Massachusetts General Hospital

This study looked at how the drug ocrelizumab changes brain inflammation in people with multiple sclerosis (MS). Researchers used special brain scans to measure inflammation before and after one year of treatment. The study included 22 adults with relapsing-remitting or progressi…

This study tested adding a precise type of radiation (SBRT) to standard targeted therapy for people with stage IV non-small cell lung cancer that has specific gene changes (EGFR, ALK, or ROS1). The 27 participants had stable disease on targeted drugs and received radiation to rem…

This study looked at whether a precise type of radiation called proton beam therapy can safely kill liver cancer cells in people whose cancer cannot be removed by surgery. 83 adults with liver cancer took part. The treatment aims to deliver high doses of radiation directly to the…

This study tested a probiotic called INF108F in 20 breastfed infants with food protein-induced allergic proctocolitis (FPIAP), a condition causing blood in stool. The goal was to see if the probiotic could improve gut bacteria and reduce symptoms like reflux and fussiness. While …

This study tested if breathing in nitric oxide gas helps severely ill COVID-19 patients on ventilators get more oxygen. 200 adults in intensive care units took part. The goal was to see if the gas improves oxygen levels and helps patients recover faster.

This study tested the drug D-cycloserine in one person with a rare genetic form of hereditary spastic paraplegia caused by a change in the SPTSSA gene. The goal was to slow down the disease and reduce harmful fat molecules in the blood and spinal fluid. The treatment aims to cont…

This study tested a new program to help people with HIV who also use opioids or stimulants stay engaged in their HIV care. The program included emotion regulation and communication skills training, plus video check-ins to support taking medication. Researchers wanted to see if th…

This study tested whether adding nutrition coaching to an existing community health worker program helps patients with high blood pressure and food insecurity. 60 adults from primary care clinics took part. The goal was to see if the program was practical and liked by patients, a…

This study tested a combination treatment for people with advanced bladder cancer that has spread. The approach uses cryoablation (freezing tumors) along with immunotherapy drugs (pembrolizumab or avelumab) to help the immune system attack cancer throughout the body. Nine partici…

This study tested a drug called denosumab in 55 people with multiple myeloma who also have kidney problems. The goal was to see if it could help control bone damage caused by the disease. Participants received denosumab and were monitored for changes in bone health and side effec…

This study tested a precise type of radiation called proton beam therapy to treat liver tumors that have spread from other cancers. 92 adults with 1 to 4 liver metastases received targeted radiation. The goal was to stop tumor growth and reduce side effects compared to standard r…

This study tested a combination of two drugs, olaparib and temozolomide, in adults with Ewing sarcoma or rhabdomyosarcoma that came back or spread after standard chemotherapy. The main goal was to find the safest dose and check for side effects. 49 people took part. This is an ea…

This early-phase study tested the safety of adding nilotinib, a drug that targets a specific growth signal in chordoma cells, to standard radiation therapy for people with high-risk chordoma. The goal was to find the highest safe dose of nilotinib when given with radiation. A tot…

This study tested the drug pembrolizumab in 21 people with recurrent respiratory papillomatosis (RRP), a rare condition where HPV causes non-cancerous growths in the throat, windpipe, or lungs. The goal was to see if the drug could shrink these growths and reduce the need for fre…

This study tested a drug called tesamorelin, which mimics a hormone that boosts growth hormone levels, in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The goal was to see if it could lower liver fat and improve liver inflammation and scarring. Participants recei…

This study tested a new radiation schedule (once a week for 5 weeks) in 10 people with B-cell lymphoma that had come back or not responded to treatment, given right before they received CAR T-cell therapy. The goal was to see if this approach made radiation easier to manage, redu…

This early-phase study tested the drug regorafenib in 16 adults with advanced blood cancers like acute myeloid leukemia (AML) that had not responded to prior treatments. The main goal was to find the safest dose and see how the drug affects cancer-related cell signals. While not …

This study tested the drug ivosidenib in 18 adults with IDH1-mutant blood cancers (like AML) who had a stem cell transplant. The goal was to find the safest dose and see if it could help prevent the cancer from coming back. Participants took the drug daily for 28-day cycles, star…

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) for older adults from minority groups who have depression, anxiety, and some physical limitations. The program combined mental health support with exercise to prevent disability. 427 participants to…

This study tested a program to help HIV-positive men who have sex with men (MSM) who also struggle with substance use and feel stigmatized. The goal was to see if the program was acceptable and feasible for improving engagement in HIV care. Fifty participants took part in a pilot…

