Massachusetts General Hospital

This study is testing whether a special behavioral program, combined with text message support, is better than basic education at helping teenagers quit vaping nicotine. About 400 teens who vape weekly and want to quit will be randomly assigned to receive either the full program …

This study is for people with stage III colon cancer who have finished their initial chemotherapy. It uses a special blood test to look for tiny, hidden traces of cancer. If the test is positive, participants are assigned to either receive extra drug treatment or just be closely …

This study is testing a type of radiation called proton beam therapy for children and young adults with neuroblastoma, a nerve cell cancer. The goal is to see if proton radiation can target the tumor more precisely than standard radiation, potentially reducing damage to nearby he…

This study is testing the safety of combining two immunotherapy drugs (atezolizumab and bevacizumab) with a precise form of radiation therapy for advanced liver cancer that cannot be surgically removed. The goal is to see if this three-part approach can better control the cancer …

This study is testing whether helping emergency room patients find and connect with local dental services improves their oral health. Researchers are comparing three approaches: giving general resource lists, giving local resource lists, or providing active help to schedule appoi…

This study is testing three different approaches to help people in Uganda and South Africa whose HIV is no longer controlled by their standard medication. It will compare standard care, personalized treatment based on test results, and an immediate switch to a different type of m…

This pilot study is preparing for a larger trial to see if connecting people to local recovery community centers helps those using medication for opioid addiction. Researchers will compare two groups: one that visits recovery centers and another that chooses other recovery activi…

This study is testing if a medication already used for diabetes and kidney disease can improve blood flow in the heart for women with HIV. Researchers want to see if better blood flow can lower their higher risk of heart attacks. The study will compare two groups: one receiving h…

This small pilot study is testing whether a standard talk therapy for PTSD (Cognitive Processing Therapy) can reduce the risk of heart disease in people with both PTSD and heart risk factors. Researchers will measure changes in brain activity, body-wide inflammation, and nervous …

This study is testing if a higher, weight-based dose of the drug omalizumab is safe and effective for people with multiple food allergies. It aims to help participants better tolerate accidental exposures to foods like peanut, milk, or egg. The trial includes people who have been…

This study is testing a new education and support program called iDECIDE for middle and high school students who have recently broken a school rule about substance use. About 300 students will be randomly assigned to either start the 4-week iDECIDE program right away or be placed…

This study is testing whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain their muscle mass and strength when they start taking certain weight-loss medications (like Ozempic or Mounjaro). The goal is to see if…

This study is testing whether adding personalized diet advice and stress management techniques to standard advanced medications helps people with active Crohn's disease or ulcerative colitis achieve better symptom control. Researchers will compare four different timing approaches…

This study is testing whether a structured meal replacement program can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower their blood sugar. Researchers will provide participants with a low-calorie nutrition plan and track their weight, bl…

This study is testing whether a medication called dexmedetomidine, given at night to help patients sleep, can prevent delirium (sudden, severe confusion) in older adults after heart surgery. It will involve 1,800 patients aged 60+ who are having heart surgery and will stay in the…

This study is testing a new, personalized guidance system for giving IV fluids to patients with advanced liver disease who develop sudden kidney injury. Researchers will compare this new system against the standard albumin treatment to see which is safer, more effective, and easi…

This study is testing a smartphone app designed to help people who are dealing with both depression and frequent cannabis use. The app focuses on increasing positive feelings and motivation. Researchers will compare the app to simple symptom tracking to see if it helps reduce dep…

This study is testing if freezing one growing tumor (cryoablation) while giving two immunotherapy drugs (ipilimumab and nivolumab) can help control advanced melanoma that has continued to grow despite prior immunotherapy. It aims to see if this combination is safe and effective f…

This study is testing whether adding a medication called bezafibrate to a person's current mood-stabilizing drugs can help reduce symptoms of depression in people with bipolar disorder. It will involve 30 adults over 8 weeks to check if the treatment is safe and shows signs of wo…

This study is testing whether an 8-week mindfulness and stress reduction program can reduce inflammation in the arteries of people with stable heart disease. Researchers will use PET and MRI scans to measure artery inflammation before and after the program in 36 adults who report…

This study is testing whether the drug elranatamab can help prevent multiple myeloma from returning or worsening in patients who have already received a specialized CAR-T cell therapy called idecabtagene vicleucel. The research involves about 32 adults with relapsed or hard-to-tr…

This study is testing a personalized approach for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or stopped responding to prior treatment. It uses a combination of two approved drugs first, then checks with a very sensitive b…

This study tests whether a healthy lifestyle and asthma management program works just as well when delivered through video calls compared to in-person visits. It involves 500 children aged 4-17 who have both asthma and are above a healthy weight range. The goal is to see if teleh…

This study tests whether brief, timely messages sent to a smartphone can help people use their personal safety plan to cope with suicidal thoughts. Adults recently hospitalized for suicidal thoughts will answer surveys on their phones several times a day for a month after leaving…

This study is testing if eating fewer calories before surgery helps patients with leg sarcoma heal better and have fewer wound problems. Researchers will compare a special low-calorie diet to a normal diet in 32 patients. The goal is to see if this dietary change improves recover…

This early-stage study is testing whether adding an experimental drug called ziftomenib to standard care after a bone marrow transplant is safe and can help keep acute myeloid leukemia (AML) from coming back. The study will enroll about 22 adults with specific genetic types of AM…

This study aims to see if a newer drug combination (venetoclax + azacitidine) works as well as or better than standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML), a fast-growing blood cancer. About 172 participants will be randomly assigned to recei…

This study is testing if adding a special home-visit care team to standard Medicare wellness visits improves care for older adults with multiple health problems. The goal is to see if this combined approach leads to better patient and caregiver experiences and fewer hospital stay…

