AMYOTROPHIC LATERAL SCLEROSIS (ALS)

This trial tests an experimental drug called NB-4746 in 80 people with ALS. The study has two parts: first, a short safety check with low or high doses, then a longer 12-week comparison against a placebo. Researchers will monitor side effects, how the drug moves through the body,…

This early-stage study tests whether transplanting healthy gut bacteria can help people with rapidly progressing ALS. Twenty adults with ALS will receive the transplant after antibiotics and a bowel prep. Researchers will track changes in muscle function, quality of life, and ner…

This study tests whether PHENOGENE-1A (cromolyn) can help people with mild to moderate ALS when added to their usual care. About 105 participants will receive either the drug or a placebo twice daily for 24 weeks. Researchers will measure changes in muscle function, breathing, an…

This study tests an experimental drug called COYA 302 in 120 adults with ALS. The treatment combines two substances to calm the immune system and reduce nerve damage. Participants will receive either the drug or a placebo for 24 weeks, and may continue on the drug for another 24 …

This early-stage study tests a new treatment made from stem cells that may help replace damaged nerve cells in people with ALS. The main goal is to check if the treatment is safe and tolerable for 12 adults aged 18-75 with definite or probable ALS. Participants will receive injec…

This study tests whether a daily breathing exercise using a device called the LIC Trainer can help people with ALS keep their lungs stronger longer. Fifteen adults with ALS will use the device twice a day at home and visit the clinic every three months for checkups. Researchers h…

This study tests an experimental drug called ALN-SOD in people with ALS caused by a specific gene change (SOD1 mutation). The main goal is to check safety and how well the drug is tolerated. Researchers will also measure biomarkers and drug levels in blood and spinal fluid. About…

This early study tests a brain implant in 5 adults with severe paralysis (from spinal cord injury, ALS, or similar conditions). The goal is to see if the device is safe and can help users control assistive devices like computers or wheelchairs. The implant records brain signals a…

This study tests whether a new treatment using a person's own regulatory T cells (Tregs) is safe for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Twelve adults aged 18 to 70 with ALS will receive the cell infusion and be monitored for side effects…

This small study tests whether a single 30-minute session of non-invasive electrical stimulation on the face can reduce jaw and facial pain, improve jaw movement, and make chewing easier for people with ALS or PLS. Ten participants will receive the treatment during one clinic vis…

This study is an online registry for people with ALS, MND, or PLS. Participants report their symptoms, diet, supplements, and therapies each month. Researchers will look for patterns to see which approaches are linked to better outcomes. No new treatments are tested; the goal is …

This study tests a new PET imaging tracer to measure levels of a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan healthy volunteers and patients to see if…

This study is creating a large collection of information and biological samples from people with various neurodegenerative diseases like Alzheimer's, ALS, and Parkinson's. Researchers will track changes in thinking, language, and brain imaging over time. The goal is to better und…

This study looks at how speaking with a caregiver affects the speech of people with ALS. Researchers will record participants reading words and sentences during conversations with their caregivers. The goal is to understand how communication changes over time, which may help impr…

This study aims to find early markers for ALS, a nerve disease that weakens muscles. Researchers will compare blood, tears, urine, and spinal fluid from 60 people—including those with ALS gene mutations but no symptoms, early ALS patients, and healthy controls. The goal is to dev…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study aims to find better ways to detect and track ALS early by studying nerve tissue and blood from 400 people with ALS or related nerve conditions. Researchers will use advanced techniques to identify molecular changes that happen before symptoms worsen. The goal is to dis…