This study tested two drugs, bortezomib and lenalidomide, in 22 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a stem cell transplant. The goal was to find the safest dose and see if the combination could reduce cancer cells. The appro…

This early-phase study tested whether a high-dose vitamin D medication (calcitriol) alone could improve blood phosphate levels and bone health in 16 children and adults with X-linked hypophosphatemia (XLH), a genetic condition causing weak bones and poor growth. Participants took…

This study tested whether denosumab, a drug used for osteoporosis, can improve bone density in women with anorexia nervosa. Thirty women with low bone mass received either denosumab or a placebo for 12 months. The goal was to see if the drug could strengthen bones and reduce bone…

This early study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or early memory problems. The goal was to see if the drug could reach the brain and lower inflammation. Participants took the drug for 24 weeks, and researchers measured inflammatory markers …

This study looked at whether giving a special research e-cigarette to people who are stable on medication for opioid use disorder and smoke daily could help them smoke fewer regular cigarettes. 41 adults who were not ready to quit smoking were randomly assigned to get the e-cigar…

This study tested a newer, more precise type of proton radiation (pencil beam scanning) combined with standard chemotherapy for anal cancer. The goal was to see if this approach is practical and can reduce side effects by better targeting the tumor and sparing healthy tissue. 25 …

This study tested whether a newer blood thinner (rivaroxaban) is safer and more cost-effective than the standard drug warfarin for patients who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart procedures like bypass or valve repair took part. T…

This study looked at combining a chemotherapy pill (TAS-102) with targeted radiation to treat colorectal cancer that has spread to the liver. It involved 52 adults with 1 to 4 liver tumors. The goal was to find the safest dose and see how well the combination controls tumor growt…

This early-phase study tested whether combining an oral drug (decitabine) with an immunotherapy (durvalumab) could help patients with advanced head and neck cancer whose disease had worsened after standard immunotherapy. The study involved 13 adults and focused on safety and chan…

This study tested a combined bone marrow and kidney transplant from a partially matched family donor for people with both a serious blood disorder and chronic kidney disease. The goal was to treat both conditions with one procedure and possibly reduce the need for lifelong anti-r…

This study tested a combination of four chemotherapy drugs (FOLFIRINOX) plus radiation before surgery in 25 people with gastroesophageal junction cancer. The goal was to see if patients could complete the full treatment plan. The study also tracked side effects and how well the c…

This study tested whether adding lenalidomide to a standard chemotherapy regimen (MEC) could help adults with acute myeloid leukemia (AML) that either did not respond to initial treatment or came back after treatment. The trial enrolled 41 people aged 18 to 70. The main goal was …

This study tested whether blocking a hormone called aldosterone and boosting another called BNP can reduce early heart damage in people with HIV. 39 adults with well-controlled HIV and signs of early heart strain took part. The goal was to see if this approach could lower inflamm…

This small pilot study looked at whether giving free e-cigarettes to smokers who hadn't quit after lung cancer screening could help them smoke fewer regular cigarettes. Fifteen people who still smoked were offered e-cigarettes for 4 weeks and then followed for another 4 weeks. Th…

This study tested whether offering financial rewards helps homeless smokers quit. 184 adults who were currently or formerly homeless received smoking coaching, a prescription for a quit-smoking drug, and some also got cash rewards for staying smoke-free. Researchers checked if th…

This study tested a combination of two immunotherapy drugs, ipilimumab and nivolumab, in 18 adults with leptomeningeal metastases—cancer that has spread to the fluid and lining around the brain and spinal cord. The main goal was to see how long participants lived and what side ef…

This study tested different ways to deliver HIV treatment to people in South Africa who had a detectable viral load or were not engaged in care. The goal was to see which approach helped the most people achieve viral suppression at 18 months. The study enrolled 874 adults and com…

This study tested whether giving a heart medication (amiodarone) before surgery plus a small surgical cut in the heart lining can prevent a common irregular heartbeat after heart surgery. About 242 adults having bypass surgery took part. The goal was to see if this combo reduces …

This study looked at whether a dedicated clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure, including those with reduced or preserved pumping function, took part. The goal was to see if the clin…

This study tested whether the drug ritlecitinib can protect people with celiac disease from gut damage and symptoms when they eat gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. T…

This pilot study tested whether ibutamoren, a drug that boosts growth hormone, can reduce fat buildup in the liver of people with nonalcoholic fatty liver disease (NAFLD). Twelve generally healthy adults with NAFLD took the drug for 6 months. Researchers measured changes in liver…

