Massachusetts General Hospital

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) helps adults with obesity lose mostly fat while keeping muscle and bone. 63 participants will receive either the combo, tirzepatide alone, or bimagrumab alone for 52 weeks. …

This study looks at whether drinking 6 grams of instant coffee daily can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 participants will be randomly assigned to drink coffee or not for a period of time. T…

This study tests whether the drug canakinumab can reduce inflammation in the blood vessels of people who have had a heart attack or a stent placed. It includes people with and without a specific genetic change called TET2 clonal hematopoiesis. The goal is to see if the drug lower…

This study tests a 12-week phone coaching program for 280 adults with mild-to-moderate heart failure. The program uses positive psychology and motivational interviewing to help patients improve their diet, exercise, and medication habits. Participants also receive text messages f…

This study tests whether limiting calories before surgery can reduce wound complications in patients with soft tissue sarcoma of the leg who also receive radiation therapy. About 32 adults will follow a special diet or eat normally before their tumor removal surgery. Researchers …

This study tests whether combining three drugs—zanubrutinib, bendamustine, and rituximab—can achieve a very good partial response or better in people with untreated Waldenström macroglobulinemia, a rare blood cancer. About 55 participants will receive the combination therapy. The…

This study tests whether a higher dose of the drug omalizumab can help people with food allergies eat more of their trigger foods without a reaction. About 30 adults with allergies to peanut, cashew, walnut, egg, or milk will receive the drug for 16 weeks. The main goal is to see…

This study looks at whether taking a once-daily extended-release tacrolimus (Envarsus XR) helps preserve memory and thinking skills better than the standard twice-daily tacrolimus (Prograf) in older kidney transplant recipients. About 92 participants who are at least one year pos…

This early-phase study tests whether combining two immunotherapy drugs (botensilimab and balstilimab) with targeted radiation can help people with a specific type of colorectal cancer that has spread to the liver and hasn't responded to standard treatments. The study will include…

This study tests whether adding a special care program (GRACE) to regular annual check-ups can improve health and reduce hospital stays for older adults with multiple health issues. About 6,000 people aged 65 and older who speak English or Spanish will take part. The program incl…

This study tests whether taking spironolactone for three months after delivery can improve blood pressure and heart health in women who had preeclampsia or gestational hypertension and were overweight before pregnancy. About 204 women will be randomly assigned to receive the drug…

This study tests a new therapy called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines two proven approaches—12-step support and motivational therapy—to see if it helps teens stay abstinent longer and reduce substance-related problems. About 294 par…

This early-stage study tests two drugs, mezigdomide and talquetamab, in people with multiple myeloma that has come back or not responded to treatment. The goal is to find the safest dose and see how well the combination controls the cancer. About 25 adults will take part, receivi…

This study tests whether injecting a near-infrared dye near a lung tumor can help surgeons see the tumor and the first lymph node it drains to during surgery. About 100 adults having lung surgery will receive the dye, and doctors will check if it safely improves the removal of ca…

This study tests whether a special machine can restore moderately fatty donor livers so they can be safely transplanted. About 200 adults awaiting a liver transplant will receive a machine-treated liver. If successful, this approach could expand the number of usable donor organs …

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can stop the cancer from growing for at least 6 mo…

This study tests whether giving repeated doses of the BCG vaccine (traditionally used for tuberculosis) can improve blood sugar control in children aged 8 to 17 with type 1 diabetes. Researchers will measure changes in HbA1c, insulin use, and blood sugar swings over time. The goa…

This study tests a program called ADELANTE for Latino adults with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the program helps …

This study tests a new way to give radiation before surgery for retroperitoneal sarcoma, a rare tumor deep in the abdomen. About 80 adults will receive either proton or photon radiation, with a higher dose to high-risk areas of the tumor. The goal is to find the safest highest do…

This study tests whether the drug elranatamab, given after CAR T-cell therapy (idecabtagene vicleucel), can lower the chance of multiple myeloma worsening. It enrolls 32 adults with relapsed or refractory multiple myeloma. The goal is to see if this combination improves response …

This study looks at two ways to help people who have had a stroke lower their blood pressure. One way is checking blood pressure at home. The other adds group medical visits where people learn together. The goal is to see if combining both methods works better to prevent another …

This study tests proton beam radiation for children with neuroblastoma, a nerve cell cancer. Proton radiation targets the tumor more precisely than standard X-ray radiation, which may reduce damage to nearby healthy organs. Researchers will track side effects like heart, lung, an…

This study tests whether a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) can make cancer cells undetectable in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who need treatment for the first…

This study looks at whether the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. R…

This study tests two common gout treatment strategies in 650 adults: one that aims to lower urate levels to a target, and another that treats symptoms as they occur. The goal is to see which approach better reduces gout flares and improves overall health over two years. Participa…

This study tests a combination of four drugs (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) in 50 adults whose multiple myeloma has returned or stopped responding to treatment. The main goal is to see how many patients respond to this drug cocktail. This is n…

This study tests a small cap placed on cut nerves during finger amputation surgery to prevent painful nerve growths (neuromas) and chronic pain. About 20 adults who recently lost a finger due to injury will receive the Tulavi Allay™ Nerve Cap and be followed for pain levels, cold…

This study looks at 400 people with stage III colon cancer who have finished standard chemotherapy. A blood test checks for tiny bits of tumor DNA that might mean cancer is still hiding. Those with a positive test are offered extra treatments like FOLFIRI or immunotherapy to try …

This study tests whether a daily pill called ivosidenib can help prevent acute myeloid leukemia (AML) from coming back after a stem cell transplant. It is for people with a specific IDH1 gene mutation. About 75 participants will receive either ivosidenib or a placebo for up to tw…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain muscle mass and strength while taking popular weight-loss drugs like Ozempic or Mounjaro. About 100 adults who recently started or plan t…

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 gene change (mutation) in the tumor itself. The goal is to see if the drug can slow cancer growth or shrink tumors. About 30 participants will take the pill and be monitor…

