Massachusetts General Hospital

This phase 2 trial is testing whether adding hydroxychloroquine to standard radiation and chemotherapy before surgery can better control pancreatic cancer. About 50 people with resectable pancreatic cancer will receive either proton or photon radiation along with capecitabine and…

This study tests whether digoxin, a heart medication, is safe and tolerable for people with ALS. It also looks at whether digoxin can slow nerve damage. About 40 adults with early-stage ALS will take digoxin for 24 weeks. The goal is to find a new way to manage this disease.

This study tests whether a wireless monitor worn for 24 hours after an emergency C-section can alert doctors when a new mother's vital signs become dangerous. Over 3,000 women in Uganda will wear the device, which sends alerts if heart rate, blood pressure, or other readings fall…

This study tests a precise type of radiation called proton therapy for women who have had a mastectomy for invasive breast cancer. Unlike standard radiation, proton beams stop at the target area, potentially reducing damage to nearby organs like the heart and lungs. The goal is t…

This study tests whether a noninvasive brain stimulation technique called iTBS-TMS can reduce suicide risk in adults with major depression or borderline personality disorder who are experiencing suicidal thoughts. Participants receive either real or sham (placebo) stimulation to …

This study follows 62 adults with hereditary hemorrhagic telangiectasia (HHT) who previously took pomalidomide in a clinical trial. Researchers want to see if the drug safely reduces nosebleed severity and the need for iron or blood transfusions over time. Participants take pomal…

This trial studies three approaches for adults with major depression that hasn't responded to standard antidepressants. Participants either add aripiprazole (Abilify) to their current medication, add repetitive transcranial magnetic stimulation (rTMS), or switch to venlafaxine XR…

This phase 2 trial tests whether giving ruxolitinib (Jakafi) before, during, and after a stem cell transplant can improve outcomes for people with myelofibrosis. The study includes patients with intermediate-2 or high-risk disease, or intermediate-1 with additional risk factors. …

This study tests whether psyllium fiber bars can help postmenopausal women with irritable bowel syndrome and diarrhea who experience accidental bowel leakage. Researchers will examine changes in gut bacteria and stool chemicals to see if fiber improves symptoms. The study involve…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tested a mobile health tool called REACH-Español, which sends interactive text messages to help Latino adults with type 2 diabetes remember and take their medications. The trial included 70 participants who were at least 18 years old, identified as Latino or Hispanic, …

This Phase II trial tested a combination of chemotherapy drugs (FOLFIRINOX) plus the blood pressure drug losartan, followed by proton radiation, in 50 people with locally advanced pancreatic cancer. The goal was to see if this approach could shrink tumors enough to allow complete…

This study tests whether measuring tobacco smoke exposure in children, using a simple blood test, can help parents quit smoking. About 865 parents of young children (12 or younger) who smoke will be enrolled. The goal is to see if this approach, combined with support, leads to mo…

This study looked at whether giving a special research e-cigarette to people who are stable on medication for opioid use disorder and smoke daily could help them smoke fewer regular cigarettes. 41 adults who weren't ready to quit smoking were randomly assigned to get the e-cigare…

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This pilot study tested a combination of chemotherapy drugs (FOLFIRINOX plus paclitaxel and carboplatin) along with proton beam radiation before surgery in 25 people with gastroesophageal cancer. The goal was to see if this intense pre-surgery treatment could shrink tumors and be…

This study tested whether giving only calcitriol (a form of vitamin D) to 16 children and adults with X-linked hypophosphatemia (XLH) could raise blood phosphate levels and improve bone growth without causing kidney stones. Participants took increasing doses of calcitriol for one…

This study tested the drug pembrolizumab in 21 people with recurrent respiratory papillomatosis (RRP), a rare condition where HPV causes non-cancerous growths in the throat, windpipe, or lungs. The goal was to see if the drug could shrink these growths and reduce the need for fre…

This study tested a 4-month program where community health workers provided nutrition education and support to 60 primary care patients with high blood pressure and food insecurity. The goal was to see if adding nutrition help to existing blood pressure coaching was feasible and …

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) in 427 older adults from racial, ethnic, and linguistic minority groups who had depression, anxiety, and some mobility issues. The program combined mental health support with physical exercises to h…

This study tested the drug D-cycloserine in a single patient with a rare genetic form of hereditary spastic paraplegia. The goal was to see if the drug is safe and can slow the disease by lowering certain fats (sphingolipids) in the body. The patient also took pyridoxine to help …

This study tested whether the drug ritlecitinib could prevent intestinal damage and symptoms when people with celiac disease ate gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. Th…

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This study tested whether a non-invasive brain stimulation method called tACS could reduce amyloid and tau proteins in people with mild to moderate Alzheimer's. Seventeen participants received daily sessions of tACS or a sham treatment for 2-4 weeks. The goal was to see if the st…

This study tested a probiotic called INF108F in 20 breastfed infants with a food allergy that causes blood in their stool. The goal was to see if the probiotic could improve the balance of gut bacteria and reduce symptoms like reflux and fussiness. While the treatment aims to con…

This study tested whether a drug called sacubitril-valsartan (Entresto) can improve early signs of heart failure in people with HIV. The 39 participants had well-controlled HIV but showed subtle heart changes on scans. The goal was to see if the drug could reduce inflammation and…