This study tested the drug enasidenib as a maintenance therapy after stem cell transplant in 23 people with IDH2-mutant acute myeloid leukemia or chronic myelomonocytic leukemia. The goal was to find the safest dose and see if it could help prevent the cancer from coming back. Pa…

This study looked at two different at-home tests for colorectal cancer screening—FIT and Cologuard—in community health centers. Over 5,000 people aged 45-75 who were overdue for screening were mailed a test to complete at home and return. The goal was to see which test more peopl…

This study tested two culturally adapted HIV prevention programs for African-born women living in the US. One program was one-on-one, the other was group-based. The goal was to see which approach better increased condom use and PrEP uptake. 149 HIV-negative women from the Boston …

This study tested whether the drug denosumab can prevent the rapid bone loss that often happens after weight-loss surgery (gastric bypass or sleeve gastrectomy). The study included 36 postmenopausal women and men aged 50 or older who were planning to have surgery. Participants re…

This small early-phase study tested whether losartan, a common blood pressure medication, could prevent early signs of heart damage caused by radiation therapy in breast cancer patients. Five women with left-sided breast cancer who were scheduled for standard radiation took losar…

This study tested three fall prevention strategies in a hospital: a computer alert that predicts fall risk, a camera system that lets nurses see patients, or both together. Over 5,000 adult patients and their nurses took part. The goal was to see if these tools reduce falls and i…

This study tested a program to prevent obesity in mothers and their children from pregnancy through age 2. It involved over 1,600 families at community health centers in Boston, focusing on healthy eating, physical activity, sleep, and addressing social needs. The goal was to red…

This study tested whether giving nitric oxide during heart surgery can prevent acute kidney injury in patients with signs of blood vessel problems. 250 adults having long heart surgeries took part. The goal was to see if this treatment could reduce kidney damage after the procedu…

This study tested whether helping fathers get involved during pregnancy and the first year of life can prevent rapid weight gain and obesity in babies. Over 650 families from diverse backgrounds took part. The program provided extra support to parents, focusing on healthy eating,…

This study tested whether giving a decision support tool to adults aged 45-75 before their primary care visit helps them complete colorectal cancer screening. Over 9,200 average-risk participants were involved. The tool was part of a routine pre-visit questionnaire and aimed to h…

This study tested a computer-based program that combines mental and physical exercises for people with mild cognitive impairment (MCI), a condition that can lead to dementia. The program aimed to improve thinking and memory. Researchers enrolled 32 adults and measured how many co…

This study tested a special counseling program for people living with HIV who want to quit smoking. The program focused on reducing anxiety and depression to make it easier to stop smoking. 131 smokers with HIV took part, and researchers checked if they were still smoke-free one …

This study tested whether cognitive-behavioral therapy (CBT) can help children and teens aged 10-18 with avoidant/restrictive food intake disorder (ARFID), a condition where fear or lack of interest limits eating. Participants received either CBT or nutrition counseling. The stud…

This study tested a therapy program for children ages 4 to 7 who were at risk for anxiety disorders. The program included parent-only and parent-child sessions. Researchers compared children who received the therapy to those on a waitlist. The goal was to see if the therapy could…

This study tested two stress and symptom management programs delivered via live video for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The goal was to see if these programs could improve quality of life and emotional well-being. 228 participants completed the tri…

This study tested whether regular video chats and supportive texts from a trained peer mentor could help reduce depression in older adults, especially those with low income or from ethnic minority backgrounds. 34 participants aged 50 and older with mild to moderate depression too…

This study tested atomoxetine, a medication used for ADHD, in 60 children with autism who also had significant hyperactivity or inattention. The goal was to see if the drug could reduce these symptoms. The trial was double-blind and placebo-controlled, meaning neither the familie…

This study tested a new program to help people with cystic fibrosis (CF) feel better day-to-day. The program included regular check-ins on symptoms and quality of life, plus guides for doctors on how to manage common problems. Over 600 patients at 5 CF centers took part, and rese…

This study tested whether a non-invasive brain stimulation technique called TMS could improve language in 10 people with primary progressive aphasia (PPA), a rare dementia that slowly destroys the ability to speak. Participants received daily TMS sessions for two weeks, and resea…

This study tested different doses of light therapy to find the best way to improve sleep in people with Parkinson's disease. 203 participants received either bright-white or dim-red light at different times of day. The goal was to see which dose worked best for sleep and fatigue.

