Substance-related disorder

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, …

This study tests whether combining varenicline (a medication that helps people stop smoking) with financial rewards for clean urine samples can reduce alcohol and tobacco use in adults who both drink heavily and smoke daily. Participants are randomly assigned to receive either re…

This early-phase study tests whether spironolactone, a drug currently used for high blood pressure and heart failure, can be safely used in people with alcohol use disorder. Twenty participants will each stay at a clinic four times, taking either the drug or a placebo for five da…

This phase 2 trial tests whether mirtazapine, an antidepressant, can help adults who are already receiving medication for opioid use disorder to stop or reduce their methamphetamine use. Participants are randomly assigned to receive either mirtazapine or a placebo for 10 weeks, a…

This phase 3 trial investigates whether high-dose psilocybin, given alongside psychotherapy, can prevent relapse in people with severe alcohol use disorder who also have depressive symptoms. Participants receive either a high dose (25 mg) or a low dose (3 mg) of psilocybin in two…

This study will enroll 270 pregnant Native American and Alaska Native women with substance use disorders. Researchers will adapt standard pregnancy and addiction care to better fit Native cultural needs. The goal is to help mothers stay in treatment and attend follow-up visits af…

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to…

This study tests whether adding a gentle brain stimulation technique (tDCS) along with computer-based thinking exercises can improve brain function and self-control in people being treated for opioid use disorder with buprenorphine. About 160 adults will either get real or fake s…

This study tests a mobile health app called uMAT-R, designed to help Black adults recover from opioid or stimulant use and manage depression or anxiety. Participants are recruited from community treatment centers and use the app to track substance use and mental health symptoms. …

This study tests whether adding alcohol use disorder treatments (acamprosate and counseling) to standard liver therapy improves outcomes for people with severe alcohol-associated hepatitis. It also compares a new drug, F-652, against prednisone for liver treatment. About 216 adul…

This study looks at whether follow-up care for opioid use disorder via telehealth works as well as in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person clini…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce opioid cravings and prevent relapse. Researchers will compare active stimulation to a sham (fake) version in 100 adults with opioid use disorder who recently started medication like bupreno…

This study tests an updated computer tool for emergency room doctors that includes information about a patient's social risks—like unstable housing or food insecurity—alongside standard opioid use disorder treatment guidance. The goal is to see if this social-risk-informed tool h…

This study tests whether psilocybin, a psychedelic substance, can help people stop smoking. Sixty-six daily smokers who have tried and failed to quit before will receive either psilocybin or niacin (a vitamin) in two sessions one week apart. Researchers will check if participants…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study tests whether a 30-day alcohol abstinence challenge, supported by a mobile app, is feasible and helps reduce heavy drinking. Researchers will enroll 150 adults in Oklahoma who drink regularly. Participants will try to completely avoid alcohol for one month, and the stu…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This study tests whether a long-acting buprenorphine injection can be used to start treatment for opioid use disorder without causing severe withdrawal. Thirty adults with opioid use disorder will stay in a hospital for three days, receive fentanyl to prevent withdrawal, and then…

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measure…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This study tests a new, non-invasive treatment using low-intensity focused ultrasound (LIFU) to help people quit smoking. It targets deep brain areas linked to nicotine addiction without surgery or needles. The study will enroll 100 adults who have smoked for at least 5 years and…

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking…

This study tests a smartphone app designed to help young adults aged 18 to 25 who want to reduce their combined use of alcohol and opioids. The app sends timely tips based on users' daily reports. The goal is to see if the app is usable, satisfying, and worth testing in larger st…

This study tests whether a drug called donepezil, combined with cognitive training (brain exercises), can help people with alcohol use disorder drink less heavily. Researchers will compare this combo to a placebo in 160 adults aged 18-80. The goal is to see if the treatment reduc…

This study tests an experimental medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo by injection for nearly a year. The goal is to find a safe, effectiv…

This study tests a combination of two treatments for people with cocaine use disorder: deep transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, and contingency management, a program that rewards participants for staying cocaine-free. The go…

This study tests whether a smartphone app can help people reduce their use of illegal opioids while they are in treatment for opioid addiction. The app uses a short test to predict the chance of relapse in the next week and adjusts medication doses accordingly. About 225 adults w…

This study tests a new type of brain stimulation that sends paired pulses to the cerebellum and prefrontal cortex. The goal is to reduce cravings and improve cognitive flexibility in 90 adults with moderate to severe methamphetamine use disorder. Participants will receive either …

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck, combined with a nicotine patch, can help people stop smoking. Researchers at Mayo Clinic will enroll 150 motivated smokers who smoke at least 10 cigarettes a day. Participants use the d…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

This study looks at whether adding addiction counseling and monitoring after a liver transplant for alcohol-related liver disease can lower the chance of drinking again. About 720 adults who had a liver transplant for alcohol-related disease will be followed for two years. The go…

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This trial tests a short virtual therapy called IMPROVE, designed to help people on medication for opioid use disorder who also drink heavily. Participants attend three one-hour online sessions and use a mobile app to learn skills for managing emotional distress that can trigger …

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This pilot study tests whether deep brain stimulation (DBS) of the nucleus accumbens can help people with opioid use disorder who keep relapsing despite standard treatments. Only 3 participants will receive the implanted device. The main goal is to see if it is safe and whether i…

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study is testing whether giving rural smokers a two-week supply of nicotine patches or lozenges can help them quit. Researchers are recruiting 272 adults from rural areas across the U.S. who smoke at least 5 cigarettes daily. The main goal is to see how many people stop usin…

This study tests a program that combines community health worker visits with a smartphone app to help low-income women stop smoking. About 344 women in Brazil will either get the app plus health worker support or just a referral to a standard quit-smoking clinic. The goal is to s…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests whether full-spectrum or broad-spectrum CBD can help people with alcohol use disorder drink less. 180 adults who want to reduce or quit drinking will receive either CBD or a placebo for 12 weeks. Researchers will track changes in drinking habits, cravings, and an…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Researchers wi…

This study tests whether cannabidiol (CBD) can slow the progression of Alzheimer's disease in people aged 55-85 with mild cognitive impairment (early memory loss). Over 236 participants will receive either CBD or a placebo for a period, and researchers will measure changes in mem…

This study tests a digital tool called EMBED that helps emergency doctors identify patients with opioid use disorder and start them on buprenorphine, a medication that reduces cravings and withdrawal. The tool is built into the electronic health record and guides doctors through …

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how ca…

This study tests new ways to help people with opioid use disorder continue their buprenorphine medication after starting it in the emergency department. About 3,500 adults will take part. The goal is to see if better coordination between the ER and outpatient clinics helps patien…

This study is for people who smoke cigarettes but aren't ready to quit. It tests whether giving them a choice of harm-reduction products like e-cigarettes or nicotine pouches helps them smoke less or stop altogether. Participants will use their chosen product for 28 days and be f…

