Could a Nicotine-Free cigarette break the habit?
NCT ID NCT07755891
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether switching to cigarettes with very low nicotine content can reduce how much people smoke and their nicotine exposure. Adult daily smokers in South Korea will be randomly assigned to either very low nicotine or normal nicotine cigarettes for 12 weeks. Researchers will track smoking behavior, nicotine levels, cravings, and withdrawal symptoms to see if the low-nicotine option helps people smoke less.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Very low nicotine content (VLNC) cigarettes
- What this could lead to
- If effective, very low nicotine cigarettes could help smokers cut down or quit, reducing nicotine dependence and related health risks.
- What could go wrong
- The trial is early and may not show lasting changes in smoking behavior. Participants might compensate by smoking more or using other nicotine products.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Medical Education Building, Seoul National University College of Medicine
Seoul, 03080, South Korea
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