This study compared two surgical methods for trigger finger release: the standard open surgery and a newer ultrasound-guided technique. Sixty adults who needed surgery for a trigger finger were followed to see which approach led to better daily function and less pain early after …

This study looked at whether a psychological treatment can help adults with obsessive-compulsive disorder, generalized anxiety disorder, or major depressive disorder who struggle with repetitive negative thinking. The treatment focused on improving attention and cognitive control…

This study looked at whether adding medical marijuana to a 24-week support program helps adults with long-term non-cancer pain lower their opioid dose and feel less pain. 87 people on stable, high-dose opioids took part. Researchers tracked changes in opioid use and pain levels o…

This pilot study at Massachusetts General Hospital tested whether cognitive behavioral therapy (CBT) can reduce symptoms of gastroparesis, a condition where the stomach empties slowly, causing nausea, vomiting, and pain. Twenty-seven adults with idiopathic gastroparesis received …

This study tested a psychological support program for caregivers of people undergoing stem cell transplants for cancer. 100 adult caregivers took part. The program aimed to improve their quality of life and mood by teaching coping skills.

This study tested a smartphone-based breathing exercise called heart rate variability biofeedback (HRVB) in 120 adults with substance use disorder who were in their first year of recovery. Participants practiced slow, rhythmic breathing for 15 minutes daily using an app, aiming t…

This study tested whether a 12-week cognitive behavioral therapy (CBT) group program is practical and well-liked by older adults with HIV. Fifty participants aged 50+ with well-controlled HIV took part. The goal was to see if the program helps reduce stress and improve healthy ha…

This study tested a program that combines mind-body skills (like deep breathing) with a Fitbit to help people with chronic pain. 82 adults took part to see if the program was acceptable and helpful. The goal was to improve both physical and emotional well-being.

This study tested whether a special type of hot yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 healthy adults were randomly assigned to either take yoga classes twice a week for 8 weeks or join a waitlist. The goal was to see if the yoga was accep…

This study tested a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce chronic low back pain. 70 adults with long-term back pain tried the treatment. The goal was to find a new way to manage pain without relying on strong painkillers.

This study tested whether a non-invasive brain stimulation technique called TMS can reduce symptoms of obsessive-compulsive disorder (OCD). 26 adults with OCD received either real or sham TMS over a brain area linked to movement planning. Researchers measured symptom changes and …

This study tested a program that combines positive psychology and motivational interviewing to help people become more physically active after bariatric surgery. Twelve adults who had surgery 6-12 months earlier and wanted to move more took part. The goal was to see if the progra…

This study looked at whether adding a palliative care team to standard cancer care improves quality of life, mood, and symptoms for people with acute myeloid leukemia (AML). Researchers enrolled 160 hospitalized adults with high-risk AML. Participants were randomly assigned to re…

This study tested whether strengthening a small thumb muscle (the first dorsal interosseous) can help people with thumb osteoarthritis. 160 adults who already used a thumb splint were enrolled. Researchers measured changes in pinch strength and pain after 12 weeks of the exercise…

This early-phase study tested whether cooling the skin before or during treatment can reduce pain for people with neurofibromatosis type 1 (NF1) who have small skin tumors. Thirteen adults received four different treatments (laser, radiofrequency, or injections) on both a cooled …

This study tested whether learning three simple skills to manage negative emotions, plus getting smartphone reminders to practice them, could reduce suicidal thoughts and emotional distress. 41 adults with recent suicidal thoughts or a suicide attempt took part. Researchers measu…

This study tested a new program called MASC for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and skills to handle challenging behaviors. 13 caregivers took part to see if the program was easy to use and helpful. The…

This study tested a mind-body resiliency group program for parents of children with learning or attention difficulties. About 28 parents took part in virtual group sessions to learn stress management skills. The goal was to see if the program was feasible and acceptable for careg…

This study tested whether a smartphone app (Healthy Minds Program) could help reduce stress in people caring for a loved one with dementia. 93 stressed caregivers used either the meditation app or a wellness podcast app for comparison. The goal was to see if the app was easy to u…

This study tested a light-based therapy called transcranial photobiomodulation (tPBM) in 38 children and teens with ADHD who also had autism traits. The goal was to see if it could safely improve social and attention symptoms. Results measured changes in ADHD and social behavior …

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could improve emotion regulation in people with bipolar disorder. Nineteen adults with bipolar I disorder who were in a stable mood participated. The st…

