Can a sleep pill boost success in opioid treatment?
NCT ID NCT05145764
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study tests whether adding the sleep medication suvorexant to standard buprenorphine treatment can improve sleep and medication adherence in people with opioid use disorder who have recently used fentanyl. Participants first stay in a residential setting for five days to start buprenorphine, then continue treatment as outpatients for three weeks. The trial compares suvorexant against a placebo, measuring sleep quality and how consistently participants take their buprenorphine.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- suvorexant
- What this could lead to
- If it works, adding suvorexant to standard buprenorphine treatment could improve sleep and help people stick with their recovery medication, potentially reducing relapse.
- What could go wrong
- This is a small, early-stage trial, so results may not hold up in larger studies. Suvorexant can cause side effects like drowsiness or unusual sleep behaviors, and its benefit for opioid use disorder is unproven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224, United States
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