Could a poop pill slow ALS? small trial launches

NCT ID NCT07017946

Recruiting now Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This pilot trial tests whether transplanting gut bacteria from healthy donors (MTP-101C) is safe and can help slow ALS. Twenty people with fast-progressing ALS will receive the treatment after a bowel cleanse. Researchers will track changes in muscle function, quality of life, and nerve damage markers over 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MTP-101C (freeze-dried fecal microbiota from healthy donors)
What this could lead to: If it works, this could point toward a new way to slow ALS progression by restoring gut health.
What could go wrong: This is a very small, early-phase pilot trial with only 20 people. It is designed mainly to test safety, not to prove effectiveness. The treatment involves a bowel prep and antibiotic conditioning, which may cause discomfort or side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS (ALS)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27705, United States

Contact Email: •••••@•••••

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