CIGARETTE SMOKING

This study compares e-cigarettes and oral nicotine pouches to see which helps smokers reduce cigarette use. 200 adult smokers who have tried quitting before will switch to one of these products for 6 weeks. Researchers will measure how many cigarettes they smoke and track health …

This study compares e-cigarettes to nicotine patches plus counseling for reducing cigarette smoking in people with opioid use disorder who are on methadone or buprenorphine. About 300 participants will be randomly assigned to one of two groups and followed for 6 months. The goal …

This study tests whether giving e-cigarettes or nicotine patches, along with counseling and text messages, helps people with serious mental illness reduce or stop smoking. 60 participants who smoke at least 5 cigarettes daily will be randomly assigned to one of two groups. The go…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people stop smoking cigarettes. Fifty adult smokers will use the pouches for 4 weeks instead of smoking. Researchers will track how many people fully switch and how much their smoking drops. The goal is…

This study tests if a once-weekly medicine called semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive the drug or a placebo while trying to quit. The goal is to see if the drug helps control appe…

This study is testing a mobile health app designed to help young adults (ages 18-26) quit using e-cigarettes and other vaping products. The app translates proven smoking-cessation methods into a smartphone format. Researchers will enroll 46 participants who vape regularly and wan…

This study aims to improve quitting success for smokers who find it hard to stop with standard medications. About 544 participants will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks, with treatment adjusted based on individual response. All vi…

This study tests whether a non-invasive brain stimulation technique called TMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to specific brain areas involved in craving and self-control. The study enrolls 64 adults aged 22-70 who smoke at l…

This study looks at whether giving smokers who don't want to quit a choice of less harmful nicotine products (like e-cigarettes or nicotine pouches) can help them smoke less or stop entirely. About 472 adult smokers will be randomly assigned to try either a harm-reduction product…

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes, their cravings, and physical reactions like heart rate and blood pressure. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and can…

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, affect brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers aged 21-60 will take part, but they won't try to quit or take the medications long-term. Th…

This study looks at what happens to inflammation in the body when menthol cigarette smokers switch to non-menthol cigarettes. Researchers want to see if this change could lower the risk of heart disease. About 68 adults who smoke menthol cigarettes daily will be followed for seve…

This study tests how smokers might change their buying habits when faced with different tax plans on regular and low-nicotine cigarettes. About 316 daily smokers will shop in a virtual store to see which products they choose. The goal is to find out which tax approach could best …

This study looks at what happens when smokers relight cigarettes instead of smoking them all at once. Researchers will measure chemicals in the smoke and how people puff. The goal is to see if relit cigarettes produce more harmful substances. The study involves 30 smokers who alr…

This study looks at how very-low-nicotine cigarettes and different prices for e-cigarettes and illegal cigarettes change what smokers buy in a simulated online store. About 70 adult smokers will take part. The goal is to understand how these rules might affect illegal product use…

This study looks at whether the flavor of e-cigarettes (fruit, tobacco, or menthol) helps people who smoke regular cigarettes switch to e-cigarettes. About 210 smokers who have tried to quit before will use flavored e-cigarettes for six weeks. Researchers will track how many ciga…