Vitamin B6 may tame mood swings from brain tumor seizure drug

NCT ID NCT07271966

Recruiting now Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study tests whether taking a daily vitamin B6 supplement can reduce anger and mood changes caused by the seizure drug levetiracetam in people with brain tumors. Fifty adults with brain tumor-related epilepsy who have been on levetiracetam for 6 weeks to 6 months will take 100 mg of vitamin B6 daily for 8 to 12 weeks. Patients and their caregivers will report mood changes through questionnaires to see if the vitamin helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin B6 (pyridoxine) 100 mg daily supplement
What this could lead to: If it works, this could offer a simple, low-cost way to reduce anger and mood problems caused by levetiracetam in brain tumor patients.
What could go wrong: This is a small, early-stage study with only 50 participants and no placebo group, so results may not be conclusive. Vitamin B6 is generally safe, but high doses can cause nerve damage in some people.

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Conditions

The condition(s) this trial relates to.

brain cancer focal epilepsy primary brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR RELATED EPILEPSY (BTRE)

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States

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