Duke University

This study is testing if a drug called atezolizumab, given before surgery, can help control recurrent glioblastoma, a very aggressive brain cancer. It will enroll 80 adults whose cancer has returned after standard treatment and who have a specific tumor characteristic called low …

This study is testing whether switching to very low nicotine cigarettes helps people with chronic pain and opioid use disorder reduce their smoking. Researchers will compare these special cigarettes to regular cigarettes to see which better reduces cravings, withdrawal symptoms, …

This early-stage study is testing the safety of a new treatment for aggressive brain tumors that have returned after standard therapy. The treatment involves directly injecting a specially engineered virus into the tumor. The virus is designed to infect and kill cancer cells whil…

This study is testing a 12-week video coaching program called WeCan-Rural, designed to help breast cancer survivors in rural areas build healthy habits. The program teaches nutrition, exercise, and symptom management skills to potentially reduce future heart disease risk. Researc…

This study is testing a new program designed to help doctors better screen for and manage chronic kidney disease in people with type 2 diabetes. It will compare a guided management program against standard education to see which leads to more people getting the right medications.…

This study is testing whether transplanting healthy gut bacteria from a donor can help slow the progression of ALS. Twenty people with ALS will take specially prepared capsules containing the transplanted microbes for eight weeks. Researchers will track their symptoms, quality of…

This study is testing whether a structured nutrition plan helps patients recover physical strength and function after major abdominal surgery due to trauma. The plan provides intravenous nutrition in the ICU, followed by nutritional shakes for 4 weeks after going home. Researcher…

This study is testing a digital tool that helps doctors diagnose and treat lung infections more accurately. It involves 765 patients in Sri Lankan hospitals and aims to see if the tool improves patient outcomes while reducing unnecessary antibiotic prescriptions. The tool provide…

This study aims to determine the best initial treatment for patients with a specific type of aortic tear (type B dissection) that hasn't caused immediate complications. Researchers will compare starting with a minimally invasive stent procedure plus medication against starting wi…

This early-stage trial is testing if a drug called deferiprone, which removes excess iron, can help people recover thinking skills after a life-threatening brain bleed from a burst aneurysm. Researchers believe iron released by the blood is toxic to the brain and causes memory pr…

This study is investigating whether a common Alzheimer's disease medication, donepezil, might also help improve bone health and reduce fracture risk in older adults. Researchers will measure changes in bone density and bone-related markers in the blood over 12 months in 45 partic…

This study is testing a coaching program in South Africa that teaches caregivers of young autistic children how to use supportive strategies during everyday activities. The goal is to improve the child's communication and development. The coaching is delivered by trained non-spec…

This study is testing whether doctors can safely lower the radiation dose for people with HPV-linked throat cancer. It uses a special scan partway through treatment to find patients who are responding very well. If the scan looks good, those patients will get less radiation, with…

This study aims to find the best next medication for children with juvenile idiopathic arthritis (JIA) when their first standard biologic drug stops working well. It will compare three newer types of approved medications against trying a second drug from the same class as the fir…

This study aims to see if a special brain scan (MRI) can predict which people with opioid addiction will succeed in quitting while taking the medication buprenorphine. It also tests whether a non-invasive magnetic brain stimulation treatment (rTMS) helps people stay off opioids b…

This small pilot study is testing whether a guided, at-home exercise program is practical and safe for people recently diagnosed with rheumatoid arthritis. The goal is to see if patients can stick to the workout plan and if it's well-received, to help design a larger future study…

This project is testing a new team-based approach to improve care for people with infections in their implanted heart devices, like pacemakers. It aims to help doctors identify these infections earlier, follow treatment guidelines better, and remove infected devices more quickly.…

This study is testing a personalized, non-invasive brain stimulation technique to see if it can improve working memory. Researchers will use magnetic pulses guided by an individual's own brain activity patterns. The goal is to help healthy older adults and those with mild cogniti…