This study compares two FDA-approved medication regimens to treat postmenopausal osteoporosis in women aged 45 and older who are at high risk of fractures. The goal is to see which combination better improves bone density in the spine over 12 months. Participants must not have us…

This early-phase study tests a drug called ASTX727 in people with a specific type of brain tumor (IDH mutant glioma) that has come back or is growing. The main goal is to find the highest safe dose. Up to 18 adults will take part, and researchers will also track how long the tumo…

This study tests a drug called epcoritamab in people with large B-cell lymphoma that has come back or not responded to treatment. Participants are those who cannot have a stem cell transplant. The goal is to see if the drug can control the cancer and improve survival without the …

This study tests whether a high-intensity statin, low-dose colchicine, or both can slow or change the buildup of fatty plaque in the heart arteries. It includes 200 adults aged 40-75 who have a high genetic risk for heart disease but no symptoms yet. Participants will get one of …

This early-phase study tests an experimental drug called ziftomenib in adults with acute myeloid leukemia (AML) who have had a stem cell transplant. The goal is to find a safe dose and see if the drug can help prevent the cancer from coming back. About 22 participants will take t…

This early study is testing a combination of two drugs, parthenolide and ipriflavone (called NPC-1), in 40 adults aged 55 and older who have early Alzheimer's or memory concerns. The goal is to see if the treatment is safe and can improve blood markers linked to Alzheimer's brain…

This study looks at people in Uganda and South Africa whose HIV medication (TLD) is no longer working well. Researchers will test different strategies to get the virus under control again. The goal is to find the best way to help these patients achieve undetectable viral levels.

This study looks at whether a 12-week home resistance exercise program can help transgender women and gender-diverse individuals starting estrogen-based hormone therapy maintain muscle mass and strength. Hormone therapy can increase the risk of muscle loss and weakness. The study…

This study tests whether giving a rescue inhaler called Airsupra to adults in the emergency department can reduce asthma flare-ups and improve control over the next 3 months. About 1,860 participants aged 18–54 with acute asthma will be randomly assigned to receive Airsupra or us…

This early-phase study tests whether the drug momelotinib is safe for people with myelofibrosis (a rare bone marrow cancer) who are getting a stem cell transplant. About 28 adults with advanced disease will receive the drug during and after transplant to find the best dose and ch…

This study tests a new combination of two drugs (elranatamab and isatuximab) given as shots under the skin for people with multiple myeloma that has come back or stopped responding to at least two prior treatments. About 30 adults will take part. The goal is to see if the combo c…

This study tests whether giving repeated BCG vaccines (a TB vaccine) can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were diagnosed with type 1 diabetes within the past year. Researchers will measure changes in HbA1c, C-peptide, and insulin u…

This study is testing proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and how it affects quality of life and side effects. Participants receive targeted proton beams to the tumor area and are fo…

This early-stage study tests whether combining two drugs (atezolizumab and bevacizumab) with targeted radiation (SBRT) is safe for people with liver cancer that cannot be removed by surgery. About 20 participants will receive the combination to check for side effects and see how …

This study tests if abatacept, a drug used for arthritis, can prevent serious heart problems in cancer patients who develop heart inflammation from immunotherapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo. The goal is to see if t…

This study looks at whether a medication called SGLT2 inhibitor, already used for diabetes and kidney disease, can improve blood flow to the heart in women with HIV who also have diabetes or kidney problems. About 80 women will be randomly assigned to health education alone or he…

This study tests a drug called sacituzumab govitecan, given before surgery, in people with localized triple-negative breast cancer. The goal is to see if it can eliminate all cancer in the breast and lymph nodes. Some participants may also receive pembrolizumab. The study involve…

This study tests a mix of three drugs (venetoclax, obinutuzumab, and possibly acalabrutinib) for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded to prior treatment. The approach is personalized: treatment is a…

This study looks at whether adding nutrition counseling and stress management to standard medication can help people with Crohn's disease or ulcerative colitis achieve remission. About 160 adults with active IBD will be randomly assigned to different combinations of dietitian and…

This study tests a program called CHAMPION that helps children with both asthma and overweight. It compares doing the program in-person versus online to see which works better. About 500 children aged 4-17 with asthma and a high BMI will take part. The goal is to improve their we…

This study tests whether meal replacements can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and improve blood sugar control. About 20 participants will follow an intensive nutrition program for several weeks. The goal is to see if this approach…

This study tests whether giving G-CSF (a drug that boosts white blood cells) alongside standard chemoradiation can help preserve brain structure and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be rand…

This study tests whether giving a sleep-promoting drug called dexmedetomidine at night can lower the risk of delirium (sudden confusion) in older adults after heart surgery. About 1,800 patients aged 60 and older will receive either the drug or a placebo through an IV or under th…

This study tests if freezing part of a growing tumor (cryoablation) combined with two immunotherapy drugs (ipilimumab and nivolumab) can help control advanced melanoma that stopped responding to prior treatment. About 37 adults with unresectable melanoma will receive the combinat…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to find which approach is safer and works better. About 50 hospitali…

This study tests whether time-restricted intermittent fasting can reduce liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). Researchers will enroll 25 participants to follow a fasting schedule and measure changes in liver fat using MRI. The …

This study tests if adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to stress, intense exercise, or eating disorders. Participants receive either romosozumab or placebo for 6 months, plus estrog…

This study tests whether combining two drugs, afatinib and pemigatinib, is safe and can shrink tumors in people with advanced solid cancers that have certain genetic changes (FGFR alterations). About 70 adults whose standard treatments have stopped working will take part. The mai…

This study tests two drugs—palbociclib alone or combined with pembrolizumab—in people whose cancer has spread to the brain and is growing despite prior treatment. The goal is to see if these drugs can shrink or stabilize brain tumors. About 45 adults with solid tumors (Cohort 1) …

This study tests whether adding a new drug (liposomal irinotecan) to standard chemotherapy before chemoradiation can completely eliminate cancer in people with advanced gastroesophageal junction or esophagogastric cancer. About 40 adults with stage T3/4 or node-positive disease w…