This study tested a drug called TAS-102 (Lonsurf) combined with a precise type of radiation (SBRT) in 52 people whose colorectal cancer had spread to the liver. The goal was to find the safest dose and see if the combination could control the liver tumors. The trial is complete, …

This study tested whether breathing in nitric oxide during and after heart surgery can prevent acute kidney injury. It included 250 adults with signs of blood vessel problems who were having long heart surgeries. Patients received either nitric oxide gas or a placebo (nitrogen) d…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This pilot study tested a newer, more precise form of proton radiation called pencil beam scanning, given alongside standard chemotherapy drugs (5-FU and mitomycin-C), for people with anal cancer. The goal was to see if this combination is practical and might cause fewer skin sid…

This study tested the drug denosumab in 55 people with multiple myeloma and severe kidney problems. The goal was to see if it could help control bone damage caused by the cancer. Researchers measured changes in bone turnover markers and monitored side effects like low calcium and…

This completed phase 2 trial tested a combination of cryoablation (freezing tumors with a needle) and immunotherapy drugs (pembrolizumab or avelumab) in 9 people with metastatic bladder cancer. The goal was to see if this approach could shrink tumors that were not frozen. The stu…

This early-phase trial tested a combination of two chemotherapy drugs, bortezomib (Velcade) and lenalidomide (Revlimid), in 22 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) had returned after a stem cell transplant. The main goal was to find the safe…

This pilot study looked at whether giving free e-cigarettes to smokers who hadn't quit after lung cancer screening could help them smoke fewer regular cigarettes. Fifteen people who smoked at least 5 cigarettes a day were given NJOY ACE e-cigarettes for 4 weeks and asked to switc…

This study tested different ways to deliver HIV treatment to people in South Africa who had detectable virus or were not in care. About 874 adults took part, receiving either incentives, community-based care, or home delivery of medication. The goal was to see which approach help…

This early-phase study tested the drug regorafenib in 16 adults with advanced blood cancers like acute myeloid leukemia (AML) that had stopped responding to other treatments. The main goal was to find the safest dose and see how the drug affects cancer-related cell signals. While…

This pilot study tested a drug called ibutamoren in 12 adults with nonalcoholic fatty liver disease (NAFLD). The goal was to see if it could lower fat in the liver. Participants took the drug for 6 months, and researchers measured liver fat using special MRI scans. The study was …

This study looked at how ocrelizumab, a standard MS medication, changes brain inflammation in 22 people with multiple sclerosis. Researchers used special PET and MRI scans to measure inflammation before and after one year of treatment. The goal was to see if the drug reduces harm…

This study tested a wearable device that guides users through slow, rhythmic breathing to help manage stress and cravings. 120 adults with substance use disorder used the device daily for 8 weeks while continuing their usual treatment. Researchers measured changes in mood, cravin…

This study tested a combination of two drugs, olaparib and temozolomide (with or without irinotecan), in 49 adults with Ewing sarcoma or rhabdomyosarcoma that had come back or spread after standard chemotherapy. The main goal was to find the safest dose and see if the combo could…

This early-phase study tested the safety of combining the drug nilotinib with standard radiation therapy for people with high-risk chordoma, a rare bone tumor. The goal was to find the highest safe dose of nilotinib that could be given alongside radiation without causing severe s…

This study tested adding a precise type of radiation (SBRT) to standard targeted therapy pills for people with stage IV lung cancer that has specific gene changes (EGFR, ALK, or ROS1). The goal was to see if this combination could delay the cancer from spreading to new areas. 27 …

This study tested a new radiation schedule (once a week for 5 weeks) in 10 people with B-cell lymphoma that came back or didn't respond to treatment. The goal was to see if this schedule is practical and reduces side effects before patients receive CAR T-cell therapy. The approac…

This study tested a program called iSTRIVE for 42 adults with HIV who also use opioids or stimulants and were not well engaged in HIV care. The program combined emotion regulation and communication skills training with video check-ins and small rewards to encourage daily HIV medi…

This study tested a program to help HIV-positive men who have sex with men (MSM) who also struggle with substance use. The program aimed to reduce feelings of stigma and shame that can keep them from getting HIV care. Fifty men took part to see if the program was helpful and easy…

This study tested a two-part approach to prevent a common complication called atrial fibrillation after heart surgery. About 242 people having coronary bypass surgery received a preventive dose of the drug amiodarone and a surgical technique called posterior pericardiotomy. The g…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug is designed to increase growth hormone levels, which may help reduce liver fat and inflammation. Researchers measured changes in liver fat using special scans an…

This phase 2 trial tested a combination of two immunotherapy drugs, ipilimumab and nivolumab, in 18 adults with leptomeningeal metastases—cancer that has spread to the lining of the brain and spinal cord. The study aimed to see if this drug combo could improve survival. Results s…

This study tested the drug ivosidenib as a maintenance therapy for people with IDH1-mutant blood cancers (like AML) after a stem cell transplant. The goal was to find the safest dose and see if it could help prevent the cancer from coming back. 18 participants took the pill daily…

This study tested whether denosumab, a drug used for osteoporosis, can improve bone density in women with anorexia nervosa. Thirty women received either denosumab or placebo injections over 12 months, with an optional year of alendronate. The goal was to see if bone density and s…