This early-stage study is testing whether a three-drug combination is safe and practical for preventing graft-versus-host disease (GVHD) after a specific type of stem cell transplant for blood cancers. The transplant uses specially processed cord blood cells. Researchers will enr…

This study is testing if providing free boxes of fresh fruits and vegetables, with or without extra health coaching, helps people with chronic heart failure. Researchers want to see if this 'food prescription' approach reduces trips to the emergency room, hospital stays, and deat…

This study is testing a program called CO-LEAD, designed to improve how patients with lupus and their doctors talk about medication use. It trains doctors in better communication skills and gives patients a tool to share their reasons for missing doses. The goal is to build trust…

This study looks at whether free exercise classes in community parks help older adults improve their health. Researchers will analyze data from 1,000 Miami-Dade County residents aged 50+ who participate in regular park-based fitness sessions. The program includes aerobic exercise…

This study is testing two different phone-based support programs for families of children with complex health needs who are leaving the hospital. Researchers want to see if weekly check-in calls for a month work better than a single call at reducing return trips to the emergency …

This study is testing whether transplanting a donor's abdominal wall is a safe and effective way to repair severe damage or defects in a patient's own abdominal wall. It will involve up to 5 patients at Duke University, who may receive the wall transplant alone or along with anot…

This study is testing whether adding the drug selinexor to a newer type of immunotherapy (called a bispecific antibody) is safe and more effective for people with multiple myeloma that has come back or stopped responding to other treatments. It will enroll 27 patients who have al…

This study is testing whether adding a second immunotherapy drug (relatlimab) to an existing one (nivolumab) can better help the body's immune system fight a fast-growing brain tumor called glioblastoma. About 92 adults with newly diagnosed glioblastoma will receive the drug comb…

This study aims to find the most effective settings for a gentle, focused ultrasound treatment to help improve arm weakness after a stroke. Researchers will test different power levels and timing patterns on 24 stroke survivors to see which best helps the brain relearn movement. …

This study is testing a new 3D ultrasound imaging technique to better measure heart size and function in children and young adults born with only one working heart pumping chamber. Researchers will compare this new method against the current gold standard, cardiac MRI, to see if …

This study is testing a new handheld eye scanner designed to be more comfortable, especially for children and babies, than current devices. Researchers will compare images from the new scanner to a standard camera in about 42 participants, including both healthy volunteers and pe…

This study is testing whether a special light-scanning technology can help doctors better identify cervical cancer during routine exams. Researchers will use the device on 350 women who are already scheduled for cervical cancer screening or follow-up procedures. The goal is to se…

This study is testing a new blood test called HeLP™ that analyzes proteins in platelets to see if it can better detect prostate cancer and assess its seriousness. Researchers are enrolling 300 men aged 40+ who are already being checked for possible prostate cancer. Participants w…

This study is testing whether a portable CT scanner, already approved for head imaging, can safely take pictures of children's chests and bellies. It focuses on children under 5 years old who are too sick to be safely moved to the hospital's radiology department. Researchers will…

This study is testing four new designs for the tip of an eye pressure test device. The goal is to find a tip that is comfortable enough to use without needing numbing eye drops. Researchers will compare the new tips to the standard one that requires drops. The most comfortable de…

This study is testing a new urine test that looks for specific DNA markers to help doctors better diagnose and monitor upper tract urothelial cancer (UTUC). Researchers will collect urine samples from 50 adults with UTUC before their surgery and during follow-up visits. The goal …

This study is developing a smartphone app that uses artificial intelligence (AI) to help doctors interpret sounds from a handheld artery 'stethoscope'. Researchers will collect sound recordings from 180 patients who need routine artery testing and compare the AI's analysis to sta…

This study is testing whether a new device called 'Calla' could replace the traditional speculum during routine cervical cancer screening (Pap smears). Researchers want to see if patients find the Calla device more comfortable and easier to use than the standard speculum. Some pa…

This study is testing a new 3D imaging system that gives eye surgeons a live, detailed view inside the eye during surgery. The goal is to see if this technology helps surgeons perform delicate procedures more precisely and safely. The study is enrolling patients undergoing variou…

