Fruity vs. tobacco: which E-Cig flavor gets smokers to quit?

NCT ID NCT06264154

Recruiting now Knowledge-focused Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. 210 smokers who have tried to quit before will use fruit, tobacco, or menthol flavored e-cigarettes for 6 weeks. Researchers will track how many cigarettes they smoke and how satisfying the flavors feel.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: e-cigarettes with flavored nicotine pods (fruit, tobacco, or menthol)
What this could lead to: If successful, this could show which e-cigarette flavors make it easier for smokers to switch away from combustible cigarettes, potentially informing public health strategies.
What could go wrong: This is an early-stage observational study, not a treatment trial. Results may not apply to all smokers, and long-term health effects of e-cigarettes are still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence Smoking Tobacco Use Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKING E-CIG USE SMOKING TOBACCO USE

Contacts and locations

Locations

University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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