This pilot study tested a program called PROWESS that uses wearable fitness trackers and coaching to help Black and Hispanic men with prostate cancer exercise more. The goal was to reduce side effects from hormone therapy and improve quality of life. Fourteen men participated, an…

This study looked at whether providing overnight infant care (respite) can help new mothers with substance use disorder get better sleep and feel better. 41 mothers living in residential treatment programs took part. The goal was to see if this approach is practical and acceptabl…

This study tested two ways to improve burn scars: a laser and a small tool that removes a bit of scar tissue (punch biopsy). Seventeen adults with burn scars each had three small areas treated differently—laser, punch, or nothing—to compare results. The goal was to see which meth…

This study tested a nurse-led program to help adults with cancer who are taking part in early-phase clinical trials feel better day-to-day. The program included regular check-ins on symptoms and well-being, plus team meetings to address concerns. Researchers wanted to see if the …

This study tested a new 3-session mind-body pain management program called PACE CF for adults with cystic fibrosis (CF). The program was delivered via telehealth by a CF care team member. The goal was to see if the program was acceptable and helpful for managing pain and its impa…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve depression in people whose depression hasn't improved with standard antidepressants. 14 adults with treatment-resistant depression were randomly given either omega-3 or a placebo for 12 weeks. Re…

This study tested a new program called MASC (Mindful and Self-Compassionate Care Program) to help caregivers of people with Alzheimer's or related dementias manage stress. 82 caregivers took part in a pilot study to see if the program was feasible and helpful. The program teaches…

This study tested a new way to help people with long-term low back pain. It combined virtual reality (VR) with guided imagery of acupuncture, without using real needles. 31 adults with chronic pain tried it. The goal was to see if people would stick with the treatment, how satisf…

This study tested a new, non-invasive treatment called transcranial photobiomodulation (tPBM) for adults with autism spectrum disorder. Over 8 weeks, 41 participants received either the light therapy or a placebo to see if it was safe and could improve social and behavioral sympt…

This study tested two natural supplement combinations—omega-3 plus inositol versus N-acetylcysteine (NAC)—to see if they could help children and teens (ages 5-17) with emotional ups and downs. Over 6 weeks, 27 participants took one of the two treatments. The goal was to find a ge…

This study tested a program called CONTINUUM for people with advanced cancer leaving the hospital. Within three days of going home, patients had a video visit with a specialized nurse to support their transition. The goal was to see if this extra support helps patients feel more …

This study tested a mind-body program called 'Recovering Together after Cardiac Arrest' for survivors and their caregivers. The goal was to see if the program was feasible and helpful for reducing emotional distress. 14 survivor-caregiver pairs participated in a mix of in-person …

This study tested a non-invasive brain stimulation method called tACS in 17 people with early to moderate Alzheimer's. The goal was to see if daily sessions over 2-4 weeks could safely reduce amyloid and tau buildup in the brain and improve memory and thinking. Participants recei…

This study tested whether a package of extra support—including a smart sleep bassinet, wearable breast pump, 24/7 online perinatal care, and a faculty mentor—could improve wellbeing and reduce burnout in pregnant trainee doctors. 156 pregnant residents and fellows from four hospi…

This small pilot study tested a mindfulness-based therapy adapted for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nine…

This study looked at 20 adults with short bowel syndrome who receive nutrition through a tube at home. Researchers compared giving the nutrition during the day versus at night to see if it improved sleep quality and blood sugar levels. The goal was to find a simple change that co…

This small pilot study tested a mindfulness-based therapy adapted for older Black adults (age 50+) who have both chronic pain and depression. The goal was to see if this approach could improve quality of life and reduce pain interference. The study enrolled 12 participants and me…

This small pilot study tested a new mind-body program to help female colorectal and anal cancer survivors improve their sexual well-being. Six women who had finished initial cancer treatment took part in group sessions. The goal was to see if the program was acceptable and helpfu…

This study tested a program to help stem cell transplant survivors who have sexual problems. About 230 adults who had a transplant at least three months earlier took part. The program aimed to improve sexual function, quality of life, and mood. Results were measured using patient…

This study tested a program that helps advanced cancer patients recover at home after a hospital stay. The program uses remote monitoring of symptoms, vital signs, and weight, along with home visits and nurse calls to manage any issues. The goal was to see if this approach is pra…

This study looked at whether a virtual mind-body program called SMART-3RP can help caregivers of cancer survivors feel more resilient and less distressed. About 94 people (cancer survivors and their caregivers) took part. The program was compared to an online support group to see…

This study tested a smartphone app called SiS-H designed to help people with HIV quit smoking. 66 participants used either SiS-H or the standard QuitGuide app for 8 weeks. The goal was to see if the new app is easy to use and helps people smoke less.

