TOBACCO USE

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study looks at whether switching to e-cigarettes (nicotine vapes) can help people who smoke and are in treatment for substance use disorder quit cigarettes. About 240 participants will either use e-cigarettes or FDA-approved nicotine patches and lozenges. The study lasts 6 m…

This study tests a harm reduction approach for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to reduce smoking-relat…

This study compares e-cigarettes and oral nicotine pouches to see which helps smokers reduce cigarette use. 200 adult smokers who have tried quitting before will switch to one of these products for 6 weeks. Researchers will measure how many cigarettes they smoke and track health …

This study tests two counseling approaches—Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement—to help people on methadone treatment quit smoking and reduce use of opioids and other drugs. Researchers will enroll 420 adults who are on methadone and smoke cigar…

This study tests a program to help homeless people stop smoking. It offers coaching sessions and nicotine replacement therapy (like patches) to 150 adults in San Francisco and Los Angeles. The goal is to see if this support helps them quit and stay smoke-free for at least 6 month…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke will get either standard quit-smoking support or extra reminders and encouragement. The goal is to see which approach gets more people to use quit-smoking tools like…

This study is testing whether a compound from cannabis called cannabidiol (CBD) can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take oral CBD during practice quit attempts. The goal is to see if CBD increases short-…

This study looks at whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in daily smokers who have chronic pain and are being treated for opioid use disorder with buprenorphine. About 60 participants will be randomly assigned to either very …

This study tests whether a non-invasive brain stimulation technique called TMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to specific brain areas involved in craving and self-control. The study enrolls 64 adults aged 22-70 who smoke at l…

This study looks at whether giving smokers who don't want to quit a choice of less harmful nicotine products (like e-cigarettes or nicotine pouches) can help them smoke less or stop entirely. About 472 adult smokers will be randomly assigned to try either a harm-reduction product…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing. The goal is to find better ways to help people with chronic pain quit smoking. About 132 sm…

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes, their cravings, and physical reactions like heart rate and blood pressure. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and can…

This study looks at whether a simple indoor air quality monitor can help cancer patients who smoke keep their homes smoke-free. Ten patients from Memorial Sloan Kettering's Tobacco Treatment Program will use the device for two weeks and attend workshops. The goal is to see if thi…

This study looks at how smoking little cigars affects oxidative stress (a type of cell damage) compared to regular cigarettes. Fifty daily smokers will try three different smoking options: a high-oxidant little cigar, a low-oxidant little cigar, and their usual cigarette. Researc…

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes, their cravings, and physical reactions like heart rate. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. Th…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 adults who regularly use both substances. The goal is to understand the combined health effects and inform public health policie…

This study looks at what happens when smokers relight cigarettes instead of smoking them all at once. Researchers will measure chemicals in the smoke and how people puff. The goal is to see if relit cigarettes produce more harmful substances. The study involves 30 smokers who alr…

This study looks at brain activity to understand why people who try to quit smoking often start again. Researchers will use MRI scans to watch changes in the brain right before a person smokes. The goal is to find patterns that could help predict and prevent relapse. About 150 ad…

This study looks at how very low nicotine cigarettes change heart rate and heart rate variability in people who smoke daily or occasionally. About 49 adults aged 21 and older who have smoked at least once in the past month will participate. Researchers compare the effects of low-…

This study looks at how likely people are to abuse five new oral nicotine products. Researchers will measure cravings and nicotine levels in 40 healthy smokers after they use the products. The goal is to understand the products' addiction potential, not to treat any disease.

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate what might happen if certain flavor…

This study looks at whether the flavor of e-cigarettes (fruit, tobacco, or menthol) helps people who smoke regular cigarettes switch to e-cigarettes. About 210 smokers who have tried to quit before will use flavored e-cigarettes for six weeks. Researchers will track how many ciga…