CIGARETTE SMOKING

This study is for people who smoke cigarettes but aren't ready to quit. It tests whether giving them a choice of harm-reduction products like e-cigarettes or nicotine pouches helps them smoke less or stop altogether. Participants will use their chosen product for 28 days and be f…

This study compares e-cigarettes to standard counseling and nicotine patches/lozenges for reducing smoking in people with opioid use disorder. About 300 participants who smoke at least 5 cigarettes daily and are in treatment for opioid addiction will be followed for 6 months. The…

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests whether a weekly injection of semaglutide (a drug used for weight loss and diabetes) can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will also use nicotine patches to help them quit. The goal is to s…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study compares two approaches to help people with serious mental illness reduce their cigarette smoking: using e-cigarettes or nicotine patches and lozenges, combined with counseling. Sixty participants who smoke at least 5 cigarettes a day will be randomly assigned to one o…

This study tests a mobile health app designed to help young adults (ages 18-26) quit using e-cigarettes and other nicotine products. The app delivers personalized motivational messages and skills training over 6 weeks. Researchers will measure if participants stop vaping, confirm…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to brain areas involved in craving and self-control. The trial involves 64 smokers who will receive either real or…

This study looks at how different tax plans affect what smokers choose to buy in a simulated online store. About 316 daily smokers will use a virtual marketplace where cigarettes and other nicotine products have different prices based on tax rules. The goal is to see if certain t…

This study looks at how the drug propranolol and nicotine patches, alone or together, change brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers will undergo brain scans while viewing these cues. The goal is to understand the brain mechanisms b…

This study looks at what happens to markers of inflammation in the blood when menthol cigarette smokers switch to non-menthol cigarettes. The goal is to understand if removing menthol could lower heart disease risk. About 68 adult menthol smokers will be followed for several week…

This study looks at whether e-cigarettes or oral nicotine pouches can help people who smoke cigarettes cut down or switch completely. Two hundred adult smokers who have tried to quit before will be randomly assigned to use one of these products instead of cigarettes for six weeks…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. 210 smokers who have tried to quit before will use fruit, tobacco, or menthol flavored e-cigarettes for 6 weeks. Researchers will track how many cigarettes they smoke and how sati…

This study aims to understand if relighting a cigarette (smoking it in parts) produces more harmful chemicals than smoking it all at once. Researchers will observe 30 smokers who already relight their cigarettes, measuring their smoking habits and collecting cigarette butts. No t…

This study looks at how setting a very-low-nicotine standard for cigarettes and changing prices of illegal cigarettes and e-cigarettes affects what people buy in a virtual marketplace. About 70 adult smokers and dual users of cigarettes and e-cigarettes will take part. The goal i…

This study looks at how THC, the active part of cannabis, affects cigarette cravings and smoking habits. Researchers will give 100 adults who smoke both tobacco and cannabis different doses of THC or a placebo, then measure how many cigarette puffs they take and how they feel. Th…