This study tested a short, web-based program for parents of children with anxiety who are waiting for cognitive behavioral therapy (CBT). The program aims to reduce how much parents accommodate their child's anxiety, which can make anxiety worse. 47 parents of children aged 5-12 …

This study tested a short, nurse-led program to help breast cancer survivors who were hesitant or delayed in starting hormone therapy. The program aimed to support patients in making informed decisions. The study enrolled 35 women and measured how feasible and acceptable the prog…

This study tested whether a mind-body walking program is practical and helpful for adults with long-term muscle or bone pain. About 92 people took part, comparing the walking program to a health education class. The goal was to see if people would join, stick with it, and find it…

This study looked at how a nerve stimulation device (like a gentle zap on the neck) combined with stress-reduction training affects the brains of people with migraine. Researchers compared brain scans and inflammation levels in 193 adults with migraine and healthy volunteers. The…

This study tested a stress management and resilience-building program for nurses who care for people with HIV in South Africa's public clinics. The program taught coping skills through group sessions. Researchers wanted to see if nurses found the program helpful and practical, an…

This study followed 10 people with late onset Tay-Sachs or Sandhoff disease for six months. Researchers measured changes in movement, coordination, and brain chemistry to better understand how the disease progresses. The goal was to gather information that will help design future…

This study explored whether offering sexual health services like PrEP, STI testing, and birth control in hair salons would be used by women in Umlazi, South Africa. About 436 women took part, with some salons offering services and one serving as a comparison. The goal was to see …

This study tested whether adding a gentle brain-stimulation technique (tDCS) to acupuncture can improve chronic low back pain. 116 adults with long-term back pain received one month of either real or fake acupuncture combined with real or fake brain stimulation. Researchers used …

This study looked at how playing sounds during sleep affects brain waves and memory in children with Rolandic epilepsy. Researchers used brain scans and memory tasks to understand the condition better. The goal was to find new treatment ideas, not to test a cure or therapy.

This pilot study looked at whether the BCG vaccine (used for tuberculosis) changes certain markers in the blood and spinal fluid of healthy older adults. Twenty participants aged 55-80 received the vaccine, and researchers measured immune responses and Alzheimer's-related protein…

This study tested a new computer app designed to help anesthesia clinicians manage medications during surgery. Forty clinicians used either the new app or the standard method in a simulated operating room with a manikin. The goal was to see if the app made tasks faster and easier…

This study tested whether a rapid 30-minute test for gonorrhea and chlamydia helps doctors make better treatment decisions compared to the current standard test. About 100 adults with symptoms of urethritis or cervicitis took part. The goal was to see if the rapid test reduces un…

This study looked at how surgery might cause thinking and memory problems in people with obstructive sleep apnea. Researchers used brain scans and memory tests before and after surgery to track changes. The goal was to understand the mechanisms behind these problems, not to test …

This study looked at whether analyzing social media messages (like WhatsApp and Instagram) can help identify young women at risk for HIV. Researchers studied 400 women aged 18-24 in Kisumu, Kenya, using AI to examine their online conversations. The goal was to see if this approac…

This study looked at whether a blood test can predict how prostate cancer responds to the drug abiraterone. Researchers collected blood samples from 40 men with advanced prostate cancer before and during treatment. They measured tumor cells in the blood to see if changes in these…

This study tested two different brain health programs in 60 older adults who had memory concerns and lifestyle risks for dementia. The goal was to see if the programs were believable, useful, and easy to stick with. No treatment was given; instead, the researchers measured how we…

This study looked at how different electrical stimulation settings affect abnormal brain activity in people with epilepsy that doesn't respond to medication. Researchers tested settings from animal studies against those used in standard care. The goal was to find which settings b…

This study developed a new questionnaire called the Down Syndrome Health Instrument (DHI) to measure health in people with Down syndrome. Researchers worked with caregivers, individuals with Down syndrome, and doctors to create and test the tool. Over 750 caregivers participated …

This study looked at whether adding a special care model (GRACE) to regular annual wellness visits helps older adults with complex health needs. Researchers worked with 110 people aged 65 and older to see if this approach is practical and could reduce hospital stays. The goal was…

This study looked at whether having a dermatologist (skin doctor) see patients admitted to the hospital for cellulitis (a skin infection) within 24 hours could improve their care. About 246 adults took part, with some getting a dermatology consult and others receiving standard ca…

This study combined data from over 1,700 patients who had a heart attack or unstable angina to find what predicts plaque erosion—a common cause of heart attacks. Researchers looked at imaging and health records from multiple international sites. The goal was to better understand …

This study used brain imaging to understand how a low dose of the sedative dexmedetomidine relieves pain. Seventeen healthy adults between 18 and 45 years old took part. The goal was to see changes in brain fluid flow linked to pain relief, not to test a new treatment.

