Can filtering the blood slow ALS in people with a troubling antibody?
NCT ID NCT07726563
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
About 10-20% of people with ALS have a specific antibody (anti-NRIP) in their blood that is linked to faster disease progression. This trial tests whether removing that antibody through plasmapheresis — a procedure that filters the blood — can slow the decline. Twenty participants will receive three rounds of plasmapheresis, each three months apart, and be followed for an additional six months to measure changes in motor function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- plasmapheresis (blood filtering) to remove anti-NRIP autoantibodies
- What this could lead to
- If it works, this could point toward a personalized treatment for a subset of ALS patients who carry a specific autoantibody linked to faster decline.
- What could go wrong
- This is a very small, early-stage trial with no control group, so results may not be conclusive. Plasmapheresis carries risks such as infection, bleeding, and allergic reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Taiwan University Hospital
RECRUITINGTaipei City, Taipei, 100, Taiwan
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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