This study is testing a special machine that keeps donor livers warm and functioning outside the body. The goal is to see if this machine can safely prepare moderately fatty livers, which are often discarded, for transplantation. If successful, this could significantly increase t…

This study compares two surgical approaches for people who develop new back pain at a level adjacent to a previous spinal fusion. Researchers want to determine whether a simpler decompression surgery or a more complex decompression with additional fusion provides better outcomes.…

This study is testing whether a home-based brain stimulation device can help reduce ADHD symptoms. Sixty adults with ADHD will use the device daily for four weeks to see if it improves focus, organization, and daily functioning. The research aims to make advanced ADHD treatments …

This study is testing if a new support tool called 'Savvy' can help people who have had a stroke remember to take their blood pressure medicine. The tool includes a weekly pill organizer, text message reminders, and short phone exercises. Researchers will compare 150 stroke survi…

This study is testing whether combining three drugs—zanubrutinib, bendamustine, and rituximab—can effectively control Waldenström macroglobulinemia, a rare blood cancer, in people who have not yet received treatment. About 55 adults with this condition will receive the drug combi…

This study is testing if time-restricted eating (a form of intermittent fasting) can reduce fat in the liver for adults who have non-alcoholic fatty liver disease (NAFLD) but are not obese. Researchers want to see if this lifestyle change, independent of major weight loss, can be…

This study is testing if a safe, injectable fluorescent dye can help surgeons see the edges of bone and soft tissue tumors more clearly during removal surgery. The goal is to help surgeons remove all of the tumor in one operation, which may lower the chance of the cancer coming b…

This study is testing two different talk therapy programs to help teens and young adults (ages 14-21) who struggle with alcohol or drug use. Researchers want to see if adding 12-step program support to standard therapy works better than standard therapy alone. The study will foll…

This study is testing if using two investigational drugs together—tirzepatide and bimagrumab—alongside a lifestyle program leads to better body composition changes than either drug alone in adults with obesity. The goal is to see if the combination helps people lose more fat whil…

This study is testing whether a drug called abatacept can reduce serious heart complications in people who develop heart inflammation (myocarditis) as a side effect of immune-based cancer treatments. It will involve 390 hospitalized patients who are already receiving standard ste…

This study is testing whether adding a bone-building medication called romosozumab to standard hormone replacement helps improve bone density in young women (ages 14-30) with functional hypothalamic amenorrhea (FHA). FHA is when periods stop due to high stress, intense exercise, …

This study aims to determine whether critically ill patients on breathing machines and feeding tubes should stop eating before medical procedures. Researchers will compare two approaches: stopping tube feeding 8 hours before procedures versus continuing feeding until right before…

This study is testing whether giving the BCG vaccine (typically used against tuberculosis) multiple times can help children aged 8-18 who already have type 1 diabetes. Researchers want to see if the vaccine can improve long-term blood sugar control and reduce insulin needs over f…

This study is testing whether the drug sacituzumab govitecan, alone or combined with pembrolizumab, can shrink tumors before surgery in people with localized triple-negative breast cancer. About 260 participants will receive the study treatment for up to 12 weeks, followed by sta…

This study is testing whether a special support program called ADELANTE helps Latino adults with HIV better control their virus and stay out of the hospital. Participants will either receive the ADELANTE program—five sessions with a community health worker who helps solve problem…

This early-stage study is testing the safety and highest tolerable dose of a two-drug combination called ASTX727 for adults with recurrent IDH-mutant brain tumors that have started growing again. The trial will enroll 18 participants to determine how much medication can be given …

This study is testing if providing a specific research e-cigarette can help people who are in stable treatment for opioid addiction and who smoke daily, but are not ready to quit, reduce their cigarette use. 40 participants will be randomly assigned to receive the e-cigarette eit…

This study is testing whether the drug epcoritamab can help control aggressive lymphoma that has returned or stopped responding to initial treatment. It's for patients who are not candidates for a stem cell transplant. Researchers will give the drug in an outpatient setting and m…

This early-stage study aims to find the safest and most tolerable dose of an investigational drug called momelotinib for people with myelofibrosis, a serious bone marrow cancer. It will involve up to 28 patients who are already scheduled to receive a stem cell transplant, a stand…

This study is testing whether adding a new drug called ivonescimab to standard chemotherapy (FOLFOX) works better for people with advanced stomach or esophagus cancer that is HER2-negative. The goal is to see if this combination can help control the cancer for longer and shrink t…

This study aims to find out if adding physical therapy to standard steroid injections provides better results for frozen shoulder than injections followed by watchful waiting. Researchers will enroll 260 adults with frozen shoulder and randomly assign them to one of these two sta…

This study is testing if using multiple lower-power laser pulses is more comfortable and works as well as the standard single high-power pulse for treating port wine birthmarks. About 15 adults with non-facial birthmarks will receive three monthly laser treatments, with different…

This study is testing if a drug called G-CSF (Filgrastim) can help protect the brain and preserve thinking skills in people with a specific type of brain cancer (MGMT-methylated glioblastoma) while they receive standard radiation and chemotherapy. Researchers want to see if addin…

This study is testing if a 3-month course of the medication spironolactone, started soon after delivery, can help control blood pressure and improve heart health in women who had high blood pressure during pregnancy and have overweight or obesity. Researchers want to see if this …

This study is testing if a short, 5-day course of a common anti-inflammatory drug (ketorolac) given right after major bone surgery can help prevent patients from needing opioid painkillers long-term. It will enroll 458 adults with serious orthopedic injuries. Researchers will com…

This small study is testing a new 6-week phone coaching program designed to help patients prepare for surgery to repair an aortic aneurysm. The program, called 'Ready for Recovery,' helps participants set goals for exercise, diet, and breathing exercises, and provides support for…