This study tests whether low-intensity focused ultrasound can help people with severe brain injury who have not fully regained consciousness. Researchers will measure changes in behavior and brain activity after the ultrasound sessions, and also interview family members about the…

This study tests a tool called Savvy that combines phone exercises, a weekly pill organizer, and text reminders to help stroke survivors take their medication as prescribed. The goal is to see if it improves medication adherence and blood pressure control. The study involves 150 …

This study involves 25 adults with Crohn's disease who are scheduled for possible surgery. Researchers will use a special PET/MR scan with a collagen-binding tracer to see if it can accurately tell the difference between scar tissue (fibrosis) and active inflammation in narrowed …

This early-phase study tests a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 participant…

This study aims to develop a test that finds ovarian cancer earlier by looking at DNA from a uterine wash and proteins in the blood. Researchers will collect samples from 250 women before surgery for a suspected ovarian mass or as a preventive measure. The goal is to see if these…

This study tests a new, compact imaging capsule that people swallow to take pictures of the esophagus. It is designed for those with Barrett's esophagus, a condition that can lead to cancer. The goal is to see if the capsule is safe, easy to use, and provides clear images. About …

This study is testing a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, which is an early sign of scarring. Researchers will compare scans from healthy relatives of people with pulmonary fibrosis and from patients with early lung abnormaliti…

This study tests a new tool: a capsule about the size of a fish oil pill attached to a string that takes pictures inside the lower gut. It is inserted without sedation and moves slowly upward using a motor. The goal is to see if it can get clear images of the lower GI tract in 30…

This study tests a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of healthy volunteers and patients with these diseases to compare tissue stiffness. The goal is to d…

This study tests whether a special dye called indocyanine green (ICG) can help surgeons see tumor edges more clearly during bone or soft tissue mass removal. About 100 adults having surgery at Massachusetts General Hospital will receive the dye, and doctors will compare how well …

This study looks at whether a special PET scan (flotufolastat F 18) can find prostate cancer that has come back in men with very low PSA levels (0.20 ng/mL or less) after their prostate was removed. About 50 men who had surgery for prostate cancer and now have a small rise in PSA…

This study looks at whether certain RNA molecules in saliva can signal when heart failure is getting worse. Researchers will compare these molecules in people with stable chronic heart failure, those with sudden worsening, and healthy controls. The goal is to develop a simple, no…

This study is testing better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will use skin tests and controlled drug challenges in 300 adults aged 18-70 who have had a possible allergic reaction. The go…

This early-stage study aims to find a reliable test for oxytocin deficiency in young people with hypopituitarism. Researchers will give a single dose of a hormone pill to 20 participants (10 with a related condition and 10 healthy controls) and measure oxytocin levels in blood an…

This study tests a special PET scan probe called [68Ga]CBP8 to see if it can detect early signs of radiation damage in lung and pancreatic cancer patients. About 72 adults who are getting radiation therapy will have scans before and 3-6 months after treatment. The goal is to find…

This study explores whether a simple, at-home smell test can help detect early signs of Alzheimer's and other brain diseases. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute smell test using scratch-and-s…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs of people with pulmonary fibrosis and lung cancer. Researchers will compare scans from healthy volunteers and patients to see if the age…

This study tests whether an AI tool that analyzes routine chest X-rays can help doctors identify patients at high risk for lung cancer and encourage them to get a screening CT scan. About 1,500 current or former smokers aged 50-77 will take part. The goal is to see if the AI aler…

This study is testing a new type of PET/MRI scan to see if it can give doctors a clearer picture of liver cirrhosis, liver cancer, and related high blood pressure. About 45 adults with cirrhosis will get this scan. The goal is to improve how doctors detect and monitor these serio…

This early-phase study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower certain markers in the body linked to colorectal cancer risk. It involves 20 adults aged 18-50 with a BMI between 27 and 40 who have had a recent colonoscopy. Researchers will me…

This study tests a brief group therapy called Resilience Training for Teens. It aims to prevent serious mental illness in high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens will participate to see if the training hel…

This study is testing a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program combines problem-solving support to address barriers like depression and anxiety. About 132 pregnant women at risk for HIV will participate…

This study tests a brain health program for adults aged 50 and older who have mild memory issues but not dementia. The program is offered at senior centers and focuses on healthy lifestyle changes like exercise, diet, and social activity. Researchers want to see if the program is…

This study tests a program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can prevent them from developing a serious mental illness. About 192 students aged 18-30 will …

This study tests a long-acting injectable HIV prevention medication (cabotegravir) in 100 adults who inject non-prescription drugs and are at risk for HIV. Participants receive the shot plus support services. The goal is to see if people stick with the treatment over 7 months.

This study tests a program that gives HIV self-test kits and counseling to new mothers in South Africa whose partners' HIV status is unknown. The goal is to help women start PrEP (a daily pill to prevent HIV) and help partners who test positive get treatment. The study involves 1…

This study tests whether a simple writing exercise can prevent post-traumatic stress disorder (PTSD) in women who had a stressful childbirth. Participants will write about their birth experience for 15 minutes a day for three days, starting shortly after delivery. Researchers wil…

This study tests a program called PrEP My Way, designed to help young women aged 16-24 in Kisumu, Kenya, continue using HIV prevention medicine. Participants can choose between a daily pill, a long-acting injection, or a vaginal ring, along with support from peers. The goal is to…

This study tests whether putting special air filters (HEPA cleaners) in elementary school classrooms can lower the amount of viruses in the air and reduce how often students, teachers, and their families get sick. About 200 children and adults from inner-city schools will take pa…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if learning their personal risk motivates them to make healthy lifestyle and diet changes that might p…

This study tests a short, virtual program for people recently diagnosed with young onset dementia (before age 65) and their care-partners. The goal is to prevent long-term emotional distress and improve well-being for both. About 388 pairs will take part in six online sessions to…

This study tests whether 30 adults with myeloproliferative neoplasms (a type of blood disorder) can stick with a 12-week program that teaches healthy eating and physical activity. The main goal is to see if at least 70% of participants complete 9 weeks of the program. If successf…

