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Scientists map Brain's 'Roads' to predict dementia spread

NCT ID NCT07567664

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 years. The goal is to create models that predict how and where brain damage will progress, which could improve early diagnosis and monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to better prediction of how neurodegenerative diseases progress, helping doctors plan care earlier.

What could go wrong

This is an observational study, not a treatment trial. It may not directly benefit participants, and the models may not accurately predict individual outcomes.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis behavioral variant of frontotemporal dementia corticobasal syndrome frontotemporal dementia neurodegenerative disease primary progressive aphasia progressive non-fluent aphasia progressive supranuclear palsy semantic dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS (ALS) BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA (BVFTD) CORTICAL BASAL SYNDROME (CBS) NEURODEGENERATIVE DISEASE PRIMARY PROGRESSIVE APHASIA(PPA) PROGRESSIVE SUPRANUCLEAR PALSY(PSP)

Contacts and locations

Locations

  • IRCCS San Raffaele

    Milan, Lombardy, 20132, Italy