This study is testing proton radiation therapy for adults with benign or slow-growing brain tumors. The main goal is to see how well the treatment controls tumor growth over five years. Researchers will also closely track the patient's quality of life and any side effects from th…

This small, early-stage study is testing whether high doses of inhaled nitric oxide gas can help critically ill adults with pneumonia who are on breathing machines. Researchers will compare the gas treatment to a placebo to see if it helps patients recover and will closely monito…

This small pilot study is testing whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel highly stressed. About 30 participants will be randomly assigned to either learn mindfulness and relaxation techniques or receive no interventio…

This study aims to find the best way to help people lower their blood pressure after a stroke to prevent a second one. It will compare two methods: 1) just checking blood pressure at home, and 2) checking at home PLUS attending virtual group medical visits with other stroke survi…

This study is testing if a pill called pregnenolone can help reduce depression in people living with HIV. About 120 participants will take either pregnenolone or a placebo (sugar pill) for 8 weeks while staying on their current depression medications. Researchers will use brain s…

This study is testing a new support program designed to help people in South Africa who have HIV and/or tuberculosis (TB) quit smoking. The program, called QUIT-AD, combines counseling and support to help people stop smoking and also stick to their important HIV or TB medications…

This study is testing if adding a newer drug (liposomal irinotecan) to a standard, strong pre-surgery treatment plan works better for people with advanced cancer where the stomach meets the esophagus. The goal is to shrink the tumor as much as possible before surgery, aiming for …

This study is testing a 9-session group program for adults hospitalized with serious mental illness (like depression, bipolar, or psychotic disorders) who are also involved with the legal system. The program aims to help participants better understand their mental health and redu…

This study is testing whether wearing earplugs for six months can reduce the harmful effects of traffic noise on heart health. Researchers will enroll 26 adults who are bothered by noise and have risk factors for heart disease. They will use brain and blood vessel scans to see if…

This early-stage study is testing the safety and initial effectiveness of combining two targeted cancer drugs, pemigatinib and afatinib, in people with advanced solid tumors that have specific genetic changes and have stopped responding to standard treatments. The main goals are …

This study is testing if adding a patient's own concentrated bone marrow cells (called BMAC or PRP) during hip labral tear surgery leads to better recovery and pain relief. It will involve 400 adults with a torn hip labrum who are already scheduled for a standard repair surgery. …

This study is testing whether a single intravenous dose of a natural brain hormone called allopregnanolone can help people with PTSD. Researchers want to see if this medication helps the brain better process traumatic memories during a standardized laboratory procedure that measu…

This study is testing whether a long-term treatment plan using ketamine and esketamine can help reduce suicide risk in people with severe depression. It will involve 100 patients who are currently hospitalized for suicidal thoughts. Participants will receive a series of ketamine …

This study is testing whether a nasal spray containing oxytocin can help adults with binge-eating disorder. Over 8 weeks, researchers will compare the spray to a placebo (inactive spray) to see if it safely reduces how often people binge eat. They will also check if early changes…

This study is testing if a combination of two drugs, elranatamab and isatuximab, can help control multiple myeloma that has returned or stopped responding to other treatments. It will enroll 30 adults whose cancer has progressed after at least two prior therapies. The goal is to …

This study aims to find the best long-term strategy for managing gout by comparing two common approaches. It will follow 650 adults with gout for two years to see which method better prevents painful flare-ups and improves quality of life. The trial focuses on practical care that…

This study is testing a combination of four medications for people with multiple myeloma that has returned or stopped responding to prior treatments. The goal is to see how well this new combination controls the cancer and for how long. About 50 participants will receive the trea…

This study is testing a new three-drug combination for people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal is to see how many participants achieve a state where no cancer cells can be detected by a very sensitive …

This study is testing whether repeat doses of the BCG vaccine, typically used against tuberculosis, can help children recently diagnosed with type 1 diabetes. Researchers want to see if the vaccine can improve long-term blood sugar control and help the body preserve its own insul…

This study is developing and testing a new program called 'One Mind One Heart' that combines mindfulness training with behavior change support delivered through text messages. It aims to help older adults with HIV (age 50+) who are experiencing psychological distress reduce their…

This study is testing whether a more targeted form of radiation (using protons or advanced photons) given before surgery can better control rare abdominal tumors called retroperitoneal sarcomas. Researchers want to find the safest, most effective dose and see if this approach red…

This study is testing whether two different drug regimens can help control cancer that has spread to the brain and is growing again. One group receives a drug called palbociclib, while a second group receives palbociclib combined with an immunotherapy drug, pembrolizumab. The goa…

This study is testing if a drug called ritlecitinib can protect people with well-managed celiac disease from intestinal damage and symptoms if they accidentally eat gluten. Forty participants will take either the drug or a placebo pill daily while also consuming a small, controll…

This study is testing if a single dose of intravenous iron can improve exercise capacity in people with a specific type of heart failure who also have low iron. About 66 participants will be randomly assigned to receive either the iron treatment or a placebo. The main goal is to …

This program aims to reduce health inequities by connecting people in Massachusetts with support for three key health areas: cancer screening, weight management, and mental health. It will work with local clinics to offer evidence-based help to adults who are overdue for screenin…

This study is testing whether a drug called ivosidenib can help prevent a specific type of leukemia (AML with an IDH1 mutation) from coming back after a patient has received a stem cell transplant. About 75 participants will be randomly assigned to receive either the study drug o…

This study is testing whether a 45-minute smell test can help detect early signs of Alzheimer's disease. Researchers want to see if changes in a person's sense of smell can predict who might develop memory problems. Participants will sniff different odors and answer questions abo…

This study aims to find the best way to test for allergies to a common class of antibiotics called cephalosporins. Researchers will enroll 300 adults who have had a suspected allergic reaction to one of these drugs. They will use skin tests and controlled drug challenges to confi…