This study is testing a new device that attaches to hospital toilets to automatically measure how much urine and stool a patient produces. The goal is to see if this device is as accurate as manual nurse measurements and if it can save nurses time and reduce their exposure to che…

This study is testing a portable, AI-powered camera called the Pocket Colposcope to improve cervical cancer screening for women who test positive for HPV. It aims to help doctors in clinics quickly and accurately identify pre-cancerous changes, so women can get the right treatmen…

This study is testing new portable devices that aim to measure eye pressure more accurately and consistently than current methods. Researchers will compare two experimental devices against the standard eye pressure tests used in clinics today. The goal is to develop better tools …

This study is testing a new, easier-to-use version of a handheld eye scanner. The goal is to see if its automatic alignment feature can take clear pictures of the back of the eye (retina) in both adults and children. Researchers will enroll 50 volunteers and patients to see how w…

This study is testing whether new diagnostic tools can accurately detect a specific genetic mutation in gonorrhea bacteria that makes the infection resistant to a common antibiotic, ciprofloxacin. Researchers will compare the results of these new tests against a standard genetic …

This study is testing if a new type of imaging scan can help doctors better see and diagnose heart damage caused by sarcoidosis, an inflammatory disease. Researchers will compare the new scan's results to those from standard heart scans in 15 adults who either have or are suspect…

This study aims to compare two types of handheld eye scanners to see which works better for imaging children's retinas. Researchers will test both a contact scanner and a non-contact scanner on 20 pediatric patients and 10 healthy adults. The goal is to determine which system pro…

This study is testing a new, handheld eye scanner designed for babies and young children. The goal is to see if this scanner can detect early signs of inherited retinal diseases that can cause vision loss. Researchers will use the scanner on 80 children, both with and without the…

This study is testing a new screening tool called SenseToKnow to see how well it can detect autism in children 16 to 36 months old. Parents will use an app on a device to collect information while their child watches videos. The tool's results will be compared to a doctor's exper…

This large study aims to see if taking a daily cholesterol-lowering statin pill (atorvastatin) can help prevent dementia, disability, and death in healthy adults aged 75 and older. About 20,000 participants will be randomly assigned to take either the statin or a placebo (inactiv…

This study aims to see if it's safe to give infants the preventive RSV antibody shot at the same time as their other routine childhood vaccines. Researchers will compare giving the shots together versus giving them at separate visits. They will track fever and other reactions in …

This study is testing a mobile phone app called mSaada, designed to help community health volunteers in Kenya find and screen more women for cervical cancer. The goal is to see if the app helps more women get screened, understand their risk, and receive treatment if they test pos…

This study is testing whether offering a long-acting injectable HIV prevention medication (lenacapavir) through a trusted community organization helps Latine gay/bisexual men and transgender women stay on the medication longer. The program provides culturally-tailored support thr…

This study is testing if finding and treating malaria very early in pregnancy can prevent serious problems for newborns. It will compare a new strategy—using a highly sensitive malaria test in the first three months of pregnancy—against standard prenatal care. The goal is to see …

This study is testing whether a medication called inclisiran, given as an injection twice a year, can prevent serious heart and limb complications in people who have just had a procedure to open clogged arteries in their heart or legs. It will involve about 6000 participants who …

This study is testing a new online program called UPDOs Protective Styles to help more people in the southeastern United States start using PrEP, a daily pill that prevents HIV. The program uses weekly videos and blog discussions, delivered through beauty salons, to build trust a…

This study aims to see if a simple 5-day skin and nose treatment for pregnant women can reduce the amount of Staph bacteria they carry and lower the chance of passing it to their newborn. Researchers will measure bacteria levels in 20 mother-baby pairs and ask mothers about their…

This study is testing whether offering HIV prevention medication (PrEP) on a medical van is a practical way to reach people who use drugs and are at high risk for HIV. Researchers will enroll 20 adults who are active drug users and/or sexually active. The main goal is to see if t…