Bariatric surgery can lead to bone loss and increase fracture risk. This study tested whether denosumab, a drug used for osteoporosis, could prevent that bone loss. The trial included 36 postmenopausal women and men aged 50 and older who were planning weight-loss surgery. Partici…

This study tested whether offering financial rewards for staying smoke-free helps homeless smokers quit. 184 participants received varenicline (Chantix) and coaching, with some also getting escalating cash rewards for passing saliva tests. The goal was to see if incentives boost …

This phase 2 trial tested whether adding lenalidomide to standard MEC chemotherapy helps adults with relapsed or refractory acute myeloid leukemia (AML) achieve remission. 41 participants received the combination. The main goal was to see how many achieved complete remission. Thi…

This phase 1 study tested the drug enasidenib as a maintenance therapy after a stem cell transplant in 23 people with IDH2-mutant acute myeloid leukemia or chronic myelomonocytic leukemia. The goal was to find the safest dose and see how well patients tolerated it. Enasidenib wor…

This study tested a precise type of radiation called proton beam therapy for people whose cancer has spread to the liver. 92 adults with 1 to 4 liver tumors received this treatment. The goal was to see if it could stop tumor growth and cause fewer side effects than standard radia…

This study tested whether a special clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure took part over 12 weeks. The clinic aimed to improve medication use, health status, and heart function.

This study followed 13 people with HIV who agreed to receive a solid organ transplant (like a kidney or liver) from a deceased donor who also had HIV. The goal was to see if this practice is safe and works as well as transplants from donors without HIV. Researchers tracked patien…

This early-phase study tested a combination of two drugs—oral decitabine and durvalumab—in 13 adults with advanced head and neck cancer that had stopped responding to standard immunotherapy. The goal was to see if the combo could safely boost the immune system's ability to fight …

This study tested proton beam radiation, a highly targeted form of radiotherapy, in 83 people with liver cancer that could not be surgically removed. The goal was to see if this precise approach could control tumors while reducing damage to healthy tissue. Participants received d…

This study tested a new type of microscope called SECM to see if it can take clear pictures of pigmented skin lesions like moles. Sixteen healthy adults with moles on their forearms had their skin imaged with both a standard dermatoscope and the SECM device. The goal was simply t…

This study tested whether a rapid 30-minute desktop test for gonorrhea and chlamydia could help doctors make better treatment decisions compared to the current standard (a gram stain). 98 adults with symptoms of urethritis or cervicitis took part. The goal was to see if the rapid…

This trial tests whether giving children a single dose of the antibiotic azithromycin right after a household member tests positive for cholera can prevent them from getting infected. The study enrolls children aged 1 to 15 who share cooking facilities with a cholera patient. Res…

This study tests a simple writing exercise for new mothers who had a stressful childbirth. In the days after giving birth, participants write about their experience for 15 minutes a day for three days. The goal is to see if this can prevent post-traumatic stress disorder (PTSD) a…

This study compares two ways to provide HIV prevention pills (PrEP) to young people in South Africa: the usual clinic-based approach versus a community-based model where pills are delivered and monitored outside clinics. Researchers will enroll 2,500 participants aged 16-30 to se…

This pilot study tested whether offering sexual health services like HIV prevention pills (PrEP), STI testing, and birth control in hair salons could reach women who might not visit a clinic. About 436 women in Umlazi, South Africa, took part. Some salons offered these services, …

This study tested whether giving extra health coaching to new parents—especially fathers—could help prevent rapid weight gain in babies and reduce obesity risk. Researchers enrolled 657 parents from Massachusetts General Hospital and randomly assigned them to either receive coach…

This study tested three ways to prevent hospital patients from falling: a computer alert that warns nurses when a patient is at risk, a camera system that lets nurses see patients, or both together. Over 5,000 adult patients and their nurses took part. The goal was to see which m…

This early-phase study tested whether losartan, a common blood pressure medication, could prevent early heart damage caused by radiation therapy in breast cancer patients. Five women with left-sided breast cancer who were scheduled for radiation took losartan. Researchers used he…

This completed trial tested whether a decision support tool given before primary care visits helps more people get screened for colorectal cancer. Over 9,000 average-risk adults aged 45-75 who were overdue for screening took part. The tool was included in a pre-visit questionnair…

This study tested two HIV prevention programs for African immigrant women: one-on-one counseling (Dada Kwa Dada) and group sessions (DADA). The goal was to see which approach increases condom use and PrEP uptake. 149 HIV-negative women from the Boston and New York areas took part…

This completed study tested a program to prevent obesity in mothers and children from pregnancy to age 2. It involved 1,645 families at community health centers in Boston. The program used education, text messages, and provider training to promote healthy eating, physical activit…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This study looks at two ways of delivering palliative care—specialized support to ease symptoms and stress—for people recently diagnosed with advanced lung cancer. One approach starts with basic palliative care and adds more if needed, while the other provides full palliative car…

This study tests whether bezafibrate, a drug currently used for high cholesterol, can safely improve depression in people with bipolar disorder. Thirty adults with bipolar I or II who are already on a mood-stabilizing medication will take bezafibrate for 8 weeks. Researchers will…