This study tests whether hemp-derived CBD (with or without a tiny amount of THC) can help people who use cannabis concentrates regularly to cut down or stop. 165 adults who want to reduce their cannabis use will take either CBD or a placebo for 8 weeks, plus attend therapy. Resea…

This study tests whether a drug called troiluzole can reduce the appeal of methamphetamine for people with methamphetamine use disorder. About 40 adults who use meth but are not seeking treatment will take the drug and then choose between meth and money in a lab setting. The goal…

This study tests whether a 12-week group therapy program called Mom Power can help new mothers with opioid use disorder improve their mood, reduce stress, and strengthen the bond with their child. About 160 mothers with a child aged 5 or younger will be assigned to either the Mom…

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study tests whether pentoxifylline, an anti-inflammatory drug, can reduce how rewarding cocaine feels. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine and money. The goal is to see if calming immune inf…

This study tests whether reducing methamphetamine use—without requiring complete abstinence—can improve health and quality of life. Researchers will give 300 adults with methamphetamine use disorder payments for providing drug-free urine samples over 12 weeks. They will measure b…

This study tests whether a combined computer- and counselor-delivered alcohol treatment program can help people who receive an early liver transplant for severe alcoholic hepatitis stay alcohol-free. Researchers will compare this program to standard care in 200 participants, trac…

This early-phase study tests whether suvorexant, a drug used for insomnia, can reduce people's motivation to drink alcohol. Thirty adults with moderate to severe Alcohol Use Disorder will receive suvorexant or a placebo, then choose between alcohol and money. Researchers will mea…

This study tests a computer-based training called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. Participants use a joystick to push away alcohol-related images, aiming to retrain their automatic urges. The trial will enroll 176 veterans and measure cha…

This study tests whether a monthly extended-release buprenorphine injection works better than daily sublingual tablets for adults with opioid use disorder who are about to be released from jail. 240 participants will be randomly assigned to one of the two treatments while still i…

This study tests whether a behavioral sleep intervention combined with the drug varenicline can help heavy smokers quit. Researchers will measure sleep quality, smoking habits, and brain activity in 114 participants. The goal is to see if improving sleep reduces negative emotions…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This Phase 3 trial tests whether a combination of extended-release naltrexone (Vivitrol) and bupropion XL (Wellbutrin) can help people with moderate to severe methamphetamine use disorder reduce their drug use. About 360 participants will receive either the active drugs or placeb…

This study tests whether giving smokers a choice of e-cigarette flavors (tobacco, menthol, mint, or other) helps them stop smoking regular cigarettes. About 1,280 adult smokers will use a provided e-cigarette device for 13 weeks, and researchers will check who stays away from cig…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study tests whether rosuvastatin, a cholesterol-lowering drug, can safely slow or stop liver scarring (cirrhosis) compared to a placebo. About 256 adults with compensated cirrhosis will take the drug or placebo for 2 years. The main goal is to measure changes in liver stiffn…

This phase 3 trial tests whether adding N-acetylcysteine or extending prednisolone treatment beyond the standard 30 days can improve outcomes for people with severe alcoholic hepatitis. About 477 participants will be enrolled. The goal is to see if these strategies increase the n…

This study compares a once-monthly injection of buprenorphine to daily sublingual buprenorphine for treating opioid use disorder in people who use fentanyl or other strong synthetic opioids. About 60 adults aged 18–65 will be enrolled and followed for 4 weeks after starting treat…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study tests whether semaglutide (Wegovy), a drug used for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder cut back or stop using. The trial has two parts: a small pilot study with 25 people, followed by a larger randomized trial…

This study tests whether a slow-release form of dexamphetamine, a drug used for ADHD, can help people with cocaine and opioid addiction reduce their cocaine use. About 204 adults who are already on methadone for opioid addiction will receive either dexamphetamine or a placebo for…

This pilot study tests whether offering financial incentives (contingency management) can help people who started medication for opioid use disorder in the emergency department keep attending outpatient treatment. Thirty adults will be randomly assigned to receive either standard…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This study aims to reduce racial disparities in opioid overdose deaths by training peer recovery coaches and using an AI-driven texting tool. The coaches will send personalized texts to participants (Black and Latinx adults with opioid use disorder) to help them connect with trea…

This study tests a program called Fathers for Change (F4C) for 280 fathers who struggle with substance misuse and have been violent toward family. The program aims to help them control emotions, stop substance use, and prevent violence. Researchers compare F4C to standard drug co…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenor…

This study tests whether adding buprenorphine (a partial opioid) to the standard shot XR-naltrexone helps people with opioid use disorder stay in treatment and avoid relapse. 180 adults will receive either the combo or a placebo for 24 weeks. The goal is to see if the combo impro…

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests a health system strategy called SAIA to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with jail and clinic staff to identify bottlenecks and improve treatment continuity. The study invo…

This study tests whether 8 weeks of combined resistance breathing training and aerobic exercise can improve physical health and quality of life in male drug rehabilitation patients. Ninety men aged 18-50 will be randomly assigned to one of three groups: combined training, breathi…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management classes, and relationship skills training to help couples reduce alcohol use. Researchers wi…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This study is testing a tailored tobacco cessation program for cancer survivors and their caregivers. The program includes four sessions delivered by phone or video, focusing on quitting techniques and support. Researchers want to see how many people enroll and complete the progr…

This study tests whether deep transcranial magnetic stimulation (TMS) can help Veterans with alcohol use disorder reduce relapse. About 100 participants will receive TMS targeting brain circuits linked to craving and emotional processing. The goal is to increase alcohol-free days…

This study tests a program called Hastiin Bidziil (Strong Man) to help Native American men ages 18 and older reduce their use of alcohol and drugs. About 160 men from Arizona communities will take part. The program focuses on cultural strengths and community support to lower subs…

This phase 4 trial tests whether giving the NSAID ketorolac (Toradol) for the first five days after orthopedic trauma surgery can reduce the chance of patients still needing opioids six months later. About 458 adults aged 18–70 with acute musculoskeletal injuries requiring surger…

This study tests whether semaglutide (Wegovy), a drug used for weight loss, can help adults with cannabis use disorder use less cannabis. 100 participants will receive either semaglutide or a placebo injection weekly for 20 weeks. The main goal is to see if the drug reduces total…

This pilot trial tests two long-acting injectable buprenorphine medications (Sublocade and Brixadi) in 60 incarcerated individuals with opioid use disorder who are about to be released from prison. Participants either choose their preferred medication or are randomly assigned one…

This study tests whether guanfacine extended release (Intuniv), a drug currently used for ADHD and high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take either guanfacine or a placebo daily for 12 weeks, and report the…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This study looks at whether different e-cigarette flavors can help people who smoke cigarettes and are being treated for opioid use disorder with buprenorphine to smoke fewer cigarettes. About 90 adults who smoke at least 5 cigarettes daily will try either a tobacco, sweet-coolin…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study is testing whether a private Facebook group, called Wiidookaage'Win, can help Native American women in Minnesota stay off opioids. The group includes social support, mindfulness, and cultural practices. Sixty women who are already on medication for opioid use and have …