This study is testing if a series of community plays can reduce stigma and increase support for young women using HIV prevention medication (PrEP) in Kenya. Researchers will perform six plays for local audiences and measure if people's attitudes change. The goal is to see if this…

This study tests a family program designed to prevent multiple health problems common in Latino immigrant families. The six-session program, led by community health workers, helps families manage stress, build resilience, and access community resources. Researchers want to see if…

This study aims to see if helping families afford healthy food can prevent obesity in young children. Researchers will give 228 families $50 per week for one year, either as cash or as groceries with expert guidance, to see which approach better supports a healthy weight. The goa…

This study is developing and testing a counseling program to help young women who have finished cancer treatment make informed decisions about having children. The program involves four video sessions with a nurse to provide education and emotional support about family planning o…

This study is testing if giving patients a menu of pain control options before an IUD insertion improves their experience. Researchers want to see if the menu helps patients feel more in control, more satisfied, and have less pain. They will compare survey answers from about 200 …

This study aims to create and test a new support program designed specifically for older adults living with lung cancer. Researchers will first interview patients, caregivers, and doctors to design the program, then test it with a small group of patients. The goal is to help pati…

This study is testing whether yoga can help children and teenagers (ages 8-18) who have overactive bladder, a condition that causes sudden urges to urinate and sometimes accidents. Participants will attend weekly yoga sessions for six weeks while researchers track their symptoms …

This study is testing whether a single session combining a non-invasive brain stimulation technique (rTMS) with training in emotion regulation skills can help people who struggle to calm down when upset. Researchers want to see if this combined approach changes brain activity and…

This study is testing two different talk-based therapies to see which helps teenagers with ADHD manage their symptoms better. Thirty teens will be randomly assigned to either learn organizational skills or practice mindfulness techniques over eight group sessions. Researchers wil…

This study is testing whether a 10-week therapy program designed for pregnant women can help them better manage difficult emotions and stress, and whether this improves their heart health. Researchers at Duke University will enroll 100 pregnant women who struggle with emotional c…

This study is testing whether a 6-session video support program can help older adults who have cancer and mild memory problems, along with their spouse or caregiver. The program aims to reduce distress, improve communication, and enhance quality of life for both people in the pai…

This study is testing a digital health program called AYA STEPS that helps young adult cancer survivors manage symptoms like pain, fatigue, and emotional distress. The program teaches skills to improve communication with healthcare providers and engagement with recommended follow…

This study is testing a mobile app called Blueprint, designed to help people manage depression, anxiety, and PTSD after surviving a serious heart or lung condition in the hospital. Researchers will enroll 400 people from four hospitals and randomly assign them to use either the B…

This study is testing a new training program for family caregivers to help them manage pain in loved ones with mild to moderate dementia. The program teaches caregivers pain coping skills to coach their family member, aiming to improve pain management and reduce caregiver stress.…

This study is testing a mobile app called ICUconnect, designed to help families of older adults in intensive care. The app helps families report their needs and stress levels, aiming to improve communication with doctors and reduce emotional distress. The trial will involve 350 p…

This study is exploring whether using virtual reality (VR) can help patients in the Intensive Care Unit (ICU). Researchers want to see if VR can help patients move more and improve their mood and mental well-being. The study will involve 60 adult patients who have been in the ICU…

This study is testing whether a mindfulness-based program can help adults with blood cancer who are struggling with poor sleep during and after a hospital stay. The program includes a mobile app with meditation and sleep tips during hospitalization, followed by video therapy sess…

This study is testing whether a mobile app and a special headset can help people manage chronic low back pain. Participants use the app for 10 minutes, four times a week for three months, aiming to train their brain to reach a more relaxed state. Researchers will compare results …

This study is testing a new telehealth counseling program called ENGAGE, designed to help people with advanced cancer better manage their symptoms. It will compare ENGAGE to standard supportive care in 190 patients with Stage IV breast, prostate, lung, or colorectal cancer. The m…