This study tests whether a virtual cognitive behavioral therapy program can help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home. The goal is to see if the program is easy to use and helpful for improving…

This study tests whether a hospital-at-home care model can help people with advanced blood cancers receive end-of-life care at home instead of in the hospital. Participants use remote monitoring and home-based supportive care, with researchers tracking how many enroll and complet…

This study is testing a new program called Resilient Families for parents whose babies are in the Neonatal Intensive Care Unit (NICU). The goal is to reduce emotional distress like depression, anxiety, and stress, and improve the couple's relationship. Ten parent couples are taki…

This study tests whether a mild electrical pulse to the ear (taVNS) can change how the brain and stomach interact in people with chronic indigestion or gastroparesis. Researchers will use brain scans and stomach electrical readings to see if the stimulation helps. The goal is to …

This study tests whether a specific type of talk therapy called cognitive behavioral therapy (CBT) can help people with body dysmorphic disorder (BDD). Participants receive 22 weekly one-on-one CBT sessions that teach them to challenge negative thoughts and behaviors about their …

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This small pilot study tested a mindfulness-based therapy designed for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nin…

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This study tested two treatments for avoidant/restrictive food intake disorder (ARFID) in 53 children and teens aged 10-18. One group received cognitive-behavioral therapy (CBT-AR) and the other received nutrition counseling. The goal was to see which approach better reduces fear…

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested whether cognitive behavioral therapy (CBT) can reduce symptoms of gastroparesis, a condition where the stomach empties slowly, causing nausea, bloating, and pain. Twenty-seven adults with idiopathic gastroparesis received CBT sessions and were assessed before an…

This study explores whether practicing tai chi, a gentle mind-body exercise, can reduce symptoms of irritable bowel syndrome with constipation (IBS-C). Adults aged 18 to 70 with IBS-C will take part in tai chi sessions and report their symptom severity and satisfaction. The goal …

This study compared an online yoga program with an online behavioral therapy for adults with depression. Over 500 participants were randomly assigned to either yoga or therapy for 12 weeks. Researchers measured depression symptoms and well-being at several points to see which app…

This study tested whether Collaborative Problem Solving (CPS), a behavioral approach that teaches caregivers to address children's underlying thinking skill deficits, can improve executive function and reduce behavioral symptoms in 54 youth receiving home-based mental health care…

This study tested whether giving acetaminophen (Tylenol) through an IV works better than taking it as a pill for pain after knee replacement surgery. Researchers measured pain scores and how much extra opioid painkiller patients needed. The goal is to find the best way to manage …

This study tested two virtual, 8-week programs (Active Brains 1 and 2) in 267 older adults with chronic pain and early cognitive decline. Both programs taught skills like relaxation, cognitive training, and positive psychology to help manage symptoms. Researchers measured changes…

This study tested two 8-week stress management programs delivered via secure video calls for 196 adolescents aged 12–17 with neurofibromatosis (NF1 or NF2). The goal was to see if these programs could improve emotional, social, and physical quality of life. Both programs taught c…

This study looked at whether a type of talk therapy called cognitive-behavioral therapy (CBT) can help reduce the severe tiredness that many people feel after a stem cell transplant for blood cancer. 66 adults who had a transplant at least 6 months earlier and still had significa…

This study tested a therapy program called 'Being Brave' for children ages 4 to 7 who were at risk for anxiety disorders. The program involved parents and children learning coping skills together. Researchers compared 65 children who received the therapy to those on a waitlist. R…

This study tested a 30-minute web-based program for parents of children with anxiety who are waiting for cognitive behavioral therapy. The program aims to reduce how much parents accommodate their child's anxiety, which can make anxiety worse. Researchers recruited 47 parents and…

This study tested whether laser treatment or a small punch biopsy (removing a tiny piece of scar tissue) improves burn scars better than no treatment. Seventeen adults with burn scars each had three small areas on one scar treated differently: laser, punch biopsy, or nothing. Res…

This study tested a 9-session virtual mind-body program (SMART-3RP) to see if it helps caregivers of cancer survivors feel less stressed and more resilient. It compared the program to a standard online support group. The trial enrolled 94 participants and focused on whether the p…

This study tested a program to help stem cell transplant survivors who have sexual problems. Participants met with a nurse for three months and got educational materials. The goal was to see if this improved their sexual satisfaction, quality of life, and mood. The study involved…

This study tested whether repeated sessions of transcranial magnetic stimulation (TMS) could improve language in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Ten participants received both real and sham (fake) TMS ove…

This study looked at two surgical methods for trigger finger: the standard open surgery and a newer ultrasound-guided technique. Researchers wanted to see if the ultrasound-guided method helps people recover faster and have less pain. Sixty adults who needed surgery for trigger f…

This study tested a psychological program to help caregivers of stem cell transplant patients cope better. 100 caregivers were split into two groups: one received the coping program, the other standard care. The goal was to see if the program was practical and improved caregivers…

This study tested a virtual program called MASC (Mindful and Self-Compassionate Care) for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and behavioral management skills through six group sessions and home practice. T…

This study tested two natural supplement combinations—omega-3 plus inositol versus N-acetylcysteine (NAC)—to see if they could help children and teens (ages 5-17) with emotional ups and downs. Over 6 weeks, 27 participants took one of the two treatments. The goal was to find a ge…

This study tested a device that stimulates a nerve in the ear to treat chronic low back pain. 70 adults used the device daily for four weeks. Researchers measured changes in pain intensity and physical disability to see if this drug-free approach could help.