This study is testing a new type of PET scan to see if it can detect and monitor tissue scarring (fibrosis) caused by radiation therapy. It will enroll 72 adults with lung or pancreatic cancer who are scheduled to receive radiation treatment. The goal is to see if this scan can s…

This study is testing a new type of microscope that scans the cornea to measure its stiffness. Researchers want to see if this scan can better detect early signs of corneal weakening diseases like keratoconus and ectasia. They will compare scans from people with healthy eyes to t…

This study is testing whether a simple saliva test can detect when heart failure is getting worse. Researchers will collect saliva and blood samples from 90 people, including those with stable heart failure, those hospitalized for it, and a control group. The goal is to see if mo…

This study is testing whether lung cancer screening using low-dose CT scans is practical and acceptable for Black individuals with a history of smoking. Researchers want to see if this screening approach works well for a group that often doesn't qualify for current screening guid…

This study is testing a new type of medical scan that combines two imaging techniques (PET and MRI) into one session. The goal is to see if this 'one-stop' scan can give doctors a clearer, more complete picture of liver damage, scarring (fibrosis), and cancer risk in people with …

This study is testing a new, non-invasive scanner called OCT Vibrography. The goal is to see if it can safely measure the stiffness of tissues in the eye, skin, and gums. Researchers will compare scans from 90 healthy volunteers and people with an eye condition called keratoconus…

This study is developing a new test to detect ovarian cancer at an earlier, more treatable stage. Researchers will collect a uterine wash fluid sample and a blood sample from 250 women before they have surgery. They will analyze these samples to see if specific genetic and protei…

This study aims to understand if repeated exposure to blasts affects the brain health of Navy SEALs and to create a new testing method to detect this type of injury. Researchers will follow 100 active-duty SEALs for four years, performing brain scans and blood tests to look for s…

This study is testing a new imaging technique to help surgeons see cancer spread more clearly during lung surgery. Doctors inject a safe, fluorescent dye near the tumor and use a special camera to make the first lymph nodes that drain from the tumor glow. The goal is to see if th…

This study is testing a new type of combined PET/MR scan that uses a special dye to find and tell apart scar tissue from inflammation in the bowels of people with Crohn's disease. The goal is to see if this scan can give doctors better information before surgery, potentially help…

This study is testing a new, easier-to-use imaging device to look at the esophagus. Participants swallow a small capsule attached to a thin tether, which takes pictures as it moves down the throat. The goal is to see if this new system is safe, easy to use, and takes good picture…

This study is testing whether wearable devices like Fitbits can help detect complications earlier in patients recovering from heart or chest surgery. About 1,200 patients will wear a device before and after their operation, and a computer program will analyze their activity and s…

This early-stage study is testing a new type of PET scan designed to detect and measure collagen, the main component of scarring (fibrosis) in the lungs. It aims to see if this scan is safe and can accurately spot and track fibrosis in people with lung cancer, pulmonary fibrosis,…

This study is testing a new, swallowable capsule device designed to improve screening for Barrett's Esophagus, a condition that can lead to esophageal cancer. The capsule takes detailed pictures inside the esophagus and can collect tiny, targeted tissue samples for genetic analys…

This study is testing a new, low-cost tool to take pictures inside the lower intestines. The tool is a tiny capsule, about the size of a vitamin pill, attached to a thin string. Doctors will gently guide the capsule up the colon in awake participants to see if it can capture clea…

This early-stage study is testing a new imaging tracer called 64Cu-FBP8 to see if it can safely and accurately detect blood clots throughout the body using a PET-MR scan. Researchers are enrolling 165 healthy volunteers and patients with conditions like atrial fibrillation, COVID…

This study is testing how well a new type of PET scan can find prostate cancer that has returned after surgery, specifically when blood test (PSA) levels are very low. It will involve about 50 men who have had their prostate removed but show signs of possible cancer recurrence. T…

This study aims to help more Hispanic smokers get screened for lung cancer. Researchers want to understand what stops people from getting screened and test if a short educational video can encourage screening. About 2,000 Hispanic current and former smokers will watch the video a…

This study is testing if a brief writing exercise can help prevent post-traumatic stress disorder (PTSD) in new mothers who had a stressful childbirth. Women at risk for childbirth-related PTSD will be asked to write about their birth experience for 15 minutes a day for three day…

This study is testing whether a 6-month physical activity program can improve hormone health and lower the risk of developing diabetes in girls aged 8-12 who are at higher risk. It compares a full program with health coaching and text messages to a lighter program with just text …

This study is testing whether two common medications—a cholesterol-lowering statin and an anti-inflammatory drug called colchicine—can slow down the buildup of early, hidden plaque in the arteries of people at high genetic risk for heart disease. It involves 200 adults aged 40-75…

This study is testing a new program designed to help prevent dementia in older adults who are worried about their memory. Participants will attend 8 weekly group sessions at senior centers to learn about healthy lifestyle changes like exercise, sleep, and diet. The main goal is t…

This study is testing a group therapy program called Resilience Training for Teens that aims to prevent high school students with mild emotional symptoms from developing serious mental illnesses. Researchers will work with 70 teens aged 14-19 who are experiencing early signs of d…

This study is testing if special air cleaners (HEPA filters) placed in elementary school classrooms can reduce the spread of viruses that cause colds and other respiratory infections. Researchers will compare classrooms with real air cleaners to those with fake ones to see if the…

This early-stage study is testing whether tirzepatide, a medication used for diabetes and weight loss, might help prevent colorectal cancer in younger adults. Researchers will give the weekly injection to 20 participants aged 18-50 who have had precancerous colon polyps removed. …

This study is testing a new web-based tool that gives people with a family history of Crohn's disease a personalized estimate of their own risk. Researchers want to see if receiving this risk information motivates healthy changes in diet, exercise, and smoking, and if those chang…

