New Sugar-Based tracer could spot brain tumors on SPECT scans

NCT ID NCT04288518

Completed Diagnosis Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a radioactive sugar-like tracer called 99mTc-1-thio-D-glucose to see if it can make brain tumors visible on SPECT scans. Sixteen adults with primary or recurrent brain tumors received one injection, then had scans at several time points. Researchers measured how the tracer spread in the body and compared the images to MRI and PET scans. The goal was to see if this tracer is safe and could be a simpler, cheaper alternative for brain tumor imaging.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Technetium-99m labeled 1-Thio-D-Glucose (99mTc-1-thio-D-glucose)
What this could lead to: If successful, this could provide a more accessible imaging method for detecting brain tumors using SPECT instead of PET.
What could go wrong: This is a very small, early-phase study (16 people) focused on imaging, not treatment. The tracer may not prove accurate enough for routine use.

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Conditions

The condition(s) this trial relates to.

neoplasm primary brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN NEOPLASMS

Contacts and locations

Locations

TomskNRMC

Tomsk, Russia

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