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Can a once-weekly antibiotic help people with opioid use disorder beat serious infections at home?

NCT ID NCT05521880

Terminated Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adults hospitalized with a drug-related infection who are stable enough to go home. Participants receive oritavancin doses at a clinic that also provides opioid treatment and peer support, and are followed for 12 weeks to see if the infection clears.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an antibiotic called oritavancin given weekly by IV
What this could lead to
If it works, this approach could offer a way for people with opioid use disorder to complete treatment for serious infections at home rather than in a nursing facility.
What could go wrong
This is a very small early-phase trial with only one participant enrolled, so results may not apply broadly. The infection may not respond to oritavancin, or patients may struggle to stay in treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial arthritis bacterial infectious disease with sepsis infective arthritis opiate dependence osteomyelitis Soft Tissue Infections substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTEREMIA INFECTION, SOFT TISSUE OSTEOMYELITIS ACUTE SEPTIC ARTHRITIS SUBSTANCE USE DISORDERS

Contacts and locations

Locations

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

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