This study tests a new behavioral therapy called CM-PST, designed to help young adults (ages 18-24) with alcohol use disorder achieve and maintain abstinence. The therapy combines rewards for abstinence with skills to manage daily challenges. The trial first checks if the therapy…

This Phase 3 trial tests an experimental drug called larsucosterol in 350 people with severe alcohol-associated hepatitis. The goal is to see if the drug helps patients survive for 90 days without needing a liver transplant. Participants receive either the drug or a placebo by IV…

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo, and researchers will…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study tests whether a virtual reality experience can help people in early recovery from alcohol use disorder drink less and stay abstinent longer. About 500 participants who have been sober for at least two weeks but less than a year will use a VR program designed to strengt…

This study tests a program that combines brief advice, nicotine replacement therapy (like patches or gum), and text-message support to help smoking parents quit. The goal is to reduce children's exposure to secondhand smoke. About 1,200 smoking parents in Hong Kong who live with …

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery will either receive the program or standard care. The goal is to see if the pr…

This study tests a simple program for smokers visiting emergency rooms. Participants get a $300 gift card for nicotine replacement products, self-help materials, and six months of phone support from a specialist. The goal is to see if this approach helps more people quit smoking …

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This study tests a digital group program called WORTH Paths for women aged 18-44 who have been involved in the criminal legal system, have a substance use disorder, and need contraception but aren't using it. The program includes three virtual group sessions with interactive acti…

This study tests whether adding financial coaching to standard smoking cessation counseling helps low-income smokers quit. 602 participants will receive either standard counseling or integrated financial-smoking counseling, plus nicotine patches. The goal is to see if addressing …

This phase II trial tests whether adding a cannabis-based mouth spray (nabiximols) to standard chemotherapy helps people with recurrent glioblastoma live longer. About 120 adults whose brain tumor has returned after initial treatment will receive either the cannabis spray or a pl…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests whether hemp-derived CBD can reduce the harmful effects of cannabis in young adults aged 18-25 who use cannabis at least five days a week but aren't looking to quit. Participants will take either CBD or a placebo for 8 weeks, and researchers will measure changes …

This study tests a smartphone app called Smart-T Alcohol that sends personalized messages to help homeless adults reduce their drinking. About 600 people from shelters in Dallas and Oklahoma City will either get the app plus usual care, or usual care alone. The goal is to see if …

This study tests whether cannabidiol (CBD), a non-psychoactive compound from cannabis, can reduce cannabis concentrate use and cravings in people who use concentrates regularly but aren't trying to stop. 120 participants will take either 200 mg or 400 mg of CBD or a placebo daily…

This study is testing whether apremilast (Otezla), a drug currently used for psoriasis and arthritis, can reduce alcohol cravings in people with moderate to severe alcohol use disorder. Researchers will compare two different doses of the drug against a placebo in 100 adults who w…

This study is testing a medication called brexpiprazole to see if it can help people with alcohol use disorder drink less. Researchers want to know if a person's genes affect how well the drug works. The study involves 250 adults who are not currently seeking treatment for their …

This study tests a new approach called SINI to help people with opioid use disorder start buprenorphine treatment more comfortably. Participants receive small doses of naloxone to trigger mild withdrawal, then take buprenorphine to ease symptoms, followed by a long-acting injecti…

This study tests a program called Peer Activate, where trained peer recovery specialists help people with opioid addiction stay on their medication and cut down on other drug use. The program teaches skills like finding rewarding activities without drugs. Researchers will compare…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will participate, comparing the online program to standard w…

This early-stage study tests whether the psychedelic drug DMT, combined with psychotherapy, can help people with alcohol use disorder. 63 participants will receive either a moderate or low dose of DMT, or a placebo, and their safety and desire to drink will be measured. The goal …

This study tests whether bringing mobile health clinics to rural communities and pairing patients with a certified peer support specialist (someone who has personally recovered from opioid use disorder) can help more people start and stay on medication for opioid use disorder. Re…

This early-stage trial is testing whether alirocumab, a drug approved for high cholesterol, is safe for heavy drinkers and might reduce liver inflammation. One hundred healthy adults who drink heavily will receive either alirocumab or a placebo injection over 8 weeks. Researchers…

This phase 2 trial tests whether moderate to high doses of LSD can reduce heavy drinking in people with alcohol use disorder. 128 participants who have recently detoxified will receive either LSD or a low-dose placebo, along with therapy. The study tracks drinking behavior and br…

This study is testing two counseling approaches—Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE)—to help people on methadone treatment reduce their use of tobacco, opioids, and other drugs. Researchers will enroll 420 adults who are currently on…

This study tests whether a 5-day course of accelerated deep transcranial magnetic stimulation (aTMS) can help adults aged 18–65 quit smoking. Participants receive 4 brain stimulation sessions per day for 5 days. The main goal is to see if the treatment is tolerable and practical,…

This study tests a vaccine that helps the body produce antibodies against oxycodone, a commonly abused prescription opioid. The goal is to reduce the drug's ability to reach the brain and lower its pleasurable effects. The trial involves 45 adults with opioid use disorder and foc…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This pilot study is testing whether a noninvasive brain stimulation device, used at home along with guided mindfulness, can help people with cannabis use disorder reduce their use. Forty-six adults who want to cut back on cannabis will receive either real or sham stimulation over…

This study tests a new way to help people stop smoking by combining standard quit-smoking programs with a computer task that retrains unconscious urges to approach cigarettes. About 300 adults who want to quit will be randomly assigned to one of three groups: standard treatment p…

This study looks at how to bring a program called Just Care for Families to more counties in Oregon. The program helps parents who use opioids or methamphetamine reduce their substance use and improve family outcomes, like being reunited with their children. Researchers will test…

This study tests whether short behavioral therapy sessions can improve sleep and reduce alcohol and cannabis use in young adults aged 18-29 who struggle with insomnia and heavy drinking or marijuana use. Researchers will enroll 800 participants in Washington State and compare tho…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This pilot study is testing whether mailing buprenorphine to people with opioid use disorder after a hospital stay can help them stay in treatment. The goal is to overcome common barriers like lack of transportation or trouble getting to a pharmacy. Researchers will track whether…

This study tests whether cannabidiol (CBD), a compound from hemp, can help people who want to quit smoking reduce their cigarette use. 120 adults with tobacco use disorder will receive either CBD or a placebo twice daily for 56 days. Researchers will measure nicotine levels and c…

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This study tests whether a mobile app can help adults in Singapore quit smoking. About 100 participants will be randomly assigned to receive the app-based support or standard care, and researchers will track how many stay smoke-free for 6 months. The goal is to see if this approa…