This study tested a group program to help parents of children with learning or attention difficulties manage stress. About 28 parents took part in either a mind-body resiliency group or a health education group, both held online. The goal was to see if the program was practical a…

This study tested a computer-based program that combines mental exercises and relaxation techniques for people with mild cognitive impairment (MCI). The goal was to see if this approach is practical and acceptable for improving thinking and memory. The study involved 32 participa…

This study tested a type of therapy called Emotion Regulation Therapy - Attention Regulation (AR-ERT) to help people with obsessive-compulsive disorder, generalized anxiety disorder, or major depressive disorder who struggle with repetitive negative thinking. 65 adults in Massach…

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants used either bright-white or dim-red light boxes at different times of day. The goal was to find the most effective dose to ease slee…

This study tested whether adding a palliative care team to standard cancer care improves quality of life for people with acute myeloid leukemia (AML). 160 hospitalized patients with high-risk AML were randomly assigned to receive either usual oncology care or care that included a…

This study tested whether combining a gentle electrical nerve stimulation device (tVNS) with stress reduction training can ease migraine. Researchers measured brain activity and inflammation in 193 adults with migraine before and after 8 weeks of treatment. The goal was to see if…

This study tested a brief, nurse-led videoconference program designed to help breast cancer survivors who were hesitant or delayed in starting recommended hormone therapy. The program aimed to address cultural and personal concerns. Researchers measured how many people enrolled, …

This pilot study tested a 6-session virtual program called MASC that teaches mindfulness, self-compassion, and behavior management skills to caregivers of people with Alzheimer's or related dementias. 82 caregivers participated to see if the program is feasible and acceptable. Th…

This study tested whether a non-invasive brain stimulation technique called TMS could reduce symptoms of obsessive-compulsive disorder (OCD) in 26 adults. The treatment targeted a brain area involved in movement planning. Researchers also looked for clues about how TMS works and …

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study tested whether giving pregnant trainee doctors extra support—like a smart bassinet, wearable breast pump, 24/7 online perinatal care, and a faculty mentor—could reduce burnout and improve wellbeing. 156 pregnant residents and fellows from four hospitals were randomly a…

This study tested a 10-week phone-based program that combines positive psychology and motivational interviewing to help people become more active after bariatric surgery. Twelve adults who had surgery 6-12 months earlier and were not very active took part. The goal was to see if …

This study tested a device called transcranial photobiomodulation (tPBM), which shines invisible light on the front of the brain through a headband. Researchers wanted to see if it is safe and can improve social and behavioral symptoms in adults with autism. Forty-one adults took…

This study tested whether a 10-week mind-body walking program (GetActive-Fitbit) is feasible for adults with chronic musculoskeletal pain. 92 participants were randomly assigned to either the walking program or a health education group. The goal was to see if people would join, s…

This study tested whether watching a virtual reality (VR) video of acupuncture needles being applied could help people with chronic low back pain. 31 adults with pain lasting over 6 months participated. The goal was to see if people would stick with the treatment and find it sati…

This study tested whether a program called PQ-ResPOND could help manage pain in children with severe neurologic disabilities like cerebral palsy. About 54 children and their parents took part, with some receiving the program (surveys plus a palliative care team consult) and other…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This pilot study tested a mindfulness-based cognitive therapy program, called Quiet Focus, in 12 older Black adults with chronic pain and mild depression. The goal was to see if the program is acceptable and helpful, and to gather information for a larger future study. Participan…

This study tested two stress and symptom management programs for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The programs were delivered through live videoconferencing over 8 weekly sessions. Researchers measured changes in quality of life and emotional well-bei…

This study tested a new 3-session mind-body pain management program called PACE CF for adults with cystic fibrosis (CF). The program was delivered via telehealth and aimed to help people cope with pain without medication. Researchers wanted to see if the program was acceptable an…

This study tested a light therapy called transcranial photobiomodulation (tPBM) to see if it could safely reduce autistic traits and ADHD symptoms in children and teens. 38 participants aged 9 to 17 with ADHD and at least moderate autism symptoms received the treatment. The goal …

This study tested whether a 12-week group therapy program based on cognitive behavioral therapy (CBT) is practical and well-liked by older adults (50+) living with HIV. The program teaches skills to manage stress related to aging and HIV, and encourages healthy habits like physic…

This study tested a nurse-led program to help adults with cancer who are taking part in early-phase clinical trials feel better day-to-day. The program included regular check-ins on symptoms and well-being, plus team meetings to address concerns. Researchers wanted to see if the …

This study looked at whether strengthening a small thumb muscle (the first dorsal interosseous) can help people with thumb arthritis. 160 adults who already used a thumb splint were assigned to do specific exercises. Researchers measured changes in pinch strength and pain after 1…

This early-stage study tested a new mind-body program designed to help female survivors of colorectal and anal cancer improve their sexual well-being. Six women who had finished initial cancer treatment took part in group sessions. The main goal was to see if the program was acce…