This study is testing a new approach to help people with misophonia, a condition where common sounds like chewing or breathing cause intense distress and anger. Researchers at Duke University are combining a brain stimulation technique (rTMS) with emotion regulation training to s…

This study is testing if using cold wraps with compression on the hands and feet during chemotherapy is as good as cold wraps alone at reducing nerve pain, a common side effect. It involves 190 women with gynecologic cancers like ovarian or cervical cancer who are receiving a spe…

This study aims to find out if giving children a single dose of a long-acting opioid (methadone) during tonsil removal surgery provides better and longer-lasting pain relief after the operation compared to standard short-acting opioids. Researchers will enroll 440 children and te…

This study is testing two different talk therapy programs to help people with type 1 diabetes who also struggle with eating disorders like binge eating or restricting insulin for weight control. Researchers want to see if these therapies can improve blood sugar levels, reduce eat…

This study is comparing two different non-surgical treatments for liver cancer to see which one helps patients maintain a better quality of life. It's for people with small liver tumors who cannot have surgery. Researchers will measure how patients feel physically and emotionally…

This study is testing if changing the timing of doctor visits can improve the hospital experience for pregnant women who need to stay in the hospital for a high-risk pregnancy. Researchers will compare two different schedules for doctor visits to see which one leads to better com…

This study is testing a new remote therapy program called Nite2Day. It aims to help women with breast cancer in rural areas manage common and difficult symptoms like insomnia, fatigue, stress, and pain. Participants will have six video or phone sessions with a therapist to learn …

This study is testing whether sending daily text messages with care tips is better than giving paper handouts to help patients recover after lower back fusion surgery. It will involve 224 adults having surgery at Duke University Hospital. The main goal is to see if the text messa…

This study is testing a new online program called Mindset Moments to see if it's a practical and helpful way to support young cancer survivors. It aims to help 19-25 year olds who have finished their main cancer treatment but are still struggling with anxiety, depression, or dist…

This study is testing if a medication called zuranolone is safe and can help reduce depression symptoms in people who have had a stroke. Six participants will take the pill daily for two weeks. Researchers will check for side effects and see if mood improves using standard questi…

This study aims to measure how often a common nerve block for shoulder surgery causes temporary paralysis of the diaphragm muscle, which can affect breathing. Researchers will compare three different long-acting numbing methods in 60 patients undergoing shoulder surgery. They wil…

This study is testing whether two types of medical images—MRI and ultrasound—can be successfully combined to create a more precise 3D map for guiding radiation treatment (brachytherapy) in patients with uterine cancer. The goal is to see if this fusion technique is feasible and c…

This study aims to find out what factors predict whether someone with sickle cell disease will develop severe, long-lasting pain. Researchers will follow 70 participants, aged 15-40, for up to four years, using surveys and pain sensitivity tests. The goal is to gather information…

This study aims to test and improve tools used to measure pain in infants and young children under 2 years old. Researchers will conduct interviews with 60 caregivers and clinicians to see if the assessment questions are clear, complete, and relevant. The goal is to create reliab…

This study aims to better understand how sleep timing and daily rhythms relate to ADHD symptoms in children. Researchers will measure sleep patterns in 250 children aged 6-9 with ADHD using home sensors, sleep diaries, and one nighttime lab visit. The goal is to learn how sleep a…

This study aims to collect and store blood samples from adults with brain tumors to create a research repository. Researchers will analyze these samples to find biological markers in the blood that may predict how patients respond to radiation therapy. The goal is to gather knowl…

This study aims to understand why some patients' blood cancers relapse or become resistant after CAR T therapy, a powerful cell-based treatment. Researchers will track 50 patients over time, analyzing their blood to see if specific immune system patterns can predict if and when t…

This study is testing whether showing people what they've eaten—based on DNA analysis of their stool samples—helps them improve their diet. Researchers will enroll 600 participants, including infants and their caregivers, who will provide stool samples before and after receiving …