This study tests a program called QuitVaping, which combines coaching and text message support, to help teens ages 14-18 quit vaping. About 400 teens who vape at least weekly will be randomly assigned to either the QuitVaping program or standard advice and resources. The main goa…

This study is testing whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain for people with chronic low back pain, with or without mild-to-moderate depression. About 80 adults will receive either CBD or a placebo for a period o…

This study tests a coaching program for pregnant or new-mom doctors in training. About 48 participants will either get coaching (one-on-one and group sessions) or not. Surveys over 7 months will measure burnout, well-being, and confidence. The goal is to see if coaching helps the…

This study looks at whether doing heated yoga or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression and track changes using a standard depression questionnaire. The goal is to see if either type of yoga offers meaningful…

This study tests a new program that gives brain tumor patients an information guide and one-on-one coaching sessions to help them cope after diagnosis. Researchers want to see if the program is practical and helpful for patients. About 50 adults recently diagnosed with a malignan…

This study tests whether using a gentle electrical brain stimulation device at home for four weeks can reduce ADHD symptoms and improve focus in adults. Researchers will enroll 60 adults aged 18-65 with ADHD. Participants will use a headset daily and complete questionnaires and c…

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. The ma…

This study tests a virtual, therapist-led sleep program (Survivorship Sleep Program) for cancer survivors with chronic insomnia. About 198 participants will be randomly assigned to the program or usual care. The goal is to see if the program reduces insomnia severity, emotional d…

This study tests two experimental drugs (siltuximab and erenumab) to see if they can safely reduce chronic pain in people with schwannomatosis, a rare condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either the drug or a placeb…

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can help adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to either get PEACE plus standard …

This study tests whether a special exercise program, guided by a physical therapist, can improve strength and walking ability in people with myotonic dystrophy type 2 (DM2). About 24 adults with DM2 will be split into groups that exercise with a therapist either once or twice a w…

This study tests a specially adapted mindfulness program for older Black adults (age 50+) who have both chronic pain and mild to moderate depression. The goal is to see if this approach can improve quality of life and reduce how much pain interferes with daily activities, compare…

This study tests a new approach to treat PTSD by weakening traumatic memories. Participants take propranolol (a blood pressure drug) before briefly recalling their trauma, sometimes in an unexpected way (like singing the story). The goal is to see if this 'mismatch' method reduce…

This study tests a self-guided writing program for adults with long-term muscle or joint pain who tend to catastrophize (expect the worst). Ten participants will complete writing exercises at home over several weeks. The goal is to see if the program is practical, acceptable, and…

This study is testing a mobile app called PROMOTE to help lung cancer survivors improve their physical function and overall wellness. The app provides support for managing breathlessness, sleep problems, physical activity, and diet. Researchers will enroll 250 people with stage I…

This study is testing a new supportive care program called POISE for people with advanced non-small cell lung cancer. The program includes four visits with a specially trained palliative care clinician to help patients cope with uncertainty and manage their cancer journey. Resear…

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients receiving stem cell transplants. The program is designed to improve quality of life during a difficult treatment. Researchers will enroll 40 adults to see if the progra…

This study tests whether tranexamic acid (TXA), a medicine that reduces bleeding, can decrease fluid buildup and shorten the time surgical drains stay in after breast reduction surgery. About 160 adults having elective bilateral breast reduction will be randomly assigned to recei…

This study tests a 12-week remote program that combines positive psychology and motivational interviewing, plus text messages, to help 280 heart attack survivors who are not very active. The goal is to see if the program increases moderate to vigorous physical activity compared t…

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Sixty adults aged 40 and older with early-stage thumb arthritis will take turmeric and report their pain levels and hand function. The goal is to see if this natural o…

This study tests whether bezafibrate, a drug used for high cholesterol, can safely improve depression in people with bipolar disorder. About 30 adults with bipolar depression will take bezafibrate alongside their usual mood-stabilizing medication for 8 weeks. Researchers will mon…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will measure pain levels and brain activity in 80 adults aged 18-60 who have had low back pain for over 6 months. The goal is to see if tACS can c…

This early-stage study tests a new program designed to help older adults (65+) recover after ostomy surgery. The goal is to improve quality of life and make the recovery process easier. Researchers will interview participants and use questionnaires to see if the program is easy t…

This study tests whether a single dose of intravenous iron can improve exercise capacity in adults with a specific type of heart failure (HFpEF) who also have low iron levels. Researchers will measure changes in peak oxygen uptake during exercise tests over 12 weeks. The trial in…

This study compares two medications used to sedate patients during endoscopy (a procedure to look inside the body). The goal is to see if a newer drug called remimazolam works as well as or better than the standard drug propofol. About 100 adults having planned endoscopy will tak…

This study tests whether using a virtual reality headset and scented necklace can lower pain and anxiety in people recovering from heart or lung surgery. Researchers want to see if this approach is a safe, drug-free alternative to opioids and anxiety medications. About 80 adults …

This study tests whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can improve heart health…

This study tests a group-based telehealth program called HORIZONS for adults with chronic graft-versus-host disease (cGVHD) after a bone marrow transplant. The goal is to see if the program improves quality of life and self-management compared to usual care. About 350 participant…

This study tests a smartphone app called SHIFT to help stem cell transplant survivors with sexual health concerns. About 300 adults who had a transplant more than three months ago and feel distressed about their sexual health will use the app or receive standard care. The goal is…

This study tests a five-session palliative care program designed for people with metastatic breast cancer and their caregivers. The goal is to help patients talk with their doctors about what matters most to them. The study will include 400 participants and aims to make palliativ…

This study tests two different doses of a gel called Purified Cortrophin Gel to see how well it eases pain from sudden gout attacks. About 150 adults with gout will get one injection and be followed for a week. The goal is to find out if the gel can quickly reduce joint pain and …

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists learn to use proven methods like cognitive behavioral therapy and mindfulness to help with anxiety, depression, pain, fatigue, …