This early-stage trial tests a new drug called NTX-2001 in 50 adults with alcohol use disorder. Participants take the drug or a placebo daily for two weeks. Researchers will measure how much alcohol they drink and check for side effects. The goal is to see if this drug can safely…

This pilot study tests whether metformin, a diabetes drug, can help protect brain white matter in young adults (18-25) with early psychosis who use cannabis. Participants will take metformin for 6 months and undergo brain scans and questionnaires. The goal is to see if this appro…

This early-stage study tests the safety of nalmefene implants in 24 healthy adults. Participants receive one or two implants that stay in place for 4 or 12 weeks. Researchers monitor side effects and how the drug moves through the body to plan future studies in people with opioid…

This study tests whether varenicline (Chantix), a drug already used to help people quit smoking, can also help them reduce cannabis use. Two hundred adults in South Carolina who smoke cigarettes and use cannabis will receive either varenicline or a placebo, plus counseling. The g…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This study is testing a new drug called CMND-100 (MEAI) in healthy volunteers and people with alcohol use disorder. The goal is to find a safe dose and see if it can reduce drinking and cravings. The trial is currently recruiting 84 participants.

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study tests a program called PAL that gives hospital patients personalized feedback on smoking, drinking, diet, and exercise. About 788 patients will be split into two groups: one gets the feedback and support, the other gets usual care. The goal is to see if this low-cost a…

This study works with 300 women in rural Kentucky jails who have opioid or stimulant use disorders. The goal is to lower their risk of overdose when they return to their communities. The program offers support and connects them to treatment options before and after release.

This study tests different combinations of an online program called CARRII, designed to help Native American women reduce their risk of alcohol-exposed pregnancy. Over 500 participants will be randomly assigned to one of eight versions of the program for three months. The goal is…

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study tests whether well-timed text messages can help young Air Force trainees avoid binge drinking and its consequences. About 7,000 trainees will either get the standard alcohol intervention or that plus automated texts sent just before, during, and after they first get ac…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This study tests whether a program called Bright Horizons can help prevent binge drinking and drug use in Native American youth aged 10 to 24. The program teaches skills like managing emotions, coping with stress, and setting goals. Researchers will compare it to standard case ma…

This study tests an online parenting program called Family Check-Up Online, adapted for Latinx families, to help prevent substance use in youth aged 11-14. Researchers will enroll 108 Latinx families and compare a culturally adapted version, a Spanish-only version, and a waitlist…

This study aims to create and test a prevention program for e-cigarette use among 6th-8th graders in rural Hawaii. The program includes classroom lessons, social media content, and a print campaign, all designed with Hawaiian culture in mind. Researchers will work with 500 studen…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study tests whether a drug prevention program called Project ALERT, combined with a support tool called Getting to Outcomes, can reduce substance use among 7th and 8th graders. Researchers will track students' alcohol, cigarette, marijuana, and other drug use, as well as the…

This study tests a parenting program designed to help Hispanic teens who are gay, lesbian, or bisexual. The goal is to see if the program can prevent or reduce drug use and symptoms of depression by improving family support and reducing stress. About 306 teens and their parents w…

This study tests a 9-month program called NE+ for American Indian youth aged 12-18. The program includes educational modules and cultural teachings to encourage abstinence, condom use, and avoid substance use. It also involves parents and school staff. The goal is to see if the p…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study tests a web-based program called T.E.C.H. Parenting that teaches parents of middle-schoolers how to talk about media and set rules around it. The goal is to reduce kids' exposure to substance use in movies, shows, and online content, which may lower their risk of tryin…

This study tests whether adding extra supports—like telehealth coaching and practical help—to a group parenting program can prevent language delays in young children (12-42 months) of parents with substance use disorders. 244 parents will be assigned to the group program alone or…

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests a support service designed specifically for transgender women, men, and non-binary people in Thailand who have used chemsex drugs or other substances in the past year. The program offers HIV prevention (PrEP), mental health support, and STI care. Researchers will…

This study tests a program called CHORUS+ that helps people who inject opioids get HIV prevention medication (PrEP) and treatment for opioid use disorder (MOUD). Participants receive HIV self-testing, rapid access to medications, and 6 months of support from a peer coach. The goa…

This study tests a program called Mobile Enhanced Prevention Support (MEPS) for people recently released from jail or prison who have substance use disorders. The program pairs participants with a peer mentor, offers cash incentives for using health services, and provides a smart…

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

This study tests whether combining text message support with financial incentives helps low-income pregnant women quit smoking more than text messages alone. Thirty pregnant women who smoke will be split into two groups to see which approach is more acceptable and effective. The …

This study tests a behavioral program called QuitVaping, which combines counseling sessions with text message support, to help teenagers aged 14-18 quit vaping. About 400 participants who vape nicotine at least weekly will be randomly assigned to either the QuitVaping program or …

This study compares two versions of a smartphone app called Living Free from Tobacco (LiFT) to help young adults ages 18-30 quit using nicotine and tobacco products. About 140 participants will use one of two app versions: one focuses on building mental flexibility to support qui…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This study tests whether adding alcohol-related smells to virtual reality (VR) scenes is feasible and tolerable for people with alcohol dependence. Twenty participants will experience VR cue exposure with scents like beer or wine, and researchers will measure craving, side effect…

This study tests a smartphone chatbot designed to help Black adults quit smoking. The chatbot sends alerts during times when a person is most likely to smoke and suggests ways to handle triggers. 120 participants will be randomly assigned to use the chatbot or not, and researcher…

This study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers…

This study compares two types of nerve blocks—SPSIPB and ESPB—for pain relief after breast surgery. 54 women will be randomly assigned to receive one block before anesthesia. Researchers will measure pain scores and opioid use in the first 24 hours to see which block works better…

This study is testing a smartphone-based system called STAR that uses machine learning to predict when someone with alcohol use disorder might relapse. Participants will complete surveys and use the system to receive personalized recovery support messages. The goal is to see if t…

This study is testing a short, values-based therapy for Veterans who have recently started medication for opioid use disorder (like buprenorphine). The therapy focuses on helping them clarify their personal values, set goals, and improve social connections. The study has three ph…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study tests whether a smartphone-based program is practical and helpful for young adults aged 18-25 who have ADHD and drink heavily. Participants use the app for 31 days to improve awareness and self-control around alcohol. The goal is to see if the app reduces binge drinkin…

This early-stage study is testing whether inhaled cannabis can reduce withdrawal symptoms in people with opioid use disorder who are not currently seeking treatment. Researchers will give participants either cannabis or a placebo and measure how they feel, including withdrawal se…

This study tests a hybrid dialectical behavior therapy (DBT) program for veterans with PTSD who have already completed inpatient treatment. The goal is to reduce lingering symptoms and prevent relapse. About 24 veterans will take part, combining in-person skill groups with online…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 40 adults undergoing open abdominal aortic aneurysm repair. The goal is to see if avoiding opioids reduces the body's stress response and inflammation during and after surgery. Researchers will meas…

This Canadian study is testing whether cannabinoid oils (CBD and THC) can safely help manage symptoms like pain in children aged 4-17 with relapsed or refractory cancer. The trial will enroll 60 kids across three hospitals, giving them different ratios of CBD to THC oils to see w…

This study tests whether bright light therapy can help people going through cocaine withdrawal in a hospital. Cocaine withdrawal often disrupts sleep, mood, and daily rhythms, making it hard to stay drug-free. The therapy uses a special lamp to mimic daylight, which may improve s…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This early-stage study tests whether mavoglurant, a drug taken as a pill, can reduce alcohol cravings and drinking in people who drink heavily. Researchers will give the drug or a placebo to 63 adults with Alcohol Use Disorder and measure how much they drink and crave alcohol. Th…

This study tests a new program where community health workers provide extra support to pregnant women who smoke. The goal is to help them quit smoking during pregnancy. About 105 women in San Bernardino County will take part and receive coaching to stop tobacco use.