This study aims to find the best time to discuss the possibility of a cesarean delivery (C-section) with pregnant patients planning a vaginal birth. Researchers will randomly assign 200 participants to have this consent conversation either when they are admitted to the hospital o…

This study aims to understand what factors influence survival and quality of life for adults with glioblastoma, a serious brain cancer. Researchers will ask 200 participants to complete online surveys about their health history and lifestyle. Participants can also choose to provi…

This is a large, long-term registry study that aims to collect health information from children and young adults with rheumatic diseases like juvenile arthritis. By tracking up to 20,000 participants for up to 10 years, researchers hope to better understand the safety and effecti…

This study aims to understand why people with chronic pain find it harder to quit smoking. Researchers will use brain scans and smartphone surveys to see how temporary smoking withdrawal changes pain signals in the brain and affects quit attempts. The goal is to gather informatio…

This study aims to understand how aging changes the way our bodies respond to exercise, especially for older adults with prediabetes or related heart and metabolic risks. It will enroll 26 people who previously completed an exercise study to participate in a new 6-month aerobic e…

This study is creating a registry to collect information about short-term side effects in patients receiving targeted, high-dose radiation for cancer that has spread. It will enroll 300 adults with metastatic cancer who are planning to receive, currently receiving, or have comple…

This study is creating a registry to learn more about how autoimmune diseases affect pregnancy. It will follow 1,000 pregnant women with conditions like lupus or rheumatoid arthritis to identify risk factors for complications. The goal is to gather information that can help impro…

This study aims to better understand how children's bodies process and eliminate standard leukemia drugs. Researchers will observe 200 children under 21 who are already receiving these medications as part of their normal care. The goal is to gather detailed information on drug le…

This study aims to understand how a breast cancer treatment that nearly eliminates estrogen affects the heart. Researchers will compare heart function in 90 premenopausal women receiving this therapy to those receiving other treatments, using heart scans over two years. The goal …

This study aims to learn more about hypophosphatasia (HPP), a rare inherited disorder that causes soft bones and dental problems. Researchers will follow 200 patients with HPP over time to document how the disease progresses, how treatments work, and how it affects patients' qual…

This study aims to understand how common and severe acid reflux symptoms are in children with cystic fibrosis. Researchers will ask 20 children to fill out a symptom survey. For some children already on reflux medication, the study will also check if their symptoms get worse when…

This study tests whether a virtual assistant or a human trainer is better at teaching lung cancer patients to use home monitoring devices. Researchers will compare how easy each method is for patients to learn from. The goal is to understand which approach works better for helpin…

This study aims to find biological markers in blood and tumor samples that can predict which prostate cancer patients will benefit most from an experimental drug combination being tested in a related trial. It involves 48 participants who are already enrolled in the main treatmen…

This study aims to measure how much medication passes from breastfeeding mothers to their infants through breast milk. Researchers will collect breast milk and blood samples from 1600 mothers taking common prescription drugs and blood from their babies. The goal is to understand …

This study aims to better understand how medicines work in critically ill children with heart conditions. Researchers will collect leftover blood samples from about 2000 children already receiving standard medications in the cardiac intensive care unit. The study only observes ex…

This study is testing a new training program for advanced practice providers (like nurse practitioners) in the emergency department. The goal is to teach them how to use portable ultrasound machines to quickly scan a patient's heart. Researchers want to see if this training is pr…

This study aims to collect medical information from people with several ultra-rare glycogen storage diseases (GSDs) to better understand how these conditions progress over time. Researchers will review medical records from about 200 participants to create a detailed database of s…

This study aims to understand the long-term course of Gaucher disease by reviewing medical records of 200 patients over many years. Researchers will track how the disease affects different body systems and evaluate the long-term effectiveness and safety of standard treatments. Th…

This study aims to understand how long-term opioid use and chronic pain change activity in the brain and spinal cord. Researchers will use MRI scans, questionnaires, and simple tests to compare women with these conditions to healthy women. The goal is to gather knowledge that cou…