This study tests tenapanor, a drug already approved for irritable bowel syndrome with constipation, in 25 adults with cystic fibrosis who also have constipation. Participants take one 50 mg tablet twice daily for 4 weeks and fill out questionnaires and daily diaries to track bowe…

This study tests whether an 8-week course of intranasal oxytocin (a hormone nasal spray) can reduce how often adults with binge-eating disorder binge eat. About 60 participants will receive either the spray or a placebo. The goal is to see if it safely lowers binge frequency and …

This study tests whether a supplement called pregnenolone can help reduce depression in people living with HIV. Researchers will give either pregnenolone or a placebo pill to 120 adults with HIV and depression, while they continue their usual antidepressant medications. Brain sca…

This study tests whether the drug ruxolitinib can reduce troubling symptoms like fatigue and itching in people with low-risk essential thrombocythemia (ET) or polycythemia vera (PV). About 60 adults with significant symptom burden will take ruxolitinib and be monitored for improv…

This study is testing a smartphone app called TEC-S designed to help adults who have frequent suicidal thoughts. The goal is to see if the app is safe, easy to use, and can reduce the urge to die by suicide. About 20 adults living near Boston will use the app and report their fee…

This study tests a digital app called DREAMLAND to see if it can improve quality of life and emotional well-being for adults with acute myeloid leukemia (AML) who are receiving intensive chemotherapy. About 200 participants will use either DREAMLAND or a standard wellness app. Th…

This study tests a high dose of inhaled nitric oxide gas in very sick pneumonia patients who need a breathing machine. The main goal is to see how the body handles the gas and if it can help more patients recover from pneumonia. About 34 adults will receive either the gas or a pl…

This study tests whether a single IV dose of allopregnanolone (a natural brain chemical) can help people with chronic PTSD get more out of therapy. The drug may help the brain better process traumatic memories by either strengthening new learning or weakening old fear responses. …

This study tests a behavioral health program called InSTILL for nursing home residents who feel down and their main support person. The program teaches ways to handle stress and build resilience. Researchers want to see if the program is practical, liked by participants, and help…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines existing methods to support smoking cessation and improve HIV/TB treatment outcomes. Researchers will enroll 86 da…

This study is testing two short mind-body programs for people who survived a cardiac arrest and the family or friends who care for them. The goal is to see if these programs are practical and helpful for reducing anxiety, depression, and emotional distress. About 84 pairs (surviv…

This study tests whether adding platelet-rich plasma (PRP) from the patient's own bone marrow to standard hip labral repair surgery leads to better pain relief and function. About 400 adults with hip labral tears will be randomly assigned to receive surgery with or without PRP. T…

This study tests whether parents of children ages 2-7 can better manage their child's anxiety by completing a brief, online, self-guided education program. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much pa…

This study tests whether a type of talk therapy called Cognitive Processing Therapy (CPT) can reduce heart disease risk in people with PTSD. Thirty adults with PTSD and heart risk factors will receive either CPT or be placed on a waitlist. Researchers will measure changes in brai…

This study tests a short therapy program for young adults (ages 25-39) with cancer and their partners. The goal is to see if it helps them cope with stress and stay connected as a couple. About 20 couples will take part in 8 sessions. The study focuses on whether people find it h…

This study looks at how well a special implant (IlluminOss) works to reduce pain and improve daily function in people with pelvic fractures caused by cancer spread or aging. About 100 adults will receive the implant as part of their normal care and will report their pain and mobi…

This study is for adults with major depression who are at high risk for suicide. Participants will receive a series of ketamine infusions followed by esketamine nasal spray over 24 weeks. The goal is to see if this treatment plan is safe, tolerable, and effective at reducing suic…

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app improves mood, reduces cannabis use, and is easy to use.

This study tests a virtual cognitive behavioral therapy program designed to help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home and report how easy and helpful it is. The goal is to see if this approach …

This study tests an 8-week remote program that combines positive psychology and motivational interviewing to help people with type 2 diabetes increase their physical activity. 280 adults with type 2 diabetes who are not very active will participate. The program includes weekly se…

This study looks at whether adding coaching sessions can make ketamine or esketamine work better for people with treatment-resistant depression. About 20 adults who already get ketamine at Massachusetts General Hospital will try 12 coaching sessions over 3 months. The goal is to …

This study tests if a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both laser treatments on small skin areas. Researchers will measure pain scores and track healing through photos and i…

This study tests a special support program (BMT-CARE) for people caring for a loved one undergoing a bone marrow transplant. The goal is to see if the program improves the caregiver's quality of life compared to standard care. The study will enroll 800 caregivers and track their …

This study tests a program designed to help improve thinking and memory in refugees and asylum seekers who have had a traumatic brain injury (TBI). Researchers want to see if the program is practical and well-liked. About 50 people will be split into two groups: one starts the pr…

This study tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm repair. Ten adults having elective surgery will try the program to see if it is feasible and helpful. The goal is to improve readiness and recovery, not to cure the aneurysm.

This study tests a non-invasive technique called auricular transcutaneous vagal nerve stimulation (taVNS), which uses a small device to stimulate a nerve in the ear. The goal is to see if it can improve stomach sensitivity and digestion in people with functional dyspepsia or gast…

This study tests whether heated yoga, sauna sessions, or a mindfulness app can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will be assigned to one of the three approaches and monitored for changes in…

This study tests a program called WISH, which uses positive psychology exercises (like gratitude and optimism) to help people with irritable bowel syndrome (IBS). Researchers want to see if it's practical and can improve gut-brain communication. About 50 adults with IBS will eith…

This study compares a 10-week program called GetActive+ (which combines mind-body techniques with walking) to usual care for 200 older adults aged 55+ who have had musculoskeletal pain for at least 3 months. The goal is to see if the program improves physical function, such as wa…

This study tests whether whole body hyperthermia, a sauna-like procedure, can reduce Long COVID symptoms, especially fatigue. Researchers at Massachusetts General Hospital will enroll 21 adults aged 18-65 who have had COVID-19 and now suffer from ongoing symptoms. Participants wi…