This study followed 344 infants who have a sibling with autism from birth to age 3. Researchers collected blood, stool, urine, and saliva samples to find early biological signs that might predict autism. The goal is to better understand what causes autism and eventually help with…

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—causes worry or increases the risk of lymphedema (arm swelling) in these patients. The study tracke…

This study looked at how the skin heals after taking many very small skin samples (micro-biopsies). The goal is to reduce pain, infection, and scarring from standard skin grafts used for burns or large wounds. Eight healthy adults having tummy tuck surgery took part, and research…

This study tested whether a gentle electrical current applied to the scalp (transcranial electrical stimulation) can improve performance on a challenging computer task that simulates docking a spacecraft. 44 healthy adults with advanced degrees completed the task while receiving …

This study tested whether playing quiet sounds during a nap can change brain activity and improve memory. 30 healthy adults took part. Researchers measured brain waves and memory before and after the nap to see if the sounds made a difference.

This study looked at how video-guided acupuncture imagery treatment (VGAIT) changes brain activity in people with knee osteoarthritis. Researchers used brain scans to compare real acupuncture, sham acupuncture, and imagery-based treatment in 125 adults aged 40-70. The goal was to…

This study tested a before-school physical activity program called BOKS in three schools. About 188 children aged 5 to 14 took part. Researchers measured changes in body mass index, thinking skills, and quality of life to see if the program helped.

This study looked at whether a non-invasive brain stimulation technique called TMS can improve emotion regulation in people with bipolar disorder. Researchers used brain scans and special tasks to measure how the brain handles emotional distractions. The goal was to understand th…

This study looked at how a gentle brain stimulation technique called tDCS affects the way people with OCD learn to stop being afraid. Researchers measured skin responses and brain waves in 86 participants to see if stimulation helped them "unlearn" fear. The goal was to gather kn…

This study looked at how inherited genes influence the way people respond to two common diabetes medications, metformin and glipizide. Over 1,000 adults at risk for or with type 2 diabetes took part. Researchers measured blood sugar and insulin levels after taking the drugs to se…

This study tested a new way of caring for young adults (ages 18-30) with type 1 or type 2 diabetes as they move from pediatric to adult diabetes clinics. 45 participants were split into two groups: one received the new collaborative care model, the other received usual care. Rese…

This study tested whether a mild electrical current applied to the scalp (tDCS) could temporarily change how the brain handles attention and impulse control in adults with ADHD compared to healthy people. 83 volunteers completed tasks measuring focus and decision-making during th…

This study aimed to find better ways to predict if cancer is getting worse in people with advanced colorectal, pancreatic, bile duct, or stomach cancers. Researchers tracked 159 patients starting new cancer therapy, collecting blood samples and patient surveys over time. The goal…

This study looked at how a low dose of ketamine, a medicine often used for anesthesia, affects breathing and brain activity in 15 critically ill patients who were on breathing machines (ventilators) in the ICU. The goal was to see if ketamine could help stimulate breathing and im…

This study looked at why some people with depression feel better after taking a placebo (a pill with no active medicine). Researchers studied 76 adults to find brain and body markers that predict who will respond to placebos. The goal is to improve future depression treatments an…

This study tested a special camera that uses near-infrared light to help surgeons see blood flow during minimally invasive lung and esophagus surgery. 38 adults took part at Massachusetts General Hospital. The goal was to see if the camera could clearly show which parts of the ti…

This study followed 13 HIV-positive people who agreed to receive a solid organ transplant (like a kidney or liver) from a deceased HIV-positive donor. Researchers tracked their survival, organ rejection, and HIV progression to see if this practice is safe and effective. The goal …

This study used brain imaging techniques like MEG, EEG, and MRI to explore how the brains of people with autism spectrum disorder process sensory information. 85 participants aged 14 to 32 took part. The goal was to better understand the neural basis of autism, not to test a trea…

This study looked at whether firefighters have different lung scan results than non-firefighters. It involved 734 current and retired firefighters. Researchers used low-dose CT scans and a blood test to better understand lung cancer risk and find early warning signs.