This study tested whether cooling the skin before or during laser and injection treatments for neurofibromatosis type 1 (NF1) skin bumps can reduce pain. Thirteen adults with NF1 received four different treatments (two lasers and two injections) on both cooled and non-cooled skin…

This study tested whether a special type of heated yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 people were randomly assigned to either take yoga classes twice a week or join a waitlist. The main goals were to see if people would stick with the …

This study tested the drug atomoxetine in 60 children with autism who also had significant hyperactivity, inattention, or impulsivity. Over 8 weeks, researchers measured changes in ADHD symptoms using a standard rating scale. The goal was to see if atomoxetine could safely reduce…

This study tested whether teaching people three simple skills to manage negative emotions, plus getting smartphone reminders to practice them, could reduce suicidal thoughts and emotional distress. 41 adults who had recently attempted suicide or had current suicidal thoughts took…

This study tested a mind-body program called 'Recovering Together after Cardiac Arrest' for survivors and their caregivers. 14 pairs (survivor and caregiver) took part to see if the program was feasible and helpful. The goal was to reduce emotional distress and improve well-being…

This study tested a new program called 'Improving Life with CF' at five cystic fibrosis (CF) centers. The program helps doctors regularly check in on patients' symptoms and quality of life, and provides guides for managing common problems. Over 600 people with CF took part to see…

This study tested a smartphone app that sends automated reminders to use personalized coping strategies for adults hospitalized with suicidal thoughts. Participants answered surveys up to six times daily, and when they reported high distress, some received prompts to use their sa…

This study tested whether a smartphone app called Healthy Minds Program can help reduce stress in people caring for a loved one with dementia. 93 stressed caregivers used either the Healthy Minds app or a wellness podcast app for a few weeks. The main goal was to see if using the…

This study tested a mind-body program called GetActive for adults with chronic pain. The program combines relaxation techniques, coping skills, and physical activity (with or without a Fitbit). 82 participants completed the program, and researchers measured satisfaction, safety, …

This study tested whether support from a peer mentor through video chats and texts could help reduce depression in older adults, especially those with low income or from ethnic minority groups. 34 participants aged 50 and older with mild depression took part in 8 weekly video cha…

This pilot study tested a behavioral program called PROWESS for Black and Hispanic men with prostate cancer who are on hormone therapy (ADT). The program included video or in-person sessions with a psychologist or social worker and a FitBit to track activity. The goal was to see …

This study tested a program called CONTINUUM, where advanced cancer patients had a video visit with an oncology nurse within three days of leaving the hospital. The goal was to help patients feel more confident managing their health and improve communication with their care team.…

This study tested a new program called 'Dementia Care Quality at Home' in two home-based primary care clinics. The program trained clinic staff to assess the needs of people with dementia and their caregivers, provide educational materials, and hold team meetings to address chall…

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to under…

This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women…

This study follows about 1,000 adults in South Africa and Uganda who are switching to a common HIV treatment called TLD, which combines three drugs into one pill. The goal is to see how effective TLD is in everyday conditions, not just in controlled trials. If the treatment stops…

This study investigates how watching guided acupuncture videos changes brain activity in healthy adults. Participants receive real acupuncture, sham acupuncture, or video-guided imagery while undergoing fMRI scans. The goal is to understand the brain mechanisms behind mind-body i…

This study compares two catheters used during the mapping step before radioembolization for liver cancer. One is a standard microcatheter, the other is a pressure-enabled device (TriNav). The goal is to see if the pressure-enabled catheter delivers more radioactive tracer directl…

This study tests whether a children's book and video called 'The Science Tooth Fairy' can improve parents' willingness to donate their child's baby teeth for scientific research. About 120 parents of children aged 4 to 10 will be randomly assigned to read or watch the story, or a…

This pilot study tests whether automated text messages and voice calls can help pregnant women in Uganda better prepare for planned cesarean deliveries. Participants receive reminders about timing, warning signs, and logistics before their scheduled C-section. The goal is to see …

This study looks at Cesarean section (C-section) rates in Uganda, where national averages hide big differences between rich and poor, urban and rural women. Researchers will track over 11,000 deliveries at multiple hospitals to see who gets a C-section, why, and what happens to m…

This pilot study at Massachusetts General Hospital tests whether allowing a slightly lower blood pressure (MAP above 60 mmHg) after heart surgery is safe and reduces the need for blood-pressure-raising drugs. 80 adults having elective heart surgery are randomly assigned to either…

This study investigates how the brain's use of glucose and oxygen changes when processing unpredictable sights and sounds. Healthy adults aged 21-35 will undergo combined PET and fMRI scans while performing tasks with predictable or random stimuli. The goal is to understand the l…

This study tests whether suvorexant (Belsomra), a sleep medication, can lower brain activity linked to cannabis cravings. Twenty adults who use cannabis daily will take the drug for 14 days and undergo brain scans before and after. The goal is to see if the medication reduces the…

This study looked at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers collected samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotiona…

This study tested a program that lets recently hospitalized cancer patients recover at home with remote monitoring of symptoms, vital signs, and weight. The program includes home visits and close communication with the oncology team. Researchers wanted to see if this approach is …

This study looked at how people living with HIV in rural Uganda experience stigma, including feelings of shame, loss of self-respect, and mistreatment by others. Researchers surveyed 180 adults to understand these experiences better. The goal was to gather information, not to pro…