This study looks at whether adding physical therapy to steroid injections helps people with frozen shoulder more than steroid injections alone. About 260 adults with frozen shoulder will be split into two groups: one gets physical therapy plus steroid shots, the other gets steroi…

This study tests a new approach to help breast cancer survivors with nerve pain caused by chemotherapy. Instead of real needles, participants watch guided acupuncture videos at home. The study is small (20 people) and focuses on whether this method is practical and satisfying, no…

This study tests a type of talking therapy (exposure-based CBT) for adults who have both functional dyspepsia (stomach pain or fullness after eating) and avoidant/restrictive food intake disorder (ARFID) with weight loss. The goal is to see if the therapy helps people eat more co…

This study looks at how well people tolerate laser treatment for port wine birthmarks using an FDA-approved 532 nm laser. Researchers want to compare the standard single high-energy pulse with a new approach using multiple low-energy pulses. Fifteen adults with non-facial port wi…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study is testing a smartphone app called PDAC-PATHWAYS designed to provide information and support to people with pancreatic cancer who are about to start treatment. About 50 participants will use the app to see if it is helpful and easy to use. The goal is to improve the pa…

This study tests a digital sleep improvement program (a mobile app and a wrist tracker) in 50 older adults (65+) who are having hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surgery. Participants must have mild i…

This study tests whether giving a low-dose nonsteroidal anti-inflammatory drug (ketorolac) for the first five days after orthopedic trauma surgery can reduce the risk of chronic opioid use. About 458 adults with serious bone injuries will be randomly assigned to receive either st…

This study looks at whether telling people they have a high genetic risk for heart disease helps them improve their heart health over one year. About 200 adults aged 40 to 75 who have a high genetic risk but no current heart disease will take part. Half will learn their genetic r…

This study looks at bone health in teenagers recently diagnosed with Crohn's disease compared to healthy teens. Researchers use MRI and other scans to measure bone marrow fat and bone density. The goal is to understand how Crohn's disease affects bones early on, which could help …

This study uses a special PET-MR scan to measure a protein called HDAC in the heart. Researchers will compare HDAC levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how HDAC relates to heart disease. About 96 partic…

This study looks at why some people develop chronic pain after surgery and how it affects the brain. Researchers will study 110 teens and adults who have had pain for at least 3 months after an operation. The goal is to find better ways to measure and treat this type of pain in t…

This study looks for markers in blood and urine that can show how active and severe Duchenne muscular dystrophy is. The goal is to find a less invasive way to track the disease instead of taking muscle biopsies. Researchers will compare samples from people with Duchenne or Becker…

This study looks at how the brain controls arm movement after a stroke and how rehabilitation therapy changes those brain pathways. Fifty people who had a stroke 3 to 6 months ago and have moderate to severe arm weakness will either receive 30 hours of specialized arm training or…

This study looks at how different areas of the brain connect and communicate in healthy adults. Researchers use safe, non-invasive methods like magnetic pulses and brain wave recordings to measure these connections. The goal is to better understand brain function, not to treat an…

This study looks at why Hispanic current and former smokers may not get screened for lung cancer. Researchers will give 2000 participants an educational video and then ask them questions. The goal is to find better ways to help more people get this important screening.

This study looks at whether telling people their genetic risk for heart disease helps them lower their cholesterol and improve heart health. About 500 adults aged 30-75 who are not on cholesterol medication will take part. Half will get their genetic risk score right away, the ot…

This study is observing 3000 adults with various types of heart failure to learn how the disease develops and progresses. Researchers will collect medical data, blood samples, and imaging to find better ways to match treatments to individual patients. The goal is to improve preci…

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve memory and brain function in older adults with mild memory problems or early Alzheimer's. About 30 participants will receive daily stimulation sessions over two 10-day periods, wit…

This study looks at whether stopping tube feeding for at least 8 hours before a procedure (fasting) or stopping it right before (not fasting) is better for critically ill patients on breathing machines. About 1,072 adults in the ICU will be randomly assigned to one of two groups.…

This study compares two educational programs designed to help adults with neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their annual check-ups. Participants live across the U.S. and do not visit a specialized NF clinic. Th…

This study looks at how prolonged exposure therapy helps people with PTSD. Researchers will measure brain activity, stress responses, and symptoms before, during, and after 10 therapy sessions. The goal is to understand why the therapy works and who benefits most. 50 adults with …

This study aims to measure levels of a protein called fibrin in the brains of people with Alzheimer's disease and related dementias, compared to healthy volunteers. Researchers will use a special PET scan to see if fibrin builds up differently in certain brain regions. The study …

This study is tracking 8,000 stroke survivors to understand why some develop memory and thinking problems (dementia) after a stroke. Researchers will use brain scans, blood tests, and thinking assessments to find factors that predict cognitive decline. The goal is to help doctors…

This study tests whether showing a video about advance care planning to patients with life-limiting illnesses at home can improve their understanding and use of hospice care. About 500 adults with a one-year prognosis or less will be randomly assigned to receive the video or usua…

This study is a registry that collects information from children under 22 who receive radiation therapy for cancer. Researchers want to compare proton beam therapy with standard photon therapy to see which causes fewer long-term side effects. The goal is to learn from real-world …

This study aims to find biological markers in people who may inherit a rare, fatal brain disease called prion disease. Researchers will collect blood, spinal fluid, and cognitive test results from 150 adults who carry a genetic mutation or have a family history. The goal is to pr…

This study is testing a program designed to help older adults (65+) recover after colorectal surgery. The program focuses on improving the transition from hospital to home. Researchers want to see if it reduces hospital readmissions and is practical to use in real hospitals. Abou…

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from unconsciousness caused by the sedative dexmedetomidine. Researchers will also test if a brain measurement technique called TMS-EEG can safely track brain activity du…

This study follows 40 children and adults with Angelman syndrome for one year to see how their communication, motor skills, and behaviors change. Participants visit the study site every three months for tests and questionnaires, plus have brain activity measured with EEG and wear…