This study tests a social media program called Quit the Hit Toolkit to help teens and young adults stop vaping. Coaches are trained to lead small support groups for 5 weeks. The goal is to see if this approach is practical and helpful for quitting nicotine.

This study tests whether yoga can lower tobacco cravings in men aged 18-65 who want to quit. 96 participants will either do low-impact yoga or receive standard quitting advice. Researchers will measure cravings and relapse over three months to see if yoga is a helpful addition.

This study compares two pain management plans after laparoscopic tubal sterilization: one with opioids and one without. About 38 women will report their pain levels and satisfaction. The goal is to see if non-opioid drugs like Tylenol and ibuprofen work just as well.

This study is testing a wearable device called Sparrow Link that sends gentle electrical pulses to nerves in the ear to help reduce opioid withdrawal symptoms. About 50 hospitalized adults with opioid use disorder will receive either the active device or a sham version, along wit…

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioi…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers aim to see if coaching improves pain, anxiety, and overall well-being. The trial is recruiting 468 veterans across the U.S.

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests a wearable earpiece that gently stimulates nerves to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device or a sham version for 5 days during detox. Researchers will measure withdrawal severity, cravings, and …

This study looks at two types of nerve blocks given before mastectomy to see which one better prevents chronic pain. About 132 adults having a mastectomy will be randomly assigned to receive either an erector spinae block or a paravertebral block. Researchers will track pain, opi…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people with opioid and alcohol use disorders. Sixty adults enrolled in an intensive outpatient program will receive daily TMS sessions for four weeks, alongside their usual ther…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This study tests whether an app-based therapy called A-EMDR can help people who have both PTSD and substance use disorders. Twenty-four adults will use the app three times a week for four weeks, while researchers track changes in PTSD symptoms and substance use. The goal is to se…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with overweight or obesity quit smoking. 300 smokers will receive either the drug or a placebo, plus nicotine patches, for 16 weeks. The goal is to see if the drug improves quit rates …

This study tests whether a type of talk therapy for insomnia, delivered via telemedicine, can improve sleep and reduce cannabis use in adults who have trouble sleeping and use cannabis regularly. 200 participants will be randomly assigned to either cognitive behavioral therapy fo…

This study tests whether IGC-AD1, a THC-based oral medication, can safely reduce agitation in people with mild to severe Alzheimer's dementia. About 164 participants will receive either the drug or a placebo twice daily for several weeks. Researchers will measure changes in agita…

This study tests a program that combines a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults who drink heavily. Researchers want to see if these tools are easy to use and helpful for drinking more moderately. The study inv…

This study tests whether a digital avatar (virtual coach) program can help young adults aged 18-29 who come to the emergency department with alcohol misuse and suicidal thoughts. About 60 participants will either use the avatar program with supportive texts or a free suicide safe…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study looks at whether a therapy called prolonged exposure, given through video calls, can help people with both opioid use disorder and PTSD. About 135 adults on stable medication for opioid use will take part. The goal is to see if this approach improves therapy attendance…

This study tests a 9-week mindfulness program (MBRP-SA) designed to help cancer survivors quit smoking and reduce heavy drinking. Six hundred participants in Florida will either get the mindfulness program plus nicotine patches or standard quitline support. The goal is to see if …

This study tests whether a personalized exercise program can help smokers who are afraid of bodily sensations (like a racing heart) quit smoking. 360 adults will take part at YMCA locations. The goal is to see if exercise reduces smoking relapse and helps people stay smoke-free f…

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests whether adding either dexamethasone or dexmedetomidine to a standard numbing medicine (bupivacaine) in a nerve block can provide longer pain relief after abdominal surgery. About 96 adults aged 25-65 will be enrolled. The goal is to reduce pain and the need for s…

This study tests four different approaches—behavioral therapy, physical therapy, medication changes, and buprenorphine rotation—to help cancer survivors reduce their opioid use while keeping pain under control. It involves 294 veterans who have finished cancer treatment but still…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study is testing a smartphone app designed to help people who are starting medication for opioid use disorder get better sleep. The app uses proven sleep therapy techniques and daily sleep diaries. Researchers will enroll 40 adults who are stable on buprenorphine and have po…

This study tests whether a 4-week breathing muscle training program can improve lung function, reduce shortness of breath, and lessen cravings in people with substance use disorder. Thirty-four adults receiving inpatient treatment will either do breathing exercises with a device …

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This Phase 2 trial tests whether adding buspirone (an anxiety medication) to lofexidine (a withdrawal drug) can reduce opioid withdrawal symptoms and cravings during detox. About 100 adults with opioid use disorder will stay in a residential setting for 10–12 days, undergo a step…

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This early-phase study tests whether a device that delivers specific smells can reduce cigarette cravings and help people stop smoking. About 132 smokers will use a smartphone app with or without the scent device for a week, then report cravings and quit attempts. The goal is to …

This study tests whether a natural hormone called pregnenolone can reverse the effects of cannabis intoxication. Researchers at Johns Hopkins will give 20 healthy adults who have used cannabis before either pregnenolone or a placebo, then measure changes in drug effects, thinking…

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This study tests a program called Thrive that helps young adults (ages 18-25) with fetal alcohol spectrum disorders (FASD) set personal goals and build support networks. Participants are randomly assigned to start the program right away or after a delay, and then to work individu…

This study tests whether placing a steroid (Depo-Medrol) directly on the spine during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having one- or two-level lumbar decompression will be randomly assigned to get the steroid or a placeb…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This study looks at whether teaching college students protective strategies (like pacing drinks or avoiding shots) and setting personal goals can reduce risky drinking. About 300 students aged 18-25 who drink at least once a week will be split into three groups: one gets basic ad…

This pilot study tests a smartphone app called eMind that delivers an 8-week mindfulness programme to help smokers quit. Researchers want to see if smokers find the app acceptable and easy to use. The study involves 40 adult smokers motivated to quit, who will use the app and pro…