This study aimed to better measure how many people experience food and water insecurity. Researchers surveyed 1,550 adults in a rural parish in Rwanda using a special technique called a list experiment to get more honest answers. The goal was to understand the true extent of hung…

This completed study surveyed over 1,500 adults in Nyakabare Parish, Uganda, to learn how people perceive tobacco and alcohol use in their community. Participants answered questions about how often they think others smoke or drink. The goal was to understand perceived norms, whic…

This study tested whether giving adults in a rural Ugandan village simple facts about how many of their neighbors get tested for HIV could increase their own intention to test. Over 1,300 adults completed a survey with or without this personalized feedback. The goal was to see if…

This study looked at how a low dose of ketamine, a medicine often used for anesthesia, affects breathing and brain activity in 15 critically ill patients who were on breathing machines (ventilators) in the ICU. The goal was to see if ketamine could help stimulate breathing and im…

This study looked at how often people with certain blood cancers or related conditions have an acquired deficiency of an enzyme called pyruvate kinase, which can cause anemia. Researchers took a single blood sample from 18 participants to measure enzyme activity and check for rel…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study tested whether a gentle electrical current applied to the scalp (transcranial electrical stimulation) could help healthy adults perform a complex computer task faster and more accurately. Forty-four volunteers with advanced degrees completed a track-and-capture task wh…

This study looked at why some people with depression feel better after taking a placebo (a sugar pill with no active drug). Researchers used brain scans and other tests to find biological markers linked to this placebo response. The goal is to improve future depression treatments…

This study looked at whether women with different types of gestational diabetes respond differently to meals with varying amounts of carbs, protein, and fat. Nineteen women with gestational diabetes wore a continuous glucose monitor and ate two test meals. The goal was to see if …

This study tested a new way to help young adults (ages 18-30) with type 1 or type 2 diabetes move from pediatric to adult diabetes care. Researchers compared a collaborative care model to usual care, looking at how many visits patients completed and changes in diabetes-related di…

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This study tested different electrical stimulation settings to see which ones best reduce abnormal brain activity in people with epilepsy. Researchers compared settings from animal studies to those used in standard practice. The goal is to improve how brain stimulation is used to…

This study created a new questionnaire called the Down Syndrome Health Instrument (DHI) to measure health in people with Down syndrome. Researchers worked with caregivers, individuals with Down syndrome, and experts to develop and test the tool. Over 750 participants took part in…

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This study used brain scans like MEG, EEG, and MRI to learn how the brains of people with autism spectrum disorder process sensory information. 85 people between the ages of 14 and 32 took part. The goal was to better understand the condition, not to test a new treatment.

This study created a database of 40 people, including healthy volunteers and those with autism spectrum disorder, to make it easier to recruit for future research. Participants were between 14 and 32 years old. The goal was to build a pool of willing volunteers for upcoming studi…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …

This study followed 344 infants with a sibling diagnosed with autism from birth to age three. Researchers collected blood, stool, urine, and saliva samples to find early biological markers that might predict autism. The goal is to better understand how autism develops and eventua…

This study tested a 10-week program that combined positive psychology and motivational interviewing to help people become more physically active after bariatric surgery. 58 adults who had surgery 6-12 months earlier and wanted to move more took part. The program aimed to see if i…

This study looked at how the hormone kisspeptin affects the body's response to sugar. Sixteen healthy adults received either kisspeptin or a placebo during an oral glucose tolerance test. Researchers measured changes in insulin sensitivity to better understand kisspeptin's role i…

This study tested whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, could improve emotion regulation in people with bipolar disorder. Fifty-six participants, including healthy controls, underwent brain scans while performing tasks design…

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could help people with bipolar disorder regulate their emotions. Nineteen participants, including healthy controls, completed behavioral tasks measuring…

This study followed 10 people with late onset Tay-Sachs disease to see how their symptoms and body chemistry changed over six months. Researchers measured balance, coordination, and brain chemicals. The goal was to gather information that will help design better clinical trials f…

This pilot study tested how skin heals after taking very small biopsies, called micro-biopsies, which are smaller than a sewing pin. Eight healthy adults scheduled for tummy tuck surgery had these micro-biopsies taken from skin that would later be removed. The goal was to see if …

This study tested whether shining near-infrared light on the head (called transcranial photobiomodulation) can improve thinking, memory, and mood in healthy adults. Eighty volunteers aged 18-25 or 65-85 received the light treatment or a placebo. The goal was to see if this safe, …

This study tested whether a program to improve physical fitness, nutrition, and sleep before surgery is possible for older adults with esophageal cancer. Fifteen patients aged 65 and older who had completed chemotherapy or radiotherapy took part. The goal was to see if patients w…

This study tested a specially adapted mind-body program (the Relaxation Response Resiliency Program) to help nurses in South Africa who care for people with HIV manage stress and prevent burnout. About 60 nurses took part in a small pilot to see if the program was practical and w…

This study looks at whether adding a special care model (GRACE) to regular annual wellness visits can help older adults with complex health needs stay healthier and avoid hospital stays. Researchers will work with 110 participants aged 65 and older to see if this approach is prac…

