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Mint vs. fruit: which makes oral nicotine pouches more addictive?

NCT ID NCT06506162

Knowledge-focused Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study investigates how flavor (mint vs. fruit) and nicotine strength (2mg vs. 4mg) influence the appeal and abuse liability of oral nicotine gums and pouches. Researchers will recruit 320 young adults aged 21–25 who currently use e-cigarettes exclusively, including a subset of sexual and gender minority participants. Participants will rate sensory appeal and complete tasks measuring motivation to use the products, helping to identify factors that could make these products more addictive.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oral nicotine products (gums and pouches) with varying flavor (mint vs. fruit) and nicotine strength (2mg vs. 4mg)
What this could lead to
If successful, this research could inform regulations on flavors and nicotine levels in oral nicotine products to reduce their appeal and abuse potential among young adults.
What could go wrong
This is an observational study measuring preferences and behavior, not testing a treatment. Results may not predict real-world use or long-term addiction patterns.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 320 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. aged 21-25 years 2. current exclusive EC user (defined as at least weekly use over the past 3 months) and recent nicotine use confirmed by positive urine test (\>1 semiquantitative Total Nicotine Equivalent; see below) 3. not currently using another tobacco/nicotine product (defined as no use in the past 6 months) 4. have never used any ONP (medicinal or nonmedicinal) 5. willing to try study provided ONPs. Exclusion Criteria: 1. recent COVID-19+ (positive test in the past 30 days) 2. a recent COVID-19 hospitalization (past 3 months) 3. unstable or significant psychiatric conditions (past and stable conditions allowed) 4. history of cardiac event or distress within the past 3 months 5. currently pregnant (based on urine pregnancy test), planning to become pregnant, or breastfeeding.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nicotine dependence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Southern California

    RECRUITING

    Los Angeles, California, 90089, United States

  • University of Southern California

    RECRUITING

    Los Angeles, California, 90089, United States

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