This study tests whether ear acupuncture, combined with mindfulness therapy, can reduce emotional distress in active-duty service members and veterans with PTSD. Sixty-six participants will receive either mindfulness therapy alone or mindfulness plus a one-time ear acupuncture tr…

This study tests whether adding cognitive processing therapy (CPT) to standard relapse prevention (RP) helps people with both PTSD and alcohol use disorder more than RP alone. About 200 adults with moderate to severe alcohol use disorder and current PTSD will receive either CPT+R…

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medication can reduce the amount of opioids needed after preventive femur surgery. The study includes 60 adults with bone lesions from cancer who are getting a metal rod placed in the thig…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce cravings and opioid use in people with opioid use disorder. One hundred participants will receive either real or sham TMS sessions over 8 weeks, with follow-up visits for about 5 months. The…

This study compares two behavioral programs for people with chronic pain, chronic insomnia, and long-term opioid use. One program uses cognitive behavioral therapy for insomnia (CBT-I), the other is standard treatment. The goal is to see if improving sleep can also reduce opioid …

This study tests whether peer recovery specialists—people who have themselves recovered from mental health or substance use problems—can effectively deliver a therapy called behavioral activation to reduce depression and substance use. The trial will enroll 250 low-income adults …

This study tests whether dronabinol, a synthetic form of THC (the psychoactive compound in cannabis), can reduce severe breathlessness in people with advanced COPD. Thirty participants will receive both dronabinol and a placebo in random order to compare effects. The goal is to s…

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a …

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to brain areas involved in craving and self-control. The trial involves 64 smokers who will receive either real or…

This study tests whether giving testosterone to men with chronic back pain who take opioids can improve their pain, sexual function, fatigue, and quality of life. The men have low testosterone caused by opioids. Half will get testosterone injections and half a placebo. The trial …

This study partners with community organizations to adapt a smoking cessation program for adults who smoke and receive care at behavioral health clinics. Researchers will enroll 24 participants to test whether the program is feasible and acceptable. The goal is to learn how to be…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study is testing whether a social media and smartphone app program can help teens and young adults who vape to cut back or quit. Participants will be recruited through social media, screened by a chatbot, and given a mobile app with tailored tips and encouragement. The goal …

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study tests a 6-month holistic behavioral health program called EASE for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, case management, peer support, and education. Researchers will measure changes in depression…

This study compares two brief behavioral interventions for emerging adults aged 18-25 who use cannabis frequently (at least 20 days per month). Participants attend two 40-50 minute sessions a week apart and are followed for 6 months. The goal is to see if either program helps red…

This study tests whether a continuous pump delivering numbing medicine into the belly can reduce pain and the need for narcotics after minimally invasive hysterectomy. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive either a numbing drug…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the real patch or a placebo, along with standard pain…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study investigates how THC and CBD in cannabis affect recognition memory in healthy adults who use cannabis regularly. Participants perform a memory task after smoking cannabis and on a separate sober day, while their brain activity is recorded via EEG. Blood samples measure…

This study is testing whether simple saliva tests done at home can accurately show when someone has not used cannabis. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples over 3-4 weeks, and resea…

This study is creating and testing simple computer tasks that can be done inside an MRI scanner to measure brain activity related to behavior. Researchers want to better understand how alcohol use disorder affects the brain. The study involves up to 400 healthy volunteers and peo…

This study explores whether a short substance use questionnaire and brief counseling session can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 participants will fill out a screening tool and, if needed, receive supportive counseling during…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study will follow 40 adults aged 18-70 who currently take tirzepatide, a medication for blood sugar and appetite control. Researchers will temporarily stop the drug for 3-4 weeks and then restart it for 6-8 weeks, using brain scans, questionnaires, and stool samples to track…

This phase 1 trial at Ohio State University is studying how nicotine analogs compare to regular nicotine in e-cigarettes. Researchers want to understand if these newer chemicals are just as addictive and what they do to the heart and blood vessels. The study involves 70 adult e-c…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study is developing a way to measure resilience in people with opioid use disorder. Researchers will have 125 adults complete tasks that test thinking, emotions, and sense of control, both with and without stress. The goal is to see if these tasks match how resilient people …

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This early-phase study at the University of Maryland is testing whether suvorexant, a sleep medication, can reduce the desire for drugs in people with opioid use disorder. Researchers will measure how much participants are willing to 'pay' for a study drug in a lab task, and whet…

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study tracks 1,500 people over two years to see how the COVID-19 pandemic has changed their drinking habits and related stress. Participants complete surveys about alcohol use, stress, and well-being, comparing before and during the pandemic. The goal is to understand the pa…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can change how the brain responds to alcohol-related cues in people with alcohol use disorder (AUD). Researchers will use brain scans to measure dopamine activity in healthy volunteers and people w…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study looks at how cooling ingredients like WS-3 and menthol in e-cigarettes affect how much people like them and find them addictive. Researchers will have 66 adult e-cigarette users try different e-liquid mixtures and report their feelings of liking, craving, and harshness…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study investigates how acetate, a substance produced when the body breaks down alcohol, is used by the brain in heavy drinkers. Researchers will use a special imaging technique to track acetate metabolism and measure stress hormone levels. The goal is to understand the link …

This study looks at how smoking little cigars affects levels of harmful chemicals called oxidants in the body. Researchers will compare three types of smoking: high-oxidant little cigars, low-oxidant little cigars, and regular cigarettes. Fifty daily smokers will provide breath, …

This observational study at Yale University aims to understand how people with opioid use disorder (OUD) learn to avoid pain compared to healthy individuals. About 180 participants will perform a learning task inside an fMRI scanner to measure brain activity. Those with OUD will …

This study looks at how alcohol changes a brain protein called PDE4B, which may be linked to alcohol use disorder. Healthy social drinkers aged 21 to 70 will have brain scans before and after receiving alcohol. The goal is to understand how alcohol affects this protein, which cou…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This early-phase study is looking at how cannabidiol (CBD) affects the appeal and pain-relieving effects of cannabis. Researchers will give 23 healthy adults different doses of CBD for 14 days and then measure how much they like active cannabis and how it changes their pain sensi…

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study follows 32 people with cocaine use disorder as they go through detox. Researchers use wearable sleep monitors, questionnaires, and urine tests to track sleep quality and body rhythms during active use, early withdrawal, and late withdrawal. The goal is to understand ho…

This study looks at how preterm and full-term babies adapt to noises and lights—a skill called habituation. Researchers will compare 70 infants near their due date to see if differences in this ability can help spot those at risk for developmental delays. The goal is to find earl…

This study looks at young adults aged 18 to 25 who use both tobacco/nicotine products and cannabis. Researchers want to understand what happens to cannabis use when participants try to quit nicotine. All participants receive remote counseling and incentives to stop using nicotine…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study looks at whether regular cannabis users can adjust how much they vape when using high-potency concentrates (30%, 60%, and 90% THC). Researchers will measure blood THC levels, puffing behavior, and subjective feelings of intoxication. The goal is to understand if people…