This study looked at whether having a dermatologist see patients within 24 hours of being admitted to the hospital for cellulitis (a skin infection) could improve their care. Researchers compared patients who got a dermatology consult to those who only saw their regular hospital …

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home to track glucose and sleep for 10 days. The goal was to see if this kind of remote monitoring is practical and to gather early …

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—caused worry or raised the risk of lymphedema (arm swelling) in these patients. The study collected…

This study combined data from over 1,700 patients who had a heart attack or unstable angina and underwent a special imaging test (OCT) of their heart arteries. Researchers aimed to find factors that predict plaque erosion, a common cause of heart attacks. The goal is to better un…

This study tested an 8-week group program called My Healthy Brain for older adults with memory concerns and lifestyle risk factors for dementia. The program, delivered via Zoom, taught mindfulness and behavior change skills to help participants improve exercise, sleep, diet, and …

This study compared two at-home colorectal cancer screening tests—FIT and Cologuard—in over 5,000 patients at community health centers. Participants were mailed a test kit and asked to complete it at home. The goal was to see which test had higher completion rates and was more pr…

This study tested whether a special PET/CT scan can predict which patients with deep vein thrombosis (DVT) will later develop post-thrombotic syndrome (PTS), a condition causing chronic leg pain, swelling, and ulcers. Researchers imaged 51 patients shortly after their DVT and fol…

This study looked at whether a before-school physical activity program called BOKS could improve body weight, thinking skills, and quality of life in 188 children aged 5 to 14. The program ran three mornings per week for 12 weeks. Researchers measured changes in BMI, executive fu…

This study tested whether a mild electrical current applied to the scalp (tDCS) could temporarily improve attention and self-control in adults with ADHD. 83 people, including those with ADHD and healthy volunteers, completed tasks measuring focus and decision-making while receivi…

This pilot study gave the BCG vaccine (used for tuberculosis) to 20 healthy older adults aged 55-80. Researchers measured changes in immune markers and Alzheimer's-related proteins in blood and spinal fluid over 90 days. The goal was to see if this common vaccine might influence …

This study tested a 4-session resiliency program designed to help medical interpreters in cancer care manage stress and build coping skills. Twenty-eight interpreters from three hospitals took part in the program, which included relaxation techniques and cognitive skills training…

This study tested a special camera system that uses near-infrared light to help surgeons see blood flow during minimally invasive lung and esophagus surgery. 38 adults took part at Massachusetts General Hospital. The goal was to see if the camera could clearly show tissue blood s…

This completed study looked at whether the COVID-19 vaccine triggers a strong immune response in 146 people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose. The goal was to see if these patients, …

This study tested a new computer tool designed to help anesthesia clinicians avoid medication errors in the operating room. Forty anesthesia staff members used either the new tool or the standard method in a realistic simulation with a manikin and fake patient data. Researchers m…

This study looked at whether firefighters have different lung scan results compared to non-firefighters, and if a blood test can help better predict lung cancer risk. Over 700 current and retired firefighters took part. The goal was to improve early detection of lung cancer and o…

This study looked at whether a blood test could predict how prostate cancer responds to the drug abiraterone. Instead of taking a tissue sample (biopsy), researchers measured tumor cells circulating in the blood of 40 men with advanced prostate cancer. The goal was to see if chan…

This study tested a communication tool designed to help adults who are about to have fecal ostomy surgery. Researchers wanted to see if patients and their clinicians found the tool acceptable and easy to use. About 25 patients and 4 clinicians took part, with at least half of the…

This study tested a device called the Augmented Infant Resuscitator (AIR), which attaches to standard bag-mask ventilators used to help newborns breathe. It gives real-time visual feedback to clinicians on their ventilation technique. Researchers enrolled 250 birth attendants to …

This completed study tested whether analyzing social media messages (like WhatsApp and Instagram) from 400 young women aged 18-24 in Kisumu, Kenya could help identify those at risk for HIV. Researchers used AI to look at language patterns and compared them to standard HIV risk sc…

This study followed 155 children with brain or central nervous system tumors who received proton radiation therapy at Massachusetts General Hospital. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment.…

This study tested whether combining acupuncture with a gentle brain-stimulation technique (tDCS) can improve chronic low back pain more than either treatment alone. 116 adults with long-term back pain were split into four groups receiving different combinations of real or fake ac…

This study looked at how video-guided acupuncture imagery treatment (VGAIT) changes brain activity in people with knee osteoarthritis. Researchers used brain scans to compare real acupuncture, sham acupuncture, and guided imagery in 125 adults aged 40-70. The goal was to understa…

This study looked at how sleep apnea might make brain problems worse after surgery. Researchers enrolled 32 adults with moderate-to-severe sleep apnea who were scheduled for surgery. They used brain scans and memory tests before surgery, two days after, and six months later to tr…

This study looks at how the brains of fibromyalgia patients and their acupuncturists work together during electroacupuncture treatment. Using special MRI scans that record both people at once, researchers hope to see if matching brain activity leads to better pain relief. The goa…

This study looked at 20 adults with short bowel syndrome who rely on home parenteral nutrition. Researchers compared giving the nutrition overnight versus during the day to see if timing affects blood sugar levels and sleep quality. Participants wore glucose monitors and activity…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…