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Can magnetic pulses to the brain boost speech in aphasia?

NCT ID NCT04188067

Completed Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether repeated sessions of transcranial magnetic stimulation (TMS) could improve language in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Ten participants received both real and sham (fake) TMS over ten days. Researchers measured changes in naming ability and brain connectivity to see if the stimulation helped.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a non-invasive treatment to temporarily improve language in people with primary progressive aphasia.
What could go wrong
This is a very small, early study with only 10 people. Benefits may be short-lived or not work for everyone. The condition is progressive, so any improvement may not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

logopenic progressive aphasia progressive non-fluent aphasia semantic dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOGOPENIC VARIANT PRIMARY PROGRESSIVE APHASIA NON-FLUENT VARIANT PRIMARY PROGRESSIVE APHASIA SEMANTIC VARIANT PRIMARY PROGRESSIVE APHASIA

Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02129, United States

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