Zapping the brain to beat opioid addiction: new trial tests rTMS
NCT ID NCT06585709
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study at Duke University is testing whether a brain scan (MRI) can predict who will successfully quit opioids using buprenorphine, and whether adding brain stimulation (rTMS) to the treatment helps more than a sham version. 80 adults with opioid use disorder who are starting buprenorphine will receive either real or placebo rTMS for up to 30 sessions. Researchers will track who stays opioid-free for 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive Transcranial Magnetic Stimulation (rTMS)
What this could lead to
If successful, this could provide a new, non-drug brain stimulation method to help people with opioid use disorder stay off opioids when combined with standard medication.
What could go wrong
This is an early-stage study with only 80 participants, so results may not apply to everyone. The rTMS is compared to a sham (placebo) and may not provide additional benefit over buprenorphine alone.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University
RECRUITINGDurham, North Carolina, 27705, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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