Duke University

This study tests whether transplanting healthy gut bacteria can help people with rapidly progressing ALS. Twenty adults with ALS will receive the transplant after a short course of antibiotics and bowel prep. Researchers will track changes in muscle function, quality of life, and…

This study tests whether adding the drug selinexor to standard bispecific antibody therapy can improve outcomes for people with multiple myeloma that has come back or stopped responding to treatment. About 27 adults will receive the combination for up to 12 months, with researche…

This study aims to see if new tests can quickly identify a genetic mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. Researchers will collect samples from over 3,000 people already diagnosed with gonorrhea and compare the new tests' results to standard gene…

This study is testing a new blood test that looks at proteins in platelets (a type of blood cell) to see if it can detect prostate cancer more accurately than current methods like PSA tests and biopsies. Researchers at Duke University will enroll 300 men who are already being che…

This study tests two different eye imaging machines (OCT) to see which one takes better pictures of the back of the eye in children. About 30 people, including healthy adults and children with eye conditions, will have their eyes scanned. The goal is to find the best way to diagn…

This study is testing whether taking atorvastatin (a statin) can prevent dementia, disability, and death in healthy adults aged 75 and older who do not have heart disease or dementia. About 20,000 participants will receive either the drug or a placebo. The goal is to see if this …

This study tests whether using cold wraps with compression (cryocompression) is better than cold wraps alone at preventing or reducing nerve damage caused by chemotherapy in people with gynecologic cancers. About 190 participants will wear the wraps during chemo sessions and repo…

This study uses special eye cameras to take detailed pictures of the retina (the back of the eye) in people with and without brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers want to see if changes in the eye's tiny blood vessels and layers can hel…

This study aims to see if a new type of CT scanner (photon-counting CT) can measure lung damage from COPD more accurately than current methods. About 40 adults from an existing COPD study will get one extra scan. The goal is to improve how doctors track emphysema and airway chang…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing and whether it makes quitting harder. The goal is to find better ways to help people with ch…

This study is testing a new 4D camera attached to a surgical microscope to see if it helps surgeons get better views during eye surgery. It will be used on up to 8 patients already scheduled for eye surgery at Duke. The goal is to see if the camera is easy to use, safe, and provi…

This study is creating a long-term registry to track children and young adults with rheumatic diseases like juvenile arthritis. Researchers will follow up to 20,000 participants for 10+ years to collect information about their treatments, side effects, and health outcomes. The go…

This study aims to understand why and how oxygen becomes toxic to the human body, specifically in scuba divers. Researchers will test how factors like respiratory muscle training, sleep deprivation, common medications, and carbon dioxide exposure affect this risk. Healthy, non-sm…