This study is testing a special type of talk therapy for adults who have chronic stomach pain (functional dyspepsia) and, as a result, avoid eating certain foods and have lost weight. The therapy uses gentle, repeated exposure to feared foods to help people eat more comfortably. …

This study is testing a behavioral health program designed to help nursing home residents experiencing depression and their primary caregivers. The program focuses on building resilience and coping skills during the transition to nursing home care. Researchers will compare this p…

This study is testing whether short, self-guided online programs can teach parents skills to better manage anxiety in their young children (ages 2-7). Researchers will randomly assign 90 parents to one of three educational programs and track changes over 8 months. The goal is to …

This small pilot study is testing whether a virtual sleep therapy program is practical and helpful for people with liver cirrhosis who struggle with insomnia. Researchers will enroll 10 participants to try a telehealth version of cognitive behavioral therapy for insomnia. The mai…

This study is testing two different drugs to see if they can safely reduce chronic pain in adults with schwannomatosis, a rare genetic condition that causes painful nerve tumors. Up to 40 participants will be randomly assigned to receive either an active drug or a placebo for a p…

This study is testing a counseling program designed to help young adults with cancer and their caregiving partners cope better together. It involves eight therapy sessions based on proven methods, tailored for couples facing cancer. The main goal is to see if the program is pract…

This study is testing whether a safe, non-invasive brain stimulation technique can help improve motivation and memory in older adults, including those with very early signs of Alzheimer's disease. Researchers will use a device called rTMS to gently stimulate a brain area involved…

This study is testing a smartphone app called TEC-S, which is designed to help reduce suicidal thoughts and behaviors. It will involve 20 adults in the Boston area who have frequent suicidal thoughts. The main goal is to see if the app is safe, easy to use, and shows early signs …

This pilot study is testing a culturally adapted mindfulness program called 'Quiet Focus' for older Black adults who experience both chronic pain and depression. The research aims to see if this tailored therapy is a practical and acceptable approach for this community. The main …

This study is testing a new support program designed to help people cope after being diagnosed with a malignant brain tumor. Participants will receive a guide and one-on-one coaching sessions. The main goal is to see if patients find the program helpful and are able to complete i…

This study aims to see if switching older kidney transplant patients from a twice-daily anti-rejection pill to a once-daily version improves their thinking skills, sleep, and overall quality of life. Researchers will compare two groups of about 92 patients to measure changes in m…

This study is testing a new supportive care program called POISE for people with advanced lung cancer who are receiving targeted therapy. The program involves four visits with a specially trained palliative care clinician to help patients cope with uncertainty, build confidence i…

This study is testing whether a combination of virtual reality (VR) and pleasant scents can help reduce pain and anxiety for people recovering from major heart or lung surgery. The goal is to see if this drug-free approach can be a practical alternative to strong pain medications…

This study is testing whether a virtual group support program can help people who have had a bone marrow transplant and are now living with a serious complication called chronic graft-versus-host disease. About 350 adults with moderate to severe symptoms will be randomly assigned…

This study is testing whether cannabidiol (CBD) can reduce inflammation in the brains of people with chronic low back pain, some of whom also have mild to moderate depression. Researchers will use special brain scans to measure inflammation before and after participants take eith…

This study is testing a psychological support program called BMT-CARE to see if it improves the quality of life for caregivers of patients undergoing a bone marrow transplant for blood cancer. About 800 caregivers and their patients will be randomly assigned to receive either the…

This study is testing whether a 5-session palliative care program can help people with metastatic breast cancer and their caregivers communicate better with doctors, manage symptoms, and improve quality of life. 400 patients and their caregivers will be randomly assigned to recei…

This study is testing whether a special exercise program guided by a physical therapist can help people with myotonic dystrophy type 2 (DM2). Over 6 months, 24 adults with DM2 will try different schedules of supervised and at-home exercises. Researchers will measure changes in mu…

This study tests a 6-session virtual program designed to prevent chronic emotional distress in both people with young-onset dementia and their care partners. The program brings patients and partners together to build coping skills, mindfulness, and resilience. Researchers aim to …

This study is testing two different doses of an injected medication called Cortrophin Gel to see how well and how quickly it can relieve the intense pain of a sudden gout attack. It is for adults who have just started a gout flare and cannot take common gout medicines like NSAIDs…

This study is testing whether a medication called tenapanor, already approved for IBS with constipation, can help relieve constipation in people with cystic fibrosis. Twenty-five participants will take the drug twice daily for four weeks while tracking their bowel movements and s…

This study is testing whether a gentle, non-painful electrical stimulation applied to the outer ear can improve communication between the brain and stomach. Researchers want to see if this stimulation can reduce symptoms like nausea, fullness, and pain in people with chronic indi…

This study is testing whether heated yoga or regular yoga is more effective at reducing symptoms of moderate depression. Researchers will enroll 120 adults who don't regularly practice yoga or meditation and have them attend in-person classes with certified instructors. The goal …

This study aims to find the best way to deliver online sleep therapy to cancer survivors struggling with insomnia. Researchers will test two factors: whether therapy works better in individual or group sessions, and whether adding follow-up 'booster' sessions helps. The goal is t…

This study is testing a more precise form of whole brain radiation therapy designed to protect healthy brain tissue while treating cancer that has spread to the brain. Researchers want to see if this approach improves patients' quality of life and reduces symptoms like memory pro…

This study is testing whether a gentle, non-invasive brain stimulation technique can help reduce chronic low back pain. Researchers will recruit 80 adults who have had significant back pain for over six months. They will measure changes in pain levels and brain activity before an…

This study is testing two different mind-body programs designed to help cardiac arrest survivors and their caregivers manage emotional distress like anxiety and depression. The programs involve weekly sessions that teach mindfulness and resilience skills, starting in the hospital…