This study looks at tiny particles called extracellular vesicles that come from fat tissue. Researchers want to understand how these particles carry signals that might affect the heart and liver, especially in people with obesity. About 100 adults having weight-loss surgery will …

This study is looking for a less invasive way to measure how active and severe myotonic dystrophy is. Instead of taking a piece of muscle (biopsy), researchers want to see if they can use a blood or urine sample to find biomarkers. They will compare samples from 215 people with a…

This study follows 500 infants who have a close family member with celiac disease and are under 6 months old. Researchers will track their genes, diet, and gut bacteria over time to learn what triggers the disease. The goal is to find ways to prevent or detect celiac disease earl…

This study looks at whether a blood test can detect tiny cancer cells shed by prostate tumors. Researchers will compare the number of these cells before and after surgery in 200 men with early-stage prostate cancer. The goal is to see if the test can help predict how the cancer b…

This study looks at how the liver's immune system reacts when chemotherapy is given directly to the liver for eye melanoma that has spread there. Ten adults with this condition will have small liver tissue samples taken before and after treatment to measure immune cell changes. T…

This study looks at how feeling lonely and being socially isolated affect the brains of people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these links. The goal is to find new ways to he…

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will track 1.2 million people to see if longer fasting leads to problems like nausea, low blood pressure, or kidney injury. The goal is to improve fasting guidelines for…

This study tests whether a special video and a helper (navigator) can improve how parents and doctors talk about treatment goals for children with cancer. About 567 parents of children aged 0-12 with any type of cancer will take part. The goal is to see if this tool leads to bett…

This study is a small test to see if a larger trial comparing two pain management plans after major orthopedic surgery is possible. One plan uses only non-opioid pain relievers, while the other includes opioids as usual. The study will enroll 100 adults to check if patients can b…

This study watches sleep and body rhythms in 150 older adults (70+) before major orthopedic surgery. Researchers collect blood samples and use a wrist monitor to see if sleep problems link to postoperative delirium. No treatment is given—the goal is to find early warning signs.

This study is testing a new device called OCT Vibrography that uses light and gentle vibrations to measure the stiffness of tissues like the cornea, skin, and gums. Researchers will enroll 90 healthy volunteers to see if the tool is safe and works well. This is not a treatment st…

This study aims to see if low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers will enroll 900 participants to check how many people agree to join and how well the scans find cancer. The goal is to improve early d…

This study aims to create a test that tells doctors whether a donated liver is healthy enough to transplant after being treated with a special machine. Researchers will collect small tissue samples from livers before and after transplant in 60 patients. By studying these samples,…

This study aims to find less invasive ways to track muscular dystrophy, replacing painful muscle biopsies with simple blood and urine tests plus painless ultrasound and electrical muscle scans. Researchers will compare these new methods in 465 people with different types of muscu…

This study tests a short, 6-session program for patients with acute brain injury and their informal caregivers. The goal is to prevent long-term emotional distress and improve quality of life for both. The program is delivered together as a pair and focuses on building resilience…

This study uses advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will measure heart rate, blood pressure, and inflammation in arteries and bone marrow. T…

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve executive functions like memory, attention, and decision-making. Researchers will enroll 600 adults with conditions such as traumatic brain injury, depression, bipolar disorder, schizophren…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will learn mindfulness techniques and get special PET/MRI scans to measure changes. The goal is to see if c…

This study tests a 9-session group program for people with serious mental illness who have been in trouble with the law. The program aims to help them understand their mental health and reduce their chances of future legal problems. About 40 adults at Worcester Recovery Center an…

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have mild to severe depression. Using smartphone surveys several times a day, researchers will track how recent cannabis use and withdrawal affect mood, suicidal thoughts, and urges. The goal is to u…

This study tests whether brief smartphone messages can help adults hospitalized for suicidal thoughts use their safety plan and lower their risk. Participants answer surveys up to 4 times daily and may receive a tailored intervention based on their current urges. The goal is to s…

This study looks at whether a physical activity program can help improve hormone health and reduce diabetes risk in girls ages 8 to 12 who are at higher risk for PCOS. About 40 girls will either get a full program with coaching and messages, or a lighter version with just message…

This study looks at whether using a standard system to describe voice therapy sessions helps people with muscle tension dysphonia (a voice disorder caused by muscle strain) improve more. About 600 adults will receive standard voice therapy, but their therapists will use a special…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling—as early as possible. Researchers use arm measurements, symptom surveys, and quality-of-life questionnaires to spot changes during and after treatment. The goal is to improve outcomes by catching l…

This study talks to patients and health center staff to find out what makes it hard for people ages 45-54 to get screened for colorectal cancer. About 40 participants will be interviewed one time, either online or in person. The goal is to learn how to make screening easier and m…

This study uses a gentle, noninvasive technique called transcranial alternating current stimulation (tACS) along with EEG to see how brain rhythms influence working memory. Researchers will test 32 healthy adults on memory tasks before and during stimulation. The goal is to under…

This study looks at bone health in teenagers with cystic fibrosis (CF) compared to healthy teens. Researchers will use MRI scans to measure bone marrow fat and other tests to check bone density. The goal is to learn why teens with CF may have weaker bones, which could help improv…

This study tests a program called iDECIDE, which teaches middle and high school students about drugs and their effects as an alternative to punishment for breaking school substance policies. About 300 students who recently violated these rules will be randomly assigned to either …

This study looks at how the osteoporosis drug romosozumab works on bone cells in postmenopausal women. Researchers will take bone samples to see changes in bone-building cells early and late in treatment. The study involves 16 women who are already prescribed the drug for high fr…

This study uses three types of brain scans (PET, MRI, and EEG) to see how epilepsy affects brain activity and energy use. Researchers will compare scans from 30 adults with epilepsy and healthy volunteers. No treatments or drugs are given—the goal is simply to learn more about th…

This study looks at whether giving emergency room patients information about nearby dentists and social services can help them actually go to the dentist. About 2,927 adults with dental problems will be split into three groups: one gets general info, one gets local info, and one …