This study looks at how differences in personality, brain activity, and behavior may make some young adults more likely to use substances like cannabis. Researchers will track eye movements and brain scans in 294 people aged 18-22. No treatment or medication is involved—the goal …

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study is developing and testing a program called THRiVE for veterans who recently left the military. The program consists of six weekly virtual group sessions led by a peer (another veteran). The goal is to see if the program is practical, well-liked, and may help improve me…

This study looks at whether a short screening and brief counseling session can help reduce unhealthy alcohol use among adults visiting public hospitals in a post-war area. About 262 outpatients who drink at risky levels will either receive advice and follow-up or just follow-up a…

This study uses brain scans to see how stress hormones interact with certain brain receptors in people with cocaine use disorder. Researchers will compare 80 adults with and without the disorder to understand these interactions and whether they predict relapse. The goal is to lea…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study uses brain scans (PET) to measure how much dopamine is released after a low dose of amphetamine in people with cocaine use disorder. Researchers want to understand brain changes linked to addiction. About 30 adults aged 18-55 with cocaine use disorder will participate.…

This study looks at how strong desires (cravings) change the way people make decisions. Researchers will use brain scans and decision-making tasks to see how craving for opioids or a specific snack affects what people are willing to pay for items. The study involves 160 adults, i…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study is testing whether a smartwatch can pick up on body changes—like skin temperature—that happen during opioid withdrawal and cravings. Twenty people with opioid use disorder will wear the device for 14 days while their symptoms are tracked. The goal is to see if the watc…

This study looks at how psilocybin, the active ingredient in magic mushrooms, affects brain circuits linked to motivation and self-control in people with opioid use disorder. Twenty-four adults in the Philadelphia area will receive either a low or high dose of psilocybin, then un…

This study looks at how binge drinking in mid-life (ages 50-64) affects blood pressure, small blood vessels, and nerve activity. It compares binge drinkers to non-drinkers and moderate drinkers. In a second phase, binge drinkers will try 8 weeks of aerobic exercise to see if it i…

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study looks at whether older adults (55+) in methadone treatment for opioid use disorder can use smartphone-based cognitive games to track and possibly improve their thinking skills. Thirty participants will play short brain-training tasks twice a day for 15 days. The main g…

This study adapts a parenting program called 'Proud of Baby and Me' for new mothers who are receiving medication for opioid use disorder. The goal is to see if the program helps mothers stay in treatment, reduce stress, and improve bonding with their baby. Ten women will particip…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study uses brain scans to see how stress-related proteins change in heavy drinkers compared to healthy people. Researchers give a stress hormone (hydrocortisone) and then scan the brain to measure these proteins. The goal is to understand if these proteins play a role in rel…

This study screens up to 10,000 adults aged 18-99 who have current, past, or no substance or alcohol use disorders. Participants undergo one visit with tests like physical exams, blood work, memory tests, and mental health evaluations. The goal is to find eligible volunteers for …

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study uses repeated fMRI brain scans to track changes in people receiving medication for opioid use disorder. Ten participants will be scanned every two weeks for six months while performing tasks. The goal is to understand how the brain changes during recovery and identify …

This study tests whether a 4-week ketogenic diet changes how the brain responds to alcohol. Twenty adults will follow the diet and undergo alcohol tolerance tests and brain scans before, during, and after the diet. The goal is to understand how ketosis affects alcohol metabolism …

This study looks at why alcohol use disorder is increasing faster in women than men. Researchers will measure brain activity, hormone levels, and drinking behavior in 100 adults to find sex-specific risk factors. The goal is to create better prevention and treatment strategies ta…

This study looks at how a person's mental state—like anxiety, sleep problems, and fear of pain—affects how well numbing medication works during surgery. Researchers will follow 1,000 adults to see if these factors change pain levels, opioid use, and the chance of long-term pain. …

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study follows 7,500 heavy drinkers over time to learn how alcoholic liver disease develops and worsens. Researchers will use non-invasive tests like ultrasound and blood markers to identify who is at risk for cirrhosis and liver cancer. The goal is to improve screening and e…

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors…

This study looks at how impulsivity and the way people feel when drinking alcohol are connected in young adults aged 21-25. Researchers will give alcohol or a placebo intravenously and track participants' responses in the lab and in daily life using a phone app. The goal is to fi…

This study aims to create a lab-based test to help screen medications for Alcohol Use Disorder (AUD). Researchers will observe how 90 adults with AUD resist drinking in a controlled setting. The goal is to develop a reliable method to test new treatments, not to provide direct th…

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disor…

This study is testing a program called Project REACH, which offers telehealth services at syringe service programs (places where people can get clean needles). The goal is to see if this makes it easier for people who use drugs to get HIV prevention (like PrEP) and addiction trea…

This study is observing heavy drinkers with jaundice to learn more about alcoholic hepatitis, a serious liver condition. Researchers will track survival and liver function over 12 months, and collect genetic samples to better understand the disease. The goal is to improve diagnos…

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study uses brain scans (MRI, MRS, EEG) to see how ibogaine affects the brain in 20 people with moderate to severe opioid use disorder. Participants will already be receiving legal ibogaine treatment outside the U.S. The research team only observes and measures brain activity…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study looks at how a single session of exercise changes blood markers related to brain health in people who use cannabis regularly compared to those who don't. Researchers will measure endocannabinoids and other substances in the blood, along with cognitive tests. The goal i…

This study looks at how romantic partners who both smoke can support each other when trying to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while attempting to quit, tracking their smoking, cravings, and stress. The goal is to understand which ty…

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This study aims to see how Jägerbombs (a mix of energy drink and alcohol) affect young adults differently than drinking alcohol alone during a binge-drinking session. Researchers will measure reaction time, coordination, vision, stress hormones, and hangover symptoms in 24 health…

This study is testing how the drugs alprazolam (Xanax) and oxycodone (an opioid) interact when taken together. Researchers will give small, non-therapeutic doses to 25 healthy adults who already use these drugs. They will measure how much participants like the drug combination, a…

This study looks at how the body handles synthetic nicotine compared to natural nicotine from tobacco. Eighteen experienced e-cigarette users will vape three different nicotine blends in a controlled setting. Researchers will measure nicotine levels in the blood, heart effects, c…

This early-stage study is testing a new implantable pellet (BICX104) that slowly releases naltrexone over 3 months. Researchers want to see how the body processes the drug and if it's safe, comparing it to a standard monthly naltrexone shot. The study involves 30 healthy adults a…

This study follows 400 parents in rural Ohio who are part of the Ohio START program, which connects them to substance use treatment and peer mentors. Researchers want to see if having treatment services close to home and strong social support helps parents recover and improves th…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and reward in people with alcohol use disorder (AUD). Researchers will compare brain activity in people with AUD and healthy volunteers using MRI scans and a mild electrical stimulation techn…