This study is testing a new educational video to help people with BRCA gene mutations make more informed decisions about hormone replacement therapy (HRT) after having their ovaries and fallopian tubes removed to prevent cancer. Researchers will compare the video plus standard co…

This study aims to find the best way to get people with type 2 diabetes the recommended screening for chronic kidney disease (CKD). Researchers will enroll 750 adults with diabetes who are overdue for kidney tests. They will compare whether sending a home test kit or a standard l…

This study aims to learn how infants born with a severe heart defect called single ventricle disease process the heart medication digoxin. Researchers will collect small blood samples from up to 20 infants during their regular medical care to measure drug levels and heart-related…

This is a long-term observational study, or registry, that aims to collect detailed information from 3000 people diagnosed with progressive lung scarring diseases, including Idiopathic Pulmonary Fibrosis (IPF). The goal is to understand how these diseases naturally progress, how …

This study aims to understand if men and women maintain their physical activity levels differently during and after completing cardiac rehabilitation. Researchers will track 150 participants' daily steps and exercise habits over 10 months to identify potential differences and bar…

This study is testing a new 4D camera attached to a surgical microscope to take detailed pictures during eye surgery. The goal is to see if this new imaging tool is safe, easy for surgeons to use, and provides clear views of eye structures. Up to 5 adult patients having planned e…

This study is testing a new, advanced type of CT scanner to see if it can take more consistent and accurate pictures of the lungs. Researchers will scan 40 people with COPD to compare the new scanner's measurements of lung damage and airways against standard scanners. The goal is…

This study aims to understand the long-term effects of Pompe disease on the brain and nervous system. Researchers will observe 45 children with Pompe disease for 3 to 6 years, using brain scans and developmental tests. The goal is to learn how the disease progresses and affects t…

This study aims to understand how blood vessels develop around a critical part of the eye (the fovea) in premature infants. Researchers will use special eye scans to observe these vessels in up to 16 infants who are at risk for retinopathy of prematurity, a leading cause of child…

This study is observing whether a free, daily after-school program in community parks improves children's health. Researchers will analyze data from about 5,000 kids aged 6-14 who participate in the program, which includes sports, games, and nutrition lessons. The goal is to see …

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study aims to understand the effects of a free, park-based afterschool program on teens' health and well-being. Researchers will analyze existing data from about 1,000 participants, aged 12-17, in Miami-Dade County's 'Fit2Lead' program. The program offers academic help, spor…

This study is creating a long-term registry to track how lupus changes over time in patients treated at Duke. Researchers will collect health information and optional blood samples during regular clinic visits from 1000 participants. The goal is to gather data to understand the d…

This study aims to improve care for children who develop sudden kidney injury during a hospital stay. Researchers will interview families and healthcare providers to understand challenges and create better educational tools. The goal is to develop resources that help families man…

This study is testing a new, gentle eye imaging technology for very premature babies in the hospital. Researchers want to see if detailed pictures of the back of the eye can help predict which babies might need treatment for a common eye condition (ROP) or have future vision and …

This study aims to see if a simple blood test can predict which hormone therapies will work for men with advanced prostate cancer that has spread. Researchers will follow 120 men receiving standard treatment, checking their blood for cancer cells to look for genetic clues linked …

This study aims to understand how the brain creates feelings of fear and anxiety in people with conditions like PTSD and generalized anxiety. Researchers will measure brain activity, heart rate, and skin responses in 80 participants who already have special brain-monitoring impla…

This study aims to understand why and how scuba divers can experience oxygen toxicity, a dangerous condition from breathing high oxygen levels under pressure. Researchers will test how factors like breathing muscle training, sleep loss, common medications, and carbon dioxide expo…

This study aims to find out what support methods work best to help Latino teenagers attend therapy for depression. Researchers will interview teens, their parents, and healthcare providers to learn their preferences. The goal is to identify the most promising strategies to connec…

This study aims to understand the challenges people with rheumatoid arthritis face in controlling their high blood pressure, which increases their risk of heart disease. Researchers will work with 25 participants from the Duke Health System to identify barriers and test a support…