This study aims to find out if heated yoga, regular sauna use, or a mindfulness app can help reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression and assign them to one of these three activities for 12 weeks. They will measure changes in depr…

This small pilot study is testing whether a new support program is easy to use for older adults recovering from ostomy surgery. Researchers want to see if this program helps improve quality of life during the first days after surgery. The study involves 16 participants aged 65+ a…

This study is testing whether the drug ruxolitinib can reduce the often severe symptoms experienced by people with low-risk essential thrombocythemia (ET) or polycythemia vera (PV). About 60 participants with significant symptom burdens will take the drug for at least 6 months to…

This study is testing whether a virtual program to help with memory and thinking skills is practical and helpful for refugees and asylum seekers who have a traumatic brain injury (TBI). Researchers will enroll 50 English or Spanish-speaking participants to try an 8-session progra…

This study is testing a new smartphone app called SHIFT, designed to help people who have had a life-saving stem cell or bone marrow transplant. The app provides private, at-home guidance to address common and distressing sexual health problems that often arise after transplant. …

This small pilot study is testing whether a new, non-drug approach can help manage nerve pain and numbness caused by chemotherapy. Researchers want to see if it's practical for breast cancer survivors to follow 16 video-guided sessions where they imagine receiving acupuncture. Th…

This study is testing an online therapy program designed to help cancer survivors who struggle with chronic insomnia. Researchers will compare a 6-week virtual counseling program to standard sleep advice to see which is better at reducing sleep problems. The study aims to include…

This study is testing whether a 9-week phone program focused on building positive emotions and resilience can help people with irritable bowel syndrome (IBS). Researchers will enroll 50 adults with IBS to see if the program is practical and acceptable, and to check for early sign…

This study is testing whether a smartphone app called DREAMLAND can help improve the quality of life and emotional well-being of adults with acute myeloid leukemia (AML) while they are in the hospital for intensive chemotherapy. The app provides coping skills, education, and psyc…

This study is testing whether a newer sedation drug called remimazolam works as well as the commonly used drug propofol for keeping patients comfortable during routine endoscopic procedures like colonoscopies. It will enroll 100 adults to see if the new drug is a practical option…

This study tests a 6-session support program for adults recently hospitalized with a sudden brain injury and their primary caregiver. The program, delivered partly in the hospital and partly via video calls after discharge, aims to prevent long-term emotional distress, anxiety, a…

This study is testing whether a medication called tranexamic acid (TXA) can help patients heal faster after breast reduction surgery. Researchers want to see if TXA reduces the amount of fluid that drains from the surgical site, which could allow doctors to remove drains sooner a…

This study is testing a mobile app called PROMOTE, designed to help people being treated for lung cancer. The app aims to improve physical function, manage symptoms like shortness of breath and sleep problems, and support healthier habits. Researchers will compare the app's effec…

This study is testing whether turmeric, a common spice sold as a supplement, can help reduce pain and stiffness in people with thumb arthritis. Researchers will compare turmeric against a placebo in 60 adults with early-stage thumb arthritis. The goal is to see if this natural op…

This pilot study is testing whether patients can manage pain after major orthopedic surgery without opioid painkillers. Researchers will compare two groups: one receiving opioid-free pain medication at discharge and another receiving usual care that includes opioids. The study ai…

This small pilot study is testing a self-guided writing program designed to help people with chronic musculoskeletal pain manage negative, catastrophic thoughts about their pain. About 10 participants will complete writing exercises to see if the program is practical, acceptable,…

This small pilot study is testing whether a sauna-like whole-body heat treatment can help reduce symptoms of Long COVID, especially fatigue. Researchers will enroll 21 people with Long COVID to test the treatment's feasibility and see if it improves fatigue, sleep, and inflammati…

This study is testing whether a 12-week nutrition and exercise program is practical and helpful for people with myeloproliferative neoplasms (MPNs), a type of chronic blood cancer. Researchers want to see if patients can complete the program and if it improves their fatigue, anxi…

This study is testing a special light-activated bone implant called IlluminOss to see if it helps reduce pain and improve movement in people with pelvic fractures. It's for two groups: cancer patients whose disease has spread to the bone and older adults with fragility fractures.…

This study aims to train therapists to provide personalized mental health therapies to cancer patients and their caregivers who are experiencing significant distress, anxiety, depression, or sleep problems. About 100 patients and caregivers in Massachusetts will receive therapy s…

This study is testing whether a 10-week program combining gentle walking goals with mind-body skills (like breathing exercises and mindfulness) can help older adults with chronic musculoskeletal pain move more easily and feel better. The program, called GetActive+, is being compa…

This study is testing a new online program designed to help adults manage chronic facial pain. The program teaches relaxation and coping skills through five short video sessions. Researchers want to see if the program is easy to use and acceptable to participants before testing i…

This study is testing a new coaching program designed to help pregnant medical residents and fellows. The program aims to reduce burnout, improve well-being, and help them balance their demanding jobs with starting a family. About 48 participants will either receive the coaching …

This study is testing whether special glasses that display live speech captions are helpful and easy to use for adults with NF2-related schwannomatosis who have hearing loss. About 20 participants will try the glasses for 12 weeks and share their experiences through surveys and i…

This study aims to understand the ethical concerns and gather opinions about new brain scan technologies (like MRI and EEG) used to detect hidden consciousness in patients with severe brain injuries. Researchers will interview patients, their families, doctors, and researchers to…

This study aims to understand how a non-invasive brain stimulation treatment works for depression. Researchers will use MRI scans and mood tests to see how stimulating different brain networks affects connectivity and symptoms in 80 participants, including both healthy individual…

This study is testing a new type of brain scan to measure a protein called fibrin in people with and without Alzheimer's disease. Researchers want to see if there are differences in fibrin levels between healthy individuals and those with memory problems. The goal is to better un…