This study aims to identify immune markers that show whether a person is protected from cholera after vaccination or natural infection. Over 1,200 participants will receive either a cholera vaccine or a typhoid vaccine, and their blood will be tested for two years. Finding these …

This pilot study works with staff at community health centers to identify and test ways to make colorectal cancer screening easier for patients. Researchers will hold group discussions and analyze health records to see what strategies work best. The goal is to increase screening …

This study uses a special MRI technique to look at the microscopic structure of the heart muscle in people at risk for heart failure. Researchers want to understand how heart muscle fibers change over time, which could help explain why some people develop heart failure. The study…

This study aims to collect DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, as well as their family members. Researchers will use blood samples to perform whole genome sequenc…

This study looks at spinal fluid and brain activity in people with myotonic dystrophy type 1 to find early signs of the disease. Researchers will compare fluid samples from affected and unaffected volunteers. No treatment is given; the goal is to better understand the condition a…

This study is building a large database of health information from up to 5,000 people with ALS and other motor neuron diseases. Participants attend regular clinic visits where researchers record their symptoms, test results, and disease progression. The de-identified data is then…

This pilot study is testing whether connecting people to recovery community centers (RCCs) can improve recovery outcomes for those taking medications for opioid use disorder (MOUD). Researchers will compare two groups: one that visits an RCC and one that does other recovery activ…

This study looks at whether suvorexant, a drug approved for insomnia, can reduce brain activity linked to cannabis use. Twenty adults who use cannabis daily or near-daily will take the medication for 14 days and have two brain scans. The goal is to see if the drug lowers the brai…

This study tests a new swallowable capsule that takes detailed images of the esophagus and collects tiny tissue samples from suspicious areas. The goal is to see if this method can safely and effectively gather tissue for genetic analysis, potentially improving early detection of…

This registry enrolls pregnant women aged 18-45 who take psychiatric medications like antidepressants or ADHD drugs. Researchers will track the health of their babies for the first year of life to see if the medications cause birth defects. The goal is to fill gaps in current saf…

This study follows 100 active-duty Navy SEALs over 4 years to see if repeated exposure to blasts affects their brain health. Researchers will use brain scans and blood tests to look for early signs of injury. The goal is to create a test that can detect blast-related brain damage…

This study works with clinics in Massachusetts to offer proven programs for weight management, cancer screening, and mental health to adults in underserved areas. Researchers will track changes in body mass index, cancer screening rates, and mental health scores. The goal is to r…

This study is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of a protein called alpha-synuclein in the brain using PET scans. Researchers will scan 40 people, including those with Parkinson's disease, multiple system atrophy, dementia with Lewy …

This study looks at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers will collect samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotio…

This study looks at how a gentle, noninvasive nerve stimulation (applied to the ear) changes activity in the brain and stomach. Researchers will use MRI scans and heart/stomach monitors to measure these effects in healthy adults and people with functional dyspepsia. The goal is t…

This study uses a non-invasive brain stimulation technique called rTMS to see how stimulating specific brain networks changes brain activity and mood in people with depression and healthy volunteers. The goal is to understand why rTMS works for depression and how to make treatmen…

This study compares two surgical treatments for lumbar adjacent segment disease, a condition that can develop after a previous spine fusion. Researchers will enroll 96 adults who have had a prior lumbar fusion and now have symptoms at the level above. The goal is to see if decomp…

This study looks at 1,200 people with T-cell or NK-cell lymphoma, a rare blood cancer. Researchers will use machine learning (a type of artificial intelligence) and genetic testing to find patterns that predict how well treatments work. The goal is to move toward personalized tre…

This study observes brain activity related to speech in 80 people with Parkinson's disease, essential tremor, or dystonia who are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record electrical signals from brain regions involved in speech while par…

This study is for women aged 60 and older with newly diagnosed breast cancer who are scheduled for chemotherapy. Researchers want to understand how chemotherapy affects thinking skills and the brain over time. Participants will complete thinking tests and some may have brain scan…

This study is testing whether wearable devices like Fitbits and Apple Watches can help predict and detect early complications after heart or lung surgery. Researchers will use machine learning to analyze data from 1,200 patients. The goal is to catch problems sooner and improve r…

This study looks at why some people don't get a follow-up colonoscopy after a positive FIT (stool) test for colorectal cancer. Researchers will test simple strategies to help more people complete the colonoscopy, especially in underserved communities. About 45 adults aged 45-75 f…

This study tests a new wireless pill that measures temperature inside the gut. The goal is to see if it can help detect diseases like Crohn's disease. Ten healthy adults will swallow the capsule and researchers will check if it sends accurate temperature readings.

This study is testing a simple, non-invasive device that uses motion sensors on the chest and belly to measure breathing effort in children. The goal is to see if it can detect breathing problems early, even before they are obvious to doctors. About 20 children aged 28 days to 17…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes the drug for two weeks and measure blood sugar, insulin, and other factors after a test meal.…

This study looks at how to ethically use advanced brain tools like MRI and EEG to detect hidden consciousness in people with severe brain injuries. Researchers will interview patients, families, and caregivers to understand their views on using these technologies. The goal is to …

This study looks at whether a single session of mindfulness-based neurofeedback can change brain activity in teens who often get stuck in negative thought loops. Researchers will compare 50 at-risk teens with 50 healthy teens, using real or fake neurofeedback. The goal is to unde…

This study looks at whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain function in healthy older adults and those with early signs of Alzheimer's. Participants will receive daily stimulation sessions for two weeks, wit…

This study looks at whether blocking out noise from cars, planes, and trains with earplugs can reduce stress and lower the risk of heart disease. Researchers will study 26 adults who are bothered by noise or live in noisy areas and have heart disease risk factors. Participants wi…

This study is testing two ways to help adults with neurofibromatosis 1 (NF1) who have low health literacy. Participants get personalized care letters and either educational videos or a call with a peer navigator. The goal is to see if these tools are helpful and easy to use. Abou…

This study aims to understand how the human brain processes and understands language. Researchers will record brain activity from 40 adults with epilepsy who are already undergoing monitoring for their condition. By analyzing these recordings while participants listen to speech, …