This study tests a program that combines help with quitting smoking and getting a lung cancer screening (a special CT scan) for African American smokers. The goal is to reduce the high rate of lung cancer in this group. About 250 people will take part, and researchers will track …

This study recruits 600 adults who want to quit smoking. Participants use a smartphone app to take photos of their environment when they smoke and at random times. Researchers use artificial intelligence to analyze these images and identify environmental triggers that lead to rel…

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate how changing flavor availability mi…

This study tests a new program designed to help liver doctors provide treatment for alcohol use disorder. The program includes education for doctors and patients, decision support tools, and feedback on performance. Researchers want to see if this approach is practical and accept…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study tests whether combining neurofeedback with integrative body-mind training can change brain function and reduce cravings and substance use in adults who regularly use alcohol, cannabis, and cigarettes. Researchers will use brain scans to measure changes in connectivity …

This study looks at how sleep and body clock disruptions impact the brain's reward and impulse control systems in teenagers. Researchers will monitor sleep, brain activity, and decision-making in 100 healthy high school students. The goal is to understand why poor sleep may incre…

This trial tests two types of opioid-free anesthesia in 70 people having weight-loss surgery. One method uses a gas called desflurane, the other uses intravenous drugs. Researchers will measure stress hormones in the blood to see which approach causes less stress on the body. The…

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study tests whether a non-invasive brain stimulation technique called TMS can change how people with severe cannabis use disorder recognize their cannabis-related problems. Twenty-four participants will receive real and sham TMS while researchers measure brain activity and e…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This study is investigating how common cannabis use is among lung cancer patients under 60 and whether it is linked to more aggressive tumors. Researchers will collect blood and hair samples from 150 participants across three French hospitals. The goal is to better understand if …

This study uses brain scans (fMRI) to see what happens in the brain just before a smoker lapses (takes a cigarette during a quit attempt). Researchers will have 150 smokers complete a task where they can delay smoking for money, while their brain activity and feelings are measure…

This study is testing a new center in Seattle where people who have had an opioid overdose can stay for up to 24 hours. The center offers monitoring, medication for opioid use disorder, and connections to ongoing care. Researchers will compare outcomes like repeat overdoses and t…

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app sends rem…

This study aims to understand the different reasons people with alcohol use disorder are motivated to drink. Researchers will give participants IV alcohol and ask them to press a button for more doses, while measuring mood, cravings, and thinking skills. The goal is to link these…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This study explores why ketamine, a fast-acting antidepressant, works better in people with a family history of alcohol use disorder. Researchers will give a single low-dose ketamine infusion to 60 adults with treatment-resistant depression while scanning their brains with powerf…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and complete thinking tests and brain flu…

This study is collecting information on lifestyle, quality of life, and health markers from 2,000 adults in Greece, including people with chronic diseases, opioid use disorders, and those in prison. The goal is to understand why some groups have worse health and to suggest polici…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study tests a web-based program for romantic partners who are worried about their loved one's drinking. Researchers will use daily surveys from both partners to build personalized feedback that helps the concerned partner communicate better and motivate change. The goal is t…

This study looks at how the drug propranolol and nicotine patches, alone or together, change brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers will undergo brain scans while viewing these cues. The goal is to understand the brain mechanisms b…

This study tests a 10-week parenting program called Parenting in 2 Worlds (P2W), designed specifically for urban American Indian families. Researchers will compare it to a general health program in four U.S. cities with 1,440 parent-teen pairs. The goal is to see if P2W improves …

This study looks at 350 hospitalized patients with alcohol use disorder to find out what makes someone more likely to relapse after detox. Researchers will group patients by shared traits and test a feedback system that shows test results to patients and doctors. The goal is to l…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at whether oral nicotine pouches (like ZYN) can be a good substitute for cigarettes or smokeless tobacco. Researchers will test different nicotine levels and forms to see which ones reduce cravings and appeal to users. 160 adult tobacco users will try the pouches…

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers will give THC to 100 healthy adults who have used cannabis before and measure their feelings of being 'high' and memory performance. The goal is to understand why men an…

This study looks at how harm reduction care (a non-judgmental approach to drug use) in HIV clinics affects stigma and health outcomes for people living with HIV who use drugs. Researchers will survey 768 patients and providers to understand how attitudes and care practices influe…

This study looks at whether giving opioid treatment programs (OTPs) regular reports on how well they retain patients, plus a quality-improvement toolkit, can help more people stay in treatment for at least 90 days. Some clinics will also get extra help from an outside facilitator…

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. One approach focuses on improving care within doctor's offices, while the other partners with community groups. About 1,270 participants across 32 U.S. clinics will …

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study is collecting information from 80 adults who have both ADHD and an addiction. Researchers will track their symptoms and daily functioning over 12 months to better understand how these conditions affect each other. The goal is to gather data that could improve future tr…

This study is recruiting 710 adults with fatty liver disease or alcohol-related liver disease, with or without cirrhosis, to understand why some develop liver cancer. Researchers will analyze genetic markers, immune factors, and imaging data from routine liver biopsies and blood …

This study aims to improve pain relief after cesarean sections by looking at how a mother's genes affect her response to opioids. Researchers will enroll 700 women and track genetic markers linked to side effects like breathing problems and nausea. The goal is to create a persona…

This study looks at how sleep and body clocks affect the brains of teenagers and their risk for using substances like alcohol or drugs. Researchers will monitor the sleep patterns and brain activity of 200 healthy teens aged 13-18. The goal is to understand how changes in sleep a…

This study tests whether adding a tool called the Pleasuremeter to standard harm reduction services helps men who have sex with men and transgender people who use drugs or engage in chemsex talk about and improve their sexual pleasure. The goal is to see if people are willing to …

This study looks at how THC, the active part of cannabis, changes people's desire for e-cigarettes and their body's response. Researchers will give different doses of THC to 100 adults who use both e-cigarettes and cannabis, then measure how much they vape, their cravings, heart …

This study interviews 50 transgender adults in Thailand about their chemsex behaviors—reasons, patterns, and impacts—along with stigma and HIV prevention needs. Researchers also gather input from stakeholders to identify barriers and facilitators for creating transgender-friendly…

This study looks at how the brains of teens (ages 15-18) with cannabis use disorder change when they stop using cannabis for 6 weeks. Researchers will use MRI scans to measure brain activity related to reward and impulse control. Some teens will be paid to stay cannabis-free, whi…

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study is gathering information from men who have sex with men who take part in chemsex (using drugs before or during sex) in Bangkok, Thailand. Researchers will survey party hosts and guests about their drug use, sexual health, mental health, and experiences of stigma. The g…

This study looks at how drinking problems and posttraumatic stress disorder (PTSD) together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days. The goal is to better understand these connections, not t…

This study looks at how difficult childhood experiences might change brain function and make people more likely to start smoking. Researchers will give a small dose of nicotine or a placebo to 150 nonsmoking young adults aged 18-21, then use brain scans and questionnaires to meas…