This small pilot study aims to understand if men and women wake up differently from a common anesthesia drug called dexmedetomidine. Researchers will enroll 12 healthy volunteers to measure how long it takes them to become responsive after the drug is stopped. They will also test…

This study aims to understand how Crohn's disease affects bone health in teenagers. Researchers will compare bone marrow and bone density in 46 teens recently diagnosed with Crohn's disease against 46 healthy teens using MRI scans and blood tests. The goal is to learn if increase…

This study is testing a new type of heart scan to see if it can detect specific chemical changes in the hearts of people with aortic stenosis or diabetes. Researchers will compare scans from 96 participants—including healthy volunteers and people with these conditions—to understa…

This study aims to understand the immediate relationship between cannabis use, withdrawal, and mental health in teenagers. Researchers will follow 200 adolescents (ages 12-18) who use cannabis frequently and have depression symptoms. Using smartphone surveys throughout the day, t…

This study aims to find less invasive ways to measure muscular dystrophy disease activity. Researchers will test whether urine and blood samples, along with painless muscle scans, can track the disease as effectively as current muscle biopsies. The goal is to develop better tools…

This study is testing a new type of brain scan to see if it can detect clumps of a specific protein linked to Parkinson's disease, Lewy body dementia, and multiple system atrophy. Researchers will give participants a small amount of a radioactive tracer and then perform a PET/MRI…

This study aims to understand how exercise might help people with PTSD who also have a higher risk for heart disease. Researchers will use special PET/MRI scans to look at brain activity and inflammation in blood vessels before and after an exercise program. The goal is to gather…

This study aims to understand if the types of bacteria in a person's gut are connected to their risk of developing depression after childbirth. Researchers will collect samples and surveys from 30 pregnant individuals before and after delivery to look for patterns. The goal is to…

This study aims to collect detailed health information from 5,000 people living with ALS and related motor neuron diseases. Participants will have their routine clinic visit data, like symptoms and test results, securely stored in a central research database. The goal is to creat…

This study aims to understand if a person's sleep and daily rhythm patterns before surgery can help predict who might experience confusion (delirium) after a major joint operation. Researchers will observe 150 adults aged 70+ having orthopedic surgery, tracking their sleep with a…

This study aims to understand why people aged 45 to 54 are not getting screened for colorectal cancer. Researchers will interview patients and survey staff at community health centers to identify the main barriers. The goal is to use this information to develop better strategies …

This study aims to understand how a gentle, non-painful form of ear stimulation affects communication between the brain and the stomach. Researchers will use MRI scans to measure brain and stomach activity in healthy adults and people with functional dyspepsia (indigestion) while…

This study aims to understand why some people experience thinking and memory problems after a stroke, while others recover better. Researchers will follow 8,000 stroke patients over time, using brain scans, blood tests, and memory assessments. The goal is to identify early signs …

This study is testing whether watching an educational video at home helps seriously ill patients better plan for their future medical care. It involves 500 adults with a life-limiting illness who receive care at home. Researchers will compare if those who watch the video have bet…

This study aims to see if telling people they have a high genetic risk for heart disease motivates them to improve their heart health. Researchers will follow 200 middle-aged adults with no current heart disease for one year. Half will be told their genetic risk score right away,…

This study aims to understand *why* a proven talk therapy for PTSD works. Researchers will measure brain activity, heart rate, and other body signals in 15 people before, during, and after they complete a standard 10-session therapy. The goal is to identify the physical and menta…

This research study aims to understand how non-invasive magnetic brain stimulation affects memory and brain function. It involves older adults with mild memory problems and those without cognitive issues. Participants receive repeated brain stimulation sessions while researchers …

This study aims to find early biological signs in people who carry a genetic risk for rare, fatal brain diseases like Creutzfeldt-Jakob Disease (CJD). Researchers will track 150 at-risk participants over time through annual check-ups, blood tests, spinal fluid collection, and mem…

This study is testing which of two educational approaches works better to help people with Neurofibromatosis 1 (NF1) get recommended health screenings during their regular doctor visits. The research team wants to improve care for patients who don't have access to specialized NF …

This study aims to understand how tiny particles released by fat cells might influence the development of heart disease, diabetes, and other metabolic conditions. Researchers will collect fat and blood samples from 100 adults undergoing weight-loss surgery to analyze these partic…

This study aims to understand how different areas of the healthy human brain communicate and influence each other. Researchers will use safe, non-invasive magnetic pulses and brain scans on 80 healthy adults to see if they can temporarily strengthen or weaken these connections. T…

This study is testing whether using a new, more detailed system for planning and documenting voice therapy sessions leads to better results for patients with muscle tension dysphonia, a condition that causes hoarseness and voice strain. Researchers will enroll 600 patients across…

This study is testing a blood test that looks for cancer cells that have broken away from a prostate tumor and entered the bloodstream. Researchers want to see if the number of these cells in the blood before and after prostate removal surgery can tell them more about the cancer'…

This study aims to understand how the body's immune system responds to a specific liver cancer treatment. It involves 10 adults with eye melanoma that has spread to the liver. Researchers will take small tissue and blood samples before and after the treatment to see how immune ce…

This study uses a special type of MRI scan to look at the tiny structure of heart muscle in people at risk for heart failure. Researchers want to understand how the heart's internal architecture changes before symptoms develop. The study includes both healthy adults and people wh…

This study aims to discover specific immune markers that show when a person is protected against cholera, either from a vaccine or from having had the disease before. Researchers will give either a cholera vaccine or a typhoid vaccine to about 1,200 participants and track their i…

This study is testing a new wearable system designed to help astronauts maintain peak mental performance during long space missions to places like Mars. Researchers will see if gentle changes to a person's environment—like specific sounds, lights, or vibrations—can improve focus …

