to measure these connections. The goal is to better understand normal brain function, not to treat any dis…

This study looks for tiny molecules in blood and urine that could show how active and severe Duchenne muscular dystrophy is. Researchers want to find a less painful way to track the disease instead of taking muscle biopsies. About 100 people with or without the condition will giv…

This study looks at whether low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers want to see if this group is willing to get screened and how well the scans find cancer. The goal is to improve early detection and …

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 (CLCO-9) for people with serious mental illness who have been involved with the legal system. The goal is to help them understand their mental health better and reduce their chances of future legal…

This study looks for immune markers that show whether a person is protected from cholera after vaccination or natural infection. Over 1,200 people will receive either a cholera vaccine or a typhoid vaccine, and their blood will be tested for two years. The goal is to speed up dev…

This study looks at whether a single session of mindfulness-based neurofeedback can change brain activity in teens who often get stuck in negative thought loops. Researchers will compare 50 at-risk teens with 50 healthy teens, using real or fake neurofeedback. The goal is to unde…

This study looks at whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain function in healthy older adults and those with early signs of Alzheimer's. Participants will receive daily stimulation sessions for two weeks, wit…

This study looks at how the liver's immune system responds to a chemotherapy drug called melphalan, given directly to the liver through a procedure called Percutaneous Hepatic Perfusion (PHP). It involves 10 people with uveal melanoma that has spread to the liver. The goal is to …

This study looks at how the brain controls arm movement after a stroke and how rehabilitation therapy changes those brain pathways. Researchers will enroll 50 people who had a stroke 3 to 6 months ago and have moderate to severe arm weakness. Participants will either receive 30 h…

This study looks at whether blocking out noise from cars, planes, and trains with earplugs can reduce stress and lower the risk of heart disease. Researchers will study 26 adults who are bothered by noise or live in noisy areas and have heart disease risk factors. Participants wi…

This study aims to measure a protein called fibrin in the brains of people with Alzheimer's disease and healthy volunteers using a special PET scan. Researchers want to see if fibrin levels differ between the two groups and in different brain regions. The study involves 30 partic…

This study uses advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will measure heart rate, blood pressure, and inflammation in arteries and bone marrow. T…

This study aims to find out why some people aged 45 to 54 have not been screened for colorectal cancer. Researchers will interview 40 patients and survey health center staff to identify barriers and helpful strategies. The goal is to improve screening rates in this age group.

This study is testing two ways to help adults with neurofibromatosis 1 (NF1) who have low health literacy. Participants get personalized care letters and either educational videos or a call with a peer navigator. The goal is to see if these tools are helpful and easy to use. Abou…

This study follows 40 people with Angelman syndrome over one year to see how their communication, movement, and daily skills change. Participants visit the study site every three months for tests, brain activity recordings (EEG), and sleep tracking at home. The goal is to better …

This study tests whether brief smartphone messages can help adults hospitalized for suicidal thoughts use their safety plan when urges strike. Participants answer surveys up to 4 times daily and may receive a just-in-time tip. The goal is to see if these alerts make it easier to …

This study is creating a national registry to track children and young adults (under 22) who receive radiation therapy for cancer. It aims to collect long-term health data to compare the outcomes and side effects of newer proton beam therapy versus traditional photon therapy. By …

This small pilot study aims to understand if men and women wake up differently from a common anesthesia drug called dexmedetomidine. Researchers will recruit 12 healthy volunteers to measure how long it takes them to become responsive after the drug is stopped. They will also tes…

This study uses a special type of MRI scan to look at the tiny structure of the heart muscle in people at risk for heart failure. Researchers want to see how the heart's fibers change over time in people who have had a recent heart attack or have a thickened heart muscle. The goa…

This study aims to understand how the human brain processes and understands language. Researchers will record brain activity from 40 adults with epilepsy who are already undergoing monitoring for their condition. By analyzing these recordings while participants listen to speech, …

This study is testing a new wearable system designed to help astronauts maintain peak mental performance during long space missions to places like Mars. Researchers will see if gentle changes to a person's environment—like specific sounds, lights, or vibrations—can improve focus …