This study looked at how blood sugar levels affect sleep in adults with cystic fibrosis-related diabetes (CFRD). Thirty participants wore glucose monitors and sleep trackers at home for 10 days. The goal was to see if this type of remote monitoring is practical and to gather data…

This study looked at whether a program to improve physical fitness, nutrition, and sleep before surgery is possible for older adults (65+) with esophageal cancer. Fifteen people took part after finishing chemotherapy or radiation. The goal was to see if patients would join and st…

This study tested a new program called 'HBPC Dementia Care Quality at Home' for people with dementia and their caregivers who receive home-based primary care. The goal was to see if the program was practical and helpful for both caregivers and clinic staff. Researchers worked wit…

This study tested a 4-session program designed to teach resiliency skills to medical interpreters who work in cancer care. 28 interpreters from three hospitals took part. The goal was to see if the program was practical and helpful for reducing stress and building resilience.

This study followed 155 children with brain or central nervous system tumors who received proton beam radiation therapy. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment. The goal was to understand h…

This study looked at how a gentle nerve stimulation device (tVNS) affects brain stress circuits in people with major depression. Researchers tested 62 adults, comparing active stimulation to a sham (fake) version during brain scans. The goal was to see if the effects differ betwe…

This study looked at how a hormone called kisspeptin changes the body's response to sugar. Sixteen healthy adults received kisspeptin or a placebo and then drank a sugary solution. Researchers measured insulin and blood sugar levels to understand kisspeptin's effect on metabolism…

This study tested a communication program for adults undergoing fecal ostomy surgery. Researchers worked with 25 patients and 4 clinicians to see if the tool was easy to use and helpful. Participants filled out surveys at the start and four weeks later. The goal was to improve su…

This study tested whether shining a special near-infrared light on the head (called transcranial photobiomodulation) can improve thinking, memory, and mood in healthy adults. Researchers enrolled 80 volunteers aged 18-25 or 65-85. Participants received either the light treatment …

This study tested whether a special PET/CT scan can measure inflammation in deep vein thrombosis (DVT) and predict who will develop post-thrombotic syndrome (PTS), a chronic condition causing leg pain, swelling, and ulcers. Researchers followed 51 patients for up to 2 years after…

This study tested a new type of microscope called Spectrally Encoded Confocal Microscopy (SECM) to see if it can take clear images of pigmented skin spots like moles. Sixteen healthy adults with moles on their forearms had their skin scanned. The goal was simply to check image qu…

This study tested a simple, inexpensive device called the Augmented Infant Resuscitator (AIR) that attaches to standard breathing equipment for newborns. The device gives real-time feedback to birth attendants on their ventilation technique, aiming to improve their skills and con…

This study created a database of 40 volunteers, including both healthy individuals and those with autism spectrum disorder (ages 14-32). The goal was to make it easier to recruit participants for future research on autism and other developmental disorders. No treatment was given;…

This study tested a 10-week program that combines positive psychology and motivational interviewing to help people increase physical activity after bariatric surgery. 58 adults who had surgery 6-12 months earlier and wanted to be more active took part. The program was found to be…

This study tested whether women with different types of gestational diabetes respond differently to meals with varying amounts of carbs, protein, and fat. Nineteen pregnant women with gestational diabetes wore a continuous glucose monitor and ate two different test meals. The goa…

This study tested whether a full-scale trial is possible for a new approach to manage recurrent pain in children with severe neurologic impairment. 54 children and their parents participated, with some receiving the PQ-ResPOND intervention (a web-based survey system plus a pallia…

This study looked at how deep brain stimulation (DBS) influences the way people approach or avoid difficult decisions. Researchers tested 13 adults with DBS implants for severe depression or OCD, plus epilepsy patients with temporary brain electrodes. Participants played a comput…

This study tested a smartphone app that gives people real-time reminders to use their safety plan and coping strategies when they report having suicidal thoughts. 103 adults who were hospitalized for suicidal thoughts or behaviors took part. The goal was to see if the app was eas…

This study looked at how the brains of fibromyalgia patients and their acupuncturists work together during treatment. Using special brain scans, researchers measured if matching brain activity leads to better pain relief. The goal was to understand the connection, not to test a n…

This study looked at whether the COVID-19 vaccine triggers a strong immune response in people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose in 146 participants. The goal was to understand vaccin…