This study is testing whether telling people their genetic risk score for coronary artery disease (a type of heart disease) motivates them to improve their health. 500 adults aged 30-75 who are not on cholesterol medication will be randomly chosen to get their score right away or…

This study aims to understand why teenagers with cystic fibrosis (CF) often develop weaker bones. Researchers will compare 36 teens with CF to 36 healthy teens, using knee MRI scans, bone density tests, and blood work over one year. The goal is to see if increased fat in the bone…

This study aims to better understand why some people develop long-lasting pain after surgery. Researchers will measure brain activity and test a one-day therapy workshop to see if it helps people accept and manage their pain. The goal is to gather information that could lead to b…

This study aims to better understand and detect arm swelling (lymphedema) in people who have been treated for breast cancer. Researchers will follow 10,000 patients, regularly measuring their arms and asking about symptoms and quality of life. The goal is to learn how to spot thi…

This study is creating a national registry to track children and young adults (under 22) who receive radiation therapy for cancer. It aims to compare the long-term health outcomes and side effects between newer proton therapy and traditional photon therapy by following participan…

This large national registry aims to gather safety information on psychiatric medications taken during pregnancy. It will follow 5,000 pregnant women to track whether medications for depression, ADHD, anxiety, or other conditions are linked to birth defects or other pregnancy com…

This study aims to understand how the osteoporosis medication romosozumab affects bone-building cells over time. Researchers will take small bone samples from 16 postmenopausal women before they start the drug, and then again either a few weeks or several months later. The goal i…

This study is collecting detailed health information from 3,000 people with and without heart failure to better understand how different types of the condition develop and progress. Researchers will track participants over time, analyzing blood samples, genetic data, and heart im…

This study explores whether gentle ultrasound waves directed at the brain can help patients with severe brain injuries who haven't fully regained consciousness. Researchers will measure changes in awareness and brain activity in 36 patients, while also interviewing family members…

This study aims to understand how specific brain rhythms are involved in working memory. Healthy adult volunteers will receive a safe, non-invasive form of brain stimulation while performing memory tasks. Researchers will measure changes in brain activity and memory performance t…

This study aims to create a new scoring system to help doctors decide if a donated liver is healthy enough for transplant. Researchers will collect small tissue samples from 60 transplant patients to analyze how the liver's genes and chemicals relate to its function after surgery…

This study aims to understand how the human brain processes and understands speech. Researchers will record brain activity from up to 40 adults with epilepsy who are already undergoing a medical procedure involving brain monitoring. By comparing this brain activity to computer mo…

This study aims to understand how mindfulness training combined with brain feedback might help teenagers who experience frequent negative thoughts. Researchers will compare 50 at-risk teens with 50 healthy teens, using brain scans to see if the training changes specific brain net…

This study is testing a new swallowable capsule that measures temperature inside the digestive tract. The goal is to see if this 'thermal capsule' can collect useful data that might one day help doctors spot diseases like Crohn's. Researchers are enrolling 10 healthy adults to sw…

This study aims to understand myotonic dystrophy better by looking for early signs in the fluid surrounding the brain and spinal cord. Researchers will collect this fluid and measure brain activity in 88 adults with and without the condition. The goal is to find biological marker…

This study aims to understand if a mild, non-invasive brain stimulation technique can improve thinking skills like memory, focus, and decision-making. It will involve 600 people with conditions such as depression, ADHD, bipolar disorder, or a history of brain injury, as well as h…

This study aims to understand how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity from 80 participants while they perform speech tasks during deep brain stimulation surgery. The goal is to learn h…

This study aims to find easier ways to measure how Duchenne muscular dystrophy is progressing. Researchers want to see if they can detect signs of the disease in urine and blood samples instead of needing painful muscle tissue biopsies. They are enrolling 100 males with Duchenne …

This study aims to understand how chemotherapy affects thinking skills and brain health in older adults with breast cancer. Researchers will compare memory tests and brain scans from breast cancer patients receiving chemotherapy, those not receiving chemotherapy, and healthy volu…

This study aims to understand the genetic causes of rare, progressive brain disorders like Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), and Multiple System Atrophy (MSA). Researchers will collect DNA from up to 1,000 affected adults and their family members …

This study aims to find easier ways to measure myotonic dystrophy activity and severity without needing painful muscle biopsies. Researchers will collect blood and urine samples from about 215 people with or without the condition to look for specific RNA markers. The goal is to s…

This study aims to understand why many people do not get a follow-up colonoscopy after a positive stool test for colorectal cancer screening. Researchers will interview patients and staff at a Boston community health center to identify barriers and then test new support strategie…

This study aims to understand and overcome barriers that prevent people from getting screened for colorectal cancer. Researchers will work with staff at four community health centers to identify challenges and test new strategies, like text message reminders, to make screening ea…

This study aims to understand how rehabilitation therapy helps people regain arm movement after a stroke. Researchers will study 50 people who had a stroke 3-6 months ago, giving half specialized arm training and half usual care. They will use brain scans and movement tests to se…

This global study aims to understand why treatments work for some patients with rare T-cell and NK-cell lymphomas but not others. Researchers will collect genetic and treatment data from 1,200 patients over four years and use artificial intelligence to find patterns. The goal is …

This study is testing if an FDA-approved insomnia medication called suvorexant (BELSOMRA) changes brain activity in people who use cannabis frequently. Researchers want to see if the drug reduces activity in brain areas linked to cannabis cravings. Twenty participants will take t…

This study is comparing two types of lasers used for skin treatments to see which one is better for patients. Researchers want to know if a newer laser (called DFG) causes less pain and allows the skin to heal faster than the commonly used CO2 laser. They are testing this on the …

This study is testing two online approaches to help adults with Neurofibromatosis 1 (NF1) who have difficulty understanding medical information. Participants receive personalized care letters and either educational videos or a call with a peer who has NF1. The research aims to se…